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UrduMesenchymal stem cells (MSCs) are a prevalent source for stem cell therapy and play a crucial role in modulating both innate and adaptive immune responses. Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of tr
Tag: Stem Cells
Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool
Bibliographic analysis is still very rarely used in experimental basic study papers. The comprehensive bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds, whic
Organoids Derived From Gut Stem Cells Reveal Two Distinct Molecular Subtypes of Crohn’s Disease
UC San Diego researchers discover two distinct molecular subtypes of Crohn’s disease using patient-derived organoids, opening the door to personalized treatment for the chronic inflammatory bowel disease.
Pausing biological clock could boost lab-produced blood stem cells
An Iowa State University research team has discovered when and why inflammatory signaling affects the formation of blood stem cells in embryos, which will benefit efforts to develop lab-grown, patient-derived stem cell transfusions to treat blood disorders. The promising advancement in regenerative medicine could eliminate the need for bone marrow transplants.
Breaking the link between obesity and atrial fibrillation with a new cellular target
Blocking oxidative stress enzyme prevents, even reverses, heart condition in lab models
Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury
Peripheral nerve injury (PNI) is a common neurological disorder and complete functional recovery is difficult to achieve. In recent years, bone marrow mesenchymal stem cells (BMSCs) have emerged as ideal seed cells for PNI treatment due to
Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor
BACKGROUNDPulmonary fibrosis is one of the main reasons for the high mortality rate among acute respiratory distress syndrome (ARDS) patients. Mesenchymal stromal cell-derived microvesicles (MSC-MVs) have been shown to exert antifibrotic ef
Mechanistic basis of lineage restriction
ABSTRACTLineage restriction, the biological phenomenon whereby developing cells progressively lose fate potency for all but their adopted lineages, is foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body. The mechanisms of…
Groundbreaking Study Solves Mystery of Multicellularity
A team of researchers from multiple institutions including the University of Chicago and VectorBuilder, has made a significant breakthrough in the understanding of lineage restriction, a biological phenomenon foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body.
Potential New Approach to Enhancing Stem-Cell Transplants
A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body’s different blood cells.
Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury
Wharton’s jelly mesenchymal stem cells (WJ-MSCs) are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation injuries. WJ-MSCs are more naïve and have a better safe
All Stem Cell Therapies Are Not Created Equal
Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. The results challenge the current “one-cell-cures-all” paradigm in orthopedic…
Revolutionizing Cancer Treatment: Wistar and Accelerated Biosciences Collaborate to Pioneer Transformative Immune Cell Therapies
The Wistar Institute is pleased to announce a research collaboration with Accelerated Biosciences Corp. aimed at creating a platform based on human trophoblast stem cells to explore new immunotherapies that use Accelerated Bio’s proprietary technology.
Priming mesenchymal stem cells to develop “super stem cells”
The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment, genetic manipulation, and chemical and pharmacological treatment, each strategy having adva
Priming mesenchymal stem cells to develop “super stem cells”
The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment, genetic manipulation, and chemical and pharmacological treatment, each strategy having adva
RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation
BACKGROUNDValidation of the reference gene (RG) stability during experimental analyses is essential for correct quantitative real-time polymerase chain reaction (RT-qPCR) data normalisation. Commonly, in an unreliable way, several studies u
Human toxicity of Nanomaterials Verified with ‘Organoid,’ an Artificial Organ
The Korea Research Institute of Standards and Science (KRISS) has developed the world’s first organoid culture method capable of accurately assessing human toxicity of nanomaterials.
New research points to ‘stem-like’ T cells as culprits in ulcerative colitis
The researchers hope to one day target this T cell population via drug therapy. “These cells may be a very important target for treating ulcerative colitis and perhaps other autoimmune diseases…”
Q&A: New Frontiers in ALS Research
Clive Svendsen, PhD, executive director of the Board of Governors Regenerative Medicine Institute and professor of Medicine and Biomedical Sciences at Cedars-Sinai, is developing new treatments and models for amyotrophic lateral sclerosis (ALS) using stem cells.
Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments
BACKGROUNDGliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and radiotherapy. Glioma stem cells (GSCs), a subset within tumors, contribute to resistance, tumor heterogeneity, and plasticity. Re
Cedars-Sinai to Join Abu Dhabi Global Healthcare Week
Cedars-Sinai experts are participating in the inaugural Abu Dhabi Global Healthcare Week, May 13-15 in Abu Dhabi, United Arab Emirates, highlighting their dedication to enhancing innovation and medical advances that will have a positive impact on communities worldwide.
Study: Hillocks challenge our understanding of lung biology
A research team from Tufts University School of Medicine and Massachusetts General Hospital is now reporting evidence that hillocks and their stem cells are physiologically distinct from other cells within the lung and consist of a stratified outer layer of scale-like squamous cells that protect an underlying layer of rapidly expanding basal stem cells that are capable of restoring airway tissue after injury.
$2.7 million grant to explore hypoxia’s impact on blood stem cells
Indiana University School of Medicine scientists are on a mission to understand why hematopoietic stem cells, responsible for producing all types of mature blood cells, exhibit better responses in a low-oxygen environment within the bone marrow, also known as hypoxia.
Study documents safety, improvements from stem cell therapy after spinal cord injury
A Mayo Clinic study shows stem cells derived from patients’ own fat are safe and may improve sensation and movement after traumatic spinal cord injuries. The findings from the phase 1 clinical trial appear in Nature Communications.
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
BACKGROUNDColorectal cancer stem cells (CCSCs) are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer (CRC) patients. CCSCs are generally accepted to be important sources of CRC and are
Cellular preconditioning and mesenchymal stem cell ferroptosis
In this editorial, we comment on the article published in the recent issue of the World Journal of Stem Cells. They focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionine γ-lyase/hydrogen sulfide (H2S) pa
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells
BACKGROUNDCartilage defects are some of the most common causes of arthritis. Cartilage lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized
Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro
BACKGROUNDIn vitro expansion to increase numbers of hematopoietic stem cells (HSCs) in cord blood could improve clinical efficacy of this vital resource. Nicotinamide (NAM) can promote HSC expansion ex vivo, but its effect on hematopoietic
Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics
This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enha
Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer
New research from the University of Ottawa proposes using vanoxerine as a safe method for potentially eliminating cancer stem cells in colorectal tumors.
Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives
BACKGROUNDStem cell therapy has shown great potential for treating diabetic foot (DF). AIMTo conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades, with the aim of depicting the current
UC Irvine study exposes risks of direct-to-consumer stem cell, exosome COVID-19 therapy ads
Irvine, Calif., Oct. 26, 2023 — A study from the University of California, Irvine has revealed that in 2022, 38 North American businesses used direct-to-consumer advertising to promote unproven stem cell interventions and exosome products as purported treatments and preventatives for COVID-19. Collectively, these organizations operated or facilitated access to 60 clinics – with 24 in the U.
Researchers discover disease-causing stem cells in lungs of cystic fibrosis patients
Two nationally recognized experts in cloning and stem cell science from the University of Houston, Wa Xian and Frank McKeon, are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis (CF), and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.
Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis
BACKGROUNDAcute lung injury (ALI) and its final severe stage, acute respiratory distress syndrome, are associated with high morbidity and mortality rates in patients due to the lack of effective specific treatments. Gut microbiota homeostas
Enhanced wound healing and hemostasis with exosome-loaded gelatin sponges from human umbilical cord mesenchymal stem cells
BACKGROUNDRapid wound healing remains a pressing clinical challenge, necessitating studies to hasten this process. A promising approach involves the utilization of human umbilical cord mesenchymal stem cells (hUC-MSCs) derived exosomes. The
Stem cell-derived components may treat underlying causes of PCOS
UChicago researchers recently unveiled a potential new PCOS treatment that restored ovarian function and improved hormonal and metabolic regulation in mice.
