Breast Cancer

Primary Care Providers Over-Treat Patients Based on Overestimation of Medical Conditions

Primary care practitioners often over-estimate the likelihood of a patient having a medical condition based on reported symptoms and laboratory test results. Such overestimations can lead to over-diagnosis and overtreatment, according to a recent study conducted by researchers at the University of Maryland School of Medicine (UMSOM) published in JAMA Internal Medicine.

New Breast Imaging Technology at Hackensack Meridian Mountainside Medical Center Delivers Mammograms in 3D and Enhances Delivery of Care

Hackensack Meridian Mountainside Medical Center is advancing the fight against breast cancer with the purchase and installation of MAMMOMAT Revelation, an innovative mammography system designed to overcome barriers to breast cancer detection and ProFound Artificial Intelligence for digital breast tomosynthesis, a deep-learning artificial intelligence software that rapidly and accurate identifies potential malignant lesions.

Therapeutic resistance linked to softer tissue environment in breast cancer

Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells. The study, which will be published April 2 in the Journal of Experimental Medicine (JEM), shows that the softer matrix activates a signaling pathway that promotes the cancer cells’ survival, and suggests that targeting this pathway could enhance the effectiveness of chemo- and radiotherapy in TNBC patients.

Targeting microRNAs could unmask hidden vulnerability in breast cancer stem cells

Researchers in Italy have identified a pair of microRNA molecules that help maintain a population of cancerous stem cells that drive the growth of breast cancers and initiate tumor relapse after treatment. The study, which will be published April 2 in the Journal of Cell Biology (JCB), reveals that targeting these microRNAs makes cancer stem cells more susceptible to some chemotherapies and could potentially improve the prognosis of patients with aggressive forms of breast cancer.