BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune
Tag: Exosomes
Healing Diabetes Wounds with a New Superhero: Stem Cell Magic
Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.
Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study
BACKGROUNDPeripheral nerve injury can result in significant clinical complications that have uncertain prognoses. Currently, there is a lack of effective pharmacological interventions for nerve damage, despite the existence of several small
‘iTEARS’ could help diagnose diseases by isolating biomarkers in tears
In ACS Nano, researchers report a nanomembrane system that harvests and purifies tiny blobs called exosomes from tears, allowing researchers to quickly analyze them for disease biomarkers. Dubbed iTEARS, the platform could enable more efficient and less invasive diagnoses for many diseases.
Inhalable COVID-19 Vaccine Shows Promise in Rodent Model
Researchers have created an inhalable COVID-19 vaccine that is shelf stable at room temperature for up to three months, targets the lungs specifically and effectively, and allows for self-administration via an inhaler.
Study to Examine Exosomes in Ovarian Cancer
Researchers have been awarded a $3.1 million grant from the National Institutes of Health to investigate more effective ways to identify ovarian cancer earlier.
Reopen and Regenerate: Exosome-Coated Stent Heals Vascular Injury, Repairs Damaged Tissue
An exosome-coated stent with a “smart-release” trigger could prevent reopened blood vessels from narrowing and deliver regenerative stem cell-derived therapy to blood-starved, or ischemic, tissue.
New strategy blocks chronic lung disease in mice
A new study from Washington University School of Medicine in St. Louis has uncovered a previously unknown role for exosomes in inflammatory respiratory diseases. The study has implications for finding new therapies. Exosomes are tiny compartments released from cells that carry different types of cargo, including inflammatory chemicals called cytokines that can drive lung disease.
Scientists ‘Farm’ Natural Killer Cells in Novel Cancer Fighting Approach
Engineers and oncologists teamed to develop a microfluidic chip capable of capturing the body’s natural killer immune cells to harvest their cancer-killing exosomes.
Exosome treatment improves recovery from heart attacks in a preclinical study
Research in pigs shows that using the exosomes naturally produced from a mix of heart muscle, endothelial and smooth muscle cells — all derived from human induced pluripotent stem cells — yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells.
A new gene therapy strategy, courtesy of Mother Nature
Scientists have developed a new gene-therapy technique by transforming human cells into mass producers of tiny nano-sized particles full of genetic material that has the potential to reverse disease processes.