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UrduThe University of Michigan Rogel Cancer Center has named Kyle Cuneo, M.D., its new associate director for clinical research. In addition, a new position of assistant director for clinical research will be filled by John Magenau, M.D.
Tag: Transplantation
Bascom Palmer Receives Multimillion Dollar Award to Support Functional Whole-Eye Transplant
Researchers with Bascom Palmer Eye Institute are tackling the formidable task of surgically recovering a live human eye and maintaining its function for vision restoration through organ transplantation.
Fred Hutch at ASH: Plenary session on socioeconomic barriers to transplant, new leukemia treatments and phasing out ‘cumbersome’ urine test
The of the American Society of Hematology (ASH) will take place in San Diego, Calif. and online Dec. 7-10. Improving access to life-saving therapies for blood disorders is the theme of many presentations by Fred Hutch Cancer Center experts, including: Meta-analyses show socioeconomic factors limit access to transplants and clinical trials, highlighting strategies to overcome barriers.
Lurie Children’s Transplant Expertise Shines in Record-Breaking Year
Lurie Children’s surpassed a hospital record in its recent fiscal year by performing a record 140 pediatric transplants, including, heart, kidney, liver and stem cell.
Stem cell transplantation in cerebrovascular accidents: A global bibliometric analysis (2000-2023)
BACKGROUNDCerebrovascular accident (CVA) is a major global contributor to death and disability. As part of its medical management, researchers have recognized the importance of promising neuroprotective strategies, where stem cell transplan
Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury: First results of a phase I study
BACKGROUNDTraumatic brain injury (TBI) is characterized by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. Stem cell tra
New study reveals how gender affects liver transplant success in cancer patients
A groundbreaking multicenter cohort study in China has illuminated the impact of sex on the outcomes of liver transplantation (LT) for hepatocellular carcinoma (HCC), the most common type of liver cancer.
Transplanting Muscle Mitochondria among Species May Create Opportunity for New Treatments
Article title: Muscle mitochondrial transplantation can rescue and maintain cellular homeostasis Authors: Debasmita Bhattacharya, Mikhaela B. Slavin, David A. Hood From the authors: “Our study illustrates the feasibility of using mouse skeletal muscle-derived mitochondria for transplantation in intraspecies- and interspecies-specific…
Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque
BACKGROUNDUmbilical cord (UC) mesenchymal stem cell (MSC) transplantation is a potential therapeutic intervention for atherosclerotic vascular disease. Integrin beta 3 (ITGB3) promotes cell migration in several cell types. However, whether
Partial Liver Transplants for Kids Key to Preventing Waitlist Deaths and Improving Outcomes
Dozens of children die each year in the U.S. while waiting for a new liver. A new analysis suggests that greater use of partial liver transplants — either from a living donor or by splitting a deceased donor’s liver for two recipients — could save many of these young lives.
Tipsheet: Donate Life Month 2023
Experts from the Cedars-Sinai Comprehensive Transplant Center and Smidt Heart Institute are available for interviews about transplantation, immunology and organ donation in April, Donate Life Month, and throughout the year.
Laser speckle imaging can identify hearts suitable for transplantation
In the majority of cases, graft failure after heart transplantation is attributable to abnormalities like severe coronary artery disease.
Modulating a Specific Protein Could Lead to New Liver Disease Treatments
In research published in The FASEB Journal, scientists have discovered that a molecule called Yes-associated protein (YAP) plays a key role in the development of liver scarring, or fibrosis, by influencing the behavior of premature cells called liver progenitor cells.
UC San Diego Health Named Center of Excellence for Polycystic Kidney Disease
UC San Diego Health has been named a Center of Excellence for polycystic kidney disease (PKD) by the PKD Foundation – the leading advocacy group dedicated to finding treatments and a cure for PKD. UC San Diego Health is one of just 28 institutions nationwide to receive this designation.
Livers have the potential to function for more than 100 years
There is a small, but growing, subset of livers that have been transplanted and have a cumulative age of more than 100 years.
