Woman recovering from COVID-19 shares experience as monoclonal antibody clinical trial participant

When Christina Loville tested positive for the coronavirus, she was terrified. She decided to channel her fear into researching COVID-19 treatments, where she discovered a local clinical trial led by experts at The University of Texas Health Science Center at Houston (UTHealth).

Read more

UH Cleveland Medical Center enrolls first patient at the site for an AAV gene therapy trial treating OTC deficiency

A patient at UH Cleveland Medical Center received an AAV8-mediated gene transfer of human Ornithine Transcarbamylase. The infusion was well tolerated and patient was discharged without issue. The gene therapy is part of an international, multi-site trial sponsored by Ultragenyx Pharmaceutical Inc.

Read more

Back Pain with Sciatica More Likely to Improve with Immediate Physical Therapy

For people who experience back pain with sciatica, meaning their pain radiates into their leg, it may be worthwhile to start physical therapy right away, according to new research reported in Annals of Internal Medicine. That approach is different from the initial advice doctors often give patients with back pain, which is to try to remain active and give their symptoms time to subside before considering treatment like physical therapy.

Read more

Baylor Scott & White Health Enrolls First Patients in the World in Trial for Inhaled Remdesivir

Earlier this month, Baylor Scott & White Research Institute enrolled the first four patients in the world on Gilead’s new clinical trial involving an investigational inhaled solution of remdesivir (NCT04539262). This is Gilead’s first trial in COVID-19 patients examining the safety and efficacy of an inhaled solution of the drug in an outpatient setting. The study of an inhaled solution asks whether this mode of delivery can help reduce the amount of virus from the airways earlier.

Read more

Clinical trial to assess rehabilitation treatment for infants and toddlers after stroke

In the first of its kind for the tiniest stroke survivors, researchers at The University of Texas Health Science Center at Houston (UTHealth) will lead a stroke rehabilitation clinical trial in the state of Texas through a multi-institutional NIH StrokeNet initiative.

Read more

Rutgers Experts Explore Questions, Concerns Over COVID-19 Vaccine Trials

As researchers race to develop a COVID-19 vaccine, a Rutgers infectious disease expert and a Rutgers bioethicist discuss how clinical trials work, the ethics of developing and distributing a vaccine, safety and efficacy in clinical trials and what a successful vaccine may mean.

Read more

Study reveals racial disparities in clinical trial recruitment and points to strategies to achieve more inclusive clinical research

In a new study published in the journal Clinical Trials, researchers led by Stephen Juraschek, MD, PhD, Assistant Professor of Medicine at Beth Israel Deaconess Medical Center (BIDMC) compared four electronic-based recruitment methods and four traditional recruitment methods to determine how different strategies may impact enrollment of groups traditionally under-represented in the medical literature.

Read more