Carbon monoxide is best known as a potentially deadly gas. However, in small doses it also has beneficial qualities: It has been shown to reduce inflammation and can help stimulate tissue regeneration.
Scientists have identified two subtypes of lung blood vessel cells. One subtype expresses more genes involved in inflammation and the regulation of the immune response; the other expresses more genes involved in cell regeneration and proliferation. The findings could lead to better treatments for lung infections.
Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests.
The nervous system is known to communicate with the immune system and regulate inflammation in the body.
New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.
Researchers have shown for the first time in mice that heart problems seen in some of the sickest flu patients are caused by direct influenza infection of cardiac cells.
Johns Hopkins Medicine-led study finds inflammation-caused nerve damage weakens odor signals to the brain
There are myriad ways in which people can experience physical wounds – from minor scrapes and abrasions to the effects of surgery, critical injuries, burns and other major traumas.
A study in postmenopausal people suggests eating nutrient-rich prunes every day may be beneficial to bone health, reducing inflammatory factors that contribute to osteoporosis. The research will be presented this week in Philadelphia at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2022.
Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research that sought to improve understanding of the connection between obesity and gum disease.
New research suggests there may someday be a role for ibuprofen in providing older adults with lasting immunity against RSV, a virus commonly associated with infants and young kids that also rivals the flu as a dangerous wintertime infection for the elderly.
A new discovery of a physiological mechanism of psychosomatic illnesses could open a new therapeutic avenue for treating chronic inflammatory conditions such as Crohn’s disease, psoriasis, and other autoimmune conditions, by attenuating their memory trace in the brain.
Researchers have discovered neurons needed for acupuncture‘s anti-inflammatory response
Researchers at University of California San Diego School of Medicine tested the same treatment for kids with Kawasaki disease and rare COVID-19 reaction.
Researchers studying the enzyme DHPS have determined that blocking its activity in mouse macrophages leads to a reduction in proteins that drive inflammation during obesity, leading to improved glycemic control.
Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
Lab studies reveal protein HSP27’s role in blood vessel leakage, opening the possibility that therapeutically dialing its activity up or down might stabilize patients with sepsis.
Targeting a protein found in the skin may reduce the severity of psoriasis, a Michigan Medicine study found. Using a mouse model to mimic psoriasis, researchers found changing levels of interferon kappa altered the severity of inflammation.
UC San Diego Health physicians describe first known case of young, healthy adult experiencing central nervous system inflammation due to COVID-19, but without cognitive impairment.
The research found that photobiomodulation – a form of low-dose light therapy – sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein that controls cell growth and division.
Researchers find an increase in inflammatory molecules in serum and cerebrospinal fluid of C90RF72 patients, informing future anti-inflammatory therapies.
GRAND RAPIDS, Mich. (JUNE 8, 2021) — Chronic inflammation in the gut may propel processes in the body that give rise to Parkinson’s disease, according to a study by scientists at Van Andel Institute and Roche.
A new study of more than 350,000 women found that women with diets incorporating more foods that increase inflammation in the body had a 12% increase in their risk of breast cancer compared to women who consume more anti-inflammatory diets.
Scientists at the National Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach. The study was published in Gastroenterology.
Article title: Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD Authors Felix Ritzmann, Kai Borchardt, Giovanna Vella, Praneeth Chitirala, Adrian Angenendt, Christian Herr, Michael D. Menger, Markus Hoth, Annette Lis, Rainer M Bohle, Robert Bals, Christoph…
New research shows evidence of inflammation in the blood of Parkinson’s disease patients during the earliest stages of the disease, lending support to theories that inflammation is a major driver of PD. The study also points out differences between the sexes in the symptoms and course of the disease.
Consuming a diet high in pro-inflammatory foods – including foods that contain refined carbohydrates and sugar as well as polyunsaturated fats – may be associated with increased odds of developing testosterone deficiency among men, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
New research finds that quitting smoking is an effective way to resolve impaired lung function and airway inflammation associated with waterpipe smoking. The study is published ahead of print in the American Journal of Physiology-Lung Cellular and Molecular Physiology.
