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UrduPatients with obesity or type 2 diabetes are at a higher risk of developing NAFLD and NASH.
Tag: METABOLISM/METABOLIC DISEASES
Higher levels of omega-3 acids in the blood increases life expectancy by almost five years
A 1% increase in this substance in the blood is associated with a change in mortality risk similar to that of quitting smoking.
3D imaging reveals neural ‘vicious cycle’ in fatty liver disease
With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is…
Study points to remotely supervised exercise classes as best option during lockdown
Based on data for 344 volunteers, Brazilian researchers compared the physical and mental health benefits of workouts led in person by a fitness instructor, unsupervised online sessions, and classes supervised remotely via video call
Study innovates in gluten-free formulations, creating more palatable and nutritious bread
Study at the Federal University of São Paulo developed a recipe combining chickpea flour and psyllium, a plant-derived soluble fiber. The product is nourishing and rated highly by consumers in qualitative surveys.
Copper transporter potential new treatment target for cardiovascular disease
An internal transporter that enables us to use the copper we consume in foods like shellfish and nuts to enable a host of vital body functions also has the essential role of protecting the receptor that enables us to grow…
Research shows employer-based weight management program with access to anti-obesity medications results in greater weight loss
Clinical trial was conducted in the real-world setting of a workplace health plan
New guidance on how to diagnosis and manage osteoporosis in chronic kidney disease
Patients with advanced chronic kidney disease (CKD) typically suffer from impaired bone quality and quantity, with a non-vertebral fracture risk which is 4-to 6-fold higher than the fracture risk of matched controls. However, despite their high risk of fragility fractures,…
Children’s National Hospital joins the Mendelian Genomics Research Consortium, receiving $12.8 million
The National Institutes of Health’s National Human Genome Research Institute award will help discover inherited rare diseases and conditions in children
Scientists identify new gut-liver drug recycling process
Implications for developing treatments for intestinal diseases
Researchers use prenatal editing in preclinical model to correct lysosomal storage disease
In proof-of-concept study, CHOP researchers used an AAV9 vector to edit a single base mutation, halting progression of a disease that causes irreversible damage before birth
Keeping the world up to date on irritable bowel syndrome research in China
Scientists condense Chinese studies over the past decade on this common gastrointestinal disorder in a review article
CNIO researchers discover a new pathway to tackle follicular lymphoma
Alejo Efeyan’s team at the CNIO has shown in animal models that blocking signals controlled by the RagC protein delays the onset of follicular lymphoma without side effects. This strategy may also be effective in the treatment of autoimmune diseases
Using mice to open the way to prevent blocked arteries
Researchers from Tokyo Medical and Dental University (TMDU) identify pathways that link a high-fat diet to atherosclerosis in mice Tokyo, Japan – It’s long been known that a high-fat diet can lead to clogged arteries, but we have only recently…
Newborn screening for epilepsy in sight through the discovery of novel disease biomarkers
The door has finally opened on screening newborn babies for pyridoxine-dependent epilepsy (PDE), a severe inherited metabolic disorder. This screening promises to enable better and earlier treatment of the disease. To identify new biomarkers that can be used in the…
Prize winner uncovers the link between the microbiome, metabolites and neurodegeneration
Eran Blacher is the 2021 winner of the NOSTER & Science Microbiome Prize for his work in exploring the relationship between the microbiome and neurodegenerative diseases such as Alzheimer’s disease (AD) and Amyotrophic Lateral Sclerosis (ALS). The findings reveal new…
Early blood-sugar levels in type 2 diabetes crucial for future prognosis
People who get type 2 diabetes need to gain control of their blood-sugar levels — fast. The years immediately after diagnosis are strikingly critical in terms of their future risk for heart attacks and death. This is shown by a…
Rare genetic variants confer largest increase in type 2 diabetes risk seen to date
Scientists at the University of Cambridge have identified rare genetic variants – carried by one in 3,000 people – that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect. Type 2…
Research paves the way to early diagnosis of diabetic neuropathy
Diabetics exert less force to hold an object than people with other diseases that affect the nervous system. Grip force is a key behavioral biomarker to detect incipient diabetic neuropathy
Lab analysis finds near-meat and meat not nutritionally equivalent
Neither is good or bad, they are just not the same, authors say
Adult ADHD is linked to numerous physical conditions
Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet in Sweden published in The Lancet Psychiatry . “Identifying…
Evidence based recommendations to support physical exercise for adults with obesity
Synthesis of the evidence and recommendations from the European Association for the Study of Obesity Physical Activity Working Group
No pressure: Maintaining normal BP over long term is the key to heart health, study finds
Not one’s current high blood pressure, but the cumulative effect of having had hypertension for years is what significantly increases the risk of cardiovascular disease
Seeking a treatment for IBS pain in tarantula venom
For patients who have inflammatory bowel syndrome (IBS), the condition is literally a pain in the gut. Chronic — or long-term — abdominal pain is common, and there are currently no effective treatment options for this debilitating symptom. In a…
Nature article: Dieting and its effect on the gut microbiome
Bacterium associated with antibiotic-induced colitis plays a role in weight control
