Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults – and, new research in animals suggests, even in young adults.
Tag: Inflammation
Sniffing our way to better health
Imagine if we could inhale scents that delay the onset of cancer, inflammation, or neurodegenerative disease. Researchers at the University of California, Riverside, are poised to bring this futuristic technology closer to reality.
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune
Yoga provides unique cognitive benefits to older women at risk of Alzheimer’s disease, study finds
A new UCLA Health study found Kundalini yoga provided several benefits to cognition and memory for older women at risk of developing Alzheimer’s disease including restoring neural pathways, preventing brain matter decline and reversing aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.
Cleveland Clinic-Led Study Discovers Link between High Levels of Niacin – a Common B Vitamin – and Heart Disease
Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.
Body changes up to eight years before inflammatory bowel disease diagnosis
Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn’s disease and up to three years before a diagnosis of ulcerative colitis.
Some Benefits of Exercise Stem from the Immune System
Research in mice shows that the anti-inflammatory properties of exercise may arise from immune cells mobilized to counter exercise-induced inflammation. Immune cells prevent muscle damage by lowering levels of interferon, a key driver of chronic inflammation, inflammatory diseases, and aging.
Army of specialized T cells may trigger asthma attacks in older men
LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.
Long COVID patients show distinct immune, hormone responses to virus
People suffering from long COVID symptoms show different immune and hormonal responses to the virus that causes COVID-19, according to a new study led by researchers at Yale School of Medicine. An estimated 7.5% of people infected with the SARS-CoV-2…
Saturated fat may interfere with creating memories in aged brain
New research hints at a few ways fatty foods affect cells in the brain, a finding that could help explain the link between a high-fat diet and impaired memory – especially as we age.
Cholesterol and Inflammation Demonstrate Alzheimer’s Link
A recent study shows that a protein called ABCA7 plays a functional role as a potential biological link between cholesterol and inflammation in Alzheimer’s disease. The new work was published online August 25 in the journal Cells.
UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients.
UCI researchers have found that a simple sugar, N-acetylglucosamine, reduces multiple inflammation and neurodegeneration markers in people who suffer from multiple sclerosis (MS). In addition, they also found this dietary supplement improved neurological function in 30% of patients.
Inflammation may influence weight loss surgery outcomes, new study reveals
Research funded by the National Institute for Health and Care Research (NIHR) has shown that higher levels of inflammation in the blood of patients with obesity undergoing bariatric surgery predicts poorer weight loss six months after the procedure.
Training immune cells to remove ‘trash’ helps resolve lung inflammation
Acute lung injury occurs when our lung’s immune system response becomes hyperactivated and causes inflammation to continue unchecked. In fact, many deaths from COVID-19 were from acute lung injury.
Pecans give obesity and diabetes a slim chance
Daily consumption of pecans have been shown to prevent obesity and a host of related health issues like fatty liver disease and diabetes, according to a collaborative study by Texas A&M AgriLife scientists.
Atopic dermatitis associated with schizophrenia, schizoaffective disorder
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder that has well-established associations with depression and anxiety. A new Yale School of Medicine study finds AD is also associated with increased risk for schizophrenia and shizoaffective disorder. Schizophrenia is a…
Mitochondrial Changes Linked to High Blood Pressure in Pregnancy
A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.
Faster progression of multiple sclerosis associated with newly identified genetic variant
In a new study of more than 22,000 people with multiple sclerosis (MS), an international team identified for the first time a genetic variant associated with faster progression of the disease and accumulation of disability. Despite the development of effective…
Gulf War Illness Caused by Mitochondrial Dysfunction, Not Inflammation
UC San Diego scientists contest longstanding hypothesis about mysterious illness affecting Gulf War veterans, providing first direct evidence that symptoms are driven by impaired mitochondria.
Moffitt Investigates Association between Inflammation and Treatment Related Symptoms in Gynecologic Cancers
Moffitt Cancer Center researchers having been investigating what may trigger treatment related symptoms in patients with gynecologic cancers. In a new study published in the journal Cancers, they evaluated the relationship between inflammatory biomarkers and self-reported treatment related symptoms among this patient population.
A lung injury therapy derived from adult skin cells
Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma.