‘Tissue-resident memory T cells’, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection.
Researchers found two simultaneous conditions in pregnancy’s response to stress that made them realize just how complex the cross-talk between mom and baby is during gestation: Immune cells in the placenta and uterus were not activated, but significant inflammation was detected in the fetal brain.
Inflammation is a hallmark of chronic pain, and scientists at the UNC School of Medicine have discovered that anti-inflammatory cells called MRC1+ macrophages are dysfunctional in an animal model of neuropathic pain.
At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.
Chronic kidney disease (CKD) is recognized as a public health problem, affecting more than 15% of the population. Although CKD can drastically impair health, it is rarely diagnosed early due to its silent revelation. Identifying and proposing treatments to attenuate…
A new review suggests that blood vessel damage and impaired oxygen delivery related to COVID-19 play a role in mood changes and cognitive difficulties that people with the disease face during illness and recovery. The review is published in Physiological Reports.
Nick Pullen, Ph.D., an associate professor of Biological Sciences at the University of Northern Colorado (UNC), provides expertise regarding the topic of COVID-19 vaccinations and immunity. Pullen’s research centers around the body’s immune response, specifically chronic inflammation, asthma and allergies.…
The healthy human oral microbiome consists of not just clean teeth and firm gums, but also bacteria living in an environment where they constantly communicate with the immune system. A growing body of evidence has shown that this system is highly influential on, and influenced by, our overall health.
In a new study in Circulation, researchers from Tufts University School of Medicine in collaboration with investigators at Vanderbilt University and Tufts Medical Center reveal a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart.
Article title: Platelet activation contributes to hypoxia-induced inflammation Authors: Cassidy Delaney, Pavel Davizon-Castillo, Ayed Allawzi, Janelle Posey, Aneta Gandjeva, Keith Neeves, Rubin M. Tuder, Jorge Di Paola, Kurt R. Stenmark, Eva S. Nozik From the authors: “Our data provide evidence…
Researchers at Washington University School of Medicine in St. Louis have engineered cartilage cells to release an anti-inflammatory drug in response to stresses such cells undergo when they are compressed during weight bearing and movement.
Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them as a means to potentially lower cancer risk for both astronauts and people on Earth.
A new study shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive.
Macrophages, the killer cells of the immune system, are controlled by circadian rhythms, a finding which may indicate that our ability to fight disease relies more heavily on daily circadian cycles than previously assumed.
An unfortunate truth about using mechanical ventilation to save lives is that the pressure can cause further lung damage. Scientists are working to boost a natural cellular process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators.
Article title: Short chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo Authors: Yanan Gao, Brittany Davis, Weishu Zhu, Nan Zheng, Di Meng, W. Allan Walker From…
Neurologists are researching whether a novel immunomodulatory treatment, OP-101, can dampen lung and brain injury in hospitalized COVID-19 patients through a clinical trial at The University of Texas Health Science Center at Houston (UTHealth).
Stephanie Dakin, PhD, BVetMed, from the University of Oxford in the U.K., studied the microscopic characteristics of tendons in people with exercise-related tendinopathy. Tendinopathy is a tendon disorder that causes pain, inflammation and limited function of the affected joint. Her research team found an increased number of blood vessels and cells—suggestive of inflammatory response—in the injured tendon samples when compared with healthy tissue.
Beta-blockers could potentially be used to treat COVID-19, according to a new international study by Italian and Australian scientists.
New research by a University of Georgia scientist reveals that girls who are maltreated show higher levels of inflammation at an early age than boys who are maltreated or children who have not experienced abuse.
The raging lung inflammation that can contribute to death from the flu can be stopped in its tracks by a drug derived from a naturally occurring human protein, a new animal study suggests.