More than 1,000 SARS-CoV-2 Coronavirus Protein 3D Structures Available

New Brunswick, N.J. (March 3, 2021) – The 3D structures of more than 1,000 SARS-CoV-2 coronavirus proteins are freely available

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Harnessing the Power of Proteins in our Cells to Combat Disease

A lab on UNLV’s campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery — one that could potentially provide a solution for patients who have run out of options.

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Students Identify Starting Points for Potential COVID-19 Inhibitors

Two students working under the mentorship of Desigan Kumaran, a structural biologist at the U.S. Department of Energy’s Brookhaven National Laboratory, have helped to identify molecules that could potentially lead to new antiviral drugs for treating COVID-19. Though the students conducted their fall 2020 internships remotely, the potential of their work is firmly planted in the real world and could have lasting impact.

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PhRMA Foundation Awards More than $1 Million to Support Young Scientists with Grants and Fellowships in Drug Discovery and Drug Delivery

The PhRMA Foundation announced the first recipients of its new funding awards in Drug Discovery and Drug Delivery, designed to support the innovative biopharmaceutical research projects of talented young scientists in the United States. A total of 16 recipients were selected and more than $1 million was awarded.

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$11M NIH Grant Will Fund Biomedical Research at University of Delaware

the National Institutes of Health has renewed a Center of Biomedical Research Excellence (COBRE) grant at the University of Delaware. The COBRE research team is focused on discovery of new molecules that can be used to study and treat diseases such as breast cancer, renal cancer, Crohn’s disease, tuberculosis and Legionnaires disease.

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NYU, Columbia, and Takeda Form Research Alliance for Gastrointestinal and Liver Disorders

New York University, Columbia University, and Takeda Pharmaceutical Company Limited (“Takeda”) have formed a collaborative research alliance to begin and advance gastroenterology research programs, with the goal of developing new therapies for patients with gastrointestinal and liver disorders.

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University of Utah to speed process of bringing new therapeutics to patients

The Huntsman Cancer Institute, College of Pharmacy and PIVOT Center have partnered to establish the University of Utah Therapeutic Accelerator Hub. The new Accelerator will provide resources and expertise to researchers to support the process of translating research discoveries into innovative clinical applications.

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Dopamine Surge Reveals How Even for Mice, ‘There’s No Place Like Home’

“There’s no place like home,” has its roots deep in the brain. Using fiber photometry, scientists are the first to show that home evokes a surge of dopamine in mice that mimics the response to a dose of cocaine. The study demonstrates how dopamine rises rapidly in mice moved from a simple recording chamber to their home cage, but less so when they return to a cage not quite like the one they knew.

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Design and test potential COVID-19 treatments from your phone

Anyone with a smartphone can download the app ViDok, which lets users pick from a library of molecules that might bind to key proteins on the SARS-CoV-2 virus, which causes COVID-19, and then can tweak the molecules to try to find a better fit.

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Steady Progress in the Battle Against COVID-19

Researchers at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory are making progress on several fronts in the battle against COVID-19, the global pandemic sparked by the emergence of a novel coronavirus late last year. This work is part of a worldwide effort to understand the virus and the factors that affect its spread with the aim of devising treatments and other mitigation strategies.

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CARES Act funds major upgrade to Corona supercomputer for COVID-19 work

With funding from the Coronavirus Aid, Relief and Economic Security (CARES) Act, Lawrence Livermore National Laboratory, chipmaker AMD and information technology company Supermicro have upgraded the supercomputing cluster Corona, providing additional resources to scientists for COVID-19 drug discovery and vaccine research

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Researchers Identify “Druggable” Signaling Pathway that Stimulates Lung Tissue Repair

Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration, which is necessary for recovery from multiple lung injuries. The findings, which were published today in Nature Cell Biology, could lead to better therapies for patients with lung disease, including acute respiratory distress syndrome (ARDS) due to COVID-19.

