New dopamine sensors could help unlock the mysteries of brain chemistry

In 2018, Tian Lab at UC Davis Health developed dLight1, a single fluorescent protein-based biosensor. This sensor allows high resolution, real-time imaging of the spatial and temporal release of dopamine in live animals. Now, the team expanded the color spectrum of dLight1 to YdLight1 and RdLight1. The increased light penetration and imaging depth of these variants provide enhanced dopamine signal quality allowing researchers to optically dissect dopamine’s release and model its effects on neural circuits.

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Gun owner perceptions about actual firearm dangers suggest opportunities for improving gun safety

People who own guns and those living with gun owners are substantially less worried about the risk of firearm injuries than individuals living in homes without guns, says a new study by violence prevention experts at UC Davis Health.

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High-fat diet with antibiotic use linked to gut inflammation

UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.

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