Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the immunotherapy tremelimumab to a combination of durvalumab plus chemotherapy to overcome treatment resistance typically seen in this patient population.
Tag: Biotechnology
ACS president comments on award of 2024 Nobel Prize in Chemistry
On behalf of the American Chemical Society (ACS), President Mary K. Carroll congratulates today’s winners of the Nobel Prize in Chemistry: David Baker, of the University of Washington; Demis Hassabis, of Google DeepMind; and John M. Jumper, of Google DeepMind.
ReadCube expands literature management with new AI Assistant and comprehensive search
Digital Science announces the AI-powered ReadCube Pro, offering researchers new tools to simplify and accelerate literature management and literature monitoring workflows.
Greenhouse gains: cucumbers get a genetic upgrade through innovative pollen tech
Researchers have achieved a groundbreaking advancement in plant biotechnology by using a magnetofected pollen gene delivery system to genetically transform cucumbers. This cutting-edge method uses DNA-coated magnetic nanoparticles to introduce foreign genes into pollen, producing genetically modified seeds without the need for traditional tissue culture or regeneration steps. This technique significantly streamlines and accelerates crop genetic modification, opening up new avenues to boost agricultural productivity and resilience.
Swifter simulations for modern science. All of it
In a machine learning paper recently published in the journal npj Computational Materials, a team of researchers from Sandia National Laboratories and Brown University have introduced a universal way to accelerate virtually any kind of simulation.
Psilera receives positive preclinical in vivo data for frontotemporal dementia (FTD) candidate, PSIL-006
Psilera, Inc. (Psilera), a leading biotechnology company developing therapies for rare neurological disorders, has received initial toxicity readouts from maximum tolerated dose (MTD) in vivo studies showing a strong safety profile.
Bulwark of blooms: the lily’s secret armor against plant pathogens
A cutting-edge study reveals the biochemical defense system of the wild lily, Lilium regale, which demonstrates remarkable resistance against Fusarium wilt—a major threat to the floriculture industry. The research uncovers the lily’s robust defense mechanisms, spotlighting the critical role of phenylpropanoid metabolism and the regulatory influence of specific transcription factors. These findings offer valuable insights for developing crops with enhanced disease resistance.
Harrisburg University’s Charles Brumlik, PhD, Named a 2024 Fellow by the American Chemical Society (ACS)
The American Chemical Society (ACS) has added 37 new names to its roster of ACS Fellows in 2024, including Charles Brumlik, PhD, corporate faculty in the Master of Science in Biotechnology program at Harrisburg University of Science and Technology.
New brain-computer interface allows man with ALS to ‘speak’ again
A brain-computer interface developed by UC Davis Health accurately translates brain signals into speech. The device implanted in the brain of a man with ALS is the most accurate system of its kind.
The New MagBinder® Fit24 Nucleic Acid Purification System Introduced at the 2024 ADLM in Chicago
New Nucleic Acid Purification System from Omega Bio-tek to Debut at the 2024 ADLM in Chicago
Harrisburg University Research Roundup: July 2024
Harrisburg, PA – Welcome to your July 2024 Harrisburg University of Science and Technology (HU) Research Roundup! Our talented students and faculty members are busy presenting at conferences, publishing boundary-pushing research, and building fruitful partnerships with schools, agencies, and organizations.…
JMIR XR and Spatial Computing is inviting submissions for a new theme issue titled “First Look: Early Research, Viewpoints, and Experiences with Apple Vision Pro in Health Care Settings”
JMIR Publications invites submissions to a new theme issue titled “First Look: Early Research, Viewpoints, and Experiences with Apple Vision Pro in Health Care Settings” in its new open access journal JMIR XR and Spatial Computing.
Mulberry mystery solved: genetic insights into anthocyanin richness
Unlocking the genetic secrets of mulberry anthocyanin content, a study illuminates the regulatory mechanisms that dictate fruit color and nutritional quality.
Blueprint for blueberry: decoding the genetic pathways of plant regrowth
A pivotal study has shed light on the genetic factors that govern the ability of highbush blueberries to regenerate from shoots, a critical process for plant breeding and genetic engineering. By comparing the transcriptomes of two genotypes with contrasting regeneration rates, researchers identified key auxin-related genes and transcription factors crucial to this process.
Unraveling the DNA mystique of Saposhnikovia divaricata: new horizons in herbal medicine
In a pioneering study, scientists have decoded the genetic blueprint of Saposhnikovia divaricata, a traditional medicinal herb. The research provides a detailed genome sequence, shedding light on the plant’s evolutionary adaptations and the genetic foundations of its therapeutic benefits.
Yeast Fuel, Developed by Chula’s Faculty of Science Soon to Expand Its Production for the Aerospace Industry
Researchers from Chulalongkorn University have made use of forage grass to feed microorganisms and convert the resulting fat into jet fuel. They aim to expand petroleum-based oil replacement production to reduce impacts on human health and the environment.