Rap1 controls the body’s sugar levels from the brain
Managing type 2 diabetes typically involves losing weight, exercise and medication, but new research by Dr. Makoto Fukuda and colleagues at Baylor College of Medicine and other institutions suggests that there may be other ways to control the condition through…
Running in the blood: Blood lipids are linked to cancer, but depending on family history
Medical researchers identify the role of family history in the link between blood lipids and esophageal cancer
State of the art and future directions in the clinical application of HR-pQCT in adults
A new international guidance on the clinical application of high-resolution peripheral computed tomography (HR-pQCT) offers an important overview of current clinical applications in adults and direction on the interpretation of results
Beyond mere blueprints: Variable gene expression patterns and type 1 diabetes
A recently published review explores the role of epigenetic factors in the development and progression of type 1 diabetes
CNIO researchers find molecular switch that allows organisms to adapt to fasting conditions
The mechanism involved is an ancient molecular pathway we share with yeasts; despite its relevance, very little was known about its role in metabolism
Intermittent fasting ‘no magic bullet for weight loss’ says new study
New research published this week challenges a popular belief that intermittent fasting diets such as alternate day fasting or the ‘5:2’ are the most effective ways to lose weight. Over recent years, diets which see people fast on a few…
Obesity and hypertension: Researchers discover novel mechanisms
Hypertension is a widespread comorbidity of patients with obesity that greatly increases the risk of mortality and disability. In recent years, researchers have found that a high-calorie diet increases the density of blood vessels (hypervascularization) in the hypothalamus – an…
Compounds derived from hops show promise as treatment for common liver disease
CORVALLIS, Ore. – Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis. The findings, published today in eLife , are important…
Air pollution exposure during pregnancy may boost babies’ obesity risk
Women exposed to higher levels of air pollution during pregnancy have babies who grow unusually fast in the first months after birth, putting on excess fat that puts them at risk of obesity and related diseases later in life, new…
Plant-based diet protects from hypertension, preeclampsia
A plant-based diet appears to afford significant protection to rats bred to become hypertensive on a high-salt diet, scientists report. When the rats become pregnant, the whole grain diet also protects the mothers and their offspring from deadly preeclampsia. Although…
High genetic running capacity promotes efficient metabolism with aging
Adipose tissue may have a key role in healthy aging
Drug researcher receives $2.2 million NIH grant to further develop ‘fat burning’ molecule
The liver is the most resilient organ in the human body. It can remove toxins from the bloodstream, recycle red blood cells, maintain sugar levels, and it can even regenerate itself. But, when a large amount of fat builds up…
Molecular changes in white blood cells can help diagnose ‘the bends’ earlier in divers
First study to show gene expression changes in divers with ‘the bends’ reveals key role of genes for inflammation and immunity
‘Bad fat’ suppresses killer T cells from attacking cancer
Salk researchers identify how tumors cause immune cells to lose their ability to fight cancer, opening new avenues for therapies
Case study shows patient on ketogenic diet living fully with IDH1-mutant glioblastoma
British man’s brain tumor grows slowly more than 80 months after diagnosis
Calcified Tissue International announces top-cited papers
The authors of the journal’s 10 most oft-cited 2019 papers in 2019-20 have been awarded a certificate of publishing excellence; Get free online access to these notable papers until August 31
University of Minnesota Medical School identifies placental protein as possible birthweight regulator
For the first time, a reduction in a protein called mTOR has been linked as the possible cause of low birthweight, putting infants at higher risk for obesity and Type 2 diabetes in adulthood
Health benefits of low protein-high carbohydrate diets depend on carb type
New research tackles the questions around carbs
Brain alterations detected in obese children
The alterations link obesity to a brain condition similar to obsessive-compulsive disorder, which affects the same areas of the brain
Major study of diabetes trends shows Americans’ blood sugar control is getting worse
Percentage of adults with diabetes achieving glycemic control declined between 2007-2010 and 2015-2018
A new bacteria, made in Belgium (and UCLouvain)
It all started, when Patrice Cani, FNRS researcher at University of Louvain (UCLouvain), and his team repeatedly observed that a bacterium (called Subdoligranulum) is almost absent in obese and diabetic people, while it is systematically present in healthy people. So,…
Cholesterol metabolite induces production of cancer-promoting vesicles
CHAMPAIGN, Ill. — Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are…
Rice fish model of a rare metabolic disorder
Human cells are kept healthy by the activity of millions of proteins. These proteins are modified in different ways, such as by adding sugar molecules to them, which can be crucial for them to function properly. Given this importance, defects…
People who have trouble sleeping are at a higher risk of dying – especially diabetics
In a paper published by the Journal of Sleep Research , researchers reveal how they examined data* from half a million middle-aged UK participants asked if they had trouble falling asleep at night or woke up in the middle of…
Controlling insulin production with a smartwatch
Many modern fitness trackers and smartwatches feature integrated LEDs. The green light emitted, whether continuous or pulsed, penetrates the skin and can be used to measure the wearer’s heart rate during physical activity or while at rest. These watches have…