Immune Cell Receptor Provides Promising Immunotherapy Target

Drugs that target a receptor on immune cells called activin receptor 1C may combat tumor-induced immune suppression and help patients’ immune systems fight back against cancer, according to a study by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

Kidney cancer treatments and tumor biology can activate different immune-modifying processes in patients

The findings out of Dana-Farber Cancer Institute highlight that the mechanisms of immune modulation are different in patients treated with immunotherapy and anti-angiogenic combinations. The results also point to the role of tumor biology in the diversity and actions of tumor-infiltrating immune cells brought into action by these treatments. The findings might be important for predicting or understanding treatment outcomes in advanced kidney cancer.

ألوان الطيف للبول: ما هو الطبيعي وما هو غير ذلك

أوستن، ولاية مينيسوتا — يتفاوت لون البول الطبيعي ولكنه عادةً ما يتراوح بين الشفاف والأصفر الباهت. ولكن اللون الدقيق يعتمد على كمية المياه التي تشربها، حيث تخفف السوائل من الأصباغ الصفراء في البول. فكلما أكثرت من السوائل، زادت شفافية البول. ولكن عندما تشرب كمية أقل، يصبح اللون الأصفر داكنًا أكثر.

Graphene research: numerous products, no acute dangers

The largest EU research initiative ever launched has come to a successful end: The Graphene Flagship was officially concluded at the end of last year. Empa researchers were also involved, such as molecular biologist Peter Wick, who was part of the Health and Environment work package from the very beginning – and has just summarized the findings in this area with international colleagues in a comprehensive review article in the specialist journal ACS Nano.

Patients Diagnosed With New-Onset, Persistent AFib Are More Likely to Have These Risk Factors

Patients who present with persistent atrial fibrillation at diagnosis are more likely to have certain risk factors as compared with patients with occasional atrial fibrillation (AFib). The findings, led by investigators in the Smidt Heart Institute at Cedars-Sinai, published in Circulation: Arrhythmia and Electrophysiology.

Intravascular Imaging Significantly Improves Survival, Safety, and Outcomes in Cardiovascular Stenting Procedures Over Conventional Angiography

Results from this large-scale synthesis of all prior clinical trials could increase usage of several types of high-resolution imaging for guiding interventional coronary procedures

Long COVID linked to persistently high levels of inflammatory protein: a potential biomarker and target for treatments

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.

MD Anderson Research Highlights for February 21, 2024

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson offer insights into drug-drug interactions for patients with acute myeloid leukemia (AML) and myelodysplastic syndromes; patient-derived xenograft models as a viable translational research tool in early-phase clinical trials; a novel gene expression signature to stratify patients with bladder cancer; a potential therapeutic target to overcome treatment resistance in multiple myeloma; a role for mutant p53 in protecting against ferroptosis in triple-negative breast cancer; and diet modifications to improve treatment outcomes in FLT3-mutated AML.

UNC Lineberger named as a national research hub for NIH cancer screening study

UNC Lineberger Comprehensive Cancer Center has been selected as one of nine national research sites for the National Cancer Institute’s newly launched Cancer Screening Research Network, which will evaluate promising and emerging cancer screening technologies.

UAH researcher wins 2024 Worthington Medal for innovations in pumping sciences

Dr. Phillip Ligrani, Eminent Scholar in Propulsion at The University of Alabama in Huntsville (UAH), has won the 2024 American Society of Mechanical Engineers (ASME) Henry R. Worthington Medal for developing innovative micro, millimeter and macro-scale pumping devices. Ligrani’s innovations are beneficial to a variety of applications, such as transporting biological samples without significant alteration or destruction of cells, and supplying coolant to maintain the temperatures of components subject to thermal loading, like lasers.

Age, sex, race among top risk factors for revision knee surgery

Patients who are younger than about 40, male, or Black are among those most at risk for revision surgery after having had a total knee replacement, according to researchers at UT Southwestern Medical Center. The study, published in the Archives of Orthopaedic and Trauma Surgery, was the first to explore relationships among risk factors for revision after total knee arthroplasty (TKA).

RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents

RUDN University pharmacists modeled derivative molecules of the antibacterial levofloxacin to find out what biological functions its individual structural fragments – pharmacophores – are responsible for. This is necessary to increase the effectiveness of the drug, as bacteria become increasingly resistant to antibiotics.

Mapping the Future of Rural Revitalization: A New Study Sheds Light on China’s Rural Dynamics

Recent research offers a fresh perspective on the revitalization of rural China through an in-depth analysis of the interconnected development of population, land, and industry in 2020. This study shines a light on the spatial dynamics and underlying factors contributing to rural disparities, providing a critical foundation for crafting scientific, effective, sustainable development strategic plan.

Study Details Toxic Elements Found in Stranded Whales, Dolphins Over 15 Years

Researchers evaluated the prevalence, concentration and tissue distribution of essential and non-essential trace elements, including heavy metal toxicants in tissue (blubber, kidney, liver, skeletal muscle, skin) and fecal samples. Findings reveal how toxicant levels relate to their sex, breed, age and other demographic factors.

Highways through historically redlined areas likely cause air pollution disparities today

Historically “redlined” areas – neighborhoods with primarily Black or immigrant communities – are exposed to more air pollution than other urban neighborhoods. According to research published in ACS’ Environmental Science & Technology, the cause could relate to nearby highways or industrial parks.

Inaccurate pulse oximeter readings could limit transplants, heart pumps for Black patients with heart failure

University of Michigan researchers find that racially biased pulse oximeter readings may further limit opportunities for Black patients with heart failure — who are already less likely to get treatment — to receive potentially lifesaving therapies, such as heart pumps and transplants.

Weedy rice gets competitive boost from its wild neighbors

Weedy rice is an agricultural pest with a global economic impact. It is an aggressive weed that outcompetes cultivated rice and causes billions of dollars in yield losses worldwide. A study from Washington University in St. Louis offers new insights into genetic changes that give weedy rice its edge over cultivated rice in tropical regions of the world.

Membrane Technology: Looking Deep into Smallest Pores

Membranes of vertically aligned carbon nanotubes (VaCNT) can be used to clean or desalinate water at high flow rate and low pressure. Recently, researchers of Karlsruhe Institute of Technology (KIT) and partners carried out steroid hormone adsorption experiments to study the interplay of forces in the small pores. They found that VaCNT of specific pore geometry and pore surface structure are suited for use as highly selective membranes. The researchers report in Nature Communications. (DOI: 10.1038/s41467-024-44883-2)