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UrduResearchers from the University of Georgia have discovered a potential treatment for Chagas disease, marking the first medication with promise to successfully and safely target the parasitic infection in more than 50 years. Human clinical trials of the drug, an antiparasitic compound known as AN15368, will hopefully begin in the next few years.
Tag: Treatment
Mood Influences Alcohol Craving Differently in Men and Women, Pointing the Way to Alcohol Use Disorder Treatments Tailored by Sex
Drinkers’ mood shifts and exposure to alcohol-related cues — beer cans, bars, and drinking buddies — contribute to alcohol cravings in opposite ways for men and women, a new study suggests. The findings have implications for how men and women develop dangerous drinking habits and ways that this might be prevented or treated. Various theories link alcohol use to positive and negative emotions: drinking to either enhance good mood or cope with stress, potentially becoming a self-reinforcing cycle. Studies have yielded mixed findings, however, suggesting that mood interacts with subconscious cognitive processes to prompt alcohol-seeking.
Mangosteen Peel as Medicine – CU’s Faculty of Veterinary Science is Successful in Replicating Mangosteen Peel Extract! Treatment for Intestinal Inflammation in Humans and Animals
The Faculty of Veterinary Science, Chulalongkorn University has researched and replicated “hydroxy-xanthones”, the vital extracts rich in antioxidants found in mangosteen peels that kill germs and halt infections in the intestinal mucosa. It hopes to expand to include health products for humans and animals in the future.
Artificial Intelligence Edges Closer to the Clinic
TransMED analyzes patient data from similar diseases across multiple sources to understand COVID-19 patient outcome risk factors.
FINDING THE RIGHT TREATMENTS FOR GENETIC HAIR LOSS
Hereditary hair loss, also known as androgenetic alopecia or pattern hair loss, is the most common form of hair loss in both men and women, affecting millions of people worldwide.
DMIND Application for Screening Depression – An AI Innovation from CU Faculties of Medicine and Engineering Researchers
Introducing a new dimension for consultations with those suffering from depression by the Department of Mental Health and the DMIND AI Innovation from Chula’s Faculties of Medicine and Engineering that provides screening for depression through the Mor Prom Application with greater accuracy, accessibility, and convenience thus reducing the burdens on medical practitioners and psychologists in taking care of patients with depression.
First Mutation-Targeted Bladder Cancer Drug May Be Under-Used
The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a JAMA Oncology study led by the University of Pennsylvania. Researchers analyzed a large, nationwide database of cancer cases and found that bladder cancer patients potentially eligible for erdafitinib (Balversa) treatment, fewer than half had a record of being tested for the relevant gene mutation. Of those who were tested and found to have the mutation, fewer than half received the treatment.
CU Innovation Center for Veterinary Clinical Training Provides Simulated Training to Hone Students’ Skills before They Give Real Treatment
Chula opens a state-of-the-art innovation center for veterinary students to practice their clinical skills with a simulated and modern lab classroom to hone students’ skills and develop their expertise and a space for international training to promote veterinary and medical education.
Study Finds Treat-to-Target ULT Strategy Manages Gout Effectively and Safely with No Cardiovascular Toxicity
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that allopurinol and febuxostat may effectively lower urate levels when used in a treat-to-target approach. Importantly, both urate-lowering therapies were very effective with 90% of patients reaching target urate levels. Additionally, both appeared safe, with no evidence of increased cardiovascular toxicity.
IU study illustrates the need to treat smoking and mental health problems together
IU study illustrates the need to treat mental health problems and smoking together.
Stress-relief Music Therapy Can Also Effectively Relieve Pain
Medical results show that music therapy can lower blood pressure, relieve pain during chemotherapy and dialysis, as well as stimulate the elderly brain. The Faculty of Fine and Applied Arts, Chulalongkorn University is offering a Music Therapy Program aiming to heal the ever-increasing patients with various chronic diseases in society.
Researchers explore promising treatment for MRSA ‘superbug’
A new Cornell study has found the antimicrobial properties of certain stem cell proteins could offer a potential treatment to reduce infection in skin wounds.
Innovative techniques help treat boy’s rare condition
Several innovative, minimally invasive techniques used over the past 12 months to improve Carter’s health — including a first-of-its-kind procedure performed in the United States — means he can finally go home.
Researchers speed identification of DNA regions that regulate gene expression
St. Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology—identifying the genetic ‘switches’ that regulate gene expression.
