Pharmacology Expert Comments on RSV Vaccination Errors

The Centers for Disease Control and Prevention (CDC) reports that some pregnant Americans may have been given the wrong RSV vaccine, and some young children received a vaccine approved for use in adults only.  Now, a pharmacology expert at New York Institute…

Praedicare Leverages AI, Mathematical Models of Disease Progression and Mapping in World’s First In Silico Clinical Trial of Its Kind

The in silico trial demonstrated 2X the efficacy of the current treatment (>80% vs 39%); 3X shorter treatment time to cure (6 vs 18 months); 1 drug compared to a 3-drug combo for the standard of care; and preclinical results in shorter time than animal models.

Expert: Drug Store Closings Will Lead to Pharmacy Deserts

As major pharmacy retailers, including CVS, Walgreens, and Rite Aid, plan to close thousands of U.S. stores, a pharmacology expert from New York Institute of Technology College of Osteopathic Medicine (NYITCOM) is sounding the alarm. “The closure of hundreds of…

Degrading modified proteins could treat Alzheimer’s, other ‘undruggable’ diseases

A new technique that targets and breaks apart certain proteins — rather than just interfering with them — may offer a pathway toward treatment of Alzheimer’s disease. Researchers reporting in ACS Central Science have designed a compound that breaks down a protein closely associated with the disease.

COUR Pharmaceuticals Announces FDA Clearance of Investigational New Drug Application for Myasthenia Gravis

COUR Pharmaceuticals, a clinical-stage biotechnology company developing novel immune-modifying nanoparticles designed to reprogram the immune system for the treatment of autoimmune disorders (COUR NanoParticles or CNPs), today announced that the U.S. Food and Drug Administration has cleared an Investigational New Drug (IND) application to initiate a Phase 1b/2a proof-of-concept study of COUR’s investigational therapy, CNP-106.

Could monoclonal antibodies replace opioids for chronic pain?

During the pandemic, physicians used infusions of monoclonal antibodies to help patients fight off COVID-19 infections. Now, in response to the U.S. opioid crisis, researchers at UC Davis are trying to create monoclonal antibodies that can help fight chronic pain. The research is funded with a $1.5 million grant from the National Institutes of Health’s HEAL Initiative, an aggressive effort to speed scientific solutions to stem the national’s opioid crisis.

Multiple sclerosis drug works in a surprising way

Drugs called interferon betas are common treatments for multiple sclerosis. Interferon beta, a protein known to contain a zinc-binding pocket, is thought to reduce proinflammatory molecules in MS patients. But researchers now report in ACS Chemical Neuroscience that the molecule reduces the binding of three components — zinc, C-peptide and albumin — to red blood cells.

New drug candidate fights off more than 300 drug-resistant bacteria

Urinary tract infections are common, yet can be tough to treat as the bacteria that cause them become resistant to many antibiotics. In ACS Central Science, researchers report a new molecule that inhibits drug-resistant bacteria in lab experiments, as well as in mice with pneumonia and UTIs.

People respond differently to psychedelic drugs — genetics could be the reason

Psychedelic drugs have shown benefits as treatments for cluster headaches, anxiety and depression in clinical studies, but not for everyone. Now, in ACS Chemical Neuroscience, researchers report that one reason could be common genetic variations in one serotonin receptor.

Science snapshots from Berkeley Lab

New Berkeley Lab breakthroughs: engineering chemical-producing microbes; watching enzyme reactions in real time; capturing the first image of ‘electron ice’; revealing how skyrmions really move

UAH’s Baudry Lab part of half-million-dollar efforts to target COVID with drug therapies

Two different strategies to discover and perfect pharmaceuticals active against the COVID-19 virus have attracted a half million dollars in research funding to support five institutions, including the Baudry Lab at The University of Alabama in Huntsville (UAH).

Equity and Vaccine Allocation: Beyond Ethics in Prioritization to Equitable Production, Distribution, and Consumption

In a new paper in Ethics & International Affairs, Binghamton University Professor of Philosophy Nicole Hassoun first considers existing proposals for equitable vaccine allocation focusing on the COVID-19 Vaccines Global Access (COVAX) facility. She then argues that to better promote…

More than 1,000 SARS-CoV-2 Coronavirus Protein 3D Structures Available

New Brunswick, N.J. (March 3, 2021) – The 3D structures of more than 1,000 SARS-CoV-2 coronavirus proteins are freely available from the RCSB Protein Data Bank headquartered at Rutgers University–New Brunswick. The data bank reached the milestone this week, with 1,018 proteins as…

Harnessing the Power of Proteins in our Cells to Combat Disease

A lab on UNLV’s campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery — one that could potentially provide a solution for patients who have run out of options.

