Article title: Dysregulation of cholesterol homeostasis is an early signal of beta cell proteotoxicity characteristic of type 2 diabetes Authors: Tatyana Gurlo, Ruoshui Liu, Zhongying Wang, Jonathan Hoang, Sergey Ryazantsev, Marie Daval, Alexandra E. Butler, Xia Yang, Montgomery Blencowe, Peter…
Tag: Cholesterol
ADLM publishes new guidance on lipid testing to improve care for patients with cardiovascular disease
The Association for Diagnostics & Laboratory Medicine (ADLM, formerly AACC) has issued expert guidance on lipid tests, which measure blood levels of fats and cholesterol to help assess a patient’s risk of heart disease and stroke. By giving clinicians and laboratory medicine professionals much-needed clarity on how to best use these tests, the new guidelines will ensure that more patients with cardiovascular disease get the treatment they need.
MD Anderson Research Highlights for August 21, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
RNA Inhibitor Is Shown Safe and Effective in Reducing a Wide Range of Cholesterol and Triglyceride Levels in the Blood in Mount Sinai-Led Clinical Trial
A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood.
Want to cut U.S. heart risks? Get more people into primary care, study suggests
When someone has a heart attack or a stroke, specialized care can give them the best chance of surviving.
8 Key Facts About Statins and Cholesterol
Statins can help lower cholesterol and reduce the risk of heart attacks, stroke and other heart and vascular problems. But they aren’t right for all patients, and they can rarely cause side effects. Cardiologist Melissa Tracy answers patients’ most frequently asked questions about statins.
Long-term survivors of childhood cancer at higher risk of death following heart issues; threshold for treating risk factors should be lower
New research out of VCU Massey Comprehensive Cancer Center and VCU Health Pauley Heart Center indicates that survivors of childhood cancer are at a significantly higher risk of death following a major cardiovascular event — including heart failure, heart attack or stroke — than the general public.
Doctor says cholesterol is integral to our body’s cells.
Salman Gohar, MD, at Baylor Scott & White Health, says cholesterol is integral to our body’s cells. What You Need to Know: Cholesterol is a waxy substance that can build up in the blood vessels. How “bad” cholesterol differs from…
Common hair loss and prostate drug may also cut heart disease risk in men and mice
The drug finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new University of Illinois Urbana-Champaign study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.
Both High and Low HDL Cholesterol Tied to Increased Risk of Dementia
Having either high or low levels of high-density lipoprotein (HDL) cholesterol, or “good” cholesterol, is tied to a small increased risk of dementia in older adults, according to a study published in the October 4, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Cholesterol and Inflammation Demonstrate Alzheimer’s Link
A recent study shows that a protein called ABCA7 plays a functional role as a potential biological link between cholesterol and inflammation in Alzheimer’s disease. The new work was published online August 25 in the journal Cells.
MSU researchers discover link between cholesterol and diabetic retinopathy
Advancements that could lead to earlier diagnosis and treatment for diabetic retinopathy, a common complication that affects the eyes, have been identified by a multi-department research team from Michigan State and other universities.
Study reveals peculiar movements of cholesterol in cellular membranes
Cholesterol plays many critical roles in biology and medicine. Researchers have revealed for the first time how cholesterol behaves in cells at the atomistic level, information that could have broad implications for future studies of health and disease.
One pill doesn’t fit all: cholesterol study reveals effects on lung function and brain size
The first study in the world to compare cholesterol-lowering medications on a range of diseases has good and bad news for more than 200 million people.
Gut bacteria linked to fatty deposits in heart arteries
In a major Swedish study, researchers have discovered a link between the levels of certain bacteria living in the gut and coronary atherosclerotic plaques.
Fluctuating Levels of Cholesterol and Triglycerides Linked to Increased Risk of Dementia
Older people who have fluctuating levels of cholesterol and triglycerides may have a higher risk of Alzheimer’s disease and related dementias compared to people who have steady levels, according to new research published in the July 5, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. While the study found a link, it does not prove that fluctuating levels of cholesterol and triglycerides cause dementia.
