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UrduNon-alcoholic fatty liver disease (NAFLD) has emerged as a significant health challenge, characterized by its widespread prevalence, intricate natural progression and multifaceted pathogenesis. Although NAFLD initially presents as benign fa
Tag: Inflammation
Study finds targeting inflammation may not help reduce liver fibrosis in MAFLD
Researchers at UCLA Health uncovered new information about the role inflammation plays in mitigating liver fibrosis, which is associated with metabolic-associated fatty liver disease (MAFLD), one of the most common diseases in the world affecting up to 40 percent of U.S. adults.
High Levels of a Specific Antibody May Contribute to Acute Coronary Syndrome
How a person’s immune system responds to a protein called LL-37 may increase risk for developing acute coronary syndrome, but the response may also serve as a potential target for future treatments.
New study identifies two proteins that may contribute to stroke recurrence
A new study has discovered genetic markers in inflammation that may be related to a second stroke or other major cardiovascular event following a stroke. These findings could help identify drug targets to mitigate stroke-related disability and mortality.
Advanced nanofibrous membranes: tackling diabetic wounds with precision
In a pioneering study, researchers have developed a poly (L-lactic acid) (PLLA) nanofibrous membrane enhanced with curcumin and silver nanoparticles (AgNPs), aimed at improving the healing of diabetic wounds.
Older adults with insomnia at greater risk for developing depression
‘Older people who have insomnia show a very exaggerated risk of becoming depressed’
Tai Chi reduces risk of inflammatory disease, treats insomnia among breast cancer survivors
New research led by UCLA Health confirms that both Tai Chi and cognitive behavioral therapy can reduce insomnia in breast cancer survivors but also may provide additional health benefits by reducing inflammation and bolstering anti-viral defenses.
Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis
BACKGROUNDThe treatment of acute respiratory distress syndrome (ARDS) complicated by sepsis syndrome (SS) remains challenging. AIMTo investigate whether combined adipose-derived mesenchymal-stem-cells (ADMSCs)-derived exosome (EXAD) and ex
Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment: Facts and perspectives
Mesenchymal stem/stromal cells are potential optimal cell sources for stem cell therapies, and pretreatment has proven to enhance cell vitality and function. In a recent publication, Li et al explored a new combination of pretreatment condi
A genetic predisposition to alcohol use is not the same as a genetic destiny for alcohol misuse
There is a clear relationship between alcohol and neurodegeneration; for example, an alcohol use disorder correlates with a higher risk of Alzheimer’s disease. It is unclear, however, whether individual differences in brain structure and connectivity are risk factors for, or consequences of, alcohol use. New research exploring this relationship will be shared on Wednesday, 26 June 2024 at the 47th annual scientific meeting of the Research Society on Alcohol (RSA) in Minneapolis, Minnesota.
Alcohol misuse can disrupt gut microbiota, causing inflammation that leads to organ damage
Alcohol researchers have long known that excessive drinking can cause damage to the liver, pancreas, heart, muscle, bone, and brain. However, only a subset of patients with alcohol use disorder (AUD) appear to develop organ damage. New research shows that alcohol-induced gut inflammation is the missing link between unhealthy drinking and organ damage among certain AUD patients.
New research points to ‘stem-like’ T cells as culprits in ulcerative colitis
The researchers hope to one day target this T cell population via drug therapy. “These cells may be a very important target for treating ulcerative colitis and perhaps other autoimmune diseases…”
NUTRITION 2024 showcases groundbreaking research on what we eat and why it matters
Be among the first to hear breaking news in food and nutrition science at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition held June 29–July 2 at McCormick Place in Chicago.
Interplay between mesenchymal stem cells and macrophages: Promoting bone tissue repair
The repair of bone tissue damage is a complex process that is well-orchestrated in time and space, a focus and difficulty in orthopedic treatment. In recent years, the success of mesenchymal stem cells (MSCs)-mediated bone repair in clinica
Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation
Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value o
Serious flu damage prevented by compound that blocks unnecessary cell death
In a study in mice published in Nature, a research team showed that a newly developed compound was able to block necroptosis, a type of cell death that leads to lung inflammation and damage following infection with the flu virus.
