Researchers in Germany have discovered that age-dependent impairments in antiviral interferon proteins underlie the increased susceptibility of older patients to severe COVID-19. The study, published today in the Journal of Experimental Medicine (JEM), shows that aged mice infected with SARS-CoV-2 are protected from severe disease by treatment with one of these interferons, IFN-γ.
Like a case of long COVID-19 itself, the effects of the coronavirus continue to linger in pockets of the state and its economy. They affect Oregonians to a wide range of degrees, ranging from the toll of missed work and lost wages due to long COVID to disruptions with child care and an uneven recovery in the workforce, among others. Those are among the findings in the latest report by University of Oregon researchers.
In a paper published in JAMA Network Open, physician-scientists assessed how pregnancy-related complications and obstetric outcomes changed during the COVID-19 pandemic compared to pre-pandemic.
A new poll shows that 61% of people over 50 who have already gotten at least one dose of COVID-19 vaccine are very likely to roll up their sleeves this fall to get an updated booster shot once they become available.
That percentage might increase if health care providers specifically recommend the updated vaccine to their patients, the poll suggests.
IUPUI researchers are developing a “biosensing platform” for COVID-19 that’s fast, efficient, accurate and highly sensitive, which could help scientists stay on top of shifting virus variants.
To develop new COVID-19 medications, researchers are working to target nsp13, a protein coronaviruses need to replicate. In ACS Infectious Diseases, researchers describe a new approach to identifying molecules that interfere with this protein, a step toward developing pan-coronavirus antivirals.
A monoclonal antibody treatment taken by patients hospitalized with COVID-19 did not improve recovery time but did reduce deaths, according to a study published July 8 in The Lancet Respiratory Medicine.
Despite significant and stunning advances in vaccine technology, the COVID-19 global pandemic is not over.
In a letter published in the New England Journal of Medicine, physician-scientists report that the three Omicron subvariants currently dominant in the United States – officially known as subvariants BA.2.12.1, BA.4, and BA.5 – substantially escape neutralizing antibodies induced by both vaccination and previous infection.
With the end of the pandemic seemingly nowhere in sight, scientists are still very focused on finding new or alternative drugs to treat and stop the spread of COVID-19. In a first-of-its-kind study, researchers at the University of New Hampshire have found that using an already existing drug compound in a new way, known as drug repurposing, could be successful in blocking the activity of a key enzyme of the coronavirus, or SARS-CoV-2, which causes COVID-19.
For the last – and littlest – segment of the population yet to receive it, the COVID-19 vaccine is federally approved and available for all people 6 months of age and older. A Penn State Health pediatric infectious disease physician explains why it’s safe and answers questions.
Using high quality COVID-19 data from a northern Chinese city, two UAlbany researchers concluded that young people were most responsible for an increase in direct and secondary infections, and also determined that county-wide lockdowns proved effective in stemming the spread of the virus.
COVID-19 rebound following Paxlovid treatment likely due to insufficient drug exposure, UC San Diego researchers find after showing rebound patient did not show drug resistance or impaired immunity.
How well did our political institutions manage the COVID-19 pandemic and are they prepared to handle future threats to the public? A research team led by faculty at Binghamton University, State University of New York hopes to answer these questions and more after compiling an extensive dataset tracking public health government responses to COVID-19 at all levels of government throughout the world.
Researchers from the University of Helsinki and KU Leuven in Belgium investigated the arrival and spread of SARS-CoV-2 in Finland in 2020.
Finding suggests that all people with HIV might benefit from additional dose in primary vaccination.
Consortium of Hackensack Meridian CDI, Rockefeller University, Columbia University, Memorial Sloan Kettering Cancer Center, Rutgers University, Merck, Tri-Institutional Therapeutics Discovery Institute, Inc., and Aligos Therapeutics to combine expertise to ‘accelerate’ new breakthroughs
Tiny antibodies in sharks have dexterity and flexibility that human antibodies do not. They can bind tightly to the spike proteins of coronaviruses and neutralize the virus. This could help researchers develop new vaccines and therapies for COVID-19.
The new collaborative report details the impact of baby formula shortages on infant-feeding practices.
A recent study by the University of Helsinki and Helsinki University Hospital confirmed that scent detection dogs can be taught to identify individuals with a coronavirus infection from skin swabs.
Researchers note that health care providers are now able to add to their armamentarium against COVID-19 their prescription of this new antiviral drug for high-risk, newly-infected patients as soon as possible following diagnosis or within five days of the onset of symptoms.
Misperceptions of marginalized and disadvantaged communities’ level of concern regarding COVID-19, as well as other issues such as climate change, constitutes a form of social misinformation that may undermine cooperation and trust needed to address collective problems, according to new Cornell-led research.
In a recent study, scientists at the Harvard T.H. Chan School of Public Health and Beth Israel Deaconess Medical Center used live virus culture to assess how well four rapid antigen tests are able to detect these COVID variants of concern.
Cornell University researchers have identified a shift that occurs in canine coronavirus that may provide clues as to how it transmits from animals to humans.
In Physics of Fluids, researchers use principal component analysis along with fluid dynamics simulation models to show the crucial importance of proper fit for all types of masks and how face shape influences the most ideal fit. They modeled a moderate cough jet from a mouth of an adult male wearing a cloth mask over the nose and mouth with elastic bands wrapped around the ears and calculated the maximum volume flow rates through the front of mask and peripheral gaps at different material porosity levels.
