Article title: Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway Authors: Chen-Chung Steven Liu, Pui Wen Cheung, Anupama Dinesh, Noah Baylor, Theodor C. Paunescu, Anil V. Nair, Richard Bouley, Dennis Brown From the authors: “In…
The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) congratulate the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases for submitting its final report for publication.
• In individuals with kidney disease, those with high body mass index variability faced higher risks of needing kidney replacement therapy, experiencing a heart attack, experiencing a stroke, and dying prematurely.
• The sodium-glucose co-transporter 2 inhibitor dapagliflozin reduced kidney, cardiovascular, and mortality risks in patients with advanced chronic kidney disease, similar to benefits seen in individuals with normal or moderately impaired kidney function.
• Rates of serious side effects were similar in patients with advanced chronic kidney disease who received dapagliflozin or placebo.
• In this analysis of U.S. adults with advanced kidney disease, even low levels of lead in community drinking water had a negative effect on health.
• Higher lead levels were found in the drinking water of predominantly Black communities compared with predominantly white communities.
• Among individuals with chronic kidney disease, iron deficiency was linked with higher risks of death and cardiovascular events, in patients with and without anemia.
• Clinical trials are needed to test the effects of iron treatment, even in the absence of anemia, in patients with chronic kidney disease.
A novel therapeutic may halt rapid kidney function in some type 1 diabetic kidney disease patients.
Wayne State University and Henry Ford Health System announced today the launch of a basic and translational research initiative in Cardiometabolic Health and Disease as a thematic focus for program growth.
Faculty from the McKelvey School of Engineering and the School of Medicine teamed up to design better grafts for dialysis patients.
Renalytix AI plc, Atrium Health, Wake Forest Baptist Health and Wake Forest School of Medicine announced a partnership to implement an advanced clinical care model designed to improve kidney health and reduce kidney disease progression and kidney failure in high-risk populations.
The Academy of Nutrition and Dietetics supports expanding medical nutrition therapy to provide Medicare beneficiaries with the care they need and deserve to live healthy, independent lives.
Researchers at the University of New Hampshire found that to live in hotter more desert-like surroundings, and exist without water, there is more than one genetic mechanism allowing animals to adapt. This is important not only for their survival but may also provide important biomedical groundwork to develop gene therapies to treat human dehydration related illnesses, like kidney disease.
Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinwechi Nwosisi, Ming-Zhi Zhang, Raymond C. Harris From the authors:…
Article title: Cardiopulmonary and metabolic physiology during hemodialysis and inter-/intra-dialytic exercise Authors: Scott McGuire, Elizabeth Jane Horton, Derek Renshaw, Klaris Chan, Nithya Krishnan, Gordon McGregor From the authors: “This study is the first to directly compare cardiopulmonary and metabolic physiology during…
Article title: Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury Authors: Mark Hepokoski, Jing Wang, Kefeng Li, Ying Li, Purva Gupta, Tina Mai, Alex Moshensky, Mona Alotaibi, Laura E. Crotty Alexander, Atul Malhotra, Prabhleen Singh…
• A one-year trial found that the eKidneyCare smartphone app helped patients with chronic kidney disease take their prescribed medications properly.
• The app may help to prevent adverse drug reactions and other medication errors that can endanger patients.
The Wake Forest Institute for Regenerative Medicine is investigating how cats with chronic kidney disease could someday help inform treatment for humans.
An estimated 1 in 10 people worldwide have chronic kidney disease, but most of them don’t know it. That lack of awareness is especially concerning because people with Chronic kidney disease who are infected with COVID-19 are at higher risk for serious illness.
Article title: Nicotine, smoking, podocytes and diabetic nephropathy Authors: Edgar A. Jaimes, Ming-Sheng Zhou, Mohammed Siddiqui, Gabriel Rezonzew, Runxia Tian, Surya V. Seshan, Alecia N Muwonge, Nicholas J. Wong, Evren U. Azeloglu, Alessia Fornoni, Sandra Merscher, Leopoldo Raij From the authors:…
Article title: Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats Authors: Atlantis M. Hill, G. Ryan Crislip, Adam Stowie, Ivory Ellis, Anne Ramsey, Oscar Castanon-Cervantes, Michelle L.…
An artificial intelligence-enabled in vitro diagnostics company and the University of Utah today announced a partnership to improve kidney health and reduce the risk of kidney failure for large scale populations in the earliest stages of kidney disease.
A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans.
• Exposure to higher amounts of fine particulate air pollution was associated with a greater likelihood of having chronic kidney disease.
• This link was stronger in urban areas, males, younger adults, and adults without comorbid diseases.
Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients.
Newly diagnosed patients and those whose kidney disease is reclassified as more severe would have greater access to kidney specialists, faster access to the kidney-transplant waitlist.
On the flipside, patients reclassified as having more severe kidney disease may become ineligible for heart, diabetes, pain control and cancer medications or may be given lower doses for these drugs.
A new kidney function score would also increase the number of Black individuals ineligible to donate a kidney, potentially exacerbating organ shortages for Black people.
Researchers caution that clinicians and policy makers must anticipate both the benefits and downsides of changes to the current formula to ensure that Black patients are not disadvantaged, and
health disparities are not exacerbated.
Scientists say the analysis should motivate researchers and cl
• The diabetes drug canagliflozin slowed kidney function decline in patients with diabetes and advanced chronic kidney disease.
• The drug also reduced the risk of developing kidney failure and cardiovascular problems in these patients.
A new study shows that robotic-assisted kidney transplant and weight loss surgery can be performed safely.
