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UrduResearchers studying the enzyme DHPS have determined that blocking its activity in mouse macrophages leads to a reduction in proteins that drive inflammation during obesity, leading to improved glycemic control.
Tag: Inflammation
Rheumatoid arthritis treated with implanted cells that release drug
Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
What Makes Blood Vessels Leaky: New Insights for Sepsis Therapeutics
Lab studies reveal protein HSP27’s role in blood vessel leakage, opening the possibility that therapeutically dialing its activity up or down might stabilize patients with sepsis.
For psoriasis, targeting skin protein may help control inflammation
Targeting a protein found in the skin may reduce the severity of psoriasis, a Michigan Medicine study found. Using a mouse model to mimic psoriasis, researchers found changing levels of interferon kappa altered the severity of inflammation.
Young, Healthy Woman Suffers Brain Inflammation after Mild COVID-19 Infection
UC San Diego Health physicians describe first known case of young, healthy adult experiencing central nervous system inflammation due to COVID-19, but without cognitive impairment.
Study: Light therapy helps burn injuries heal faster by triggering growth protein
The research found that photobiomodulation – a form of low-dose light therapy – sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein that controls cell growth and division.
A Distinctive Inflammatory Signature Found in a Genetic Form of ALS
Researchers find an increase in inflammatory molecules in serum and cerebrospinal fluid of C90RF72 patients, informing future anti-inflammatory therapies.
Understanding gut inflammation may hold clues to mitigating Parkinson’s onset
GRAND RAPIDS, Mich. (JUNE 8, 2021) — Chronic inflammation in the gut may propel processes in the body that give rise to Parkinson’s disease, according to a study by scientists at Van Andel Institute and Roche.
Diets that Promote Inflammation Could Increase Breast Cancer Risk
A new study of more than 350,000 women found that women with diets incorporating more foods that increase inflammation in the body had a 12% increase in their risk of breast cancer compared to women who consume more anti-inflammatory diets.
Male hormones regulate stomach inflammation in mice
Scientists at the National Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach. The study was published in Gastroenterology.
Blocking Cell Death Protein Reduces COPD-associated Inflammation, Lung Damage
Article title: Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD Authors Felix Ritzmann, Kai Borchardt, Giovanna Vella, Praneeth Chitirala, Adrian Angenendt, Christian Herr, Michael D. Menger, Markus Hoth, Annette Lis, Rainer M Bohle, Robert Bals, Christoph…
Study says inflammation seen in earliest stages of Parkinson’s disease, and it is different between men and women
New research shows evidence of inflammation in the blood of Parkinson’s disease patients during the earliest stages of the disease, lending support to theories that inflammation is a major driver of PD. The study also points out differences between the sexes in the symptoms and course of the disease.
Inflammatory diet linked to testosterone deficiency in men
Consuming a diet high in pro-inflammatory foods – including foods that contain refined carbohydrates and sugar as well as polyunsaturated fats – may be associated with increased odds of developing testosterone deficiency among men, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
Quit the Hookah! Lung Damage, Inflammation Is Reversible with Smoking Cessation
New research finds that quitting smoking is an effective way to resolve impaired lung function and airway inflammation associated with waterpipe smoking. The study is published ahead of print in the American Journal of Physiology-Lung Cellular and Molecular Physiology.
Researchers Identify Immune Cells that Contribute to Transplant Rejection
‘Tissue-resident memory T cells’, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection.
How pregnancy turns the stress response on its head
Researchers found two simultaneous conditions in pregnancy’s response to stress that made them realize just how complex the cross-talk between mom and baby is during gestation: Immune cells in the placenta and uterus were not activated, but significant inflammation was detected in the fetal brain.
Could a New Cell Type Discovery Lead to Better Chronic Pain Treatments?
Inflammation is a hallmark of chronic pain, and scientists at the UNC School of Medicine have discovered that anti-inflammatory cells called MRC1+ macrophages are dysfunctional in an animal model of neuropathic pain.
Study Reveals Details of Immune Defense Guidance System
At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.
