NIBIB-funded researchers are investigating long-lasting, customizable nanobubbles for ultrasound contrast agents.
Researchers at Columbia Engineering report that they have built what they say is the world’s smallest single-chip system, consuming a total volume of less than 0.1 mm3. The system is as small as a dust mite and visible only under a microscope. In order to achieve this, the team used ultrasound to both power and communicate with the device wirelessly
RNA-based drugs may change the standard of care for many diseases, making personalized medicine a reality. So far these cost-effective, easy-to-manufacture drugs haven’t been very useful in treating brain tumors and other brain disease. But a team of researchers at Georgia Tech and Emory University has shown that a combination of ultrasound and RNA-loaded nanoparticles can temporarily open the protective blood-brain barrier, allowing the delivery of potent medicine to brain tumors.
As part of a five-year, $2 million NSF project, Georgia Tech researchers uncover new methods for using sound and vibration to treat and diagnose brain diseases. The research could eliminate reliance on MRIs, paving the way for less costly and simpler systems that could serve a wider population.
Rectal cancer, along with colon cancer, is the third-most common type of cancer in the United States, and treatment and surgery greatly affect the quality of life of patients. A multi-disciplinary team at Washington University in St. Louis has developed and tested an innovative imaging technique that is able to differentiate between rectal tissues with residual cancers and those without tumors after chemotherapy and radiation, which could one day help to avoid unnecessary surgeries in some patients who have achieved complete tumor destruction after chemoradiation.
Abnormal heart rhythms—cardiac arrhythmias—are a major worldwide health problem. Now scientists are using ultrasound for more accurate maps of arrhythmic sites in the heart for improved success of ablation procedures.
Dr. Mary Beth Cunnane, a radiologist who specializes in the imaging of patients with diseases of the eyes, ears, nose and head and neck, has been appointed Chief of Radiology at Mass Eye and Ear in Boston.
Singing may be the next-generation, noninvasive approach to determining the health of a patient’s thyroid. When a person sings, the vibrations create waves in the tissue near the vocal tract called shear waves. If a tumor is present in the thyroid, the elasticity of its surrounding tissue increases, stiffening, and causing the shear waves to accelerate. Using ultrasound imaging to measure these waves, researchers can determine the elasticity of the thyroid tissue. They demonstrate the technique in Applied Physics Letters.
Researchers have developed a method using ultrasound imaging to score a patient’s lung health, which may help predict if a patient with COVID-19 will worsen. Using 14 points in the lungs, they looked for abnormalities and assigned each spot a score out of 3 based on its severity. Adding up all the points, the researchers found the total lung ultrasound score was higher for those who had a worsening outcome of COVID-19. Umberto Sabatini’s presentation will be a part of the 179th ASA Meeting of the Acoustical Society of America.
Ultrasound can be used to treat cancer when used in combination with molecules that sensitize the system to sound waves. These sonosensitizers generate toxic reactive oxygen species that attack and kill tumor cells. In Applied Physics Review, scientists report a new type of sonosensitizer based on a vanadium-doped titanium dioxide that enhances the amount of damage ultrasound inflicts on tumors. Studies in mice showed that tumor growth was markedly suppressed when compared to a control group.
Press conferences at the 179th Meeting of the Acoustical Society of American will cover the latest in acoustical research, from the impact of face masks to the beating of mosquito wings, and will be held virtually Dec. 9-11. To ensure the safety of attendees, volunteers, and ASA staff, Acoustics Virtually Everywhere will be hosted entirely online.
Researchers have developed a technique that uses ultrasound to provide non-invasive assessments of pulmonary fibrosis and pulmonary edema. The technique has been shown to both quantify lung scarring and detect lung fluid in rats. A study on pulmonary edema in humans is under way.
A team of Johns Hopkins neurosurgeons and biomedical engineers has received $13.48 million from the Defense Advanced Research Projects Agency (DARPA) to develop implantable ultrasound and other devices that could revolutionize care for people suffering from spinal cord injuries. The results could benefit thousands of U.S. service members and civilians who sustain spinal cord injuries every year.
A Rush team of neurological and neurosurgical clinicians is the first in Illinois and among the first in the United States to offer an innovative, noninvasive treatment for medication-refractory tremor: MR-guided focused ultrasound.
The University at Buffalo has received a four-year, $1.4 million grant from the National Institutes of Health (NIH) to develop a new, portable breast-imaging system that has the potential to better identify breast cancer.
Computed tomography (CT) is used at a higher rate than ultrasound in children with developmental and cognitive impairments to diagnose appendicitis, even though CT scans increase radiation risk in smaller bodies.
Researchers have demonstrated a new technique for creating ultrasound images. The new approach is substantially simpler than existing techniques and could significantly drive down technology costs.
Brain tumors are typically diagnosed using MRI imaging, as taking a sample for a tissue biopsy is risky and may not be possible due to tumor location or a patient’s health. Researchers are developing a method to diagnose brain tumors without any incisions.