Intermittent Fasting May Help Preserve Intestinal Health as We Age
A study in mice found that intermittent fasting brought benefits beyond weight loss, suggesting it could help the body better process glucose and reduce age-related declines in intestinal function. Researchers will present their work this week at the American Physiology Summit.
UC San Diego Receives $6.7M to Develop Whole-Body Inflammation Imaging
Researchers at UC San Diego have received new grants that will help develop full-body imaging techniques to detect inflammation, which is currently very difficult to visualize in the clinic.
Fatty food before surgery may impair memory in old, young adults
Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults – and, new research in animals suggests, even in young adults.
Sniffing our way to better health
Imagine if we could inhale scents that delay the onset of cancer, inflammation, or neurodegenerative disease. Researchers at the University of California, Riverside, are poised to bring this futuristic technology closer to reality.
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune
Yoga provides unique cognitive benefits to older women at risk of Alzheimer’s disease, study finds
A new UCLA Health study found Kundalini yoga provided several benefits to cognition and memory for older women at risk of developing Alzheimer’s disease including restoring neural pathways, preventing brain matter decline and reversing aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.
Cleveland Clinic-Led Study Discovers Link between High Levels of Niacin – a Common B Vitamin – and Heart Disease
Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.
Body changes up to eight years before inflammatory bowel disease diagnosis
Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn’s disease and up to three years before a diagnosis of ulcerative colitis.
Some Benefits of Exercise Stem from the Immune System
Research in mice shows that the anti-inflammatory properties of exercise may arise from immune cells mobilized to counter exercise-induced inflammation. Immune cells prevent muscle damage by lowering levels of interferon, a key driver of chronic inflammation, inflammatory diseases, and aging.
Army of specialized T cells may trigger asthma attacks in older men
LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.
Long COVID patients show distinct immune, hormone responses to virus
People suffering from long COVID symptoms show different immune and hormonal responses to the virus that causes COVID-19, according to a new study led by researchers at Yale School of Medicine. An estimated 7.5% of people infected with the SARS-CoV-2…
Saturated fat may interfere with creating memories in aged brain
New research hints at a few ways fatty foods affect cells in the brain, a finding that could help explain the link between a high-fat diet and impaired memory – especially as we age.
Cholesterol and Inflammation Demonstrate Alzheimer’s Link
A recent study shows that a protein called ABCA7 plays a functional role as a potential biological link between cholesterol and inflammation in Alzheimer’s disease. The new work was published online August 25 in the journal Cells.
UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients.
UCI researchers have found that a simple sugar, N-acetylglucosamine, reduces multiple inflammation and neurodegeneration markers in people who suffer from multiple sclerosis (MS). In addition, they also found this dietary supplement improved neurological function in 30% of patients.
Inflammation may influence weight loss surgery outcomes, new study reveals
Research funded by the National Institute for Health and Care Research (NIHR) has shown that higher levels of inflammation in the blood of patients with obesity undergoing bariatric surgery predicts poorer weight loss six months after the procedure.
Training immune cells to remove ‘trash’ helps resolve lung inflammation
Acute lung injury occurs when our lung’s immune system response becomes hyperactivated and causes inflammation to continue unchecked. In fact, many deaths from COVID-19 were from acute lung injury.
Pecans give obesity and diabetes a slim chance
Daily consumption of pecans have been shown to prevent obesity and a host of related health issues like fatty liver disease and diabetes, according to a collaborative study by Texas A&M AgriLife scientists.
Atopic dermatitis associated with schizophrenia, schizoaffective disorder
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder that has well-established associations with depression and anxiety. A new Yale School of Medicine study finds AD is also associated with increased risk for schizophrenia and shizoaffective disorder. Schizophrenia is a…
Mitochondrial Changes Linked to High Blood Pressure in Pregnancy
A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.