Water fasts can help you lose weight, but you might gain it back quickly
Water fasts, where people consume nothing but water, may not be a long-term weight loss strategy
Cholesterol lures in coronavirus
New study shows that cholesterol aggregates can promote SARS-CoV-2 infection to help the virus invade cells
Statin alternative lowers risk of cardiac events as well as cholesterol levels
A medication called bempedoic acid reduced the risk of cardiac events as well as statins and may offer an alternative to the popular cholesterol-reducing medications, according to industry-supported research being presented Thursday at ENDO 2023, the Endocrine Society’s annual meeting, in Chicago, Ill.
Researchers discover way to reverse infertility by reducing HDL cholesterol
Houston Methodist scientists reversed infertility in sterile mice by reducing HDL cholesterol with a bacterial protein in a promising development that shows further evidence linking high cholesterol to female infertility. The researchers worked with a protein called serum opacity factor that lowered cholesterol levels by over 40% in three hours.
Rutgers Expert Available to Comment on Cholesterol Drug for Statin Intolerant Patients
Emily Aboujaoude, clinical assistant professor at Rutgers University’s Ernest Mario School of Pharmacy, can comment on the NEJM trial finding bempedoic acid (Nexletol) lowers cholesterol in patients who cannot tolerate statins. The following quotes from Aboujaoude are available to journalists…
The Medical Minute: Never had a lipid panel? Here’s why it’s important
Know your numbers? A Penn State Health cardiologist says a lipid panel can help you stave off a heart attack.
EMBARGOED: School garden-based interventions can improve blood sugar, reduce bad cholesterol in children
School garden-based interventions can improve metabolic parameters such as blood sugar and cholesterol in children, according to a new study from UTHealth Houston.
Mount Sinai Researchers First to Identify That Two Separate Eye Diseases May Contribute to Common Blinding Eye Condition
Two separate eye diseases may contribute to age-related macular degeneration (AMD), a leading cause of blindness in the United States, according to a new study from New York Eye and Ear Infirmary of Mount Sinai.
Trouble sleeping? You could be at risk of type 2 diabetes
As the Christmas season starts to ramp up, University of South Australia researchers are reminding people to prioritise a good night’s sleep as new research shows that a troubled sleep may be associated with risk factors for type 2 diabetes.
Elevated Cholesterol Found in GenX Exposure Study Participants
Elevated levels of per- and polyfluoroalkyl substances (PFAS) were associated with higher total cholesterol and non-HDL cholesterol in GenX Exposure Study participants’ blood. The effects were more pronounced in older people.
Blacks Found Twice as Likely to Have Atherosclerosis as Hispanics in Young Adult Populations in Underserved Communities
A unique Mount Sinai study focused on a multi-ethnic, underserved community in New York City shows that young Black adults are twice as likely to have atherosclerosis as similarly situated young Hispanic adults.
Haywire T cells attack protein in “bad” cholesterol
Detecting these T cells may lead to diagnostics to better detect heart disease—and disease severity.
Changes in cholesterol production lead to tragic octopus death spiral
Cholesterol metabolism is responsible for an unusual “death spiral” that some octopus mothers undergo after laying their eggs. The research, published May 12 in Current Biology, reveals that steroid hormones play critical roles in metabolism, behavior, life history and health across the animal kingdom.
Pecan-enriched diet shown to reduce cholesterol
Researchers show that pecans can improve a person’s cholesterol levels.
Researchers link neurodegenerative disease protein to defective cholesterol metabolism
Researchers in Singapore have discovered that brain cells cannot maintain the cholesterol-rich myelin sheath that protects and insulates neurons in the absence of a protein called TDP-43. The study, which will be published August 4 in the Journal of Cell Biology (JCB), suggests that restoring cholesterol levels could be a new therapeutic approach for diseases associated with TDP-43, such as amyotrophic lateral sclerosis and frontotemporal dementia.
