AI Predicts How Patients with Viral Infections, Including COVID-19, Will Fare

UC San Diego School of Medicine researchers discovered gene expression patterns associated with pandemic viral infections, providing a map to help define patients’ immune responses, measure disease severity, predict outcomes and test therapies — for current and future pandemics.

NUS engineers devise novel approach to wirelessly power multiple wearable devices using a single source

Researchers from NUS have come up with a way to use one single device – such as a mobile phone or smart watch – to wirelessly power up to 10 wearables on a user. This novel method uses the human body as a medium for transmitting power. Their system can also harvest unused energy from electronics in a typical home or office environment to power the wearables.

New Study Finds Weight-Loss Surgery Beneficial to Those with Mild to Moderate Obesity

Weight-loss surgery improves or resolves diseases including type 2 diabetes, heart disease and high blood pressure and can lead to significant and durable weight loss for many people, but the operation has largely been restricted to those with severe obesity, which means about 75 to 100 pounds overweight or a body mass index (BMI) of 35 or higher with an obesity-related disease.

Senolíticos reducen síntomas de COVID-19 en estudios preclínicos

Los investigadores de Mayo Clinic y sus colegas de la Universidad de Minnesota demostraron que la COVID-19 exacerba las consecuencias nocivas de las células senescentes en el cuerpo. En estudios preclínicos, los fármacos senolíticos descubiertos en Mayo redujeron considerablemente la inflamación, la enfermedad y la mortalidad debida a la infección por covid en ratones ancianos. Los resultados se publican en la revista Science.

Senolíticos reduzem os sintomas de COVID-19 em estudos pré-clínicos

Os pesquisadores da Mayo Clinic e colegas da Universidade de Minnesota mostraram que o COVID-19 intensifica o impacto prejudicial das células senescentes no corpo. Em estudos pré-clínicos, os medicamentos senolíticos descobertos na Mayo reduziram significativamente a inflamação, a gravidade da doença e a mortalidade da infecção por COVID em camundongos mais velhos. Essas conclusões foram publicadas na revista Science.

الأدوية المحللة للشيخوخة تقلل من أعراض فيروس كورونا المستجد (كوفيد-19) في الدراسات ما قبل السريرية

أظهر باحثو مايو كلينك وزملاؤهم في جامعة مينيسوتا أن فيروس كورونا المستجد (كوفيد-19) يفاقم التأثير الضار للخلايا الشائخة في الجسم. ففي الدراسات ما قبل السريرية، قللت الأدوية المحللة لالشيخوخة التي تم اكتشافها في مايو بشكل كبير من الالتهاب والمرض والوفيات الناجمة عن عَدوى فيروس كورونا المستجد في الفئران الأكبر سنًا. النتائج منشورة في مجلة ساينس.

抗衰老药物在临床前研究中减少COVID-19症状。

妙佑医疗国际(Mayo Clinic)的研究人员和明尼苏达大学的同事表明,COVID-19(2019冠状病毒病)加剧了体内衰老细胞的破坏性影响。在临床前研究中,妙佑医疗国际研发的抗衰老药物显著降低了老年实验鼠因COVID(冠状病毒病)感染引起的炎症、疾病和死亡率。该研究结果已发表在《科学》期刊中。

Study Identifies How COVID-19 Linked to Alzheimer’s Disease-like Cognitive Impairment

A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer’s disease-like dementia. The findings, published in Alzheimer’s Research & Therapy, indicate an overlap between COVID-19 and brain changes common in Alzheimer’s, and may help inform risk management and therapeutic strategies for COVID-19-associated cognitive impairment.

Astronomy Meets Pathology to Identify Predictive Biomarkers for Cancer Immunotherapy

Pairing sky-mapping algorithms with advanced immunofluorescence imaging of cancer biopsies, researchers at The Mark Foundation Center for Advanced Genomics and Imaging at Johns Hopkins University and the Bloomberg~Kimmel Institute for Cancer Immunotherapy developed a robust platform to guide immunotherapy by predicting which cancers will respond to specific therapies targeting the immune system.

Cause, scope determined for deadly winter debris flow in Uttarakhand, India

The Uttarakhand region of India experienced a humanitarian tragedy on Feb. 7, 2021, when a wall of debris and water barreled down the Ronti Gad, Rishiganga and Dhauliganga river valleys. This debris flow destroyed two hydropower facilities and left more than 200 people dead or missing. A self-organized coalition of 53 scientists, including researchers from the University of Washington, came together in the days following the disaster to investigate the cause, scope and impacts.

Printing Flexible Wearable Electronics for Smart Device Applications

With the increase in demand for flexible wearable electronics, researchers have explored flexible energy storage devices, such as flexible supercapacitators, that are lightweight and safe and easily integrate with other devices. Printing electronics has proved to be an economical, simple, and scalable strategy for fabricating FSCs. In Applied Physics Reviews, researchers provide a review of printed FSCs in terms of ability to formulate functional inks, design printable electrodes, and integrate functions with other electronic devices.

COVID-19 Creates Hearing, Balance Disorders, Aggravates Tinnitus Symptoms

Evidence suggests auditory and vestibular effects should be added to the growing list of physiological impacts of COVID-19. During the 180th Meeting, Colleen Le Prell from the University of Texas at Dallas will talk about hearing and balance disorders associated with coronavirus infection and how pandemic-related stress and anxiety may aggravate tinnitus symptoms. Her presentation, “Hearing disorders secondary to infection with SARS-CoV-2,” will take place Thursday, June 10.

