Genetic Variation

Sex, Genes and Vulnerability

New work led by researchers in the Blavatnik Institute at Harvard Medical School and at the Broad Institute of MIT and Harvard provides a clear genetic explanation behind the long-standing yet mysterious observation that some diseases occur more often, hit harder or elicit different symptoms in men or women.

Did archaic genetic variants help Melanesians adapt?

Compared with other world groups, the DNA of Melanesian populations carries some of the largest percentage of ancestry from now-extinct Neanderthals and Denisovans. A genomic study of Melanesians suggests that certain genetic variants inherited from archaic human-like species may have helped these modern people adapt to their tropical island environment.

We Are All Mutants, More or Less

Everyone is a mutant but some are prone to diverge more than others, report scientists at University of Utah Health. A new study published in eLife shows the number of mutations a child has compared to her parents varies dramatically with some people being born with twice as many as others, and that characteristic runs in families.