Cone Snail Venom Shows Potential for Treating Severe Malaria

Using venom from the Conus nux, a sea snail, a first-of-its-kind study suggests these conotoxins could potentially treat malaria. The study provides important leads toward the development of new and cost-effective anti-adhesion or blockade-therapy drugs aimed at counteracting the pathology of severe malaria. Similarly, mitigation of emerging diseases like COVID-19 also could benefit from conotoxins as potential inhibitors of protein-protein interactions as treatment. Venom peptides from cone snails has the potential to treat myriad diseases using blockage therapies.

Alzheimer’s Association should reveal financial conflict of interest in urging FDA to approve Biogen drug, says Dr. Leslie Norins, CEO of Alzheimer’s Germ Quest

Biogen tried, and failed, to win FDA committee approval for its anti-amyloid Alzheimer’s drug. The Alzheimer’s Association supported the application but did not reveal significant monies received from the firm.

Harrington Discovery Institute Announces Award Recipients in New UK Rare Disease Program

Announcement of the 2021 Harrington UK Rare Disease Scholar Award recipients, their organizations and fields of research:

Pietro Fratta, MD, PhD – University College London
Gene Therapy for Kennedy’s Disease, a rare neuromuscular disease

Angela Russell, DPhil – University of Oxford
New Drugs for the Treatment of Duchenne Muscular Dystrophy

Helen Waller-Evans, DPhil – Cardiff University
Novel Inhibitors to Treat Multiple Lysomal Storage Disorders, causes of widespread organ damage

Wyatt Yue, PhD – University of Oxford
Inhibitors of Primary Hyperoxaluria, a cause of kidney failure

Haiyan Zhou, MD, PhD – University College London
Novel Therapy for SPTLC1-Related Hereditary Sensory Neuropathy, a cause of shooting pain

Testing time for pills in space

Pills are being sent into space to test how they cope with the rigours of one of the harshest environments known.
The University of Adelaide is studying how exposure to microgravity and space radiation affects the stability of pharmaceutical tablet formulations. Two separate missions will send science payloads into orbit around Earth: the first will test how tablets cope with the environment inside the International Space Station (ISS) U.S. National Laboratory. The second mission scheduled for early 2021, will test how tablets cope outside the ISS.

Infectious Diseases Society of America Foundation to Collaborate with Johnson & Johnson Innovation – JLABS to Host the 2020 IDea Incubator Pitch Competition

For a third consecutive year, the Infectious Diseases Society of America (IDSA) Foundation will showcase the IDea Incubator Pitch Competition, aimed to support entrepreneurs and researchers working in the area of infectious diseases during IDWeek 2020, October 21-25.

UCLA Fielding School of Public Health expert available for comment on White House plans for an executive order directing the federal government to buy certain drugs solely from American factories.

William S. Comanor is Professor of Health Policy and Management at the UCLA Fielding School of Public Health and director of the Research Program on Pharmaceutical Economics and Policy and also organizes a Seminar by the same name. From 1991…

New book examines human right to health, pushes for rating system for pharmaceutical companies

Every human being has the right to health and new initiatives should be put in place to encourage pharmaceutical companies to ensure that everyone has access to essential medicine, according to a new book from Nicole Hassoun, professor of philosophy at Binghamton University, State University of New York.

Study describes cocktail of pharmaceuticals in waters in Bangladesh

An analysis revealed that water samples held a cocktail of pharmaceuticals and other compounds, including antibiotics, antifungals, anticonvulsants, anesthetics, antihypertensive drugs, pesticides, flame retardants and more. Not all chemicals were found at every test site.

Rutgers Experts Available to Discuss Environmental Protection During COVID-19 Crisis

New Brunswick, N.J. (April 15, 2020) – Rutgers University–New Brunswick professors Nicole Fahrenfeld and John Reinfelder are available for interviews on environmental protection issues during the COVID-19 pandemic. Fahrenfeld can discuss issues including microbial water quality, sewer issues (including what…

Robot Uses Artificial Intelligence and Imaging to Draw Blood

Rutgers engineers have created a tabletop device that combines a robot, artificial intelligence and near-infrared and ultrasound imaging to draw blood or insert catheters to deliver fluids and drugs. Their research results, published in the journal Nature Machine Intelligence, suggest that autonomous systems like the image-guided robotic device could outperform people on some complex medical tasks.

Speakers announced for 2020 Experimental Biology meeting

Renowned scientists including Nobel laureates, research pioneers and celebrated educators will convene at the Experimental Biology (EB) 2020 meeting, to be held April 4–7 in San Diego. Bringing together more than 12,000 life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.

Research shows nasal spray antidote is easiest to give for opioid overdose

Of three possible ways for people to deliver the life-saving antidote naloxone to a person experiencing an opioid overdose, the use of a nasal spray was the quickest and easiest according to research conducted by William Eggleston, clinical assistant professor at Binghamton University, State University of New York, and colleagues at SUNY Upstate Medical University.