CHIME telescope and collaborative efforts from WVU lead to the detection of more than 500 fast radio bursts

With the help of the radio telescope located at the Dominion Radio Astrophysical Observatory, operated by the National Research Council of Canada, in British Columbia, Canada, the telescope has nearly quadrupled the number of FRB discovered to date.

Study shows when people with cerebral palsy are most likely to break bones

Researchers at Michigan Medicine found people with cerebral palsy have fragile bones that present high fracture risk, but at different times across the lifespan compared to the general population. The results helped them develop new sex-specific critical periods of bone health for this population.

Headphones, Earbuds Impact Younger Generations’ Future Audio Health

As more people are taking advantage of music on the go, personal audio systems are pumping up the volume to the detriment of the listener’s hearing. During the 180th ASA Meeting, Daniel Fink from The Quiet Coalition and Jan Mayes will talk about current research into personal audio system usage and the need for public health hearing conservation policies. Their session, “Personal audio system use can harm auditory health,” will take place Thursday, June 10.

LUDWIG CANCER RESEARCH STUDY SHOWS HOW CERTAIN MACROPHAGES DAMPEN ANTI-TUMOR IMMUNITY

A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system’s cancer-killing CD8+ T cells.

Reported in the current issue of Cancer Cell and led by Ludwig investigators Taha Merghoub and Jedd Wolchok at Memorial Sloan Kettering (MSK) and Charles Rudin of MSK, the study shows that cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), a molecule that they surprisingly found on the surface of highly activated, cytotoxic and proliferative CD8+ T-cells.

Combination targeted therapy provides durable remission for patients with chronic lymphocytic leukemia

A combination of ibrutinib and venetoclax was found to provide lasting disease remission in patients with newly diagnosed chronic lymphocytic leukemia (CLL), according to researchers at The University of Texas MD Anderson Cancer Center. Findings from the single-institution Phase II study were published today in JAMA Oncology and provide the longest follow-up data on patients treated with this drug regimen.

Memory Biomarkers Confirm Aerobic Exercise Helps Cognitive Function in Older Adults

Until now, systemic biomarkers to measure exercise effects on brain function and that link to relevant metabolic responses were lacking. A study shows a memory biomarker, myokine Cathepsin B (CTSB), increased in older adults following a 26-week structured aerobic exercise training. The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer’s.

World’s largest outdoor earthquake simulator undergoes major upgrade

A major upgrade to the world’s largest outdoor earthquake simulator reached a milestone mid-April when the facility’s floor–all 300,000 lbs of it–was put back into place. When completed this fall, the simulator will have the ability to reproduce multi-dimensional earthquake motions with unprecedented accuracy to make structures and their residents safer during strong shakes. Researchers lay out the details of the upgrade in a paper published recently in Frontiers in Built Environment.

Could neutrophils be the secret to cancer’s Achilles’ heel?

A study published in the June 10, 2021 issue of Cell describes a remarkable new mechanism by which the body’s own immune system can eliminate cancer cells without damaging host cells. The findings have the potential to develop first-in-class medicines that are designed to be selective for cancer cells and non-toxic to normal cells and tissues.

NEST to open its virtual doors

The research and innovation building NEST of Empa and Eawag can now be visited virtually at any time and from anywhere in the world. The launch of the virtual NEST tour is a further step towards closing the gap between laboratory research and market entry. By making numerous innovations, developed and demonstrated at NEST, accessible to a much broader and more international audience, the virtual NEST is making a significant contribution to ensuring that sustainable innovations in the building and energy sector can spread faster and thus gain a foothold in the construction industry.

Bacteria hijack latent phage of competitor

Bacteriophages are still a relatively unknown component of the human microbiome. However, they can play a powerful role in the life cycles of bacteria. Biochemist Thomas Böttcher from the University of Vienna and PhD student Magdalena Jancheva were able to show for the first time how Pseudomonas bacteria use a self-produced signal molecule to selectively manipulate phages in a competing bacterial strain to defeat their enemy. This targeted control of phages provides entirely new biotechnological and therapeutic approaches, e.g. for phage therapies. The results produced in the context of an ERC grant have been published in the “Journal of the American Chemical Society”.

Monoclonal antibody therapy for COVID-19 safe, effective for transplant patients

Treating transplant patients with mild to moderate cases of COVID-19 with monoclonal antibodies is safe and helps prevent serious illness, according to a Mayo Clinic study recently published in Open Forum Infectious Diseases. These results are especially important because transplant patients who are infected with COVID-19 have a higher risk of severe illness and death.

Healthy fat impacted by change in diet and circadian clock, study finds

Changing your eating habits or altering your circadian clock can impact healthy fat tissue throughout your lifespan, according to a preclinical study published today in Nature by researchers with The University of Texas Health Science Center at Houston (UTHealth).

Targeted Therapy Pralsetinib Safely and Effectively Treats Lung and Thyroid Cancers with RET Alterations

Results from the multi-cohort Phase I/II ARROW clinical trial, conducted by The University of Texas MD Anderson Cancer Center researchers, showed that a once-daily dose of pralsetinib, a highly selective RET inhibitor, was safe and effective in treating patients with advanced RET fusion-positive non-small cell lung cancer (NSCLC) and RET-altered thyroid cancer.