What about the kidneys make them a hotspot for COVID-19’s cytokine storm? A research team says it’s the presence of a protein found on specialized renal transport cells.
Patients with diabetic kidney disease can potentially be treated with a new investigational medication that may slow the progress of their illness without harmful side effects to their hearts, according to the results of a global clinical trial announced Friday.
Announcement of the 2021 Harrington UK Rare Disease Scholar Award recipients, their organizations and fields of research:
Pietro Fratta, MD, PhD – University College London
Gene Therapy for Kennedy’s Disease, a rare neuromuscular disease
Angela Russell, DPhil – University of Oxford
New Drugs for the Treatment of Duchenne Muscular Dystrophy
Helen Waller-Evans, DPhil – Cardiff University
Novel Inhibitors to Treat Multiple Lysomal Storage Disorders, causes of widespread organ damage
Wyatt Yue, PhD – University of Oxford
Inhibitors of Primary Hyperoxaluria, a cause of kidney failure
Haiyan Zhou, MD, PhD – University College London
Novel Therapy for SPTLC1-Related Hereditary Sensory Neuropathy, a cause of shooting pain
Taking into account two common kidney disease tests may greatly enhance doctors’ abilities to estimate patients’ cardiovascular disease risks.
Dent disease is a rare kidney disorder characterized by excess protein in the urine (proteinuria) caused by mutation of the chloride/proton exchanger ClC-5. People with Dent disease often develop chronic kidney disease that progresses to end-stage kidney disease. A new…
Rutgers New Jersey Medical School will be a clinical test site for a study assessing the long term risk of chronic kidney disease in patients who recover from COVID-19.
If you have moderate-to-high risk of kidney failure as a young adult, you may be at risk for worse cognitive function in middle age, according to a study published in the September 2, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
• A recent analysis examines data from over the past 25 years concerning couples’ use of genetic testing for kidney diseases in embryos from in vitro fertilization.
• The analysis provides the first report on the types of genetic kidney diseases tested in this way, how often these tests result in live births of unaffected children, and what reasons couples cite for not undergoing testing.
Article title: Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension Authors: Iuliia Polina, Mark Domondon, Rebecca Fox, Anastasia V. Sudarikova, Miguel Troncoso, Valeriia Y. Vasileva, Yuliia Kashyrina, Monika Beck Gooz, Ryan S. Schibalski, Kristine Y.…
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.
• Exposure to higher amounts of fine particulate air pollution was associated with higher death rates among patients with kidney failure.
Article title: Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats Authors: Bibek Poudel, Corbin A. Shields, Andrea K. Brown, Ubong Ekperikpe, Tyler Johnson, Denise C. Cornelius, Jan M. Williams From the…
Scientists have discovered an important cell signalling pathway in the kidney which if stopped, could hold the key to treating chronic kidney disease as well as other deadly conditions, including heart attack and stroke.
The Academy of Nutrition and Dietetics supports U.S. Rep. Eliot Engel (N.Y.) and Rep. Pete King’s (N.Y.) commitment to America’s health by introducing the Medical Nutrition Therapy Act of 2020. The bill would provide coverage for Medicare beneficiaries to obtain treatment from registered dietitian nutritionists and other qualified nutrition experts for many common and costly chronic diseases.
Article title: Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease Authors: Shohei Mitsui, Yuji Oe, Akiyo Sekimoto, Emiko Sato, Yamato Hashizume, Shu Yamakage, Satoshi Kumakura, Hiroshi Sato, Sadayoshi Ito, Nobuyuki Takahashi From the authors: “These findings suggest that…
Article title: High-fructose corn syrup-sweetened soft drink consumption increases vascular resistance in the kidneys at rest and during sympathetic activation Authors: Christopher L. Chapman, Tigran Grigoryan, Nicole T. Vargas, Emma L. Reed, Paul J. Kueck, Leonard D. Pietrafesa, Adam C. Bloomfield,…
• When considering treatments, patients with glomerular disease and their caregivers gave highest priority to the health outcomes of kidney function, mortality, and need for dialysis or transplant.
• They also highly prioritized patient-reported outcomes such as life participation and fatigue that are not typically reported in clinical trials.
A new review suggests that higher-than-normal levels of an enzyme involved in blood clot prevention may be a common risk factor for developing COVID-19—a respiratory disease caused by the novel coronavirus SARS-CoV-2—in some populations. The review is published in Physiological Reviews.
Researchers from the Center for Precision Disease Modeling at the University of Maryland School of Medicine (UMSOM) have uncovered a mechanism that appears to explain how certain genetic mutations give rise to a rare genetic kidney disorder called nephrotic syndrome. Using a drosophila (fruit fly) model, they found mutations in genes that code for certain proteins lead to a disruption of the recycling of the cell membrane.
• In a study of urban-dwelling individuals, housing insecurity was linked with a higher risk of developing albuminuria, a sign of kidney disease.
• Two studies examine potential benefits of blood pressure monitoring outside of doctors’ offices for patients with kidney disease.
Article title: COVID-19 infection and mortality – A physiologist’s perspective enlightening clinical features and plausible interventional strategies Authors: Zaid A. Abassi, Karl Skorecki, Samuel Noam Heyman, Safa Kinaneh, Zaher Armaly From the authors: “Cleavage of the S-glycoprotein by furin and its…
• Study results call into question the utility of testing blood pressure load—the proportion of elevated blood pressure readings detected over 24 hours—for diagnosing hypertension in children.
WASHINGTON (Mar. 4, 2020) – Approximately 37 million American adults have chronic kidney disease and many others are at increased risk, according to the National Kidney Foundation. March is Kidney Health Month and the George Washington University (GW) School of…