MD Anderson Research Highlights for October 4, 2023

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include a computer game that helps breast cancer survivors improve symptoms of peripheral neuropathy, a publicly available single-cell atlas of CD19 chimeric antigen receptor (CAR) T cells, new targets for TP53-mutant acute myeloid leukemia (AML), a preclinical target for preventing chemobrain, a blood test to help identify patients at higher risk of developing pancreatic cancer, and genomic insights to predict the risk of outcomes in patients with bone cancer.

Shorter course of radiation therapy is safe for patients with early-stage breast cancer who have undergone mastectomy and reconstruction

Researchers at Dana-Farber Brigham Cancer Center have found that a shorter course of radiation therapy after mastectomy and breast reconstruction surgery provides the same protection against breast cancer recurrence and equivalent physical side-effects but substantially reduces life disruption and financial burden for patients.

Short-course radiation as effective as standard treatment for patients who opt for breast reconstruction after mastectomy

In a first-of-its-kind study, people with breast cancer who underwent implant-based breast reconstruction immediately following a mastectomy reported that getting fewer, higher doses of radiation was just as effective as standard radiation, did not increase side effects and saved them time and money.

Palex and Inbiomotion introduce pioneering test to aid oncologists in predicting recurrence and survival rates in breast cancer patients

Spain is the first country in the world to have this technology
• Results showing the clinical utility of the test were published in
Lancet Oncology and the Journal of National Cancer Institute
• The test is now available to oncologists and pathologists and will
benefit an estimated 24,000 patients each year in Spain

Researchers at Case Western Reserve, University Hospitals to assess effectiveness of novel MRI method for breast cancer patients

Researchers at Case Western Reserve University
(CWRU) and University Hospitals (UH) will study whether a new magnetic resonance imaging exam can predict how chemotherapy’s effectiveness for a woman with breast cancer based on a single round of treatment.

Living Beyond Breast Cancer Provides Expert Patient Perspectives during Breast Cancer Awareness Month

This fall, Living Beyond Breast cancer, the national patient information and support organization, is providing expert patient perspectives on patients living with breast cancer. Connect with members of the LBBC community to discuss living with breast cancer, racial equity in breast cancer health, and body image and reconstruction.

Study Unlocks New Insight about Breast Cancer Risk

A new study led by a researcher at New York Institute of Technology provides insight that could change how scientists and clinicians understand genetic predisposition to breast cancer, a condition that affects one in eight U.S. women in her lifetime.

Cancer screenings have saved the U.S. at least $6.5 trillion, study estimates

Americans have gotten at least 12 million more years of life to live because of preventive cancer screenings they’ve gotten the past 25 years, a new study estimates. That adds up to at least $6.5 trillion in added economic impact, because of scans and tests that look for early signs of breast, colon, cervical and lung cancer in adults at the highest risk.

Breast cancer overdiagnosis common among older women

A study of more than 50,000 women found that continued breast cancer screening after age 70 was associated with a greater incidence of cancer that likely would not have caused symptoms in the patient’s lifetime. These findings suggest that overdiagnosis may be common among older women who are diagnosed with breast cancer after screening. The study is published in Annals of Internal Medicine.

MD Anderson Research Highlights for August 2, 2023

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

Recent developments include a novel biomarker that may predict the aggressiveness of pancreatic cancer precursors, insights into the structure and function of a breast and ovarian cancer susceptibility gene, a new approach to overcoming treatment resistance in ovarian cancer, distinguishing features of young-onset rectal cancer, a biomarker and potential target for metastatic lung cancer, machine learning models to better predict outcomes of patients with mantle cell lymphoma (MCL), and a promising therapy for patients with relapsed/refractory MCL.

Study Uncovers Barriers to Mammography Screening Among Black Women

The study finds utilization of annual screening mammograms suboptimal among low-income Black women with several reported perceived and actual barriers. Most had a low breast cancer risk perception. Interestingly, participants perceived mammograms as very beneficial: 80 percent believed that ‘if breast cancer is found early, it’s likely that the cancer can be successfully treated;’ 90 percent indicated that ‘having a mammogram could help find breast cancer when it is first getting started.’

