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UrduA group of researchers from the Graduate School of Medicine at Nagoya University in Japan have discovered the impact of microRNA (miRNA) on inflammation in lupus in mice.
Tag: Inflammation
High fat diet activates early inflammation in mouse brains, supports link to neurologic disease
Researchers at Michigan Medicine have discovered that a high-fat diet promotes an early inflammatory response in the brains of mice through an immune pathway linked to diabetes and neurologic diseases, suggesting a possible bridge between metabolic dysfunction and cognitive impairment.
Chula Medicine Determines “Cytokines” as Indicator of “Degenerative Joints” Giving Hopes for Better Disease Mitigation
Chula Medicine announced the discovery of “cytokines” in the body’s immune system that can determine the severity of osteoarthritis in elderly adults, hoping to facilitate the planning of follow-up and treatment of the disease, and reduction of its severity, while also recommending vitamin D and vitamin E supplements, body weight control, and proper exercise.
Research Identifies Potential Genetic Cause for MIS-C Complication Following COVID-19 Infection
New research findings have revealed an underlying genetic cause for why some children who have had COVID-19 infection develop Multisystem Inflammatory Syndrome in Children (MIS-C), a rare but potentially life-threatening disease.
The findings, published in Science, are the first potential genetic cause identified for MIS-C, a disease that typically occurs about four weeks after COVID-19 infection and has broad symptoms such as fever, vomiting and inflammation of the heart muscle that can lead to hospitalization. States have reported about 9,000 MIS-C cases, with 71 deaths, according to most recent Centers for Disease Control and Prevention numbers.
Poor Gut Health May Drive Multiple Sclerosis — Better Diet May Ease It
A Rutgers study shows how digestive inflammation may drive MS and provides further evidence that more fiber by combat the condition.
Drug discovery offers potential treatment for common kidney disease
A serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines, a new study shows.
LJI researchers find missing piece of the asthma puzzle
“This is a very striking and significant result that essentially separates LIGHT from any of the other inflammatory cytokines that have been implicated in the process in severe asthmatics.”
Researchers ID Role of Enzyme as Regulator of Inflammation in Lung Disease
Article title: Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome Authors: Ashley Y. Gao, Ana M. Diaz Espinosa, Fiorenza Gianì, Tho X. Pham, Chase M. Carver, Aja Aravamudhan, Colleen M. Bartman, Giovanni Ligresti, Nunzia…
Trouble sleeping? You could be at risk of type 2 diabetes
As the Christmas season starts to ramp up, University of South Australia researchers are reminding people to prioritise a good night’s sleep as new research shows that a troubled sleep may be associated with risk factors for type 2 diabetes.
Study Identifies New Gene That Drives Colon Cancer
Researchers have identified a new gene that is essential to colon cancer growth and found that inflammation in the external environment around the tumor can contribute to the growth of tumor cells.
Loss of Transport Protein Function Contributes to Chronic Intestinal Inflammation
Article title: Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression Authors: Rainelli Koumangoye, Parker Penny, Eric Delpire From the authors: “We speculate that the upregulation of claudin-2, if confirmed in vivo, by increasing pore permeability…
Mount Sinai Study Uncovers Mechanisms of Reactive Oxygen Species in Stem Cell Function and Inflammation Prevention
Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could provide greater insights into the prevention and treatment of inflammatory bowel diseases (IBD), according to findings published in the journal Gut on October 3.
Garlic chives hold ‘therapeutic promise’ against heart disease and other obesity-related illness
Nebraska researchers seek to identify the bioactive molecules that give chive nanoparticles their “very strong anti-inflammatory function.”
When Recovery Goes Awry
New findings reveal how recovery progresses following inflammation triggered by injury or illness
Ochsner and Tulane collaboration uncovers what happens to genes inside artery plaques to trigger strokes
Researchers at Ochsner Health and Tulane University School of Medicine have identified the genes that become active in carotid arteries when plaque rupture causes a stroke. The work, published in Scientific Reports, was made possible by acquiring samples closer to the time of the stroke than previously possible. The results provide a picture of what the cells in the plaque are doing near the moment they induce a stroke.
Down on Vitamin D? It could be the cause of chronic inflammation
World-first genetic research from the University of South Australia shows a direct link between low levels of vitamin D and high levels of inflammation, providing an important biomarker to identify people at higher risk of or severity of chronic illnesses with an inflammatory component.
SuPAR identifies patients at high risk of blood clot formation
Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms—blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.
MD Anderson Research Highlights for July 13, 2022
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include new targets involved in protecting DNA replication forks and preventing inflammatory responses, a new treatment option for elderly patients with late-stage acute myeloid leukemia, insights into the breast cancer tumor microenvironment, biomarkers of response to targeted and immune therapies, a novel cellular therapy option for osteosarcoma and a new target for inducing ferroptosis in cancer cells.
Studying the Link Between Gum Disease and Alzheimer’s Disease
New research published in the journal Frontiers in Aging Neuroscience by Tufts University scientists and colleagues suggests a link between Fusobacterium nucleatum (F. nucleatum), a common type of bacteria that proliferates in periodontal disease, and Alzheimer’s disease.
Could Carbon Monoxide Foam Help Fight Inflammation?
Carbon monoxide is best known as a potentially deadly gas. However, in small doses it also has beneficial qualities: It has been shown to reduce inflammation and can help stimulate tissue regeneration.
A dynamic duo of cells identified in lung blood vessels
Scientists have identified two subtypes of lung blood vessel cells. One subtype expresses more genes involved in inflammation and the regulation of the immune response; the other expresses more genes involved in cell regeneration and proliferation. The findings could lead to better treatments for lung infections.
Blocking enzyme could hold the key to preventing, treating severe COVID-19
Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests.