Blood-flow Restriction Training Delay the Progression of Chronic Kidney Disease
Chronic kidney disease (CKD) is recognized as a public health problem, affecting more than 15% of the population. Although CKD can drastically impair health, it is rarely diagnosed early due to its silent revelation. Identifying and proposing treatments to attenuate…
COVID-19 Blood Flow Changes May Be Reason for ‘Brain Fog,’ Depression
A new review suggests that blood vessel damage and impaired oxygen delivery related to COVID-19 play a role in mood changes and cognitive difficulties that people with the disease face during illness and recovery. The review is published in Physiological Reports.
University of Northern Colorado Associate Professor Nick Pullen Provides Expertise on COVID-19 Vaccinations
Nick Pullen, Ph.D., an associate professor of Biological Sciences at the University of Northern Colorado (UNC), provides expertise regarding the topic of COVID-19 vaccinations and immunity. Pullen’s research centers around the body’s immune response, specifically chronic inflammation, asthma and allergies.…
What happens in the mouth … doesn’t stay in the mouth
The healthy human oral microbiome consists of not just clean teeth and firm gums, but also bacteria living in an environment where they constantly communicate with the immune system. A growing body of evidence has shown that this system is highly influential on, and influenced by, our overall health.
Uncovering a Link Between Inflammation and Heart Disease
In a new study in Circulation, researchers from Tufts University School of Medicine in collaboration with investigators at Vanderbilt University and Tufts Medical Center reveal a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart.
Low Oxygen-related Inflammation Leads to More Platelets in Mouse Lungs
Article title: Platelet activation contributes to hypoxia-induced inflammation Authors: Cassidy Delaney, Pavel Davizon-Castillo, Ayed Allawzi, Janelle Posey, Aneta Gandjeva, Keith Neeves, Rubin M. Tuder, Jorge Di Paola, Kurt R. Stenmark, Eva S. Nozik From the authors: “Our data provide evidence…
‘Smart’ cartilage cells programmed to release drugs when stressed
Researchers at Washington University School of Medicine in St. Louis have engineered cartilage cells to release an anti-inflammatory drug in response to stresses such cells undergo when they are compressed during weight bearing and movement.
Two Anti-viral Enzymes Transform Pre-Leukemia Stem Cells into Leukemia
Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them as a means to potentially lower cancer risk for both astronauts and people on Earth.
Inflamed Environment Is C. diff Paradise
A new study shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive.
Immune System Killer Cells Controlled by Circadian Rhythms
Macrophages, the killer cells of the immune system, are controlled by circadian rhythms, a finding which may indicate that our ability to fight disease relies more heavily on daily circadian cycles than previously assumed.
Protecting lungs from ventilator-induced injury
An unfortunate truth about using mechanical ventilation to save lives is that the pressure can cause further lung damage. Scientists are working to boost a natural cellular process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators.
Breast Milk + Probiotics Reduces Inflammation Associated with Necrotizing Enterocolitis in Preemies
Article title: Short chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo Authors: Yanan Gao, Brittany Davis, Weishu Zhu, Nan Zheng, Di Meng, W. Allan Walker From…
Neurologists test novel compound for lung and brain injury in severe COVID-19 patients
Neurologists are researching whether a novel immunomodulatory treatment, OP-101, can dampen lung and brain injury in hospitalized COVID-19 patients through a clinical trial at The University of Texas Health Science Center at Houston (UTHealth).
Researchers Explore How Exercise Influences Tendon Inflammation
Stephanie Dakin, PhD, BVetMed, from the University of Oxford in the U.K., studied the microscopic characteristics of tendons in people with exercise-related tendinopathy. Tendinopathy is a tendon disorder that causes pain, inflammation and limited function of the affected joint. Her research team found an increased number of blood vessels and cells—suggestive of inflammatory response—in the injured tendon samples when compared with healthy tissue.
Cancer treatment could be replicated for COVID-19
Beta-blockers could potentially be used to treat COVID-19, according to a new international study by Italian and Australian scientists.
Maltreatment tied to higher inflammation in girls
New research by a University of Georgia scientist reveals that girls who are maltreated show higher levels of inflammation at an early age than boys who are maltreated or children who have not experienced abuse.
Stopping lethal lung damage from the flu with a natural human protein
The raging lung inflammation that can contribute to death from the flu can be stopped in its tracks by a drug derived from a naturally occurring human protein, a new animal study suggests.
