COUR Pharmaceuticals, a clinical-stage biotechnology company developing novel immune-modifying nanoparticles designed to reprogram the immune system for the treatment of autoimmune disorders (COUR NanoParticles or CNPs), today announced that the U.S. Food and Drug Administration has cleared an Investigational New Drug (IND) application to initiate a Phase 1b/2a proof-of-concept study of COUR’s investigational therapy, CNP-106.
During the pandemic, physicians used infusions of monoclonal antibodies to help patients fight off COVID-19 infections. Now, in response to the U.S. opioid crisis, researchers at UC Davis are trying to create monoclonal antibodies that can help fight chronic pain. The research is funded with a $1.5 million grant from the National Institutes of Health’s HEAL Initiative, an aggressive effort to speed scientific solutions to stem the national’s opioid crisis.
There’s no cure for lupus, an autoimmune disease that attacks organs. But today, scientists report they have begun phase 2 clinical trials with a pill containing a compound that, in mice, reverses organ damage and prevents death. They will present their results at ACS Fall 2022.
Drugs called interferon betas are common treatments for multiple sclerosis. Interferon beta, a protein known to contain a zinc-binding pocket, is thought to reduce proinflammatory molecules in MS patients. But researchers now report in ACS Chemical Neuroscience that the molecule reduces the binding of three components — zinc, C-peptide and albumin — to red blood cells.
Urinary tract infections are common, yet can be tough to treat as the bacteria that cause them become resistant to many antibiotics. In ACS Central Science, researchers report a new molecule that inhibits drug-resistant bacteria in lab experiments, as well as in mice with pneumonia and UTIs.
Psychedelic drugs have shown benefits as treatments for cluster headaches, anxiety and depression in clinical studies, but not for everyone. Now, in ACS Chemical Neuroscience, researchers report that one reason could be common genetic variations in one serotonin receptor.
To develop new COVID-19 medications, researchers are working to target nsp13, a protein coronaviruses need to replicate. In ACS Infectious Diseases, researchers describe a new approach to identifying molecules that interfere with this protein, a step toward developing pan-coronavirus antivirals.
A new study from the University of Michigan describes one of the first entirely new drug delivery microencapsulation approaches in decades.
New Berkeley Lab breakthroughs: engineering chemical-producing microbes; watching enzyme reactions in real time; capturing the first image of ‘electron ice’; revealing how skyrmions really move
Two different strategies to discover and perfect pharmaceuticals active against the COVID-19 virus have attracted a half million dollars in research funding to support five institutions, including the Baudry Lab at The University of Alabama in Huntsville (UAH).
In a new paper in Ethics & International Affairs, Binghamton University Professor of Philosophy Nicole Hassoun first considers existing proposals for equitable vaccine allocation focusing on the COVID-19 Vaccines Global Access (COVAX) facility. She then argues that to better promote…
Scientists are calling for more stringent pesticide bans to lower deaths caused by deliberately ingesting toxic agricultural chemicals, which account for one fifth of global suicides.
New Brunswick, N.J. (March 3, 2021) – The 3D structures of more than 1,000 SARS-CoV-2 coronavirus proteins are freely available from the RCSB Protein Data Bank headquartered at Rutgers University–New Brunswick. The data bank reached the milestone this week, with 1,018 proteins as…
Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals.
A lab on UNLV’s campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery — one that could potentially provide a solution for patients who have run out of options.
A batch of pills will be on its way into space where they will be placed on the outside of the International Space Station (ISS) to test how they withstand the full effects of zero gravity, extreme temperatures and some of the highest levels of radiation found beyond the Earth’s atmosphere.
Using venom from the Conus nux, a sea snail, a first-of-its-kind study suggests these conotoxins could potentially treat malaria. The study provides important leads toward the development of new and cost-effective anti-adhesion or blockade-therapy drugs aimed at counteracting the pathology of severe malaria. Similarly, mitigation of emerging diseases like COVID-19 also could benefit from conotoxins as potential inhibitors of protein-protein interactions as treatment. Venom peptides from cone snails has the potential to treat myriad diseases using blockage therapies.
Shortages of many essential drugs amid the COVID-19 crisis reveal serious vulnerabilities in the systems for supplying and distributing pharmaceuticals in the United States.
Nephron Pharmaceuticals Corporation is celebrating another milestone.
Large pharmaceutical firms paid over $33 billion in penalties over the past 13 years for illegal practices, according to new research from a UNC Charlotte researcher. The study, published in today’s Journal of American Medical Association (JAMA), found that 85%…
The high price of prescription drugs is an important issue for voters, and in the past 50 years, Congress and the president have made little headway in restraining costs.
Biogen tried, and failed, to win FDA committee approval for its anti-amyloid Alzheimer’s drug. The Alzheimer’s Association supported the application but did not reveal significant monies received from the firm.
University at Buffalo spinoff Cytocybernetics is developing a high-tech tool called CyberQ to rapidly assess whether or not investigational COVID-19 drugs have arrhythmogenic properties that can result in sudden cardiac death.
Announcement of the 2021 Harrington UK Rare Disease Scholar Award recipients, their organizations and fields of research:
Pietro Fratta, MD, PhD – University College London
Gene Therapy for Kennedy’s Disease, a rare neuromuscular disease
Angela Russell, DPhil – University of Oxford
New Drugs for the Treatment of Duchenne Muscular Dystrophy
Helen Waller-Evans, DPhil – Cardiff University
Novel Inhibitors to Treat Multiple Lysomal Storage Disorders, causes of widespread organ damage
Wyatt Yue, PhD – University of Oxford
Inhibitors of Primary Hyperoxaluria, a cause of kidney failure
Haiyan Zhou, MD, PhD – University College London
Novel Therapy for SPTLC1-Related Hereditary Sensory Neuropathy, a cause of shooting pain
Rutgers researchers have reported an increased mortality risk in adults with depression who initiated augmentation with newer antipsychotic medications compared to a control group that initiated augmentation with a second antidepressant.
