A new study demonstrates cryo-EM samples can be prepared with a safer and less expensive coolant – liquid nitrogen – and these samples can produce even sharper images than those prepared with ethane. The findings may improve the safety and quality of cryo-EM.
The first nanoscale images ever taken inside intact, lithium-metal coin batteries (also called button cells or watch batteries) challenge prevailing theories and could help make future high-performance batteries, such as for electric vehicles, safer, more powerful and longer lasting.
Scientists using the Advanced Photon Source have determined that amphibian eggs release showers of zinc upon fertilization, just like mammalian eggs. This research could have implications for human fertility studies.
Researchers at the University of Chicago and the U.S. Department of Energy’s (DOE) Argonne National Laboratory have leveraged existing advanced X-ray microscopy techniques to bridge the gap between MRI (magnetic resonance imaging) and electron microscopy imaging, providing a viable pipeline for multiscale whole brain imaging within the same brain
Irvine, Calif., June 21, 2021 — Cancer immunotherapy involving drugs that inhibit CTLA-4 also activates an unwanted response that may self-limit its efficacy in fighting tumors, according to a new study led by Francesco Marangoni, Ph.D., assistant professor of physiology & biophysics and member of the Institute for Immunology at the University of California, Irvine.
PNNL’s Dongsheng Li’s crystal formation research helped reveal why nanoparticles sometimes self-assemble into five-sided shapes. The discovery will potentially be useful in medical research, electronics, and other applications.
A team of NIH microscopists and computer scientists used a type of artificial intelligence called a neural network to obtain clearer pictures of cells at work even with extremely low, cell-friendly light levels.
Portable Flamingo microscopes have the potential to democratize science by opening up new opportunities to wide ranges of researchers and institutions.
Artificial intelligence is being called “the next generation of the way we do science.” At Argonne, researchers are leveraging the lab’s state-of-the-art-facilities and unparalleled expertise to shape the very future of science.
At the Department of Energy’s Oak Ridge National Laboratory, scientists use artificial intelligence, or AI, to accelerate the discovery and development of materials for energy and information technologies.
Rectal cancer, along with colon cancer, is the third-most common type of cancer in the United States, and treatment and surgery greatly affect the quality of life of patients. A multi-disciplinary team at Washington University in St. Louis has developed and tested an innovative imaging technique that is able to differentiate between rectal tissues with residual cancers and those without tumors after chemotherapy and radiation, which could one day help to avoid unnecessary surgeries in some patients who have achieved complete tumor destruction after chemoradiation.
COSMIC, a multipurpose X-ray instrument at Berkeley Lab’s Advanced Light Source, has made headway in the scientific community since its launch less than 2 years ago, with groundbreaking contributions in fields ranging from batteries to biominerals.
Irvine, Calif., Jan. 11, 2021 – Often admired for their flawless appearance to the naked eye, crystals can have defects at the nanometer scale, and these imperfections may affect the thermal and heat transport properties of crystalline materials used in a variety of high-technology devices. Employing newly developed electron microscopy techniques, researchers at the University of California, Irvine and other institutions have, for the first time, measured the spectra of phonons – quantum mechanical vibrations in a lattice – at individual crystalline faults, and they discovered the propagation of phonons near the flaws.
ORNL story tips: Nanoscale commuting, easy driver and defect detection
Researchers used two advanced microscopy techniques to learn how crystal defects affect the performance of crystalline solar cells called lead halide perovskite cells. The research used two microscopy techniques: electron backscattering diffraction to view crystal quality at scales of 100 nanometers and ultrafast microscopy to examine how electrons move. The research shows that microscopic defects that form when the crystals are made can reduce how fast electrons move by a factor of almost 10.
Applied physicist Watt W. Webb, the S.B. Eckert Professor of Engineering Emeritus at Cornell University and a pioneer in methods for imaging living biological systems, died Oct. 29 in New York City. He was 93.
An international research team led by PNNL has published a vision for electron microscopy infused with the latest advances in data science and artificial intelligence. Writing a commentary in Nature Materials, the team proposes a highly integrated, autonomous, and data-driven microscopy architecture to address challenges in energy storage, quantum information science, and materials design.
Irvine, Calif., Oct. 21, 2020 – With one of the more awe-inspiring names in the animal kingdom, the diabolical ironclad beetle is one formidable insect. Birds, lizards and rodents frequently try to make a meal of it but seldom succeed. Run over it with a car, and the critter lives on. The beetle’s survival depends on two key factors: its ability to convincingly play dead and an exoskeleton that’s one of the toughest, most crush-resistant structures known to exist in the biological world.
