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UrduIn a new Annals “Beyond the Guidelines” feature, two internal medicine physicians discuss treatment for a patient with obesity and prediabetes in the context of American Gastroenterological Association (AGA) evidence-based recommendations for the pharmacologic management of obesity in adults.
Tag: Obesity
Medical and Psychological Harms of Obesity Depend on Where You Live, Study Indicates
Researchers led by Jana Berkessel of the University of Mannheim in Germany collected archival data on more than 3.4 million people living in the United States and United Kingdom. They found evidence that obesity tends to spur lighter medical and psychological harms when those who struggle with the disorder feel less conspicuous.
$5M Grant Launches Six-State Research Initiative to Reduce Childhood Obesity
In the past four decades, the rate of childhood obesity has quadrupled, increasing kids’ risk of serious conditions. A new research center based at University of Utah Health aims to reduce childhood obesity throughout the Mountain West, focusing on rural and small-town communities.
Alarming Surge: Global Crisis of Childhood Overweight and Obesity
Since 1990, childhood obesity has nearly doubled globally, with the U.S. at the forefront. In Southern Europe, 10-15% of children are obese, while Asia has nearly half of all overweight kids under 5. Nearly 70% of the average U.S. child’s diet consists of ultra-processed foods, which are increasingly consumed by children under 24 months, raising obesity risks and reducing immunological protection. Addressing pediatric obesity requires a multifaceted approach from tackling the influence of social media and advertising on children’s food choices to increasing physical activity.
Obesity in mums doubles the risk of autism in babies
Children born to mothers with obesity both before and during pregnancy have an increased risk of neuropsychiatric and behavioural conditions, including autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD), according to new research from the University of South Australia.
Proteins prohibitins can become new targets for drugs from obesity
Scientists from Immanuel Kant Baltic Federal University analyzed scientific works dedicated to the role of proteins prohibitins in the development of obesity. It turned out that these proteins promote development of inflammation both in separate cells and the whole organism. This happens because prohibitins stimulate emission of anti-inflammatory substances by immune cells, and also participate in destruction of mitochondria damaged during oxidative stress. Obtained information points to the fact that prohibitins can become targets for medicine aimed at struggle with obesity consequences. Results of the research are published in the magazine Frontiers in Molecular Biosciences.
American Society of Nephrology Releases Kidney Health Guidance on the Management of Obesity in Persons with Kidney Diseases
To promote high-quality, person-directed care across the spectrum of kidney health and diseases the American Society of Nephrology (ASN) is releasing its inaugural Kidney Health Guidance (KHG) on the Management of Obesity in Persons Living with Kidney Diseases in the Journal of the American Society of Nephrology (JASN) on September 18, 2024.
Obesity Management and Kidney Health: Live Expert Panel
Reporters are invited to this live event on Obesity Management and Kidney Health. Experts from the American Society of Nephrology will take questions on the inaugural Kidney Health Guidance on managing obesity in kidney disease patients
Endurance Exercise without Weight Loss May Reduce Body Fat
Participating in a high volume of exercise over a short period of time, such as cycling hundreds of miles in a few days, could reduce body fat levels without weight loss. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism and has been chosen as an APSselect article for September.
Girls may start puberty early due to chemical exposure
Girls exposed to certain endocrine-disrupting chemicals (EDCs) may be more likely to start puberty early, according to new research published in Endocrinology, the flagship basic science journal of the Endocrine Society. EDCs mimic, block or interfere with hormones in the body’s endocrine system.
Pregnant women exposed to PFAS may be at risk for obesity, heart disease later in life
Women with higher levels of per- and polyfluoroalkyl substances (PFAS) during pregnancy may experience long-term weight gain and heart problems later in life, according to new research published in The Journal of Clinical Endocrinology & Metabolism.
Breaking the link between obesity and atrial fibrillation with a new cellular target
Blocking oxidative stress enzyme prevents, even reverses, heart condition in lab models
First Patient Dosed in Phase 2 Clinical Study of Palatin’s Bremelanotide Co-Administered with Tirzepatide (GLP-1) for the Treatment of Obesity
Palatin Technologies, Inc. (NYSE American: PTN), a biopharmaceutical company developing first-in-class medicines based on molecules that modulate the activity of the melanocortin receptor system, today announced that patient dosing has started for the clinical study entitled: BMT-801: A Phase II, Randomized, Double-Blind, Placebo-Controlled, Clinical Study Investigating the Safety, Tolerability, and Effectiveness of the Co-Administration of Bremelanotide with Tirzepatide (GLP-1/GIP) for the Treatment of Obesity (ClinicalTrials.gov Identifier: NCT06565611).
