It has been well established that people who live in rural areas in the U.S. are more likely to have diabetes and experience barriers to managing their condition compared to those who live in the suburbs and cities.
Tag: Kidney Disease
UT Southwestern study shows glucagon is key for kidney health
Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers removed receptors for this hormone from mouse kidneys, the animals developed symptoms akin to chronic kidney disease (CKD).
Unveiling uremic toxins linked to itching in hemodialysis patients
Dr. Yamamoto et al. found the several uremic toxins as one of causes of itching in hemodialysis patients.
Hispanics Are Being Impacted By Diabetes and Kidney Disease
Paula Duran, MD, at Baylor Scott & White Health, answers the most common patient questions and reacts to the latest medical research impacting the Hispanic population. Why do Hispanics have a high incidence of diabetes and subsequent kidney disease? Is…
Researchers Explore Proteins’ Roles in Cilia Associated with Polycystic Kidney Disease
Article title: CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease Authors: Murali K. Yanda, Cristian Ciobanu, William B. Guggino, Liudmila Cebotaru From the authors: “Here we show that [cystic fibrosis transmembrane conductance regulator (CFTR)]…
Despite social media claims, Borax is not safe to consume
A nephrologist explains the damage that this trend can cause
Gene therapy hope for children with kidney disease
Researchers at the University of Bristol have made a remarkable step forward in finding a potential cure for a type of childhood kidney disease.
Enzyme in T Cells Worsens Salt-sensitive Hypertension and Related Kidney Damage
Article title: Functional NADPH oxidase 2 (NOX2) in T cells amplifies salt-sensitive hypertension and associated renal damage Authors: Samuel D. Walton, John Henry Dasinger, Emily C. Burns, Mary Cherian-Shaw, Justine M. Abais-Battad, David L. Mattson From the authors: “The results…
Study Shows Mitochondrial Transplantation Effective in Reversing Damage to Kidneys and Kidney Cells
According to the National Kidney Foundation, more than 100,000 Americans are waiting for a kidney transplant, and the demand for donated kidneys far exceeds the supply. In fact, only 25,498 kidney transplants were performed in 2022, and kidney disease impacts 37 million people in the U.S. But a new preclinical study, led by scientists at Wake Forest University School of Medicine, shows that a new technology called mitochondrial transplantation holds promise as a potential therapy that could change the kidney transplant landscape.
New algorithm can predict diabetic kidney disease
Researchers from Sanford Burnham Prebys and the Chinese University of Hong Kong have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. The findings could help doctors prevent or better manage kidney disease in people with type 2 diabetes.
Bypassing contrast in patients with kidney disease and contrast allergies may lead to less accurate scans
Upon an arrival to the emergency department for abdominal pain of unknown cause, most non-pregnant adult patients receive a CT scan with IV contrast to diagnose the source of the pain. However, IV contrast can be a risk in patients with severe kidney disease or at risk for an allergic reaction from the dye. When scans are performed without IV contrast, though, they are usually less accurate, which can lead to misdiagnosis.
Researchers find new pathway to prevent kidney failure for thousands
Researchers at the University of Bristol have made a breakthrough that could prevent certain kidney patients progressing towards renal failure.
Diabetes Drug Improves Kidney Function and Inflammation
Article title: Reno-protective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system Authors: Xin Chen, Denis Delić, Yaochen Cao, Linghong Shen, Qin Shao, Zheyu Zhang, Hongwei Wu, Ahmed A. Hasan, Christoph…
Study Finds Certain Substances in Urine, Blood Can Predict Kidney Disease Progression
In a new study looking at the long-term effects of hospitalized patients who have acute kidney injury (AKI), a sudden but temporary loss of kidney function, Johns Hopkins Medicine researchers found that higher levels of certain biomarkers in urine and blood can predict a patient’s risk of developing chronic kidney disease (CKD).
Baltimore PKD Research and Clinical Core Center Receives Prestigious ‘Center of Excellence’ Designation from PKD Foundation
The PKD Foundation recently recognized the University of Maryland School of Medicine’s (UMSOM) clinical center that treats polycystic kidney disease (PKD)with a highly prestigious “Center of Excellence” designation. The designation recognizes the center as a leader in providing multidisciplinary, comprehensive clinical services for families affected by autosomal dominant polycystic kidney disease (ADPKD), a hereditary condition. It is one of just 28 clinical centers in the U.S. to receive this recognition.
Migraine Drug Shows Promise in Treatment of Acute Kidney Injury
The drug lasmiditan, which is used to treat migraines, shows promise as a possible treatment for acute kidney injury, according to a new study from the University of Arizona.
