Oral Probiotic Delivers Colitis Treatment Directly to Gut in Multiple Animal Models

Article title: Oral administration of CXCL12-expressing Limosilactobacillus reuteri improves colitis by local immunomodulatory actions in preclinical models Authors: Emelie Öhnstedt, Cristian Doñas, Kristel Parv, Yanhong Pang, Hava Lofton Tomenius, Macarena Carrasco López, Venkata Ram Gannavarapu, Jacqueline Choi, Maria Ovezik, Peter Frank, Margareth…

Researchers Engineer Yeast to Transport Medicines and Lower Inflammation for Potential Treatment of Inflammatory Bowel Disease

Researchers at the UNC Eshelman School of Pharmacy and the UNC School of Medicine have engineered a probiotic yeast that enhances probiotic absorption in the gut and has the ability to suppress and even reverse inflammation in animals.

Mount Sinai Scientists Discover the Cellular Functions of a Family of Proteins Integral to Inflammatory Diseases

In a scientific breakthrough, Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

Genetics, Sex and Smoking Linked to More Health Issues for IBD Patients

Investigators at Cedars-Sinai have identified risk factors that make inflammatory bowel disease (IBD) patients susceptible to developing serious conditions in other parts of their bodies.

Inflammatory Bowel Disease Linked to Atopic Dermatitis, Penn Medicine Research Finds

Adults with atopic dermatitis (AD) have a 34 percent increased risk of developing new-onset inflammatory bowel disease (IBD) compared with individuals who do not have the skin condition, and children have a 44 percent increased risk, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.

Mayo Clinic researchers link environmental exposures to liver disease

Mayo Clinic researchers have identified a diverse range of environmental chemicals in human bile in patients with primary sclerosing cholangitis, a rare, chronic liver disease of the bile ducts. The study, published in Exposome, represents a new frontier of research at Mayo Clinic’s Center for Individualized Medicine that explores the exposome, the measure of environmental contributors to disease and health.

May Issue of AJG Features Colonoscopy Quality and Bowel Prep, CME on Social Media

The May issue of AJG features new clinical science and reviews, including bowel prep recommendations for physicians, longer withdrawal times for screening colonoscopy, the use of social media for continuing medical education, and tofacitinib de-escalation and re-escalation for ulcerative colitis.

Can Butyrate Help Hispanic Children With Ulcerative Colitis?

New study is the first of its kind to focus on Hispanic children, who often have more severe disease. A novel clinical trial at Children’s Hospital Los Angeles is investigating whether butyrate—a short-chain fatty acid typically produced by gut bacteria—can be a potential therapy for children with ulcerative colitis.

Mount Sinai Study Uncovers Mechanisms of Reactive Oxygen Species in Stem Cell Function and Inflammation Prevention

Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could provide greater insights into the prevention and treatment of inflammatory bowel diseases (IBD), according to findings published in the journal Gut on October 3.

New Gastroparesis Clinical Guideline Featured in August Issue of AJG

The August issue of The American Journal of Gastroenterology highlights new clinical science, including a brand new ACG clinical guideline for the diagnosis and treatment of patients with gastroparesis.

Multi-Population Risk Scores Could Improve Risk Prediction for Inflammatory Bowel Diseases, Study Finds

New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities

NYU, Columbia, and Takeda Form Research Alliance for Gastrointestinal and Liver Disorders

New York University, Columbia University, and Takeda Pharmaceutical Company Limited (“Takeda”) have formed a collaborative research alliance to begin and advance gastroenterology research programs, with the goal of developing new therapies for patients with gastrointestinal and liver disorders.

Genetic Risk for Fatal Blood Clots Identified in IBD Patients

Blood clots are the biggest cause of death in patients with inflammatory bowel disease (IBD) ─ ulcerative colitis or Crohn’s disease. In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases.

University of Miami Study Finds Dietary Changes May Help People with Ulcerative Colitis

A new study published in Clinical Gastroenterology and Hepatology led by Maria T. Abreu, M.D., professor of medicine and professor of microbiology and immunology at the University of Miami Miller School of Medicine, found that eating diets low in fat and high in fiber may improve the quality of life of patients with ulcerative colitis (UC) — even those in remission.

Mount Sinai Researchers Unveil Mechanisms to Prevent Crohn’s Disease and First Study Linking Metals Exposure w/ IBD

In a series of four studies published today in Gastroenterology, a journal of the American Gastroenterological Association, Mount Sinai inflammatory bowel disease (IBD) researchers, describe the identification of predictive tools and a new understanding of environmental factors that trigger IBD.

Case Western Reserve University researchers discover critical link to controlling inflammation in Crohn’s disease

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).