Chula Unveils World-Class Innovative Prosthesis Made by Thais
April 9, 2021 – Chula holds the 4th CHULA the Impact Seminar entitled “World–Class Innovative Prosthesis Made by Thais” showcasing the capabilities of Chula researchers from Chula Engineering Enterprises
Three-Drug Therapy for Most Common Genetic Cause of Cystic Fibrosis Found Safe and Effective in 6-11-Year-Olds
An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children’s Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least one copy of F508del mutation in the CFTR gene, which is estimated to represent almost 90 percent of the cystic fibrosis population in the United States.
Chula Develops a Proven Formula to Combat Hair Loss and Baldness from Mangrove Trees
Chula’s Faculty of Pharmaceutical Science has developed its very own “Mangrove–Tree (Samae–Talay) extract treatment for hair loss and baldness problem” which received the Innovation Award 2021 in Chemical Science and Pharmacy (Very Good Level) from the National Research Council of Thailand (NRCT), and is expected to hit the market this year.
Peginterferon-lambda shows strong antiviral action to accelerate clearance of COVID-19
A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year.
New immunotherapy combination shows great promise for lung cancer, McMaster researchers find
Researchers at Canada’s McMaster University have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer.
Potential New Therapies for Alzheimer’s Disease are Revealed through Network Modeling of Its Complex Molecular Interactions
Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease.
Smartphone Use Offers Tool to Treat MS, Other Diseases
Monitoring how patients with multiple sclerosis or other degenerative diseases use their smartphones could provide valuable information to help get them better treatment. In the journal Chaos, researchers used an app to record the keystroke dynamics of a control group and those of subjects in various stages of MS treatment. In doing so, they observed changes in the way people with MS typed that were not seen in subjects who did not have the disease.
ACTG Presents Data Showing Minimal Monitoring Approach to Hepatitis C Treatment is Safe and Successful at AASLD’s 2020 Liver Meeting
Study finds that in a diverse, global patient population, a minimal monitoring (MINMON) approach to hepatitis C treatment was safe and achieved comparable sustained virologic response (SVR) to current standard of care.
Stronger treatments could cure Chagas disease
Researchers have found that a more intensive, less frequent drug regimen with currently available therapeutics could cure the infection that causes Chagas disease
2020 Dickson Prize in Medicine Awarded to Pioneer Researcher in Synthetic Biology
James J. Collins, Ph.D., an innovator in synthetic biology whose ideas have contributed to novel diagnostics and treatments targeting infections and complex diseases, has been awarded the 2020 Dickson Prize in Medicine, the University of Pittsburgh School of Medicine’s highest honor.
Mount Sinai Researchers Discover Treatment Option for Rare Genetic Disorder
Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of—and a treatment for—a previously unknown severe auto inflammatory syndrome affecting an 18-year-old girl since infancy.
Researchers Identify Distinct Subtypes of Polycystic Ovary Syndrome With Novel Genetic Associations
Mount Sinai researchers have for the first time identified reproductive and metabolic subtypes of polycystic ovary syndrome (PCOS) that are associated with novel gene regions.
FDA Approves First At-Home Saliva Collection Test for Coronavirus
Rutgers’ RUCDR Infinite Biologics received an amended emergency use authorization from the FDA late Thursday for the first SARS-CoV-2 coronavirus test that will allow people to collect their own saliva at home and send to a lab for results. The decision follows the FDA’s recent emergency approval to RUCDR Infinite Biologics for the first saliva-based test, which involves health care workers collecting saliva from individuals at testing sites.
Supportive Oncodermatology Interventions Improve Patient Quality of Life
A recent survey from the GW Cancer Center found that enrollment in a supportive oncodermatology program is associated with a significantly improved quality of life score. The results are published in the Journal of Drugs in Dermatology.
University of Miami Health System to Offer Convalescent Plasma with COVID-19 Antibodies for Seriously Ill Patients
A new initiative by infectious disease experts and researchers with the University of Miami Health System offers convalescent plasma with COVID-19 antibodies as a treatment for patients who are seriously ill from the coronavirus infection or at serious risk of…
Potential new HIV treatment could mean once-a-year injection
The advance has the potential to eliminate complications that arise from missing doses of life-saving medicines, according to the study published today in Nature Materials, a leading peer-reviewed biomedical research journal.
Mount Sinai Researchers Collaborate with GenScript to Develop a COVID-19 Antibody to Treat Sick Patients
The highly targeted antibody may block the coronaviruses’ ability to enter human lung cells
Rutgers, University Hospital Lead Way in Treating COVID-19 with Convalescent Plasma from Recovered Patients
Rutgers physicians and University Hospital are leading the way in using blood plasma from patients who recovered from COVID-19 to treat new patients who are severely ill with COVID-19 infections.