Scientists examined cell abundances, size, cellular carbon mass, and how photosynthetic cells differ on polymeric and glass substrates over time, exploring nanoparticle generation from plastic like polystyrene and how this might disrupt microalgae. Conservative estimates suggest that about 1 percent of microbial cells in the ocean surface microlayer inhabit plastic debris globally. This mass of cells would not exist without plastic debris in the ocean, and thus, represents a disruption of the proportions of native flora in that habitat.
Scientists have shown that an algorithm added to image processing software can improve the resolution and accuracy of cryo-electron microscopes, which are one of the most crucial tools in microbiology and medical research.
The new Center will support a mission to drive new discoveries and insights from scientific research performed using state-of-the-art imaging systems.
Scientists at Oak Ridge National Laboratory and the University of Nebraska have developed an easier way to generate electrons for nanoscale imaging and sensing, providing a useful new tool for material science, bioimaging and fundamental quantum research.
Using properties of light from fluorescent probes is at the heart of a new imaging technique developed at Washington University’s McKelvey School of Engineering that allows for an unprecedented look inside cell membranes.
Irvine, Calif., Aug. 17, 2020 – University of California, Irvine materials scientists are learning about resilience from the mantis shrimp. The ancient crustaceans are armed with two hammerlike raptorial appendages called dactyl clubs that they use to bludgeon and smash their prey. These fists, able to accelerate from the body at over 50 mph, deliver powerful blows yet appear undamaged afterward.
Groundbreaking approach in high-resolution electron energy loss spectroscopy has been judged to be one of the 10 best microscopy innovations in the 2020 Microscopy Today Innovation Award competition.
Danforth Center scientists, Dilip Shah, PhD, Siva Velivelli, PhD, Kirk Czymmek, PhD, and their collaborators at the Pacific Northwest National Laboratory have identified a sub class of peptides in the nodules of the legume, Medicago truncatula that proved effective in inhibiting growth of the fungus causing gray mold.
The method reveals that the lattice, which forms the major structural component of the human immunodeficiency virus (HIV), is dynamic. The discovery of a diffusing lattice made from Gag and GagPol proteins, long considered to be completely static, opens up potential new therapies. The method can be applied to biomedical structure.
The age of insulin parcels may matter, researchers say, when it comes to diagnosing and treating diabetes.
ORNL Story Tips: Predicting fire risk, solid state stability check and images in a flash
Scientists at NIBIB have developed new image processing techniques for microscopes that can reduce post-processing time up to several thousand-fold.
Researchers demonstrated new ways to use electron microscopy to study liquids at high resolution. They used this technique to examine how nuclei in liquids and molecules vibrate at multiple length scales. This work can lead to new ways for scientists to describe liquids, the interfaces between fluids, and materials labeled with isotopes.
The discovery further challenges the accepted scientific dogma that the lens is shut out from the immune protection.
Rutgers student Julia Van Etten, whose @Couch_Microscopy Instagram page garnered more than 25,000 followers by showcasing microorganisms as art, is now working with NASA on research into how red algae can help explain the origins of life on Earth.
Scientists at the Department of Energy’s Oak Ridge National Laboratory have developed a new method to peer deep into the nanostructure of biomaterials without damaging the sample. This novel technique can confirm structural features in starch, a carbohydrate important in biofuel production.
The piece of gold that Richard Taylor was thrilled to track down weighed less than a single bacterium. Taylor, a postdoctoral fellow at the Max Planck Institute, was working to follow individual nanogold-labeled molecules that move just nanometers, billionths of a meter.
Scientists used unique scanning probe microscopy and spectroscopy techniques to control how electrons moved on the surface of a bismuth-based material (Bi2Te2Se).
To understand why very large molecules behave the way they do inside cells, scientists must first understand the relationship between these molecules’ structure and motion. Engineers created algorithms that provide the physics backbone for a new “microscope in a computer.”
Science Snapshots from Berkeley Lab
An advanced imaging technique reveals new structural details of S-DNA, ladder-like DNA that forms when the molecule experiences extreme tension. This work conducted at Sandia National Laboratories and Vrije University in the Netherlands provides the first experimental evidence that S-DNA contains highly tilted base pairs.
Irvine, Calif., Oct. 14, 2019 – Researchers at the University of California, Irvine have developed a new scanning transmission electron microscopy method that enables visualization of the electric charge density of materials at sub-angstrom resolution. With this technique, the UCI scientists were able to observe electron distribution between atoms and molecules and uncover clues to the origins of ferroelectricity, the capacity of certain crystals to possess spontaneous electric polarization that can be switched by the application of an electric field.