Pills are being sent into space to test how they cope with the rigours of one of the harshest environments known.
The University of Adelaide is studying how exposure to microgravity and space radiation affects the stability of pharmaceutical tablet formulations. Two separate missions will send science payloads into orbit around Earth: the first will test how tablets cope with the environment inside the International Space Station (ISS) U.S. National Laboratory. The second mission scheduled for early 2021, will test how tablets cope outside the ISS.
University of Wisconsin–Madison scientists have discovered that a majority of back-pain patients they tested who were taking opioid painkillers produced anti-opioid antibodies. These antibodies may contribute to some of the negative side effects of long-term opioid use.
The newly licensed compounds, developed at the University of Wisconsin-Milwaukee, act on a particular neurotransmitter receptor in the brain, which has shown promise for treatment of epilepsy and other convulsant disorders.
For a third consecutive year, the Infectious Diseases Society of America (IDSA) Foundation will showcase the IDea Incubator Pitch Competition, aimed to support entrepreneurs and researchers working in the area of infectious diseases during IDWeek 2020, October 21-25.
William S. Comanor is Professor of Health Policy and Management at the UCLA Fielding School of Public Health and director of the Research Program on Pharmaceutical Economics and Policy and also organizes a Seminar by the same name. From 1991…
Every human being has the right to health and new initiatives should be put in place to encourage pharmaceutical companies to ensure that everyone has access to essential medicine, according to a new book from Nicole Hassoun, professor of philosophy at Binghamton University, State University of New York.
The race to find a vaccine for the new coronavirus is well underway. Governments and researchers are aiming to provide billions of people with immunity in eighteen months or less, which would be unprecedented.
Chemists have found a way to turn alcohol into amino acids, the building blocks of life.
The University of Chicago Medicine’s Center for Personalized Therapeutics is hosting a virtual summit from June 9 to July 1 to discuss interventional pharmacoeconomics.
Midlands Medictech company Medherant has just this month (May 2020) signed a partnership agreement with Cambridge based Cycle Pharmaceuticals to develop multiple new products using Medherant technology developed by University of Warwick chemistry researchers.
Using an ultra-thin and sharp needle tipped with a single carbon monoxide molecule frozen to minus 266 degrees centigrade, researchers from the University of Warwick and Cardiff identified and mapped the location of every molecular bond on the surface of a material
An analysis revealed that water samples held a cocktail of pharmaceuticals and other compounds, including antibiotics, antifungals, anticonvulsants, anesthetics, antihypertensive drugs, pesticides, flame retardants and more. Not all chemicals were found at every test site.
New Brunswick, N.J. (April 15, 2020) – Rutgers University–New Brunswick professors Nicole Fahrenfeld and John Reinfelder are available for interviews on environmental protection issues during the COVID-19 pandemic. Fahrenfeld can discuss issues including microbial water quality, sewer issues (including what…
Rutgers engineers have created a tabletop device that combines a robot, artificial intelligence and near-infrared and ultrasound imaging to draw blood or insert catheters to deliver fluids and drugs. Their research results, published in the journal Nature Machine Intelligence, suggest that autonomous systems like the image-guided robotic device could outperform people on some complex medical tasks.
Renowned scientists including Nobel laureates, research pioneers and celebrated educators will convene at the Experimental Biology (EB) 2020 meeting, to be held April 4–7 in San Diego. Bringing together more than 12,000 life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.
Researchers have found that ozone treatment and subsequent chlorination can convert trace amounts of some pharmaceuticals in wastewater into DBPs called halonitromethanes.
Of three possible ways for people to deliver the life-saving antidote naloxone to a person experiencing an opioid overdose, the use of a nasal spray was the quickest and easiest according to research conducted by William Eggleston, clinical assistant professor at Binghamton University, State University of New York, and colleagues at SUNY Upstate Medical University.
Scientists may have figured out how dust particles can stick together to form planets, according to a Rutgers co-authored study that may also help to improve industrial processes. In homes, adhesion on contact can cause fine particles to form dust bunnies. Similarly in outer space, adhesion causes dust particles to stick together. Large particles, however, can combine due to gravity – an essential process in forming asteroids and planets. But between these two extremes, how aggregates grow has largely been a mystery until now.
Despite efforts over multiple decades, there are still no cell lines for marine invertebrates. For the first time, scientists have developed a breakthrough in marine invertebrate (sponge) cell culture, demonstrating exceptionally fast cell division and the ability to subculture the cells. This groundbreaking discovery forms the basis for developing marine invertebrate cell models to better understand early animal evolution, determine the role of secondary metabolites, predict the impact of climate change to coral reef community ecology and develop novel medicines.
The improved technique will help explore genetic diseases and benefit drug development. It could also lead to better, safer weed killers.
In one of the most diverse studies of the non-random medicinal plants selection by gender, age and exposure to outside influences from working with ecotourism projects, researchers worked with the Kichwa communities of Chichico Rumi and Kamak Maki in the Ecuadorian Amazon. They discovered a novel method to uncover the intracultural heterogeneity of traditional knowledge while testing the non-random selection of medicinal plants and exploring overuse and underuse of medicinal plant families in these communities.
In a new study, aimed at using stem cells for hair growth, Columbia researchers have created a way to grow human hair in a dish, which could open up hair restoration surgery to more people, including women, and improve the…