Scientists at St. Jude Children’s Research Hospital showed that the MYCN protein promotes a switch in the cellular state within the tumor microenvironment, with slow-growing mesenchymal cells swapping to the more dangerous and faster-growing adrenergic state.
Tag: Transcription Factor
Breakthrough microscopy technique “supersizes” cells to reveal genetic activity
Breakthrough microscopy techniques are helping researchers visualize the ways our molecules interact with the human genome. Researchers at Yale School of Medicine used a series of expandable gels to pull apart a cell and expand it to 4000 times its…
Control of rhabdomyosarcoma cell identity provides clues to possible treatments
Findings from St. Jude Children’s Research Hospital show how control of transcription factors by a common tumor suppressor gene may provide a therapeutic opportunity in a type of childhood cancer.
Research provides evidence for how a key transcription factor manages access to DNA
St. Jude Children’s Research Hospital scientists have revealed a previously unknown role for CTCF, a pivotal transcription regulator linked to cancer.
Machine learning algorithm predicts how genes are regulated in individual cells
Researchers have developed a software tool that identify the regulators of genes. The system leverages a machine learning algorithm to predict which transcription factors are most likely to be active in individual cells.