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Summer Students Tackle COVID-19

When the COVID-19 pandemic hit, many students had to rejigger summer plans. Internships they’d expected to be in-person moved to all-virtual formats. For more than 30 students participating in virtual summer programs at the Brookhaven Lab, that disruption presented an opportunity—a chance to engage in research related to the virus responsible for the upheaval.

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Novel diabetes drug candidate shows promising properties in human islets and mouse models

Researchers have discovered a new drug candidate that offers a major advance to treat diabetes. Tested on human and mouse pancreatic islets, mouse and rat cell cultures and animal models of Type 1 and Type 2 diabetes, the drug significantly improved four detrimental characteristics of diabetes.

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In Cell Studies, Seaweed Extract Outperforms Remdesivir in Blocking COVID-19 Virus

In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease. The research is the latest example of a decoy strategy researchers at Rensselear Polytechnic Institute are developing against viruses like the novel coronavirus that spawned the current global health crisis.

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New antiplatelet drug shows promise for treating heart attack

Researchers have developed a new drug that prevents blood clots without causing an increased risk of bleeding, a common side effect of all antiplatelet medications currently available. A new study published in the journal Science Translational Medicine describes the drug and its delivery mechanisms and shows that the drug is also an effective treatment for heart attack in animal models.

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Supercomputing Aids Scientists Seeking Therapies for Deadly Bacterial Disease

A team of scientists led by Abhishek Singharoy at Arizona State University used the Summit supercomputer at the Oak Ridge Leadership Computing Facility to simulate the structure of a possible drug target for the bacterium that causes rabbit fever.

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UAH boosts search for COVID-19 drugs using HPE Cray Sentinel supercomputer

University of Alabama in Huntsville (UAH) professor of biological science Dr. Jerome Baudry is collaborating with Hewlett Packard Enterprise (HPE) to use HPE’s Cray Sentinel supercomputer to search for natural products that are effective against the COVID-19 virus.

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Researchers Working on Computational Models to Design Ways to Treat COVID-19

A team of Stony Brook University (SBU) researchers is working on computer models that could help speed the discovery of drugs to combat the novel coronavirus responsible for COVID-19. They are doing this work in collaboration with scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and Argonne National Laboratory, and will be leveraging those laboratories’ computational resources and expertise.

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Lab researchers aid COVID-19 response in antibody, anti-viral research

Lawrence Livermore National Laboratory scientists are contributing to the global fight against COVID-19 by combining artificial intelligence/machine learning, bioinformatics and supercomputing to help discover candidates for new antibodies and pharmaceutical drugs to combat the disease.

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The Tri-Institutional Therapeutics Discovery Institute, Inc. Renews Partnerships with Takeda and Bridge Medicines, LLC

To date, work done within the Tri-I TDI has resulted in the launch of two New York City–based companies and the licensing of six therapeutic discovery programs.

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LLNL develops 3D ‘brain-on-a-chip’ device capable of long-term recording of neural activity

Lawrence Livermore National Laboratory engineers and biologists have developed a “brain-on-a-chip” device capable of recording the neural activity of living brain cell cultures in three-dimensions, a significant advancement in the realistic modeling of the human brain outside of the body.

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NUS and A*STAR scientists identify promising liver cancer-killing compounds with novel drug-screening platform

Scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore, and the Agency for Science, Technology and Research (A*STAR)’s Genome Institute of Singapore (GIS) have discovered four potential drug compounds that target hepatocellular carcinoma (HCC), the most common type of liver cancer.

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LI High School Students Solve Protein Structures at Brookhaven’s Light Source

Students from Long Island, New York, high schools have collaborated across districts to decipher the atomic-level structures of two proteins involved in a variety of diseases. The students used very bright x-rays at the National Synchrotron Light Source II at Brookhaven National Laboratory to identify the 3-D arrangements of atoms that make up functional components of these proteins.

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Cyp2F2-Mediated Lung Cancer, Rapid Risk Assessment of Color Additives, and More Featured in November 2019 Toxicological Sciences

Toxicological Sciences continues to deliver cutting-edge research in toxicology in the November 2019 issue. This issue features research on computational toxicology and databases, developmental and reproductive toxicology, and more.

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