Fatty Acid May Be Useful in Preventing Kidney Fibrosis, Treating Fibrotic Diseases
Article title: Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy Authors: Mi Ra Noh, Hee-Seong Jang, Fadi E. Salem, Fernando A. Ferrer, Jinu Kim, Babu J. Padanilam From the authors: “Our findings provide a…
Researchers Identify How HIV/Hepatitis Drug Harms the Kidneys
A first-of-its-kind study identifies mechanisms that explain how a drug commonly used to treat HIV and hepatitis causes kidney disease and kidney injury. The study is published ahead of print in Function.
UC San Diego Health Named Center of Excellence for Polycystic Kidney Disease
UC San Diego Health has been named a Center of Excellence for polycystic kidney disease (PKD) by the PKD Foundation – the leading advocacy group dedicated to finding treatments and a cure for PKD. UC San Diego Health is one of just 28 institutions nationwide to receive this designation.
Staph infection-induced kidney disease may be linked to bacterial gene mutation
Researchers aiming to predict which staph-infection patients might develop a related kidney disease have found a high frequency of gene mutations in the infecting bacteria of affected patients, which suggests these variants may play a role in the body’s initiation of the renal damage.
Published Real World Evidence Demonstrates KidneyIntelX™ Improved Clinical Decisions and Outcomes in High-Risk Patients with Early-Stage Diabetic Kidney Disease
Renalytix plc (NASDAQ: RNLX) (LSE: RENX) announces the publication of new real-world evidence (RWE) in Primary Care and Community Health demonstrating the Company’s KidneyIntelX bioprognostic™ test resulted in changed clinical decision making for patients in the early-stage of diabetic kidney disease (DKD) being cared for within the Mount Sinai Health System’s Population Health Ambulatory Pharmacy and Condition Management programs.
Podocyte Protectors: NIH Awards CHLA’s GOFARR Laboratory Additional Grants to Combat Chronic Childhood Kidney Disease
CHLA has received a new five-year award of $3.2 million from the National Institutes of Health (NIH) to research the underlying mechanisms that lead to kidney failure and to develop new treatments to protect kidney function.
Researchers Identify Potential New Therapeutic Target for Polycystic Kidney Disease
Article title: The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease Authors: Shirin V. Sundar, Julie Xia Zhou, Brenda S. Magenheimer, Gail A. Reif, Darren P. Wallace, Gunda I. Georg, Sudhakar R. Jakkaraj, Joseph S. Tash, Alan S.L.…
New Risk Score Predicts Mortality for Atrial Fibrillation Patients Undergoing Transcatheter Aortic Valve Replacement
Mount Sinai researchers develop new risk stratification tool to optimize patient care and outcomes after TAVR
CHOP and Penn Launch Kidney Innovation Center to Accelerate Discovery and Improve Treatment of Kidney Disease Across the Lifespan
In an effort to improve the lives of children and adults with kidney disease, Children’s Hospital of Philadelphia (CHOP) and Penn Medicine are jointly launching the Penn-CHOP Kidney Innovation Center. The first-of-its-kind center will advance research to transform patient care for those of all ages, focusing on the early detection, prevention, and treatment of kidney disease and its complications.
Albupro Plus Dietary Supplements Research from Chula for Kidney Patients and all Healthy People
A lecturer of the Faculty of Allied Health Sciences, Chula unveils her research on high egg white protein dietary supplement Albupro Plus, functional food for health lovers, now ready for sale.
Study shows HIV speeds up body’s aging processes soon after infection
HIV has an “early and substantial” impact on aging in infected people, accelerating biological changes in the body associated with normal aging within just two to three years of infection.
Intermittent Fasting Protects Kidneys of Obese Mice
New research in mice finds that time-restricted feeding improves markers of kidney and vascular health. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference.
Common Prebiotic Fiber Mitigates Harm of High-salt Diet in Rats
New research in rats finds a diet high in the fiber inulin offered a protective effect against the damage of a high-salt diet. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference
Past Kidney Disease May Increase Preeclampsia Risk, Impair Blood Vessel Health during Pregnancy
A history of kidney problems may put people at a higher risk for impaired blood vessel function, which could lead to high blood pressure, preterm labor and other adverse outcomes, according to the results of a study in rats. The researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
Vitamin D Supplements May Offset Bone Loss Caused by Diabetes Drug
Vitamin D supplementation may help offset damaging bone loss that occurs in some people who take canagliflozin, a commonly prescribed diabetes drug. Researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
The COVID-19 pandemic’s impact on treatment decision-making for older patients with kidney disease
A recent study examined how uncertainty surrounding the evolving COVID-19 pandemic influenced shared decision-making between clinicians, older patients with chronic kidney disease, and their care partners.