Revolutionizing Cancer Treatment: Wistar and Accelerated Biosciences Collaborate to Pioneer Transformative Immune Cell Therapies
The Wistar Institute is pleased to announce a research collaboration with Accelerated Biosciences Corp. aimed at creating a platform based on human trophoblast stem cells to explore new immunotherapies that use Accelerated Bio’s proprietary technology.
Intensity Therapeutics, Inc. Announces First Patient Dosed in its Global Randomized, Phase 3 Study (INVINCIBLE-3) in Metastatic Soft Tissue Sarcoma
Intensity Therapeutics, Inc. , a late-stage clinical biotechnology company focused on the discovery and development of proprietary, novel immune-based intratumorally injected cancer therapies intended to kill tumors directly and increase immune system recognition of cancers, announces that the first U.S. patient has been dosed in the Company’s Phase 3 study to treat metastatic sarcoma (NCT06263231).
Biotech entrepreneur donates $50 million to UC Irvine School of Biological Sciences
The University of California, Irvine has received a $50 million donation from Orange County biotech entrepreneur Charlie Dunlop for the School of Biological Sciences. Dean Frank LaFerla announced the gift before thousands of graduating students, faculty and family supporters at today’s school commencement, where Dunlop was the featured speaker.
Unlocking the grape’s secret scent: key gene modulates terpene aroma
A study explores the ethylene-responsive gene VviERF003’s influence on glycosylated monoterpenoid synthesis in grapes, which are pivotal for the fruity and floral notes in wines. Understanding this genetic regulation provides insights into how wine aroma can be influenced, potentially allowing for the development of grapes with enhanced or specific aromatic profiles.
Transforming agriculture: engineered nanoparticles for plant gene regulation
In a major advancement for plant biology and agriculture, researchers have developed a novel method for systemic gene silencing in plants using engineered dsRNA-protein nanoparticles. This technique, which rapidly characterizes gene functions, could revolutionize in planta gene editing.
New Pathways for Treating Never-Smoker Lung Cancer Revealed
Korean joint research team have elucidated the overexpression of estrogen signaling pathways in specific Korean never-smoking lung cancer cases using multi-omics analysis and proposed the anti-cancer drug saracatinib as a targeted therapeutic agent.
Factor Bioscience Successfully Defends Three U.S. Patents Covering Foundational Methods for Therapeutic Gene Editing
Factor Bioscience Inc., a Cambridge, Massachusetts-based biotechnology company pioneering mRNA-based cell engineering, today announced that the United States Patent and Trademark Office (USPTO) has terminated three separate ex parte reexaminations of three U.S. patents owned by Factor.
Brookhaven Lab Biophysicist F. William Studier Awarded Merkin Prize in Biomedical Technology
F. William Studier, a senior biophysicist emeritus at the U.S. Department of Energy’s ‘Brookhaven National Laboratory, has won the 2024 Richard N. Merkin Prize in Biomedical Technology for his development in the 1980s of an efficient, scalable method of producing RNA and proteins in the laboratory.
New DNA origami technique promises breakthroughs in medicine
A new study led by the University of Portsmouth in England has developed an innovative method to customise and strengthen DNA origami structures, which could lead to advances in medicine, biotechnology, and beyond.
Gene Expression and Bioinformatics Tools to Optimize Cancer Therapy
In the field of biomedical research and genomics, the advancement of bioinformatics technologies and tools is opening new frontiers in the understanding of diseases and their diagnosis and treatment.
Marriage of synthetic biology and 3D printing produces programmable living materials
Researchers report in ACS Central Science that they have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.
Factor Bioscience to Deliver Seven Presentations at the American Society of Gene & Cell Therapy (ASGCT) 27th Annual Meeting
Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 27th Annual Meeting to be held in Baltimore, MD from May 7-11, 2024.
Cello-gum Innovation Revolutionizes the Food Industry: Turning Coconut Jelly Biowaste into Billions in Raw Material Value
“Cello-gum”, a groundbreaking innovation by Prof. Dr. Hathaikarn Manuspiya from the Petroleum and Petrochemical College at Chulalongkorn University, transforms coconut jelly biowaste into valuable food ingredients worth billions of baht.
Biotechnology CEO and Inventor of SiriusXM Satellite Radio Martine Rothblatt to Deliver Graduation Address to the University of Maryland School of Medicine’s 215th Graduating Class
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Martine Rothblatt PhD, JD, MBA, Chairperson and CEO of United Therapeutics, and inventor of SiriusXM Satellite Radio, will deliver the keynote address for this year’s graduating medical student class. The UMSOM MD graduation ceremony will take place at the Hippodrome Theatre on Thursday, May 16, 2024.
Psilera Welcomes Biopharma Executive Dr. Magali Haas to its Board of Directors
Psilera, a leading biotechnology company developing groundbreaking therapies for hard-to-treat neurological disorders, is pleased to announce the appointment of Magali Haas, M.D., Ph.D., to its esteemed Board of Directors.