University of Utah biomedical engineering assistant professor Jan Kubanek has discovered that sound waves of high frequency (ultrasound) can be emitted into a patient’s brain to alter his or her state. It’s a non-invasive treatment that doesn’t involve medications or surgery and has a unique potential to treat mental disorders including depression and anxiety and neurological disorders such as chronic pain and epilepsy.
A new way to deliver therapeutic proteins inside the body uses an acoustically sensitive carrier to encapsulate the proteins and ultrasound to image and guide the package to the exact location required.
Ultrasound is probably most associated with a parent’s first glimpse of a baby in the womb. However, a new video from the Acoustical Society of America showcases the technology’s abilities to do more than show images of our insides. This video is the second in a series celebrating the International Year of Sound.
Blood can typically be stored for only six weeks after donation, but a potential solution attempts to dry blood by using a sugar-based preservative. New work in ultrasound technology looks to provide a path to inserting these sugars into human red blood cells, allowing the molecule trehalose to enter the cells and prevent their degradation when dried for preservation. The researchers discuss their work in this week’s Biomicrofluidics.
Bioengineers have created a blood-drawing robot that performed as well or better than technicians. The device could increase blood draw success from difficult- to-find veins and allow healthcare workers more time to treat patients.
Columbia Engineering researchers have used an ultrasound technique they pioneered a decade ago–electromechanical wave imaging (EWI)–to accurately localize atrial and ventricular cardiac arrhythmias in adult patients in a double-blinded clinical study. They evaluated the accuracy of EWI for localization of various arrhythmias in all four chambers of the heart prior to catheter ablation: the results showed that EWI correctly predicted 96% of arrhythmia locations as compared with 71% for 12-lead ECGs.
Need to reduce high-pitched noises? Science may have an answer. In a new study, theoretical physicists report that materials made from tapered chains of spherical beads could help dampen sounds that lie at the upper range of human hearing or just beyond.
Using a combination of magnetic resonance imaging (MRI) to target and sample suspicious prostate tissue, along with a standard prostate biopsy, is significantly more likely to detect the most aggressive prostate cancers than standard biopsy alone. This finding, published today in the New England Journal of Medicine, could allow a higher percentage of prostate cancer patients to avoid unnecessary treatment for slow-growing prostate cancers that are not likely to spread.
Rutgers engineers have created a tabletop device that combines a robot, artificial intelligence and near-infrared and ultrasound imaging to draw blood or insert catheters to deliver fluids and drugs. Their research results, published in the journal Nature Machine Intelligence, suggest that autonomous systems like the image-guided robotic device could outperform people on some complex medical tasks.
A team of researchers at the University of Arizona has found that low-intensity ultrasound waves directed at a particular region of the brain’s prefrontal cortex in healthy subjects can elevate mood, and decrease connectivity in a brain network that has been shown to be hyperactive in psychiatric disorders. The method uses transcranial focused ultrasound (‘tFUS’), a painless, non-invasive technique to modulate brain function comparable to transcranial magnetic stimulation (‘TMS’), and transcranial direct current stimulation (‘tDCS’). This study shows, for the first time, a correlation between tFUS-induced mood enhancement, and reorganization of brain circuits.
The first set of comprehensive, evidence-based clinical guidelines for surgical treatment of thyroid disease – developed by an expert panel assembled by the American Association of Endocrine Surgeons (AAES) – was published today by Annals of Surgery. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Working in an emerging field known to as “spacetime-varying metamaterials,” University at Buffalo engineers have demonstrated the ability to break reciprocity in acoustic waves. The NSF-sponsored research could have implications in communications, medicine and other fields.
In the future, robots could take blood samples, benefiting patients and healthcare workers alike. A Rutgers-led team has created a blood-sampling robot that performed as well or better than people, according to the first human clinical trial of an automated blood drawing and testing device.
Doctors have used focused ultrasound to destroy tumors without invasive surgery for some time. However, the therapeutic ultrasound used in clinics today indiscriminately damages cancer and healthy cells alike. Researchers have now developed a low-intensity ultrasound approach that exploits the properties of tumor cells to target them and provide a safer option. Their findings, reported in Applied Physics Letters, are a new step in oncotripsy, the singling out and killing of cancer cells based on their physical properties.
Ultrasound can be used to examine cervix tissue and improve diagnostics, which is essential for predicting preterm births, and ultrasound data is used to compare two techniques for evaluating changes in cervical tissue throughout pregnancy. Researchers are looking at ultrasonic attenuation coefficients that can help scientists characterize cervical changes throughout pregnancy and in preparation for birth before other symptoms, such as contractions or dilation, occur. They will discuss their work at the 178th ASA Meeting.
Looking to the future, radiologists at Mayo Clinic in Rochester saw an opportunity to bring several disparate tools together into a unified space to serve complementary roles in sophisticated, minimally invasive cancer treatments.