Combining Two Diabetes Drugs Helps Promote Weight Loss and Blood Sugar Control
New research finds a combination of drugs improves weight loss, glucose control and insulin resistance better than either drug alone. Using two diabetes medications together, such as a semaglutide like Ozempic or Rybelsus, with a second, newer class of drug, may offer a noninvasive solution to help people with Type 2 diabetes lose weight and manage their condition without the need for bariatric surgery.
Joslin Diabetes Center Investigator Rohit N. Kulkarni, MD, PhD, Awarded $10 Million NIH/NIDDK Grant for Pioneering Diabetes and Obesity Research
Rohit N. Kulkarni, MD, PhD, the Diabetes Research and Wellness Foundation Endowed Chair and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center, has been awarded $9,920,607 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH).
Brain Electrical Stimulation Suppresses Appetite. A New Frontier in Obesity Treatment?
The team led by Dr. Shin of KERI has proposed a novel approach which is to suppress appetite by stimulating cerebral cortex electrically through scalp.
The Medical Minute: The truth about diabetes
Type 1? Type 2? Do you have to take injections for the rest of your life? A Penn State Health expert discusses diabetes and how there are more options than ever to beat it.
Navigating a weight loss journey
One patient details her success story losing weight through this individualized approach
Study Uncovers Connections Between Obesity and Heart Failure
A new small study led by Johns Hopkins Medicine researchers and published July 25th in the journal Nature Cardiovascular Research has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF).
Uncontrolled Hypertension: The Old ‘Silent Killer’ is Alive and Well
High blood pressure affects about 45% of U.S. adults. In the 1970s, only about 50% of patients were aware of their hypertension. Today, 54% are aware of their high blood pressure, 40% are actively treated and 21% are actively controlled. As such, researchers alert health care providers that the old “silent killer” is alive and well.
Rutgers Names Nationally Recognized Clinician-Scientist in Obesity and Nonalcoholic Fatty Liver Disease as New Chair of Medicine
Jeanne M. Clark, a board-certified internal medicine physician with extensive research experience and a nationally renowned expert in the epidemiology and treatment of obesity, will join Rutgers Robert Wood Johnson Medical School as the Henry Rutgers Professor and chair of the Department of Medicine.
Semaglutide may show promise for smoking cessation
New use of semaglutide was associated with a lower risk for medical care related to tobacco use disorder (TUD) in smokers with type 2 diabetes compared with 7 other anti-diabetes medications.
New Cedars-Sinai Study Investigates Shifting Trends in GLP-1RA Prescription
Investigators at Cedars-Sinai and other institutions conducted a nationwide, population-based study to identify trends in the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs)—prescription medications sold under popular drug names like Ozempic and Wegovy—in the United States.
For clinicians, diagnostic criteria for obesity remains elusive
Obesity now affects 2 in 5 U.S. adults, making it one of the most important public health problems facing society. However, finding an accurate way to identify obesity in individuals remains challenging given the very diverse U.S. patient population.
Data shows surge in in new GLP-1RA prescriptions for obesity without type 2 diabetes
A nationwide study found a marked increase in new GLP-1RA prescriptions over the last decade, particularly since 2020. Semaglutide was the most prescribed GLP-1RA, by far, in 2023.
What fat cats on a diet may tell us about obesity in humans
Pet cats may be excellent animal models for the study of obesity origins and treatment in humans, a new study of feline gut microbes suggests – and both species would likely get healthier in the research process, scientists say.
GLP-1RAs not associated with increased risk for suicidal thoughts or behaviors
A target trial emulation study found no increased risk for suicidal thoughts or behaviors associated with the use of GLP-1RAs (glucagon-like peptide-1 receptor agonists) to treat type 2 diabetes (T2D).
New Study Finds 40-Percent of Cancer Cases and Almost Half of all Deaths in the U.S. Linked to Modifiable Risk Factors
A new study led by researchers at the American Cancer Society finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States could be attributed to modifiable risk factors, including cigarette smoking, excess body weight, alcohol consumption, physical inactivity, diet, and infections.
Monell Center Discovery Could Help Reduce Adverse Side Effects of Popular Next-generation Obesity Medications
By teasing apart the therapeutic benefits from the adverse effects of new-generation obesity medications, researchers from the Monell Chemical Senses Center found a population of neurons in the brain that controls food intake without causing nausea in an animal model.
Modification of Common Diabetes Drug Improved Blood Sugar Control in Mouse Model
Article title: Reduced incretin receptor trafficking upon activation enhances glycemic control and reverses obesity in diet-induced obese mice Authors: Rathin Bauri, Shilpak Bele, Jhansi Edelli, Neelesh C. Reddy, Sreenivasulu Kurukuti, Tom Devasia, Ahamed Ibrahim, Vishal Rai, Prasenjit Mitra From the authors: “Chronic…
Tip Sheet: Summer science education, new chief nursing officer, DEI program updates — and a new endpoint for multiple myeloma
Below are summaries of recent Fred Hutch Cancer Center research findings, patient stories and other news.