Nerve Stimulation Promotes Resolution of Inflammation
The nervous system is known to communicate with the immune system and regulate inflammation in the body.
Researchers Identify Potential Target for Treating Autoimmune Diseases
New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.
Flu causes cardiac complications by directly infecting the heart
Researchers have shown for the first time in mice that heart problems seen in some of the sickest flu patients are caused by direct influenza infection of cardiac cells.
Inflammation, Rather Than Virus Provoking It, May Be Key to COVID-19 Loss of Smell
Johns Hopkins Medicine-led study finds inflammation-caused nerve damage weakens odor signals to the brain
Flexible printable electrical patches for accelerated wound healing
There are myriad ways in which people can experience physical wounds – from minor scrapes and abrasions to the effects of surgery, critical injuries, burns and other major traumas.
A Prune—Or Six—a Day May Keep Inflammation at Bay
A study in postmenopausal people suggests eating nutrient-rich prunes every day may be beneficial to bone health, reducing inflammatory factors that contribute to osteoporosis. The research will be presented this week in Philadelphia at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2022.
Study: Obesity raises the risk of gum disease by inflating growth of bone-destroying cells
Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research that sought to improve understanding of the connection between obesity and gum disease.
A potential role for ibuprofen in older adults’ immunity to RSV
New research suggests there may someday be a role for ibuprofen in providing older adults with lasting immunity against RSV, a virus commonly associated with infants and young kids that also rivals the flu as a dangerous wintertime infection for the elderly.
An Inflammation to Remember
A new discovery of a physiological mechanism of psychosomatic illnesses could open a new therapeutic avenue for treating chronic inflammatory conditions such as Crohn’s disease, psoriasis, and other autoimmune conditions, by attenuating their memory trace in the brain.
Exploring the Science of Acupuncture
Researchers have discovered neurons needed for acupuncture‘s anti-inflammatory response
Same Treatment Tested for Kids with Kawasaki Disease and Rare COVID-19 Reaction
Researchers at University of California San Diego School of Medicine tested the same treatment for kids with Kawasaki disease and rare COVID-19 reaction.
Study identifies potential target for treating systemic inflammation in obesity
Researchers studying the enzyme DHPS have determined that blocking its activity in mouse macrophages leads to a reduction in proteins that drive inflammation during obesity, leading to improved glycemic control.
Rheumatoid arthritis treated with implanted cells that release drug
Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
What Makes Blood Vessels Leaky: New Insights for Sepsis Therapeutics
Lab studies reveal protein HSP27’s role in blood vessel leakage, opening the possibility that therapeutically dialing its activity up or down might stabilize patients with sepsis.
For psoriasis, targeting skin protein may help control inflammation
Targeting a protein found in the skin may reduce the severity of psoriasis, a Michigan Medicine study found. Using a mouse model to mimic psoriasis, researchers found changing levels of interferon kappa altered the severity of inflammation.
Young, Healthy Woman Suffers Brain Inflammation after Mild COVID-19 Infection
UC San Diego Health physicians describe first known case of young, healthy adult experiencing central nervous system inflammation due to COVID-19, but without cognitive impairment.
Study: Light therapy helps burn injuries heal faster by triggering growth protein
The research found that photobiomodulation – a form of low-dose light therapy – sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein that controls cell growth and division.
A Distinctive Inflammatory Signature Found in a Genetic Form of ALS
Researchers find an increase in inflammatory molecules in serum and cerebrospinal fluid of C90RF72 patients, informing future anti-inflammatory therapies.
Understanding gut inflammation may hold clues to mitigating Parkinson’s onset
GRAND RAPIDS, Mich. (JUNE 8, 2021) — Chronic inflammation in the gut may propel processes in the body that give rise to Parkinson’s disease, according to a study by scientists at Van Andel Institute and Roche.
Diets that Promote Inflammation Could Increase Breast Cancer Risk
A new study of more than 350,000 women found that women with diets incorporating more foods that increase inflammation in the body had a 12% increase in their risk of breast cancer compared to women who consume more anti-inflammatory diets.
Male hormones regulate stomach inflammation in mice
Scientists at the National Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach. The study was published in Gastroenterology.
Blocking Cell Death Protein Reduces COPD-associated Inflammation, Lung Damage
Article title: Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD Authors Felix Ritzmann, Kai Borchardt, Giovanna Vella, Praneeth Chitirala, Adrian Angenendt, Christian Herr, Michael D. Menger, Markus Hoth, Annette Lis, Rainer M Bohle, Robert Bals, Christoph…
Study says inflammation seen in earliest stages of Parkinson’s disease, and it is different between men and women
New research shows evidence of inflammation in the blood of Parkinson’s disease patients during the earliest stages of the disease, lending support to theories that inflammation is a major driver of PD. The study also points out differences between the sexes in the symptoms and course of the disease.
Inflammatory diet linked to testosterone deficiency in men
Consuming a diet high in pro-inflammatory foods – including foods that contain refined carbohydrates and sugar as well as polyunsaturated fats – may be associated with increased odds of developing testosterone deficiency among men, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
Quit the Hookah! Lung Damage, Inflammation Is Reversible with Smoking Cessation
New research finds that quitting smoking is an effective way to resolve impaired lung function and airway inflammation associated with waterpipe smoking. The study is published ahead of print in the American Journal of Physiology-Lung Cellular and Molecular Physiology.
Researchers Identify Immune Cells that Contribute to Transplant Rejection
‘Tissue-resident memory T cells’, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection.
How pregnancy turns the stress response on its head
Researchers found two simultaneous conditions in pregnancy’s response to stress that made them realize just how complex the cross-talk between mom and baby is during gestation: Immune cells in the placenta and uterus were not activated, but significant inflammation was detected in the fetal brain.