Binge Drinking and Night Shift Work Linked to Greater Likelihood of COVID Infection in Nurses
Working the night shift or binge drinking may double the risk of COVID-19 infection, according to a study of nurses published in Alcohol: Clinical and Experimental Research. Both alcohol misuse and night shift work have been shown to impact sleep and promote inflammation in the body, which has been linked to COVID disease severity. The findings from this study strongly suggest that alcohol and circadian misalignment contribute to the development of COVID disease in people exposed to the virus.
Pulmonary and neurological health effects associated with exposure to representative composite manufacturing emissions and corresponding alterations in circulating metabolite profiles
Abstract Cured-in-place pipe (CIPP) technology is increasingly being utilized to repair aging and damaged pipes, however, there are concerns associated with the public health hazards of emissions. CIPP installation involves the manufacture of a new plastic composite pipe at the…
UC San Diego First to Test Cancer Drugs in Space Using Private Astronaut Mission
The latest space experiments from UC San Diego and Axiom Space will explore therapies for breast and colorectal cancer aboard the ISS, and monitor astronauts’ stem cell health over time.
Targeting uncontrolled inflammation may hold the key to treating therapy-resistant cancers
Van Andel Institute scientists have pinpointed how a specific gene mutation triggers an inflammatory cascade that may drive development of treatment-resistant cancers.
Fiery response: “Siglec-14” receptors on human macrophages detect carbon nanotubes and provoke inflammation, finds study
Carbon nanotubes (CNTs) have become a mainstay of the field of nanotechnology.
‘Beige fat’ could hold key to age-related metabolism change
New research suggests a strategy to ward off age-related weight gain, which could prevent obesity and associated health disorders like Type 2 diabetes, heart disease and chronic inflammation.
Does getting a cold often increase your risk for dementia? New study finds link
Getting sick often may impact how quickly the brain ages and increase the risk of dementia or other forms of cognitive decline.
COVID-19 discovery could protect high-risk patients
UVA Health researchers have identified a potential treatment to prevent severe COVID-19 in patients at great risk.
With $13M, UIC scientists will study lung inflammation mechanisms
The research team consists of six investigators who will lead three separate project grants and three separate cores, in the hopes of finding new avenues for research and treatments to help patients who suffer from conditions like chronic obstructive pulmonary disorder, pulmonary fibrosis and acute respiratory distress disorder, a common and serious complication of COVID-19.
Depression linked to deadly inflammation in lung cancer patients
Lung cancer patients with moderate to severe depression are 2 to 3 times more likely to have inflammation levels that predict poor survival rates, a new study found. The results may help explain why a substantial portion of lung cancer patients fail to respond to new immunotherapy and targeted treatments that have led to significantly longer survival for many people with the disease.
Identifying the inflammatory cells behind chemo brain
Immune cells that keep the brain free of debris but also contribute to inflammation are the likely culprits behind the concentration and memory problems that sometimes follow one type of chemotherapy, a new study in mice suggests.
Vaping CBD can increase susceptibility to respiratory infection, says Roswell Park study author
Dr. Thanavala is available for virtual or in-person interviews Monday, Feb. 27 or Tuesday, Feb 28. Press release: https://www.roswellpark.org/newsroom/202302-vaping-cbd-causes-more-severe-lung-damage-vaping-nicotine-roswell-park-study-shows Link to her bio here. Dr. Thanavala has been at the forefront of research on the health effects of vaping cannabinoids.…
Vaping CBD Causes More Severe Lung Damage Than Vaping Nicotine, Roswell Park Study Shows
Vaping cannabidiol (CBD), a compound found in marijuana, leads to more severe lung damage than vaping nicotine, according to a study out of Roswell Park Comprehensive Cancer Center. Until now, research on the health effects of vaping, or using e-cigarettes, has focused almost exclusively on vaping nicotine as opposed to CBD. Previous research has documented the effects of smoking cannabis, but the effects of vaping cannabinoids such as CBD were not previously known.
Researchers Uncover Mechanisms of Brexanolone and the Role of Inflammation in Post-partum Depression
Brexanolone, an IV infusion comprised of a derivative of progesterone, was approved by the U.S. Food and Drug Administration for the treatment of PPD in 2019. The fast-acting medication significantly reduces depression symptoms and provides effects for up to 90 days. However, exactly how the drug provides these therapeutic effects has remained a mystery – until now.