AMERICAN SOCIETY OF NEPHROLOGY AND 21 KIDNEY COMMUNITY ORGANIZATIONS CALL ON CONGRESS TO PROTECT LIVING DONORS
Today, advocates of the American Society of Nephrology (ASN) and 21 other kidney health professional and patient organizations are meeting with their congressional delegations, calling on them to protect living donors and improve access to transplantation
New Review Paper Proposes Framework for Advancing Application of Animal-to-Human Transplantation
“The potential for xenotransplantation to allow for an unlimited donor supply and resolve the organ shortage is now closer than ever,” according to a new paper published today in JACC: Basic to Translational Science.
Lung Ventilation after Death May Keep Organs Healthy for Transplantation for Hours
Article title: Rapid postmortem ventilation improves donor lung viability by extending the tolerable warm ischemic time after cardiac death in mice Authors: Junyi Yu, Che Xu, Janet S. Lee, Jonathan K. Alder, Zongmei Wen, Guifang Wang, Agustin Alejandro Gil Silva,…
Cancer shortens lifespan in transplant recipients
People who have received organ transplants face an elevated risk of developing cancer, primarily due to immunosuppression from medications to prevent organ rejection, as well as underlying medical conditions.
In transplant recipients, COVID-19 vaccines reduce infection and mortality risks
Vaccination against SARS-CoV-2 substantially lowers the risks of “breakthrough” infections and death due to COVID-19 in adult organ transplant recipients, according to a pair of research letters in Transplantation, the official Journal of The Transplantation Society and the International Liver Transplantation Society. The journal is published in the Lippincott portfolio by Wolters Kluwer.
“Missing Self” Contributes to Organ Rejection after Transplantation
• After kidney transplantation, natural killer cells of the recipient become active because they miss “self” proteins on donor cells.
• These cells contribute to organ rejection, in addition to traditional modes of rejection involving T cells and antibodies.
Perfecting collagen production in osteogenesis imperfecta
By studying the controversial idea that hematopoietic stem cells could give rise to osteoblasts, researchers at MUSC Health aim to address the root cause of brittle bone disease
Cardio-cerebrovascular disease history complicates hematopoietic cell transplant outcomes
Researchers find pre-transplant cardiovascular diseases indirectly affect mortality and survival through increased post-transplant disease occurrence
Llama ‘nanobodies’ could hold key to preventing deadly post-transplant infection
Scientists have developed a ‘nanobody’ – a small fragment of a llama antibody – that is capable of chasing out human cytomegalovirus (HCMV) as it hides away from the immune system. This then enables immune cells to seek out and…
Policy changes to kidney allocation may unintentionally reduce access to transplant for South Carolina
Researchers at MUSC Health look at the outcome of the Organ Procurement and Transportation Network’s latest allocation changes and argue for further improvement
Artificial sweeteners enable delivery of carbon monoxide to treat organ injury
ATLANTA–An oral prodrug developed by a team of scientists led by Binghe Wang, Regents’ Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science .…
New guidance on how to diagnosis and manage osteoporosis in chronic kidney disease
Patients with advanced chronic kidney disease (CKD) typically suffer from impaired bone quality and quantity, with a non-vertebral fracture risk which is 4-to 6-fold higher than the fracture risk of matched controls. However, despite their high risk of fragility fractures,…
Direct flights save lives! New airline routes can increase kidney sharing by more than 7%
INFORMS Journal Management Science Study Key Takeaways: Lack of direct airline routes limit the flexibility of organ transplantation policies. A new airline route can increase the number of kidneys shared between different regions by more than 7% while also decreasing…
The ethics of split liver transplantation: Analyzing case studies to make the right decision
Split liver transplantation (SLT) provides an opportunity to divide a donor liver and offer transplants to two small patients, one or both of whom could be a child. SLT, which is underused in the United States, could be used more…
First Patients in San Diego County to Receive Lungs with Heart-Stopping Approach
The lung transplant team at UC San Diego Health performed San Diego County’s first transplant surgery with lungs donated after cardiac death, an approach that could mean more opportunities to save the lives of those in critical need of new lungs.
NYU Abu Dhabi researchers unlock secrets behind liver regrowth and regenerative medicine
New insight into the liver’s unique ability to regenerate holds promise for developing treatments for the lung, heart, and other organs that currently must be replaced by transplants
Fecal transplant plus fibre improves insulin sensitivity in severely obese
Research provides further evidence the microbiome can benefit patients’ health, says researcher Karen Madsen.