Expert available to discuss transgenic cow capable of producing human insulin in milk
A new study in Biotechnology Journal describing a transgenic cow capable of producing human proinsulin and insulin in her milk could have wide-reaching implications for millions of diabetics worldwide. The advancement provides proof-of-concept for a system that would require refinement…
Membrane Technology: Looking Deep into Smallest Pores
Membranes of vertically aligned carbon nanotubes (VaCNT) can be used to clean or desalinate water at high flow rate and low pressure. Recently, researchers of Karlsruhe Institute of Technology (KIT) and partners carried out steroid hormone adsorption experiments to study the interplay of forces in the small pores. They found that VaCNT of specific pore geometry and pore surface structure are suited for use as highly selective membranes. The researchers report in Nature Communications. (DOI: 10.1038/s41467-024-44883-2)
Ochsner Health physician granted NIH Trailblazer Award
Dr. Hernan Bazan honored for innovation in non-opioid drug development amidst the opioid crisis.
Rakuten Medical Presents AI-based Study in Two Posters on Immune Characteristics in Responders and Cellular Level Drug Quantification of Alluminox Treatment (Photoimmunotherapy) at SITC 2023
Rakuten Medical, Inc., a global biotechnology company developing and commercializing precision, cell-targeted therapies based on its proprietary Alluminox™ platform today announced the presentation of two posters of AI-based analyses at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), held November 3-5, 2023, in San Diego, CA (SITC 2023).
Rakuten Medical to Present at 2023 Jefferies London Healthcare Conference on November 14
Rakuten Medical, Inc., a global biotechnology company developing and commercializing precision, cell targeting therapies based on its proprietary Alluminox™ platform, today announced that the Company will present at the 14th Annual Jefferies London Healthcare Conference being held in London, UK, on November 14-16, 2023.
Unlocking Sugar to Generate Biofuels and Bioproducts
Plant biologists at Brookhaven National Laboratory have engineered enzymes to modify grass plants so their biomass can be more efficiently converted into biofuels and other bioproducts.
A new era for accurate, rapid COVID-19 testing
Research from Osaka University demonstrates a nanopore-based technique that can detect different variants of SARS-CoV-2, the virus that causes COVID-19. The method was very effective in detecting the Omicron variant of the virus in the saliva of people with COVID-19.
ReMDO Grants Support Commercialization of Regenerative Medicine Therapies
The grant opportunity will create a continued impact on the rate of clinical translation for regenerative medicine therapies and the commercialization of regenerative medicine products within the global market.
Green Genetic Engineering: Making Mendel’s Dream Come True with Molecular Scissors
Molecular biologist Professor Holger Puchta from Karlsruhe Institute of Technology (KIT) is granted funding within a Reinhart Koselleck Project by the German Research Foundation (DFG) for work on specific restructuring of plant genomes. Puchta, a pioneer of green genetic engineering,…
Fungal genetics could help develop novel biotechnologies
An essential pillar of Earth’s ecological system, fungi have long been used to better the lives of humans. While these organisms are still vastly understudied, a new review paper suggests that their unique genomes could be used to make progress in the biotech industry.
Former Senior Level Department of Defense Official Joins RegenMed Hub
The Regenerative Medicine Hub continues to grow and attract top talent with the addition of Ron Hann, PhD, a former senior level official with the Department of Defense.
UC San Diego’s Astrobiotechnology Hub to Drive Drug Discovery in Space
UC San Diego’s new Astrobiotechnology Hub brings together leaders in academia, biotechnology and aerospace industries under a united mission to advance stem cell science and commercialization in space.
Department of Energy Announces $80 Million for Research to Accelerate Innovations in Emerging Technologies
Today, the U.S. Department of Energy (DOE) announced $80 million, provided by the Office of Science, to support fundamental research to drive the innovation cycle in support of the Accelerate Innovations in Emerging Technologies (Accelerate) initiative.
Beans IN toast could revolutionise British diet
Researchers and chefs at the University of Reading aim to encourage British consumers and food producers to switch to bread containing faba beans (commonly known as broad beans), making it healthier and less damaging to the environment.
Scientists have enhanced polymeric material for tissue repair
In the new study the authors have examined how conditions under which an amino group attaches to the polymer (temperature and the amount of arginine) affect the resulting qualities of the polycaprolactone film
Jurata Thin Film Raises $5 Million Seed Round
Jurata Thin Film, a startup focused on stabilizing vaccines at ambient temperature has raised initial investment funds totaling $4.87 million to develop the technology.
UC San Diego Awarded $8M to Expand Stem Cell Therapy Clinical Trials
UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.
Artificial Intelligence Makes Enzyme Engineering Easy
You can’t expect a pharmaceutical scientist to switch labs to the facilities available in a television studio and expect the same research output.
A new control system for synthetic genes
Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.