Brain Cell Membranes’ Lipids May Play Big Role in Alzheimer’s Progression

Links between lipid imbalance and disease have been established, in which lipid changes increase the formation of amyloid plaques, a hallmark of Alzheimer’s disease. This imbalance inspired researchers to explore the role of lipids comprising the cellular membranes of brain cells. In Biointerphases, the researchers report on the significant role lipids may play in regulating C99, a protein within the amyloid pathway, and disease progression.

Study Compares Heart Benefits of Low-Fat and Plant-Centered Diets

There has been a long-standing debate as to whether a low-fat or a plant-centered diet is better at lowering the risk of cardiovascular disease. A new study that followed more than 4,700 people over 30 years, found that a plant-centered diet was associated with a lower long-term risk for cardiovascular disease. However, both diets were linked with lower LDL, or bad cholesterol, levels.

Most Americans Are Not Getting Enough Fiber in Our Diets

Only 5% of men and 9% of women are getting the recommended daily amount of dietary fiber, according to a study being presented at NUTRITION 2021 LIVE ONLINE. Insufficient fiber intake is associated with a higher risk of heart disease and diabetes, two of the most common diseases in the U.S.

Vast under-treatment of diabetes seen in global study

Nearly half a billion people have diabetes, but only 1 in 10 of those in low- and middle-income countries are getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data. Many don’t even know they have the condition.

Cholesterol levels sustainably lowered using base editing

Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team led by the University of Zurich has…

Study Shows Significant Reduction in Triglycerides in Patients at High Risk for Acute Pancreatitis Through Novel Monoclonal Antibody

The investigational drug evinacumab reduced triglycerides in patients with severe hypertriglyceridemia (sHTG) and a history of hospitalizations for acute pancreatitis in a phase 2 global study led by Mount Sinai

Closer to human — Mouse model more accurately reproduces fatty liver disease

Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. “NAFLD has been difficult to study mainly because we had no good animal model,”…

Metabolic derangements caused by a high-fat diet may be possible to eliminate

Intake of a high-fat diet leads to an increased risk for obesity, type 2 diabetes, cardiovascular diseases and fatty liver. A study in mice from Karolinska Institutet in Sweden shows that it is possible to eliminate the deleterious effects of…

New study finds shared origins for individual chronic diseases in multimorbidity

A new study published today in Nature Medicine has identified key risk factors that increase the likelihood of individuals developing not only one but multiple non-communicable diseases, which include cardiovascular disease, cancer, chronic respiratory disease and diabetes. The analysis of…

Association of maternal cardiovascular health during pregnancy with later health of offspring in adolescence

What The Study Did: The observational study examined associations between maternal cardiovascular health during pregnancy (as measured by body mass index, blood pressure, total cholesterol level, glucose level and smoking) with the later cardiovascular health of their offspring at ages 10…

Patient education program with mental health component reduces cardiovascular disease risks

CHAMPAIGN, Ill. — People who participated in a health education program that included both mental health and physical health information significantly reduced their risks of cardiovascular disease and other chronic diseases by the end of the 12-month intervention – and…

Vegan diet better for weight loss and cholesterol control than Mediterranean diet

A vegan diet is more effective for weight loss than a Mediterranean diet, according to a groundbreaking new study that compared the diets head to head. The randomized crossover trial, which was published in the Journal of the American College…

More years of obesity means higher risk of disease, study finds

A greater obesity duration is associated with worse values for all cardiometabolic disease factors, according to a new study published this week in PLOS Medicine by Tom Norris of Loughborough University, UK, and colleagues. People with obesity do not all…

A Novel Monoclonal Antibody Therapy Cuts LDL Cholesterol by Half in a High-Risk Patient Population, Study Shows

The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol—the so-called “bad” cholesterol—by 50 percent in patients with severe hypercholesterolemia whose condition is resistant to standard treatments, a phase 2 study from the Icahn School of Medicine of Mount Sinai and other global academic sites has found.

Muscle pain and energy-rich blood: Cholesterol medicine affects the organs differently

600,000 Danes take medicine containing statins. Statins lower the cholesterol level and thus helps prevent cardiovascular disease and blood clots. But there is a different side to the coin. Treatment with statins may also have negative side effects, some of…

Cholesterol medications linked to lower cancer-related deaths in women

Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology . The analysis included 20,046,11,719 and…

Gruthan Bioscience receives funding to develop a novel class of cholesterol-lowering drugs

Gruthan Bioscience was recently awarded funding to develop a novel class of cholesterol-lowering drugs to treat a rare form of familial hypercholesterolemia; It could one day be used to treat high cholesterol more widely