3D map reveals DNA organization within human retina cells

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. The study published in Nature Communications.

Early onset of diabetes, hypertension can predict early glaucoma, UTSW ophthalmologists report

The earlier individuals develop Type 2 diabetes or hypertension in life, the earlier they are likely to develop primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, researchers from UT Southwestern reported in a recent study. The findings, published in Clinical Ophthalmology, could lead to better screening protocols for POAG, which accounts for up to 90% of all cases of glaucoma.

Scientists Uncover Role of Alzheimer’s-Linked APOE Gene in Glaucoma Protection and Identify Promising Treatment Strategy to Prevent Vision Loss

Scientists have demonstrated that the APOE4 gene variant, which increases risk for Alzheimer’s but decreases risk of glaucoma in humans, blocks a disease cascade that leads to the destruction of retinal ganglion cells in glaucoma. Additionally, they showed in mouse models that the death of retinal ganglion cells – the cause of vision loss in glaucoma – can be prevented by using medications to inhibit a molecule called Galectin-3, which is regulated by the APOE gene. These findings taken together emphasize the critical role of APOE in glaucoma and suggest that Galectin-3 inhibitors hold promise as a glaucoma treatment, according to the authors.

High-Tech Imaging Offers New Way to Detect Signs of Early Glaucoma

Mount Sinai study shows flavoprotein fluorescence could serve as new biomarker

Black Patients Found Six Times More Likely to Have Advanced Vision Loss After Glaucoma Diagnosis Than White Patients

Black patients have a dramatically higher risk of advanced vision loss after a new diagnosis of primary open angle glaucoma (POAG) when compared to white patients, according to a new study from New York Eye and Ear Infirmary of Mount Sinai (NYEE).

UIC researchers find evidence of possible link between herpes simplex and neurogenerative diseases

A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1.In a “first of its kind” study, researchers also found a potential direct connection between neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), glaucoma, and the herpesvirus.

Research to Prevent Blindness and Association of University Professors of Ophthalmology Announce 2022 Recipient of RPB David F. Weeks Award for Outstanding Vision Research

Donald Zack, MD, PhD, is recognized for ground-breaking contributions to the field of vision research, funded by Research to Prevent Blindness, an anonymous donor, and the Association of University Professors of Ophthalmology.

High Caffeine Consumption may be Associated with Increased Risk of Blinding Eye Disease

Frequent caffeine intake could more than triple risk of glaucoma for those genetically predisposed to higher eye pressure

Research to Prevent Blindness and The Glaucoma Foundation Offer Critical Funding for Early-Career Vision Scientists

Research to Prevent Blindness and The Glaucoma Foundation are pleased to announce a new round of grants, the Career Advancement Awards (CAAs), that support early-career researchers as they seek new knowledge related to eye diseases.

New Fellowships Support Under-Represented Minorities in Glaucoma Research

The Glaucoma Foundation (TGF) and Research to Prevent Blindness (RPB) have partnered to launch a new grant aimed at supporting under-represented racial and ethnic minority researchers in the pursuit of glaucoma research. The TGF (sponsored by Patricia Hill) / RPB Fellowships in Glaucoma provide one-year, $10,000 fellowships focused on substantive glaucoma research.

New York Eye and Ear Infirmary of Mount Sinai Celebrates 200th Anniversary and Honors its Pioneering Black Physician

Hosts Dedication for a Former Slave Who Became Country’s First African American Eye and Ear Specialist

Low-Carbohydrate Diet May Be Associated With Lower Risk of Blinding Eye Disease

Following a long-term diet that’s low in carbohydrates and high in fat and protein from vegetables may lower the risk of the most common subtype of glaucoma

Exercise can slow or prevent vision loss, study finds

Exercise can slow or prevent the development of macular degeneration and may benefit other common causes of vision loss, such as glaucoma and diabetic retinopathy, new research suggests.

Breakthrough Technology Used to Discover Eye Damage from Repeated Intravitreal Injections

FOR IMMEDIATE RELEASE Contact: Ilana NikraveshMount Sinai Press [email protected] Breakthrough Technology Used to Discover Eye Damage from Repeated Intravitreal Injections Findings may lead to new treatment approaches to counteract this problem (New York, NY – April 13, 2019) – In…