Blocking Cell Death Protein Reduces COPD-associated Inflammation, Lung Damage

Article title: Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD Authors Felix Ritzmann, Kai Borchardt, Giovanna Vella, Praneeth Chitirala, Adrian Angenendt, Christian Herr, Michael D. Menger, Markus Hoth, Annette Lis, Rainer M Bohle, Robert Bals, Christoph…

Study says inflammation seen in earliest stages of Parkinson’s disease, and it is different between men and women

New research shows evidence of inflammation in the blood of Parkinson’s disease patients during the earliest stages of the disease, lending support to theories that inflammation is a major driver of PD. The study also points out differences between the sexes in the symptoms and course of the disease.

Inflammatory diet linked to testosterone deficiency in men

Consuming a diet high in pro-inflammatory foods – including foods that contain refined carbohydrates and sugar as well as polyunsaturated fats – may be associated with increased odds of developing testosterone deficiency among men, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

Quit the Hookah! Lung Damage, Inflammation Is Reversible with Smoking Cessation

New research finds that quitting smoking is an effective way to resolve impaired lung function and airway inflammation associated with waterpipe smoking. The study is published ahead of print in the American Journal of Physiology-Lung Cellular and Molecular Physiology.

Blood-flow Restriction Training Delay the Progression of Chronic Kidney Disease

Chronic kidney disease (CKD) is recognized as a public health problem, affecting more than 15% of the population. Although CKD can drastically impair health, it is rarely diagnosed early due to its silent revelation. Identifying and proposing treatments to attenuate…

University of Northern Colorado Associate Professor Nick Pullen Provides Expertise on COVID-19 Vaccinations

Nick Pullen, Ph.D., an associate professor of Biological Sciences at the University of Northern Colorado (UNC), provides expertise regarding the topic of COVID-19 vaccinations and immunity.  Pullen’s research centers around the body’s immune response, specifically chronic inflammation, asthma and allergies.…

Protecting lungs from ventilator-induced injury

An unfortunate truth about using mechanical ventilation to save lives is that the pressure can cause further lung damage. Scientists are working to boost a natural cellular process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators.

Breast Milk + Probiotics Reduces Inflammation Associated with Necrotizing Enterocolitis in Preemies

Article title: Short chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo Authors: Yanan Gao, Brittany Davis, Weishu Zhu, Nan Zheng, Di Meng, W. Allan Walker From…

Researchers Explore How Exercise Influences Tendon Inflammation

Stephanie Dakin, PhD, BVetMed, from the University of Oxford in the U.K., studied the microscopic characteristics of tendons in people with exercise-related tendinopathy. Tendinopathy is a tendon disorder that causes pain, inflammation and limited function of the affected joint. Her research team found an increased number of blood vessels and cells—suggestive of inflammatory response—in the injured tendon samples when compared with healthy tissue.

Blocking Immune System Pathway May Stop COVID-19 Infection, Prevent Severe Organ Damage

While the world waits eagerly for a safe and effective vaccine to prevent infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the COVID-19 pandemic, researchers also are focusing on better understanding how SARS-CoV-2 attacks the body in the search for other means of stopping its devastating impact. The key to one possibility — blocking a protein that enables the virus to turn the immune system against healthy cells — has been identified in a recent study by a team of Johns Hopkins Medicine researchers.

Inflammatory Protein Found to Protect against Metabolic, Gut Changes in Mice

Article title: Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice Authors: Vishal Singh, Sarah Galla, Rachel M. Golonka, Andrew D. Patterson, Benoit Chassaing, Bina Joe, Matam Vijay-Kumar From the authors: “Overall, the current study demonstrates that…

Clear Link Between Heart Disease and COVID-19, But Long-Term Implications Unknown, Researchers Find in Review of Published Studies

In a prospectus review published this week in the Journal of Molecular and Cellular Cardiology, Kirk U. Knowlton MD, from the Intermountain Healthcare Heart Institute in Salt Lake City, examined more than 100 published studies related to COVID-19 and its effects on the heart.

Three Women Scientists at Johns Hopkins Tapped to Join Exclusive Research Network

Three Johns Hopkins Kimmel Cancer Center scientists are among the first 45 members selected to join the 10x Genomics Visium Clinical Translational Research Network (CTRN), aimed at advancing translational research in some of the world’s leading health problems, including oncology, immuno-oncology, neuroscience, infectious disease, inflammation and fibrosis, and COVID-19.

Blood Test May Point to Patients at Higher Risk for COVID-19 Deterioration, Death

George Washington University researchers found five biomarkers associated with higher odds of clinical deterioration and death in COVID-19 patients. Published in Future Medicine, these findings will help physicians better predict outcomes for COVID-19 patients in the U.S.

New Study on Development of Parkinson’s Disease is ‘On the Nose’

Scientists suggest that the initial impact of environmental toxins inhaled through the nose may induce inflammation in the brain, triggering the production of Lewy bodies that can then be spread to other brain regions. However, the relationship linking olfactory dysfunction and Parkinson’s disease development remains unclear. New findings from a study add weight to this theory and identify a critical signaling molecule that may be key to the domino effect kicked off by nasal inflammation.

Supercharged bandages to revolutionise chronic wound treatment

World-first plasma-coated bandages with the power to attack infection and inflammation could revolutionise the treatment of chronic wounds such as pressure, diabetic or vascular ulcers that won’t heal on their own.

Developed by the University of South Australia, the novel coating comprises a special antioxidant which can be applied to any wound dressing to simultaneously reduce wound inflammation a¬¬nd break up infection to aid in wound repair.

Immune from Chronic Stress? Limit Inflammatory Signaling to Specific Brain Circuits

Chronic stress is associated with the pathogenesis of psychological disorders such as depression. A study is the first to identify the role of a neuronal receptor that straddles the intersection between social stress, inflammation, and anxiety in rodent models of stress. Findings suggest the possibility of developing better medications to treat the consequences of chronic stress by limiting inflammatory signaling not just generally, which may not be beneficial in the long run, but to specific brain circuits.