New clinical indicators discovered in transplant patients with COVID-19
Elisa Cordero, a doctor at the Virgen del Rocío University Hospital, researcher at the Institute of Biomedicine of Seville (IBiS) and professor in the Department of Medicine at the University of Seville, led a study involving researchers from 12 Spanish…
New analysis examines survival of older patients who undergo heart transplantation
Advanced age is often considered a contraindication for heart transplantation, but a new study published in the Journal of the American Geriatrics Society (JAGS) found that post-heart transplant survival among recipients aged ?70 years is not inferior to that of…
Heart transplants: Age is no barrier to successful surgery
Journal of the American Geriatrics Society research summary
UCI-led team develops transplant biomaterial that doesn’t trigger immune response
Irvine, Calif., June 3, 2021 — A multidisciplinary research team led by Jonathan Lakey, Ph.D., professor of surgery and biomedical engineering at the University of California, Irvine, has developed a biomaterial for pancreatic islet transplants that doesn’t trigger the body’s immune response. Based on stem cell technology, hybrid alginate offers a possible long-term treatment for Type 1 diabetes, an autoimmune reaction that destroys pancreatic islets’ beta cells, which regulate blood glucose levels.
Healing hydrogels
Biocompatible hydrogel materials can rapidly recover from mechanical stress
Antibiotics no help for mysterious lung-scarring disease, large trial finds
Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients…
NTU Singapore scientists turn aquaculture waste into new biomaterial for tissue repair
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a new biomaterial made entirely from discarded bullfrog skin and fish scales that could help in bone repair. The porous biomaterial, which contains the same compounds that are predominant in…
58th ERA-EDTA Congress: Pre-Press Conference on ‘Late Breaking Clinical Trials’
Results of the ‘Late Breaking Clinical Trial”
Innovative imaging technique for bone marrow transplants investigated
OKLAHOMA CITY — With the lifesaving potential of a bone marrow transplant comes an anxious few weeks of waiting to see if the patient begins producing new cells. A hematology oncologist at OU Health Stephenson Cancer Center is the co-leader…
CWRU-led research to determine which diabetic people can donate corneas for transplant
With five-year, $6.4M grant from National Eye Institute of NIH
Lehigh Engineering PhD students earn prestigious STEM research fellowships from NSF, DoD
Rossin College PhD students Mari-Therese Burton (materials science and engineering) and Nicole Malofsky (bioengineering) have been selected for prestigious national STEM research fellowships. Malofsky, who is advised by Lesley Chow , an assistant professor of bioengineering and materials science and…
Better donor evaluation, drug therapy in sight for kidney transplants
AUGUSTA, Ga. (May 18, 2021) – Looking to improve organ transplant success, researchers are working to learn more about how an immune molecule, which also protects a fetus, helps protect some transplanted kidneys, and to develop a synthetic version of…
How to manage osteoporosis in hematologic stem cell transplant recipients
IOF Cancer & Bone Disease Working Group summary and algorithm outlines main recommendations to maintain bone health in HSCT patients: includes guidance for bone assessment, management and treatment as well as dietary and lifestyle recommendations.
Cleveland Clinic, Lifebanc and Transplant Connect develop automated donor referral process
New system streamlines organ donation process, helping to save, heal more lives through donation, transplantation
Toward a feasible alternative to liver organ transplant
New findings could lead to ways to keep transplanted adult liver cells functioning long term
Researchers work to increase number of transplantable livers
New findings lay groundwork for turning previously unusable donor livers into transplantable organs
Can cirrhosis of the liver be treated with faeces transplantation?
Researchers from Aarhus University and Aarhus University Hospital replace sick intestinal bacteria with intestinal bacteria from healthy donors in a treatment intended to help patients with cirrhosis of the liver. The Novo Nordisk Foundation supports the
Mount Sinai Surgeons Perform First Human Tracheal Transplant Surgery
Historic case launches Mount Sinai’s Tracheal Transplant Program for treating patients worldwide, including those with severe intubation damage after COVID-19