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UrduResults of pancreas transplantation continue to improve and up to 90% of recipients with diabetes enjoy freedom from both insulin therapy and the need for close glucose monitoring following the procedure, according to a new paper published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Tag: Insulin
Alzheimer’s Association Awards Grant to Wake Forest University School of Medicine for Alzheimer’s Research
The Alzheimer’s Association, through its Part the Cloud global research grant program, has awarded Wake Forest University School of Medicine $795,000 over two years to study potential treatments for Alzheimer’s disease.
UCI-led study shows Rhodiola rosea root might be beneficial for managing type 2 diabetes
A team of researchers led by the University of California, Irvine has discovered that treatment with an extract from the roots of the Rhodiola rosea plant might be effective for helping manage type 2 diabetes, showing promise as a safe and effective non-pharmaceutical alternative. The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola rosea lowered fasting blood sugar levels, improved response to insulin injections, modulated the composition of bacteria in the gastrointestinal tract and decreased several biomarkers of inflammation.
Endocrine Society celebrates passage of historic insulin affordability measure
The Endocrine Society cheered the Senate’s passage of the Inflation Reduction Act, including meaningful measures to make insulin more affordable.
Study Reverses Long-Held Ideas About Relationship Among Diabetes, Fat and Cardiovascular Disease
In a paper published in Circulation Research, scientists describe a series of studies designed to determine the relationship among insulin, fats and the vascular system.
Vitamin B5 May Help Weight Loss by Turning on Brown Fat
Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.
Gut microbe peptide implicated in triggering type 1 diabetes
Researchers have identified a species of human gut bacterium that makes a protein containing a sequence of amino acids that mimics the insulin peptide targeted by the immune system in type 1 diabetes.
Hormone Infusion Improves Pancreatic Insulin Production in Cystic Fibrosis Patients with or at Risk for Diabetes
Medication therapy based on the hormone glucagon-like peptide-1(GLP-1) may help regulate natural insulin production in cystic fibrosis, potentially offering a better way to prevent and ultimately manage diabetes than daily insulin injections
Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find
Researchers report that exposure to cold temperatures resolved obesity-induced inflammation while improving insulin sensitivity and glucose tolerance in diet-induced obese mice.
Endocrine Society urges Congress to pass bill to make insulin more affordable for people with diabetes
The Endocrine Society announces its endorsement of the bipartisan insulin bill introduced by Sens. Jeanne Shaheen (D-NH) and Susan Collins (R-ME) that would take steps to reduce out-of-pocket costs of insulin, the escalating price of insulin, and formulary management for people with diabetes.
Helping the body make more insulin
Aresearch team is testing a protein block to suppress specific cells of the body’s immune system contribute to developing type 1 diabetes. If successful, the drug would diminish autoimmunity, preserving the body’s ability to naturally produce more insulin, the researchers said.
Increased fracture risk in patients using insulin compared to metformin
Patients with type 2 diabetes have an increased risk for fractures, despite their normal-to-high bone mineral density, according to research being presented Saturday, June 11 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
Key Protein Identified for Brain Stem Cell Longevity
A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders.
High Blood Insulin Levels Lead to More Nervous System Activity in Muscles
Article title: Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans Authors: Neil J. McMillan, Rogerio N. Soares, Jennifer L. Harper, Brian Shariffi, Alfonso Moreno-Cabañas, Timothy B. Curry, Camila Manrique-Acevedo, Jaume Padilla, Jacqueline K. Limberg…
Insulin spray improved gait, cognitive function in patients with and without type 2 diabetes, clinical trial shows
Scientists have assessed the long-term effects of intranasal insulin on cognition and on gait in people with and without type 2 diabetes mellitus.
Endocrine Society celebrates House passage of Build Back Better Act
The Endocrine Society hailed the House of Representatives for including provisions to improve insulin affordability in its version of the Build Back Better Act.
Physiologists Celebrate 100 Years of Insulin
This year marks 100 years since physiologists discovered insulin. The lifesaving drug has given millions of people with diabetes worldwide a second chance at life.
Physiologists Celebrate 100 Years of Insulin
This year marks 100 years since physiologists discovered insulin. The lifesaving drug has given millions of people with diabetes worldwide a second chance at life. APS is making available several of the leading experts in the field of endocrinology to…
Lowering blood insulin levels could lower your risk of getting COVID-19
Keeping blood insulin levels within strict, healthy parameters is a daily goal for people with diabetes.
A Cure for Diabetes?
Technion researchers are working on a novel treatment approach for treating type 2 diabetes using an autograft of muscle cells engineered to take in sugar at increased rates. Mice treated in this manner displayed normal blood sugar levels for months after a single procedure.