Blocking Immune System Pathway May Stop COVID-19 Infection, Prevent Severe Organ Damage
While the world waits eagerly for a safe and effective vaccine to prevent infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the COVID-19 pandemic, researchers also are focusing on better understanding how SARS-CoV-2 attacks the body in the search for other means of stopping its devastating impact. The key to one possibility — blocking a protein that enables the virus to turn the immune system against healthy cells — has been identified in a recent study by a team of Johns Hopkins Medicine researchers.
Reproductive Hormone May Curb COVID-19 Inflammation, Prevent ‘Cytokine Storm’
Researchers have used “omics” data containing genetic profiles of drugs to identify the hormone oxytocin as a possible treatment for COVID-19, the disease caused by the novel coronavirus (SARS-CoV-2).
Kawasaki Disease Is Not a Homogenous Disease nor are its Triggers
Researchers at UC San Diego report that while Kawasaki disease occurs in clusters, the traits, and thus the triggers of the inflammatory disease vary among clusters.
High-fibre diet, low level inflammation: sidestepping the effects of radiation
Loved or hated, the humble oat could be the new superfood for cancer patients as international research shows a diet rich in fibre could significantly reduce radiation-induced gut inflammation.
Imaging agent developed at Washington University spotlights inflammation
Researchers at Washington University School of Medicine in St. Louis have created a new PET imaging agent that detects signs of inflammation. Such a tracer could aid diagnosis and study of diseases ranging from cardiovascular disease to cancer to COVID-19.
Inflammatory Protein Found to Protect against Metabolic, Gut Changes in Mice
Article title: Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice Authors: Vishal Singh, Sarah Galla, Rachel M. Golonka, Andrew D. Patterson, Benoit Chassaing, Bina Joe, Matam Vijay-Kumar From the authors: “Overall, the current study demonstrates that…
Clear Link Between Heart Disease and COVID-19, But Long-Term Implications Unknown, Researchers Find in Review of Published Studies
In a prospectus review published this week in the Journal of Molecular and Cellular Cardiology, Kirk U. Knowlton MD, from the Intermountain Healthcare Heart Institute in Salt Lake City, examined more than 100 published studies related to COVID-19 and its effects on the heart.
NYU Dentistry Receives $2.4 Million Grant to Study Low-Grade Inflammation in Aging
The National Institute on Aging has awarded a grant to researchers at New York University College of Dentistry to explore age-related, chronic low-grade inflammation and changes in the gut microbiome.
Three Women Scientists at Johns Hopkins Tapped to Join Exclusive Research Network
Three Johns Hopkins Kimmel Cancer Center scientists are among the first 45 members selected to join the 10x Genomics Visium Clinical Translational Research Network (CTRN), aimed at advancing translational research in some of the world’s leading health problems, including oncology, immuno-oncology, neuroscience, infectious disease, inflammation and fibrosis, and COVID-19.
“Reelin” In A New Treatment For Multiple Sclerosis
DALLAS – Aug. 12, 2020 – In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.
Quieting the Storm
A team of researchers led by neuroscientists at Harvard Medical School has successfully used acupuncture to tame cytokine storm in mice with systemic inflammation.
Blood Test May Point to Patients at Higher Risk for COVID-19 Deterioration, Death
George Washington University researchers found five biomarkers associated with higher odds of clinical deterioration and death in COVID-19 patients. Published in Future Medicine, these findings will help physicians better predict outcomes for COVID-19 patients in the U.S.
New Study on Development of Parkinson’s Disease is ‘On the Nose’
Scientists suggest that the initial impact of environmental toxins inhaled through the nose may induce inflammation in the brain, triggering the production of Lewy bodies that can then be spread to other brain regions. However, the relationship linking olfactory dysfunction and Parkinson’s disease development remains unclear. New findings from a study add weight to this theory and identify a critical signaling molecule that may be key to the domino effect kicked off by nasal inflammation.
Supercharged bandages to revolutionise chronic wound treatment
World-first plasma-coated bandages with the power to attack infection and inflammation could revolutionise the treatment of chronic wounds such as pressure, diabetic or vascular ulcers that won’t heal on their own.
Developed by the University of South Australia, the novel coating comprises a special antioxidant which can be applied to any wound dressing to simultaneously reduce wound inflammation a¬¬nd break up infection to aid in wound repair.