Susan G. Komen® Commends Introduction of Legislation to Remove Financial Barriers to Diagnostic Imaging

Susan G. Komen commends commends the introduction of the Access to Breast Cancer Diagnosis (ABCD) Act of 2023 in the U.S. House of Representatives and the U.S. Senate. The legislation would remove a significant financial barrier to people receiving medically necessary diagnostic and supplemental breast imaging.

MD Anderson Research Highlights for July 19, 2023

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

Sylvester Researchers, Collaborators Seek Answers to Prostate, Breast Cancer Among People of African Ancestry

Cancer Disparities: A new African Cancer Genome Registry at Sylvester Comprehensive Cancer Center in Miami seeks to find reasons for higher prostate and breast cancer rates in people of African ancestry. Dr. Sophia George, co-principal investigator, is available for interviews, as are two breast and prostate cancer study participants.

June Tip Sheet from Sylvester Comprehensive Cancer Center

A world-renowned biochemist joins the Sylvester Cancer team, a global health leader strives to ensure more equitable cancer care, a recent study identifies disparities in federal cancer research funding, new targeted therapies for thyroid and other cancers are making surgery a secondary option for many patients, efforts to preserve women’s sexual health while they receive endocrine therapy for breast cancer, and more are highlighted in this month’s tip sheet from Sylvester Comprehensive Cancer Center.

Race and Ethnicity Affect 21-Gene Recurrence Score, Overall Survival in Women with ER+ Breast Cancer

An observational cohort study out of Roswell Park Comprehensive Cancer Center demonstrates that race and ethnicity affect a woman’s 21-gene recurrence score, a tool used to determine risk of recurrence and distant metastasis in patients with early-stage, hormone-receptor-positive breast cancer. Based on the expression of 21 cancer-related genes detected in pre-treatment tumor specimens, recurrence score is used routinely in clinical care to identify patients who might benefit from chemotherapy as part of their treatment plan. Scores range from 0-100, with a score of 26 or higher indicating greater risk of recurrence and poorer overall survival.

ASCO23: Sylvester Cancer Experts Available for Interviews on a Wide Range of Topics

In addition to presenting Sylvester Comprehensive Cancer Center research findings, Sylvester experts are available at ASCO to share perspectives on a wide variety of topics and studies ranging from breast cancer to sarcoma, prostate cancer, mesothelioma, melanoma, CNS tumors and more.

ASCO: Targeted therapy for early breast cancer, progress treating recurrent glioma, PSMA PET scan advances and more

Physicians and scientists from the UCLA Jonsson Comprehensive Cancer Center will discuss the latest research and clinical trial results on combination therapies for breast cancer, a potential new treatment for patients with recurrent glioma, and advances in PSMA PET guided radiotherapy for patients with prostate cancer, among other topics, at the American Society of Clinical Oncology’s annual meeting.

Breast Cancer Screening in Asian American & Pacific Islander Women in New Jersey

Recently, the United States Preventative Service Task Force released a draft recommendation statement on screening for breast cancer, recommending that all women get screened for breast cancer every other year starting at age 40. Rutgers Cancer Institute expert shares breast cancer data on the AAPI community.

How Breast Cancer Arises

At a glance:

Researchers trace the origin of certain breast cancers to genomic reshuffling — rearrangement of chromosomes — that activates cancer genes and ignites disease.
The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development.
The study shows the sex hormone estrogen — thus far thought to be only a fuel for breast cancer growth — can directly cause tumor-driving genomic rearrangements.

UC San Diego Health Oncologist Addresses New Breast Cancer Screening Guidelines

The U.S. Preventive Services Task Force (USPSTF) has updated mammography screening guidelines for breast cancer detection to every other year beginning at age 40 instead of 50. This recommendation is based on new evidence of a rise in breast cancer…

University Hospitals Portage Medical Center Brings New Healthcare Investments to Community

University Hospitals Portage Medical Center has made a number of recent investments in various areas to better serve patients in the community. Throughout the next few months, the hospital will be opening a new Breast Health Center, renovating its Cath Lab, enhancing women’s health services, and making new improvements in nuclear medicine, imaging, and across its facilities.

Susan G. Komen® Comments on Draft Recommendations to Begin Breast Cancer Screening at Age 40

Susan G. Komen is pleased to see that the USPSTF has taken into account more recent scientific-based evidence and believes women of average risk should begin breast cancer screening at age 40. However, Komen believes screening should be done every year to catch cancer as early as possible when outcomes are generally better and treatment costs less.