Study: Blood stem cell diversity arises in embryonic development
All humans have a diverse set of blood stem cell types that help govern overall health. As people age, they tend to lose this diversity, increasing their risk for blood cancers, cardiovascular disease and all-causes death. Yale School of Medicine…
UC Irvine-led researchers reveal new molecular mechanism for stimulating hair growth
Irvine, Calif., June 21, 2023 — The process by which aged, or senescent, pigment-making cells in the skin cause significant growth of hair inside skin moles, called nevi, has been identified by a research team led by the University of California, Irvine. The discovery may offer a road map for an entirely new generation of molecular therapies for androgenetic alopecia, a common form of hair loss in both women and men.
UTHealth Houston awarded nearly $13M in grants to study treatments for traumatic brain injury
Nearly $13 million in federal grant funds to study treatments for traumatic brain injury, which kills an average of 190 people and hospitalizes another 600 in the U.S. every day, has been awarded to UTHealth Houston by the Department of Defense’s Office of Congressionally Directed Medical Research Programs (CDMRP).
UC San Diego First to Test Cancer Drugs in Space Using Private Astronaut Mission
The latest space experiments from UC San Diego and Axiom Space will explore therapies for breast and colorectal cancer aboard the ISS, and monitor astronauts’ stem cell health over time.
NEI Scientists publish recipe for making blood vessel cells from patient stem cells
Researchers at NIH’s National Eye Institute have published a detailed protocol for making three cell types that are key components to form blood vessels and capillaries.
Research identifies new target that may prevent blood cancer
An international coalition of biomedical researchers co-led by Alexander Bick, MD, PhD, at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer. The technique, called PACER, led to the identification of a gene that, when activated, drives clonal expansion.
To Ward Off Aging, Stem Cells Must Take Out the Trash
UC San Diego researchers find stem cells use a surprising system for discarding misfolded proteins. This unique pathway could be the key to maintaining long-term health and preventing age-related blood and immune disorders.
UC San Diego’s Astrobiotechnology Hub to Drive Drug Discovery in Space
UC San Diego’s new Astrobiotechnology Hub brings together leaders in academia, biotechnology and aerospace industries under a united mission to advance stem cell science and commercialization in space.
Small Molecule Drug Reverses ADAR1-induced Cancer Stem Cell Cloning Capacity
UC San Diego researchers report that a late-stage, pre-clinical small molecule inhibitor reverses malignant hyper-editing by a protein that promotes silencing of the immune response, metastasis and therapeutic resistance in 20 different cancer types.
Nanofiber-Hydrogel Loaded with Stem Cells Shows Success Treating Severe Complication of Crohn’s Disease
In a new study using a rat model of Crohn’s disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown significant success in treating perianal fistulas (PAF) — one of the many complications of Crohn’s disease.
Lab-grown retinal eye cells make successful connections, open door for clinical trials to treat blindness
Retinal cells grown from stem cells can reach out and connect with neighbors, according to a new study, completing a “handshake” that may show the cells are ready for trials in humans with degenerative eye disorders.Over a decade ago, researchers from the University of Wisconsin–Madison developed a way to grow organized clusters of cells, called organoids, that resemble the retina, the light-sensitive tissue at the back of the eye.
NIH researchers use 3D bioprinting to create eye tissue
Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team from the National Eye Institute (NEI), part of the National Institutes of Health, printed a combination of cells that form the outer blood-retina barrier—eye tissue that supports the retina’s light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study degenerative retinal diseases such as age-related macular degeneration (AMD).
Cleveland Clinic Studying Stem Cell Treatment for Complex Regional Pain Syndrome
Cleveland Clinic was awarded $5.5 million from the National Institutes of Health to develop a stem cell treatment for complex regional pain syndrome, a disease that causes debilitating chronic pain.
The research shows long-term potential for providing patients suffering from chronic pain an alternative to addictive treatments like opioids.
Scientists Receive $4.8M to Pursue Gene Therapy for ‘Incurable’ Disease
The California Institute for Regenerative Medicine has awarded UC San Diego researchers $4.8 million to advance a gene therapy to treat Friedreich’s ataxia, a rare but devastating neuromuscular disorder.