$6M NIH Grant Launches UC San Diego Consortium to Study Insulin-Producing Cells
UC San Diego School of Medicine researchers will receive $6.4 million in National Institutes of Health grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas.
Diabetes experts available to discuss 100 years of insulin
2021 marks the centennial of the discovery of insulin at the University of Toronto. Drs. William Rostène and Pierre De Meyts just published an article that explores the history of insulin, and they are both available to discuss the importance of…
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Lifestyle Interventions to Reduce Blood Sugar: Don’t Forget Resistance Exercise
In the past 30 years, prediabetes (elevated fasting or post-meal blood sugar below the levels required for diagnosis of type 2 diabetes) has grown into a major epidemic affecting nearly one in three adults. Previous studies have shown that combining…
Endocrine Society calls on Congress to pass legislation to lower the price of insulin
The Endocrine Society is calling on Congress to pass legislation to lower the price of insulin and applauds the efforts of Energy and Commerce Committee Chairman Frank Pallone Jr. (D-NJ), Ways and Means Committee Chairman Richard E. Neal (D-MA), and Education and Labor Committee Chairman Robert C. “Bobby” Scott (D-VA) to reintroduce H.R. 3, the Elijah E. Cummings Lower Drug Costs Now Act to improve access to affordable medications. In January, the Society published a position statement on insulin access and affordability, which recommends policymakers include government negotiation as part of an overall strategy to reduce insulin prices.
Once-A-Week Insulin Treatment Could Be Game-Changing For Patients With Diabetes
DALLAS – April 19, 2021 – Treating people with Type 2 diabetes with a new once-a-week injectable insulin therapy proved to be safe and as effective as daily insulin injections, according to the results of two international clinical trials published online today in Diabetes Care. The studies suggest that the once-weekly treatment could provide a convenient alternative to the burden of daily insulin shots for diabetes patients.
Experts mark the centennial anniversary of the discovery of insulin by highlighting the critical role adipose tissue has played in understanding insulin’s control of metabolism.
2021 marks 100 years since researchers identified insulin, a hormone produced by the pancreas that regulates the amount of glucose, or sugar, in the blood. Soon after, insulin was shown to be effective in lowering blood glucose in humans with…
Weekly insulin helps patients with type 2 diabetes achieve similar blood sugar control to daily insulin
A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results, which will be presented at ENDO 2021, the Endocrine Society’s annual meeting, compared an investigational drug called basal insulin Fc (BIF) with insulin degludec, a commercially available long-lasting daily insulin, in patients with type 2 diabetes.
USDA grant seeks to enhance milk production and cow health
An animal scientist studying relationships between insulin and milk production in dairy cows has received a three-year, $500,000 grant from the U.S. Department of Agriculture National Institute of Food and Agriculture.
Experimental Treatment Appears to Subdue Type 1 Diabetes in Laboratory Mice
An experimental treatment can essentially reverse type 1 diabetes in certain types of laboratory mice, according to a series of studies led by University of Utah Health scientists. An injection of the therapeutic agent converts cells that normally control glucose production into ones that generate insulin.
Endocrine Society recommends government negotiation and other policies to lower out-of-pocket costs for people with diabetes
The Endocrine Society is calling on policymakers to include government negotiation as part of an overall strategy to reduce insulin prices in its updated position statement published today in The Journal of Clinical Endocrinology & Metabolism.
Study connects diabetes, air pollution to interstitial lung disease
A new study published in the Environmental Health Perspectives connects insulin resistance and repetitive ozone exposure to the development of interstitial lung disease.
Raising Awareness During Diabetes Awareness Month – Adult and Pediatric Diabetes Experts Available
More than 34 million people in the U.S, or 10.5% of the population, have diabetes, according to the Centers for Disease Control and Prevention. And as many as 7 million more Americans have the disease and don’t know it. Diabetes is the seventh-leading cause of death in the country..
Breastfeeding’s Legacy May Protect Against Diabetes
DALLAS – Aug. 25, 2020 – Breastfeeding secures delivery of sugar and fat for milk production by changing the insulin sensitivity of organs that supply or demand these nutrients, a new study led by UT Southwestern scientists suggests. The findings, published in this month’s print issue of Diabetes, could explain how different tissues cooperate to start and maintain lactation and offer strategies to help improve breastfeeding success for mothers who have insufficient milk production.
Researchers discover sex-specific differences in neural mechanisms for glucose regulation
Researchers from Tufts have discovered neural mechanisms in mice specific to females that switch estrogen from playing a protective role in glucose metabolism to a disruptive role. The discovery could provide clues to the increased risk of insulin resistance and diabetes among post-menopausal women.
