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UrduNational Eye Institute researchers studying human retinas discovered 87 target genes where a mix of environmental factors likely influence one’s risk of developing age-related macular degeneration (AMD), a leading cause of vision loss in people ages 65 and older.
Tag: age-related macular degeneration
Inflammation-reducing drug shows no benefit for dry age-related macular degeneration in NIH trial
The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry age-related macular degeneration (AMD), according to a phase II clinical study at the National Eye Institute (NEI),…
Extremely rare gene variants point to a potential cause of age-related macular degeneration
A study from the National Eye Institute (NEI) identified rare genetic variants that could point to one of the general mechanisms driving age-related macular degeneration (AMD), a common cause of vision loss in older adults.
AI-based systems can help identify rapidly advancing age-related macular degeneration
Researchers supported by the National Eye Institute are developing artificial intelligence/machine learning (AI/ML)-based systems that not only screen for AMD but also predict which patients will likely progress to late within two years. The systems also evaluate separately one’s risk for developing late wet (neovascular) AMD from one’s risk for late dry (geographic atrophy) AMD.
The American Macular Degeneration Foundation Premieres New Films During AMD Awareness Month 2023
The American Macular Degeneration Foundation will be hosting
multiple, awareness-spreading activities throughout February, which is AMD Awareness Month, including new films on living well with AMD.
ARVO Foundation Announces 2023 Bert M. Glaser, MD Award for Innovative Retina Research Recipient
Rockville, Md.—The Association for Research in Vision and Ophthalmology (ARVO) Foundation congratulates Miguel Flores-Bellver, PhD, recipient of the 2023 Bert M. Glaser, MD Award for Innovative Research in Retina. The award recognizes an early-career investigator who has made a novel discovery that impacted the understanding and/or treatment of a retinal disease or condition.
Combining multiple maps reveal new genetic risk factors for blindness
Researchers discover new clues for causes of adult-onset macular degeneration.
The American Macular Degeneration Foundation Drives Research and Hope With New Grants
The foundation is investing $1.1 million in studies that hold the potential to set new standards in the prevention and treatment of age-related macular degeneration
NIH researchers use 3D bioprinting to create eye tissue
Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team from the National Eye Institute (NEI), part of the National Institutes of Health, printed a combination of cells that form the outer blood-retina barrier—eye tissue that supports the retina’s light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study degenerative retinal diseases such as age-related macular degeneration (AMD).
3D map reveals DNA organization within human retina cells
National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. The study published in Nature Communications.
NIH study confirms benefit of supplements for slowing age-related macular degeneration
The AREDS2 dietary supplement formula not only reduces risk of lung cancer due to beta-carotene, but is also more effective at reducing risk of AMD progression, compared to the original AREDS formula.
Retinal cell map could advance precise therapies for blinding diseases
Researchers have identified distinct differences among the cells comprising a tissue in the retina that is vital to human visual perception. The scientists from the National Eye Institute (NEI) discovered five subpopulations of retinal pigment epithelium (RPE)—a layer of tissue that nourishes and supports the retina’s light-sensing photoreceptors. Using artificial intelligence, the researchers analyzed images of RPE at single-cell resolution to create a reference map that locates each subpopulation within the eye.
Recycling of the Eye’s Light Sensors Is Faulty in Progressive Blindness of Older Adults
With the National Eye Institute reporting that about 11 million older adults in the U.S. endure a condition that leads to progressive blindness, known as age-related macular degeneration, University of Maryland School of Medicine (UMSOM) researchers are starting to understand what goes wrong in the disease, in order to develop new therapies to treat it.
National Eye Institute launches data portal for macular degeneration research
The National Eye Institute (NEI) Data Commons now enables researchers to access data from patients with macular degeneration who participated in the Age-related Eye Disease Study 2 (AREDS2). The database complements newly available stem cell lines created by the New York Stem Cell Foundation Research Institute (NYSCF) from blood cells of AREDS2 study participants.
Focus on Healthy Vision with Six New Year’s Resolutions from Retina Specialists
For many people, the new year means making New Year’s resolutions to improve health and wellness, such as losing weight or getting more sleep. Habits that help support retina health should be top priorities as well, according to the American Society of Retina Specialists (ASRS).
American Society of Retina Specialists Launches Retina Health for Life Podcast
The American Society of Retina Specialists (ASRS) today announced the launch of a new audio and video podcast series providing consumers with critical information about the signs, symptoms and risk factors of retina disease and the importance of seeing a retina specialist for specialized care.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.
NEI researchers link age-related DNA modifications to susceptibility to eye disease
National Eye Institute (NEI) researchers profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression. The findings, published online April 21 in Cell Reports, suggest that the epigenome could be targeted as a therapeutic strategy to prevent leading causes of vision loss, such as age-related macular degeneration (AMD).
NIH researchers discover tooth-enamel protein in eyes with dry AMD
A protein that normally deposits mineralized calcium in tooth enamel may also be responsible for calcium deposits in the back of the eye in people with dry age-related macular degeneration (AMD), according to a study from researchers at the National Eye Institute (NEI).
UPMC First in the U.S. to Implant Wireless Retinal Device
UPMC is the first center in the U.S. to implant a wireless retinal device to treat advanced age-related macular degeneration.
Research to Prevent Blindness and Partners Award $1.2 Million In Grants for Novel AMD Research
Research to Prevent Blindness, the American Macular Degeneration Foundation and the International Retinal Research Foundation announce four new grantees for the Catalyst Awards for Innovative Research Approaches for AMD. New York, NY, June 24, 2019 — Research to Prevent Blindness,…