Kidney Stone Formation Linked to Polycystic Kidney Disease in Mice
Article title: Kidney stone formation in a novel murine model of polycystic kidney disease Authors: Heather A.L. Riddle, Shiqin Zhang, Feng Qian, James C. Williams Jr., Jason R. Stubbs, Peter Stanley N. Rowe, Stephen C. Parnell From the authors: “Our…
New Liver and Kidney Disease Identified
Scientists have identified a new disease in a ground-breaking discovery that could help patients with unexplained liver and kidney problems.
Calorie Count More Important than Nutrient Composition in Development of Obesity-related Kidney Disease
Article title: High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat Authors: Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton From the authors: “This work suggests that macronutrient…
Virtual Population Model Predicts and Stops Kidney Damage in Black Americans
Researchers have successfully used a virtual population to replicate a clinical trial that examined kidney damage in Black Americans, according to a new study at the University of Mississippi Medical Center in Jackson.
Chronic Kidney Disease is Curable if Detected Early – Chula’s User-friendly CKD Screening Strips with Results in 15 minutes!
A Chula research team has developed a screening strip kit to detect the early stage of chronic kidney disease (CKD) that’s easy to use, yields quick results, increasing the chance of being cured for patients, and helping to cut over 10 billion baht of the ever-increasing annual healthcare costs for CKD patients. The CKD screening strip kits are expected to be released early next year.
Researchers ID Protein Complex That Plays Important Role in Kidneys’ Water Balance Pathways
Article title: Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway Authors: Chen-Chung Steven Liu, Pui Wen Cheung, Anupama Dinesh, Noah Baylor, Theodor C. Paunescu, Anil V. Nair, Richard Bouley, Dennis Brown From the authors: “In…
Update: Reassessing Inclusion of Race in Diagnosing Kidney Diseases
The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) congratulate the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases for submitting its final report for publication.
Weight Fluctuations May Predict Poor Outcomes in Adults with Kidney Disease
• In individuals with kidney disease, those with high body mass index variability faced higher risks of needing kidney replacement therapy, experiencing a heart attack, experiencing a stroke, and dying prematurely.
Dapagliflozin Found Effective and Safe in Adults with Advanced Kidney Disease
• The sodium-glucose co-transporter 2 inhibitor dapagliflozin reduced kidney, cardiovascular, and mortality risks in patients with advanced chronic kidney disease, similar to benefits seen in individuals with normal or moderately impaired kidney function.
• Rates of serious side effects were similar in patients with advanced chronic kidney disease who received dapagliflozin or placebo.
For People with Kidney Disease, There Is No Safe Amount of Lead in Drinking Water
• In this analysis of U.S. adults with advanced kidney disease, even low levels of lead in community drinking water had a negative effect on health.
• Higher lead levels were found in the drinking water of predominantly Black communities compared with predominantly white communities.
Patients with Kidney Disease—Even without Anemia—May Benefit From Iron Treatment
• Among individuals with chronic kidney disease, iron deficiency was linked with higher risks of death and cardiovascular events, in patients with and without anemia.
• Clinical trials are needed to test the effects of iron treatment, even in the absence of anemia, in patients with chronic kidney disease.
Precision medicine helps identify “at-risk rapid decliners” in early-stage kidney disease
A novel therapeutic may halt rapid kidney function in some type 1 diabetic kidney disease patients.
Wayne State University and Henry Ford Health System announce new initiative in cardiometabolic health and disease
Wayne State University and Henry Ford Health System announced today the launch of a basic and translational research initiative in Cardiometabolic Health and Disease as a thematic focus for program growth.
Improving dialysis through design
Faculty from the McKelvey School of Engineering and the School of Medicine teamed up to design better grafts for dialysis patients.
ATRIUM HEALTH, WAKE FOREST BAPTIST HEALTH, WAKE FOREST SCHOOL OF MEDICINE AND RENALYTIX PARTNER TO ADVANCE KIDNEY HEALTH
Renalytix AI plc, Atrium Health, Wake Forest Baptist Health and Wake Forest School of Medicine announced a partnership to implement an advanced clinical care model designed to improve kidney health and reduce kidney disease progression and kidney failure in high-risk populations.
Academy of Nutrition and Dietetics Urges Swift Passage of Bill That Would Increase Access to Nutrition Care
The Academy of Nutrition and Dietetics supports expanding medical nutrition therapy to provide Medicare beneficiaries with the care they need and deserve to live healthy, independent lives.
UNH Research: More Than One Way for Animals to Survive Climate Change
Researchers at the University of New Hampshire found that to live in hotter more desert-like surroundings, and exist without water, there is more than one genetic mechanism allowing animals to adapt. This is important not only for their survival but may also provide important biomedical groundwork to develop gene therapies to treat human dehydration related illnesses, like kidney disease.
Surprise Discovery Shows Chronic Heart Dysfunction Protects against Acute Kidney Injury
Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinwechi Nwosisi, Ming-Zhi Zhang, Raymond C. Harris From the authors:…