Intermittent Fasting Protects Kidneys of Obese Mice

New research in mice finds that time-restricted feeding improves markers of kidney and vascular health. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference.

Common Prebiotic Fiber Mitigates Harm of High-salt Diet in Rats

New research in rats finds a diet high in the fiber inulin offered a protective effect against the damage of a high-salt diet. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference

Past Kidney Disease May Increase Preeclampsia Risk, Impair Blood Vessel Health during Pregnancy

A history of kidney problems may put people at a higher risk for impaired blood vessel function, which could lead to high blood pressure, preterm labor and other adverse outcomes, according to the results of a study in rats. The researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.

Vitamin D Supplements May Offset Bone Loss Caused by Diabetes Drug

Vitamin D supplementation may help offset damaging bone loss that occurs in some people who take canagliflozin, a commonly prescribed diabetes drug. Researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.

Calorie Count More Important than Nutrient Composition in Development of Obesity-related Kidney Disease

Article title: High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat Authors: Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton From the authors: “This work suggests that macronutrient…

Chronic Kidney Disease is Curable if Detected Early – Chula’s User-friendly CKD Screening Strips with Results in 15 minutes!

A Chula research team has developed a screening strip kit to detect the early stage of chronic kidney disease (CKD) that’s easy to use, yields quick results, increasing the chance of being cured for patients, and helping to cut over 10 billion baht of the ever-increasing annual healthcare costs for CKD patients. The CKD screening strip kits are expected to be released early next year.

Dapagliflozin Found Effective and Safe in Adults with Advanced Kidney Disease

• The sodium-glucose co-transporter 2 inhibitor dapagliflozin reduced kidney, cardiovascular, and mortality risks in patients with advanced chronic kidney disease, similar to benefits seen in individuals with normal or moderately impaired kidney function.
• Rates of serious side effects were similar in patients with advanced chronic kidney disease who received dapagliflozin or placebo.

UNH Research: More Than One Way for Animals to Survive Climate Change

Researchers at the University of New Hampshire found that to live in hotter more desert-like surroundings, and exist without water, there is more than one genetic mechanism allowing animals to adapt. This is important not only for their survival but may also provide important biomedical groundwork to develop gene therapies to treat human dehydration related illnesses, like kidney disease.

Surprise Discovery Shows Chronic Heart Dysfunction Protects against Acute Kidney Injury

Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinwechi Nwosisi, Ming-Zhi Zhang, Raymond C. Harris From the authors:…

Study Explores Effects of Exercise on Heart, Lung and Metabolic Physiology during Dialysis

Article title: Cardiopulmonary and metabolic physiology during hemodialysis and inter-/intra-dialytic exercise Authors: Scott McGuire, Elizabeth Jane Horton, Derek Renshaw, Klaris Chan, Nithya Krishnan, Gordon McGregor From the authors: “This study is the first to directly compare cardiopulmonary and metabolic physiology during…

Newly Identified Pathway, Biomarkers May Be Tools to Prevent Kidney Injury-induced Lung Damage

Article title: Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury Authors: Mark Hepokoski, Jing Wang, Kefeng Li, Ying Li, Purva Gupta, Tina Mai, Alex Moshensky, Mona Alotaibi, Laura E. Crotty Alexander, Atul Malhotra, Prabhleen Singh…

Nicotine Damages Kidney Filters in Smokers with Diabetes

Article title: Nicotine, smoking, podocytes and diabetic nephropathy Authors: Edgar A. Jaimes, Ming-Sheng Zhou, Mohammed Siddiqui, Gabriel Rezonzew, Runxia Tian, Surya V. Seshan, Alecia N Muwonge, Nicholas J. Wong, Evren U. Azeloglu, Alessia Fornoni, Sandra Merscher, Leopoldo Raij From the authors:…

Shift Work Disrupts Kidney Rhythms, Contributes to Kidney and Heart Disease

Article title: Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats Authors: Atlantis M. Hill, G. Ryan Crislip, Adam Stowie, Ivory Ellis, Anne Ramsey, Oscar Castanon-Cervantes, Michelle L.…

Rethinking Race and Kidney Function

Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients.

Newly diagnosed patients and those whose kidney disease is reclassified as more severe would have greater access to kidney specialists, faster access to the kidney-transplant waitlist.

On the flipside, patients reclassified as having more severe kidney disease may become ineligible for heart, diabetes, pain control and cancer medications or may be given lower doses for these drugs.

A new kidney function score would also increase the number of Black individuals ineligible to donate a kidney, potentially exacerbating organ shortages for Black people.

Researchers caution that clinicians and policy makers must anticipate both the benefits and downsides of changes to the current formula to ensure that Black patients are not disadvantaged, and
health disparities are not exacerbated.

Scientists say the analysis should motivate researchers and cl

Harrington Discovery Institute Announces Award Recipients in New UK Rare Disease Program

Announcement of the 2021 Harrington UK Rare Disease Scholar Award recipients, their organizations and fields of research:

Pietro Fratta, MD, PhD – University College London
Gene Therapy for Kennedy’s Disease, a rare neuromuscular disease

Angela Russell, DPhil – University of Oxford
New Drugs for the Treatment of Duchenne Muscular Dystrophy

Helen Waller-Evans, DPhil – Cardiff University
Novel Inhibitors to Treat Multiple Lysomal Storage Disorders, causes of widespread organ damage

Wyatt Yue, PhD – University of Oxford
Inhibitors of Primary Hyperoxaluria, a cause of kidney failure

Haiyan Zhou, MD, PhD – University College London
Novel Therapy for SPTLC1-Related Hereditary Sensory Neuropathy, a cause of shooting pain

Genetic Testing for Kidney Diseases in Embryos from In Vitro Fertilization

• A recent analysis examines data from over the past 25 years concerning couples’ use of genetic testing for kidney diseases in embryos from in vitro fertilization.
• The analysis provides the first report on the types of genetic kidney diseases tested in this way, how often these tests result in live births of unaffected children, and what reasons couples cite for not undergoing testing.

Sacubitril and Valsartan Combination Treatment May Reduce Hypertensive Kidney Disease

Article title: Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension Authors: Iuliia Polina, Mark Domondon, Rebecca Fox, Anastasia V. Sudarikova, Miguel Troncoso, Valeriia Y. Vasileva, Yuliia Kashyrina, Monika Beck Gooz, Ryan S. Schibalski, Kristine Y.…

Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.

ACADEMY OF NUTRITION AND DIETETICS SUPPORTS INTRODUCTION OF MEDICAL NUTRITION THERAPY LEGISLATION IN CONGRESS

The Academy of Nutrition and Dietetics supports U.S. Rep. Eliot Engel (N.Y.) and Rep. Pete King’s (N.Y.) commitment to America’s health by introducing the Medical Nutrition Therapy Act of 2020. The bill would provide coverage for Medicare beneficiaries to obtain treatment from registered dietitian nutritionists and other qualified nutrition experts for many common and costly chronic diseases.