Through analyzing human DNA samples in a large biobank, Penn Medicine researchers found associations between genetic variants with severe COVID and conditions involving blood clots and respiratory issues
Air transmission of SARS-CoV-2, the virus behind the coronavirus pandemic, was much higher than surface transmission at the University of Michigan, according to a study by researchers at U-M’s School of Public Health.
They say that the best defense is a good offense; and now, researchers from Japan have found that the best defense against coronavirus disease 2019 (COVID-19) infection could be a good decoy.
Vaccination policy, vaccine hesitancy and post-vaccination symptoms and effects among top topics tweeted
Irvine, Calif., April 27, 2022 – Philip Felgner, Ph.D., professor in residence of physiology & biophysics at the University of California, Irvine, is one of two scholars to win the prestigious 2022 Robert Koch Prize for fundamental contributions to the transfer of nucleic acids into cells. This pioneering technology for treating infectious diseases played a crucial role in developing the messenger RNA COVID-19 vaccines.
On top of the COVID-19 pandemic, people worldwide have dealt with an infodemic – a flood of ever-evolving information and misinformation about the virus, causing confusion and mistrust. New Cornell research finds that in remote parts of Bangladesh with little internet access, people have relied on local experts, spiritual views and their sense of social justice to evaluate new coronavirus information.
Researchers at Yale School of Medicine have discovered that an RNA molecule that stimulates the body’s early antiviral defense system can protect mice from a range of emerging SARS-CoV-2 variants. The study, published today in the Journal of Experimental Medicine (JEM), could lead to new treatments for COVID-19 in immunocompromised patients, as well as providing an inexpensive therapeutic option for developing countries that currently lack access to vaccines.
The new drug candidate, Paxlovid, significantly reduced hospitalization and death in adult patients, according to Pfizer, and will be submitted for an emergency use authorization in the United States. Data was taken at IMCA-CAT at the APS.
As part of a recently launched international phase 3 clinical trial, Montefiore Health System and Albert Einstein College of Medicine are investigating whether the Merck antiviral pill, molnupiravir, now approved in Britain for treating COVID-19, can prevent COVID-19 in unvaccinated individuals living with people who have contracted the disease. Montefiore-Einstein is the first and only New York State site for the trial and was selected due to its diverse patient population and expertise in clinical trials of COVID-19 and other infectious diseases.
The unfolded protein response plays a key role in how Middle East Respiratory Syndrome damages the lungs. MERS is much less common but much lethal than COVID-19, which is also caused by a coronavirus.
New research addresses the misconception that children are less susceptible to infection with the new coronavirus. According to a recent report in JAMA Pediatrics, children and adults have similar risks of becoming infected with SARS-CoV-2, but a much larger proportion of infected children do not show symptoms of COVID-19. When one household member is infected, there is a 52% chance they will transmit it to at least one other person with whom they live.
Three in 10 parents say they will “definitely not” get their 5- to 11-year-old vaccinated against COVID-19, according to new data from the Kaiser Family Foundation. Neil Lewis, Jr., a behavioral scientist at Cornell University who was not involved with…
Following a daylong meeting Oct. 26, the FDA authorized Pfizer’s COVID-19 vaccine for use in children ages 5 to 11. This was the first in a series of meetings to make this vaccine available to younger children. Next, the Advisory…
Many curious animals can be found on the Indonesian Island of Sulawesi – such as the deer-hog and the midget buffalo.
Researchers reporting in ACS Nano have developed a dynamic respirator that modulates its pore size in response to changing conditions, such as exercise or air pollution levels, allowing the wearer to breathe easier when the highest levels of filtration are not required.
Disruptions to the circadian rhythms that regulate the sleep-wake cycle may especially affect people working from home, according to WVU researcher Randy Nelson.
Clip Health has rebranded from Luminostics ahead of exciting product launches this fall.
The Society of Thoracic Surgeons is highlighting two particularly interesting stories from COVID survivors who were on ECMO for months, with one patient eventually underdoing a double lung transplantation.
Professor Lewis Nelson, M.D., is available to discuss the dangers of gargling, snorting, or ingesting Betadine, an iodine-based antiseptic to treat COVID-19. “Although many topical disinfectants such as povidone-iodine, which, is also known as Betadine, generally destroy viruses on direct…
Throughout history, pandemics have been a key driver of human population change, thanks to mortality and declining fertility rates. And, according to a new study co-authored by a Cornell professor, COVID-19 is no exception.
Nearly half of New York City mothers who had been trying to become pregnant again before the coronavirus pandemic began stopped in the first few months of the outbreak, a new study shows.
A new dashboard launched by the Johns Hopkins Center for Communication Programs unpacks survey findings and helps explain why some people say they definitely or probably won’t get a COVID-19 vaccine.
New research from the University of Georgia offers hope for a viable therapeutic to combat the disease that has claimed more than 4 million lives worldwide.
As students head back to school this fall, sports medicine physicians with Loyola Medicine say the risk of COVID-19 exposure among student athletes is low. As the Delta variant of COVID-19 continues to spread across the U.S., Nathaniel Jones, MD, a sports medicine physician for Loyola Medicine, emphasizes the importance of getting vaccinated.
Early social distancing results in smaller death tolls, but leads to larger second waves, according to research led by faculty at Binghamton University, State University of New York.