Tobacco and e-cigs may put healthy young people at risk of severe COVID illness, new UCLA research suggests
Smoking tobacco and vaping electronic cigarettes may increase healthy young people’s risk for developing severe COVID illness.
Harnessing good fats to relieve MS symptoms
Researchers find that fish oil derivative reduces and delays disease–causing inflammation in mouse model of multiple sclerosis
Scientists find that microRNA affects inflammation in lupus disease
A group of researchers from the Graduate School of Medicine at Nagoya University in Japan have discovered the impact of microRNA (miRNA) on inflammation in lupus in mice.
High fat diet activates early inflammation in mouse brains, supports link to neurologic disease
Researchers at Michigan Medicine have discovered that a high-fat diet promotes an early inflammatory response in the brains of mice through an immune pathway linked to diabetes and neurologic diseases, suggesting a possible bridge between metabolic dysfunction and cognitive impairment.
Chula Medicine Determines “Cytokines” as Indicator of “Degenerative Joints” Giving Hopes for Better Disease Mitigation
Chula Medicine announced the discovery of “cytokines” in the body’s immune system that can determine the severity of osteoarthritis in elderly adults, hoping to facilitate the planning of follow-up and treatment of the disease, and reduction of its severity, while also recommending vitamin D and vitamin E supplements, body weight control, and proper exercise.
Research Identifies Potential Genetic Cause for MIS-C Complication Following COVID-19 Infection
New research findings have revealed an underlying genetic cause for why some children who have had COVID-19 infection develop Multisystem Inflammatory Syndrome in Children (MIS-C), a rare but potentially life-threatening disease.
The findings, published in Science, are the first potential genetic cause identified for MIS-C, a disease that typically occurs about four weeks after COVID-19 infection and has broad symptoms such as fever, vomiting and inflammation of the heart muscle that can lead to hospitalization. States have reported about 9,000 MIS-C cases, with 71 deaths, according to most recent Centers for Disease Control and Prevention numbers.
Poor Gut Health May Drive Multiple Sclerosis — Better Diet May Ease It
A Rutgers study shows how digestive inflammation may drive MS and provides further evidence that more fiber by combat the condition.
Drug discovery offers potential treatment for common kidney disease
A serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines, a new study shows.
LJI researchers find missing piece of the asthma puzzle
“This is a very striking and significant result that essentially separates LIGHT from any of the other inflammatory cytokines that have been implicated in the process in severe asthmatics.”
Researchers ID Role of Enzyme as Regulator of Inflammation in Lung Disease
Article title: Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome Authors: Ashley Y. Gao, Ana M. Diaz Espinosa, Fiorenza Gianì, Tho X. Pham, Chase M. Carver, Aja Aravamudhan, Colleen M. Bartman, Giovanni Ligresti, Nunzia…
Trouble sleeping? You could be at risk of type 2 diabetes
As the Christmas season starts to ramp up, University of South Australia researchers are reminding people to prioritise a good night’s sleep as new research shows that a troubled sleep may be associated with risk factors for type 2 diabetes.
Study Identifies New Gene That Drives Colon Cancer
Researchers have identified a new gene that is essential to colon cancer growth and found that inflammation in the external environment around the tumor can contribute to the growth of tumor cells.
Loss of Transport Protein Function Contributes to Chronic Intestinal Inflammation
Article title: Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression Authors: Rainelli Koumangoye, Parker Penny, Eric Delpire From the authors: “We speculate that the upregulation of claudin-2, if confirmed in vivo, by increasing pore permeability…
Mount Sinai Study Uncovers Mechanisms of Reactive Oxygen Species in Stem Cell Function and Inflammation Prevention
Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could provide greater insights into the prevention and treatment of inflammatory bowel diseases (IBD), according to findings published in the journal Gut on October 3.
Garlic chives hold ‘therapeutic promise’ against heart disease and other obesity-related illness
Nebraska researchers seek to identify the bioactive molecules that give chive nanoparticles their “very strong anti-inflammatory function.”