Faster progression of multiple sclerosis associated with newly identified genetic variant
In a new study of more than 22,000 people with multiple sclerosis (MS), an international team identified for the first time a genetic variant associated with faster progression of the disease and accumulation of disability. Despite the development of effective…
Gulf War Illness Caused by Mitochondrial Dysfunction, Not Inflammation
UC San Diego scientists contest longstanding hypothesis about mysterious illness affecting Gulf War veterans, providing first direct evidence that symptoms are driven by impaired mitochondria.
Moffitt Investigates Association between Inflammation and Treatment Related Symptoms in Gynecologic Cancers
Moffitt Cancer Center researchers having been investigating what may trigger treatment related symptoms in patients with gynecologic cancers. In a new study published in the journal Cancers, they evaluated the relationship between inflammatory biomarkers and self-reported treatment related symptoms among this patient population.
A lung injury therapy derived from adult skin cells
Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma.
Binge Drinking and Night Shift Work Linked to Greater Likelihood of COVID Infection in Nurses
Working the night shift or binge drinking may double the risk of COVID-19 infection, according to a study of nurses published in Alcohol: Clinical and Experimental Research. Both alcohol misuse and night shift work have been shown to impact sleep and promote inflammation in the body, which has been linked to COVID disease severity. The findings from this study strongly suggest that alcohol and circadian misalignment contribute to the development of COVID disease in people exposed to the virus.
Pulmonary and neurological health effects associated with exposure to representative composite manufacturing emissions and corresponding alterations in circulating metabolite profiles
Abstract Cured-in-place pipe (CIPP) technology is increasingly being utilized to repair aging and damaged pipes, however, there are concerns associated with the public health hazards of emissions. CIPP installation involves the manufacture of a new plastic composite pipe at the…
UC San Diego First to Test Cancer Drugs in Space Using Private Astronaut Mission
The latest space experiments from UC San Diego and Axiom Space will explore therapies for breast and colorectal cancer aboard the ISS, and monitor astronauts’ stem cell health over time.
Targeting uncontrolled inflammation may hold the key to treating therapy-resistant cancers
Van Andel Institute scientists have pinpointed how a specific gene mutation triggers an inflammatory cascade that may drive development of treatment-resistant cancers.
Fiery response: “Siglec-14” receptors on human macrophages detect carbon nanotubes and provoke inflammation, finds study
Carbon nanotubes (CNTs) have become a mainstay of the field of nanotechnology.
‘Beige fat’ could hold key to age-related metabolism change
New research suggests a strategy to ward off age-related weight gain, which could prevent obesity and associated health disorders like Type 2 diabetes, heart disease and chronic inflammation.
Does getting a cold often increase your risk for dementia? New study finds link
Getting sick often may impact how quickly the brain ages and increase the risk of dementia or other forms of cognitive decline.
COVID-19 discovery could protect high-risk patients
UVA Health researchers have identified a potential treatment to prevent severe COVID-19 in patients at great risk.
With $13M, UIC scientists will study lung inflammation mechanisms
The research team consists of six investigators who will lead three separate project grants and three separate cores, in the hopes of finding new avenues for research and treatments to help patients who suffer from conditions like chronic obstructive pulmonary disorder, pulmonary fibrosis and acute respiratory distress disorder, a common and serious complication of COVID-19.
Depression linked to deadly inflammation in lung cancer patients
Lung cancer patients with moderate to severe depression are 2 to 3 times more likely to have inflammation levels that predict poor survival rates, a new study found. The results may help explain why a substantial portion of lung cancer patients fail to respond to new immunotherapy and targeted treatments that have led to significantly longer survival for many people with the disease.
Identifying the inflammatory cells behind chemo brain
Immune cells that keep the brain free of debris but also contribute to inflammation are the likely culprits behind the concentration and memory problems that sometimes follow one type of chemotherapy, a new study in mice suggests.