Biologists used whole-genome sequences of 48 contemporary weedy rice plants to show how herbicide resistance evolved by gene flow from crop rice. Almost all other cases of herbicide resistance in agricultural weeds result from selection of tolerant genotypes in the weed species.
The first full genome in the tomatillo tribe adds to the rich story of the tomato family.
With super-resolution imaging, Penn Medicine researchers discovered that cells change the physical structure of their genome when they’re affected by disease
A new UCLA-led study has identified multiple new risk genes for Alzheimer’s disease and a rare, related brain disorder by using a combination of new testing methods allowing for mass screening of genetic variants in a single experiment.
Biologists investigated the oldest known seeds from a watermelon relative, dating back 6,000 years. The researchers shared two new genomes of ancient seeds and described how Neolithic humans in Libya likely used the seeds, not the bitter flesh, from the melons.
Scientists from the RIKEN Center for Integrative Medical Sciences in Japan in collaboration with other researchers from around the world have discovered that recombinations of specific genomic sequences that are repeated millions of times in the genome of each of our cells are pervasively found in both normal and in disease states. Identifying the mechanisms that lead to this myriad of recombinations involving DNA sequences that were once considered as “junk”, may be crucial to understanding how our cells develop and what can make them unhealthy.
Three new species of black-bellied salamander have been discovered by a research team led by R. Alexander Pyron, the Robert F. Griggs Associate Professor of Biology at the George Washington University. The new salamanders, which are found in the southern Appalachian Mountains of the eastern United States, stem from black-bellied populations that were long considered to be a single species.
A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.
A biologist from the Faculty of Science, Chulalongkorn University working with researchers from Germany and Myanmar has discovered two of the world’s newest stream frogs in Myanmar highlighting the remaining diversity of ecosystems in Southeast Asia and cautions all those involved of the need to conserve our forests before our valuable wildlife become extinct.
A new study has implicated several genes involved in a variety of bodily functions associated with the hypothalamus, a notoriously difficult-to-study region of the brain. The findings could help clinicians identify potential causes of dysfunction for many important traits regulated by the hypothalamus, such as sleep, stress, and reproduction.
For the first time, researchers have shown that there is a genetic component underlying the amazing spatial memories of Mountain Chickadees. Although the genetic basis for spatial memory has been shown for humans and other mammals, direct evidence of that connection has never before been identified in birds.
Opentrons, the lab automation platform comprised of Opentrons Robotics, Pandemic Response Lab, Neochromosome, and Zenith AI, receives $200 million to scale its platform for life sciences and healthcare.
An international team of researchers led by the University of New Hampshire has sequenced the shea tree’s genome, providing a valuable resource for the strategic development of the species which is best known for the popular product shea butter—a multimillion-dollar ingredient used in cosmetics, personal care products, pharmaceuticals and chocolate.
St. Jude Children’s Research Hospital scientists have revealed a previously unknown role for CTCF, a pivotal transcription regulator linked to cancer.
St. Jude scientist Vibhor Mishra, Ph.D., is homing in on the location where important processes in gene regulation occur, and where single-stranded transcripts are converted into double-stranded RNAs (dsRNAs).
St. Jude Children’s Research Hospital study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient’s cancer.
An international team of researchers co-led by the University of Adelaide and the University of Arizona has analysed the genomes of more than 2,500 modern humans from 26 worldwide populations, to better understand how humans have adapted to historical coronavirus outbreaks.
UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates – polygenic risk scores – for specific diseases in people from diverse populations and mixed ancestries.
They are some of the most beautiful, and elusive, animals on the plant. Leopards. In a major scientific step, the whole genome DNA sequence of 23 individual leopards have been interpreted.
Unprecedented novel discoveries have implications for characterizing biodiversity for all life, conservation and human health and disease.
Overfishing likely did not cause the Atlantic cod, an iconic species, to evolve genetically and mature earlier, according to a study led by Rutgers University and the University of Oslo – the first of its kind – with major implications for ocean conservation.
Evolutionary forces drive a glaring gender imbalance in the occurrence of many health conditions, including autism, a team of genetics researchers has concluded.
Scientists at the University of Adelaide have challenged the common assumption that genetic diversity of a species is a key indicator of extinction risk.
Biologists at Washington University in St. Louis lead a team awarded $1.7 million from the National Science Foundation to streamline the genome of a cyanobacterium with the goal of developing a green cellular factory for sustainable production of food, feed and fuels.
Researchers have produced a groundbreaking new reference genome for the Asian malaria vector mosquito Anopheles stephensi. The achievement will help scientists engineer advanced forms of defense against malaria transmission, including targeted CRISPR and gene drive-based strategies.
Mutations that occur in certain DNA regions, called tandem repeats, may play a significant role in autism spectrum disorders, according to research led by Melissa Gymrek, assistant professor in the UC San Diego Department of Computer Science and Engineering and School of Medicine. The study, which was published in Nature on Jan. 14, was co-authored by UCLA professor of human genetics Kirk Lohmueller and highlights the contributions these understudied mutations can make to disease.
A new approach for studying phage-bacteria interactions will help scientists study the intricate offensive and defensive chemical tactics used by parasite and host. These microscopic battles have implications for medicine, agricultural research, and climate science.