Researchers use live virus to identify 30 existing drugs that could treat COVID-19
Scientists at Sanford Burnham Prebys Medical Discovery Institute, the University of Hong Kong, Scripps Research, UC San Diego School of Medicine, the Icahn School of Medicine at Mount Sinai and UCLA have identified 30 existing drugs that stop the replication of SARS-CoV-2, the virus that causes COVID-19. The study was placed on bioRxiv (pronounced “bio-Archive”), an open-access distribution service for preprints of life science research.
Compound in Fruit Peels Halts Damage and Spurs Neuronal Repair in Multiple Sclerosis
Ursolic acid, abundant in fruit peels and some herbs, both prevents and repairs neurons in animal models of multiple sclerosis.
Rutgers Launches Genetic Testing Service for New Coronavirus
Rutgers’ RUCDR Infinite Biologics has launched a test for the SARS-CoV-2 coronavirus and is using its automation experience and infrastructure to test as many as tens of thousands of samples daily. RUCDR has also submitted an emergency use authorization request for a saliva collection method that will allow for broader population screening.
UC Davis launches two clinical studies to treat COVID-19
UC Davis Health has two clinical trials underway for hospitalized patients with severe COVID-19, the disease caused by the novel coronavirus, SARS-CoV-2.
Five language outcome measures evaluated for intellectual disabilities studies
Expressive language sampling yielded five language-related outcome measures that may be useful for treatment studies in intellectual disabilities, especially fragile X syndrome. The measures were generally valid and reliable across the range of ages, IQs and autism symptom severity of participants. According to the study, led by UC Davis researchers and funded by NIH, the measures are also functional in supporting treatments that can improve language, providing far reaching benefits for individuals with intellectual disabilities.
COVID-19 Appears Less Severe in Children, Says Review in Pediatric Infectious Disease Journal
As outbreaks of COVID-19 disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue worldwide, there’s reassuring evidence that children have fewer symptoms and less severe disease. That’s among the insights provided by an expert review in The Pediatric Infectious Disease Journal, the official journal of The European Society for Paediatric Infectious Diseases. The journal is published in the Lippincott portfolio by Wolters Kluwer.
COVID-19 Appears Less Severe in Children, Says Review in Pediatric Infectious Disease Journal
As outbreaks of COVID-19 disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue worldwide, there’s reassuring evidence that children have fewer symptoms and less severe disease. That’s among the insights provided by an expert review in The Pediatric Infectious Disease Journal, the official journal of The European Society for Paediatric Infectious Diseases. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Mount Sinai and Harbour BioMed Collaborate to Advance Novel Biotherapies for the Treatment of Cancer and Coronavirus COVID-19
Collaboration combines Harbour BioMed’s proprietary H2L2 Harbour Mice® platform for fully human monoclonal antibody generation with Mount Sinai’s translational medical research expertise.
Investigational Drug for People with Treatment-Resistant Epilepsy
Imagine not being able to drive, shower alone or even work because you are never quite sure when the next seizure will leave you incapacitated. Hope may be on the horizon for epilepsy patients who have had limited success with seizure drugs. In a study, led by a Johns Hopkins lead investigator, of 437 patients across 107 institutions in 16 countries, researchers found that the investigational drug cenobamate reduced seizures 55% on the two highest doses of this medication that were tested over the entire treatment period.
Mount Sinai Researcher’s Examine the Metabolic Effects of an Oral Blood Cancer Drug
Recent study found that an effective blood cancer treatment was associated with weight gain, obesity, and increased systolic blood pressure
Better Biosensor Technology Created for Stem Cells
A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons), according to a study in the journal Nano Letters.
Artificial Pancreas System Better Controls Blood Glucose Levels than Current Technology
Study based at the Icahn School of Medicine at Mount Sinai and other centers finds new system has safety, efficacy benefits for people with type 1 diabetes
Young adults not seeking treatment for substance use disorders
A growing number of young adults are dealing with a substance use disorder – in some cases, multiple substance use disorders – and not seeking help, according to a study led by an Iowa State University researcher. The results show two in every five young adults reported a past-year SUD.
Moderate to Heavy Drinking During Pregnancy Alters Genes in Newborns, Mothers
Mothers who drink moderate to high levels of alcohol during pregnancy may be changing their babies’ DNA, according to a Rutgers-led study.