Insulin Cost-Sharing Caps May Help Kids, Young Adults With Type 1 Diabetes
Although additional policies are needed to relieve insulin’s financial burden, researchers find a national cost-sharing cap helps privately insured children and young adults with type 1 diabetes pay less out-of-pocket.
Gene in Fat Plays Key Role in Insulin Resistance
DALLAS – July 23, 2020 – Deleting a key gene in mice in just their fat made tissues throughout these animals insulin resistant, in addition to other effects, a new study by UT Southwestern researchers shows. The findings, reported in a recent issue of PNAS, could shed light on Type 2 diabetes and other insulin resistance disorders, which remain poorly understood despite decades of study.
Sorting and secreting insulin by expiration date
The age of insulin parcels may matter, researchers say, when it comes to diagnosing and treating diabetes.
2020 Warren Alpert Prize Recognizes Seminal Discoveries in Metabolism
The 2020 Warren Alpert Foundation Prize has been awarded to a trio of researchers for seminal discoveries about the function of key intestinal hormones, their effects on metabolism and the subsequent design of treatments for type 2 diabetes, obesity and short bowel syndrome.
Sea Snail, Human Insulin Hybrid Could Lead to Better Diabetes Treatments Sea Snail, Human Insulin Hybrid Could Lead to Better Diabetes Treatments Sea Snail, Human Insulin Hybrid Could Lead to Better Diabetes Treatments Sea Snail, Human Insul
Nearly a century after insulin was discovered, an international team of researchers including University of Utah Health scientists report that they have developed the world’s smallest, fully functional version of the hormone, one that combines the potency of human insulin with the fast-acting potential of a venom insulin produced by predatory cone snails. The finding, based on animal studies, could jumpstart the development of insulin treatments capable of improving the lives of those with diabetes.
Diabetes reversed in mice with genetically edited stem cells derived from patients
Researchers at Washington University School of Medicine in St. Louis have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.
Wearable delivery device allows patients with type 2 diabetes to safely use more affordable insulin option
Adults with type 2 diabetes requiring insulin therapy can safely achieve good blood sugar control using regular human insulin (RHI) in a wearable, patch-like insulin delivery device called V-Go®, a new study finds. Results of the randomized controlled study—which was accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting, and will be published in a special supplemental section of the Journal of the Endocrine Society—suggest “a more affordable option” for insulin therapy than newer insulin types, the researchers said.
Diabetes care reaches new heights as drone delivers insulin for patient
The international medical team that accomplished the world’s first documented drone delivery of insulin for a patient living in a remote community described the project in an ENDO 2020 abstract that will be published in the Journal of the Endocrine Society.
Deleting a gene prevents Type 1 diabetes in mice by disguising insulin-producing cells
Removing a gene from the cells that produce insulin prevents mice from developing Type 1 diabetes by sparing the cells an attack from their own immune system, a new UW–Madison study shows.
Hohe Insulinkosten sind für Diabetespatienten lebensbedrohlich
Die am häufigsten verwendeten Formen von Insulin kosten in den USA 10-mal mehr als in jedem anderen Industrieland, wie aus einem Kommentar in Mayo Clinic Proceedings hervorgeht.
High cost of insulin has life-or-death implications for diabetic patients
The most commonly used forms of insulin cost 10 times more in the U.S. than in any other developed country, according to a commentary in Mayo Clinic Proceedings. This prohibitive cost is causing some U.S. patients with Type 1 diabetes to ration the amount of insulin they use, with life-threatening implications.
Researchers discover a new way in which insulin interacts with its receptor
The biological actions of insulin are mediated by its receptor—the insulin receptor—which is localized on the cell surface. In a new study, researchers from Germany, Canada, and Finland show how insulin interacts with its receptor at a second binding site. The scientists hope that these new details concerning insulin–receptor interactions will ultimately expand the current models of insulin binding to its receptor and pave the way towards new approaches to structure-based drug design.
Researchers engineer insulin-producing cells activated by light for diabetes
Researchers have transplanted engineered pancreatic beta cells into diabetic mice, then caused the cells to produce more than two to three times the typical level of insulin by exposing them to light. The light-switchable cells are designed to compensate for the lower insulin production or reduced insulin response found in diabetic individuals.
Artificial Pancreas System Better Controls Blood Glucose Levels than Current Technology
Study based at the Icahn School of Medicine at Mount Sinai and other centers finds new system has safety, efficacy benefits for people with type 1 diabetes
Rising Insulin Costs Forcing Families with Diabetes to Forego Basic Needs – @UofUHealth @uofunursing Expert Available
New research by Michelle Litchman, Ph.D., FNP-BC, an assistant professor at the University of Utah College of Nursing is showing just how bad that rising out of pocket costs and deductibles, along with escalating costs of diabetes medications and supplies,…