A new study details the latest efforts to predict traits in corn based on genomics and data analytics. The data management technique could help to “turbo charge” the seemingly endless amount of genetic stocks contained in the world’s seed banks, leading to faster and more efficient development of new crop varieties.
Darwin’s theory of evolution should be expanded to include consideration of a DNA stability “energy code” – so-called “molecular Darwinism” – to further account for the long-term survival of species’ characteristics on Earth, according to Rutgers scientists. The iconic genetic code can be viewed as an “energy code” that evolved by following the laws of thermodynamics (flow of energy), causing its evolution to culminate in a nearly singular code for all living species, according to the Rutgers co-authored study in the journal Quarterly Review of Biophysics.
Red algae have persisted in hot springs and surrounding rocks for about 1 billion years. Now, a Rutgers-led team will investigate why these single-celled extremists have thrived in harsh environments – research that could benefit environmental cleanups and the production of biofuels and other products.
Researchers generated genome sequences for nearly 600 green millet plants and released a very high-quality reference S. viridis genome sequence Analysis of these plant genome sequences also led them to identify for the first time in wild populations a gene related to seed dispersal.
A study finds that cancer mutations occur in distinct patterns based on the 3D structure of the genome and the underlying cause of the mutation. This helps us to understand cancer better and may lead to new treatment approaches.
Researchers have found at least 10 distinct “hotspot” mutations in more than 80% of randomly selected SAR-CoV-2 sequences from six countries, and these genome hotspots – seen as “typos” that can occur as the virus replicates during cellular division – could have a significant impact in the fight against the COVID-19 pandemic.
From Weight Watchers to wearable tech – wherever we look, there are messages encouraging us to stay fit and healthy. But diets and training methods aside, when it comes to heart health, research from the University of South Australia shows that a far more personalised approach is needed…and it all starts with your genes.
An Iowa State University scientists contributed to a global effort to assemble the genome of the tuatara, a rare reptile species native to New Zealand. The tuatara genome sheds light on the genomic structure of a huge range of species, including humans.
Scientists from the University of Adelaide and South Australian Museum have collaborated with Otago University, New Zealand and a global team to sequence the genome of the tuatara – a rare reptile whose ancestors once roamed the earth with dinosaurs.
UC Santa Cruz researchers played a crucial role in early planning of the human genome project, in assembling the genome sequence, developing tools for its visualization and ensuring it remained in the public domain. They continue to have a major role in the ongoing analysis of the human genome.
When Pulitzer Prize and Grammy award winner Kendrick Lamar rapped “I got millions, I got riches buildin’ in my DNA,” he almost certainly wasn’t talking about the humble tomato. But a new study unveiling more than 230,000 DNA differences across 100 tomato varieties which will allow breeders and scientists to engineer larger, juicier, more profitable plants, proves that tomatoes indeed have riches buildin’ in their DNA, too.
An analysis of genetic studies covering 266,000 women has revealed 32 new sites on the human genome where variations in DNA appear to alter the risks of getting breast cancer.
• Newly discovered gene variant in Peruvian populations is powerfully linked with height
• Five percent of Peruvians carry the variant, which originates exclusively from Native American populations
• The variant occurs on a gene that, when mutated, causes Marfan syndrome, a condition marked by connective tissue abnormalities, including serious cardiovascular problems
• The newly discovered variant is not associated with disease and may confer adaptive evolutionary advantage to populations that carry it
The promise of personalized medicine has not fully materialized, say two McMaster researchers, because the full sophistication of the genetic blueprint has a more complex and far-reaching influence on human health than scientists had first realized.
National Eye Institute (NEI) researchers profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression. The findings, published online April 21 in Cell Reports, suggest that the epigenome could be targeted as a therapeutic strategy to prevent leading causes of vision loss, such as age-related macular degeneration (AMD).
The Weizmann Institute’s Prof. Ron Milo and colleagues at Caltech and Berkeley used his biomass-analyzing techniques to sort the mass of coronavirus data, with interesting results. For example, they found that the coronavirus mutation accumulation rate is relatively slow, which is good news for vaccines
An Indiana University scientist has identified eight new genomic regions that increase a person’s risk for skin cancer.
Dinosaur blood vessels, giant viruses, and antibiotic-building enzymes
Using an innovative genome sequencing technology, researchers assembled the complete genetic blueprint of two basmati rice varieties, including one that is drought-tolerant and resistant to bacterial disease. The findings, published in Genome Biology, also show that basmati rice is a hybrid of two other rice groups.
Pavel Volchkov heads the Genome Engineering Lab at the Moscow Institute of Physics and Technology (MIPT), that has several key projects, all of them involving genome editing mediated by the CRISPR/Cas technology. Discovered just a few years ago, CRISPR/Cas has…
Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.
Researchers identified a set of cis-regulatory elements – namely enhancers and the promoter – in the non-coding region of the genome, which affect the expression of FOXA1 gene, one of the major drivers or oncogenes involved in prostate cancer development.
Domesticated rice has fatter seed grains with higher starch content than its wild rice relatives — the result of many generations of preferential seed sorting and sowing. But even though rice was the first crop to be fully sequenced, scientists have only documented a few of the genetic changes that made rice into a staple food for more than half the world’s population.
Science Snapshots from Berkeley Lab