Higher levels of omega-3 acids in the blood increases life expectancy by almost five years
A 1% increase in this substance in the blood is associated with a change in mortality risk similar to that of quitting smoking.
Research shows employer-based weight management program with access to anti-obesity medications results in greater weight loss
Clinical trial was conducted in the real-world setting of a workplace health plan
Using mice to open the way to prevent blocked arteries
Researchers from Tokyo Medical and Dental University (TMDU) identify pathways that link a high-fat diet to atherosclerosis in mice Tokyo, Japan – It’s long been known that a high-fat diet can lead to clogged arteries, but we have only recently…
Intermittent fasting ‘no magic bullet for weight loss’ says new study
New research published this week challenges a popular belief that intermittent fasting diets such as alternate day fasting or the ‘5:2’ are the most effective ways to lose weight. Over recent years, diets which see people fast on a few…
Brain Cell Membranes’ Lipids May Play Big Role in Alzheimer’s Progression
Links between lipid imbalance and disease have been established, in which lipid changes increase the formation of amyloid plaques, a hallmark of Alzheimer’s disease. This imbalance inspired researchers to explore the role of lipids comprising the cellular membranes of brain cells. In Biointerphases, the researchers report on the significant role lipids may play in regulating C99, a protein within the amyloid pathway, and disease progression.
Cholesterol metabolite induces production of cancer-promoting vesicles
CHAMPAIGN, Ill. — Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are…
Brain alterations detected in obese children
The alterations link obesity to a brain condition similar to obsessive-compulsive disorder, which affects the same areas of the brain
Most Americans Are Not Getting Enough Fiber in Our Diets
Only 5% of men and 9% of women are getting the recommended daily amount of dietary fiber, according to a study being presented at NUTRITION 2021 LIVE ONLINE. Insufficient fiber intake is associated with a higher risk of heart disease and diabetes, two of the most common diseases in the U.S.
New Research Examines the Science Behind Superfoods
Superfoods like turmeric and honey have long been recognized for their ability to promote health and wellness. New studies being presented at NUTRITION 2021 LIVE ONLINE take a closer look at the science behind the health benefits of superfoods.
Study Compares Heart Benefits of Low-Fat and Plant-Centered Diets
There has been a long-standing debate as to whether a low-fat or a plant-centered diet is better at lowering the risk of cardiovascular disease. A new study that followed more than 4,700 people over 30 years, found that a plant-centered diet was associated with a lower long-term risk for cardiovascular disease. However, both diets were linked with lower LDL, or bad cholesterol, levels.
Milk makeover: a great start for a healthy heart
A dash of milk could make all the difference to a healthy heart as new research from the University of South Australia finds that people who regularly consume milk have a lower risk of heart disease.
Featured research from NUTRITION 2021 LIVE ONLINE
Press materials for virtual event now available
COVID-19 increases rate of heart attacks in people at genetic risk for heart disease
New research from FH Foundation underscores importance of diagnosing and treating familial hypercholesterolemia
Changes in how cholesterol breaks down in the body may accelerate progression of dementia
Study suggests that some cholesterol medications may impact signaling pathways in the brain, particularly in men
Vast under-treatment of diabetes seen in global study
Nearly half a billion people have diabetes, but only 1 in 10 of those in low- and middle-income countries are getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data. Many don’t even know they have the condition.
Cholesterol levels sustainably lowered using base editing
Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team led by the University of Zurich has…
Study Shows Significant Reduction in Triglycerides in Patients at High Risk for Acute Pancreatitis Through Novel Monoclonal Antibody
The investigational drug evinacumab reduced triglycerides in patients with severe hypertriglyceridemia (sHTG) and a history of hospitalizations for acute pancreatitis in a phase 2 global study led by Mount Sinai
Omega-3 supplements help kids with high cholesterol improve lipid profile
Fatty acid supplementation could fend off later heart disease in high-risk children
Closer to human — Mouse model more accurately reproduces fatty liver disease
Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. “NAFLD has been difficult to study mainly because we had no good animal model,”…