Could Dad’s Diet Influence His Offsprings’ Health?
A study performed in mice has uncovered a potential new tool to combat the escalating issue of childhood obesity. The research suggests that a simple dietary change, in the form of a fish oil supplement taken by fathers, might help address this pressing health concern.
Compound from Olives Shows Promise for Treating Obesity and Diabetes
Findings from a new mouse study suggest that elenolic acid, a natural compound found in olives, can lower blood sugar levels and promote weight loss. The research could pave the way to the development of safe and inexpensive natural products for managing obesity and type 2 diabetes in people.
Pilot Study Provides ‘Blueprint’ for Evaluating Diet’s Effect on Brain Health
Researchers from Johns Hopkins Medicine and the National Institutes of Health’s National Institute on Aging say their study of 40 older adults with obesity and insulin resistance who were randomly assigned to either an intermittent fasting diet or a standard healthy diet approved by the U.S. Department of Agriculture (USDA) offers important clues about the potential benefits of both eating plans on brain health.
From the Pakistan-India Border to Our Borderplex: A Doctor’s Journey Dr. Muhammad Moiz Tahir tackles El Paso’s health challenges with community-driven care
EL PASO, Texas — Some people claim borders are barriers. Others see them as frontiers worthy of exploration. Muhammad Moiz Tahir, M.D., is one of the newest assistant professors in the Foster School of Medicine’s Department of Internal Medicine. Dr.…
Cleveland Clinic Study Shows Weight Loss Surgery Cuts Risk of Heart Complications and Death in Patients with Obstructive Sleep Apnea and Obesity
A Cleveland Clinic study shows that bariatric surgery performed in patients with obesity and moderate to severe obstructive sleep apnea is associated with a significantly lower risk of death and major adverse cardiovascular events, compared with patients who did not have the surgery. This study was published in the Journal of the American College of Cardiology.
Ali Aminian, M.D., director of Cleveland Clinic’s Bariatric & Metabolic Institute and primary investigator of the MOSAIC study, said, “The research shows that weight loss achieved with bariatric surgery is significantly associated with a 42% lower risk of major adverse cardiovascular events and 37% lower risk of death in patients with obesity and moderate to severe obstructive sleep apnea.”
Weight loss: Go nuts or go home
New research from the University of South Australia shows that including nuts in calorie-controlled weight loss diets does not hinder weight loss, and instead may have the opposite effect.
American diets have a long way to go to achieve health equity
Poor diet continues to take a toll on American adults. In a study from the Food is Medicine Institute at the Friedman School of Nutrition Science and Policy at Tufts University published today in the Annals of Internal Medicine, researchers found that diet quality among U.S. adults improved modestly between 1999 and 2020. However, they also found that the number of Americans with poor diet quality remains stubbornly high. Most notably, disparities persist and, in some cases, are worsening.
Obesity-cancer connection discovery suggests strategies for improving immunotherapy
The study reported in the journal Nature provides a mechanistic explanation for the “obesity paradox” — that obesity can contribute to cancer progression but also improve response to immunotherapy.
Physicians debate best management strategy for patient with type 2 diabetes and CKD
In a new Annals ‘Beyond the Guidelines’ feature, an endocrinologist and a nephrologist discuss controversies regarding the care of patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) and how they would apply the consensus statement to the care of an individual patient with T2D who is unaware that he has CKD.
Icahn School of Medicine at Mount Sinai Awarded $21 Million NIH Grant to Advance Understanding of Aging-Related Hormone
Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $21 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH), to further advance understanding of an aging-related hormone known as follicle-stimulating hormone (FSH), including its potential role in obesity, osteoporosis, and Alzheimer’s disease.
NUTRITION 2024 showcases groundbreaking research on what we eat and why it matters
Be among the first to hear breaking news in food and nutrition science at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition held June 29–July 2 at McCormick Place in Chicago.
Comparative Study on Dual vs Single Cardioversion for Atrial Fibrillation in Obese Patients
A team of Ochsner Health cardiologists recently published an article in the Journal of the American Medical Association (JAMA) Cardiology comparing two treatment strategies for patients with atrial fibrillation and obesity.
Summer holidays aren’t all fun and games for children’s fitness
The summer holiday break is often considered a time of fun and relaxation for school children, but hand in hand with a respite from routine comes an increase in sedentary behaviour and screen time, and in turn, poorer health and academic outcomes.
Retrospective Study Based on Electronic Health Records Finds Popular Diabetes and Weight-Loss Drugs Associated with Reduction in Incidence and Recurrence of Alcohol-Use Disorder by at Least Half
A new study by researchers at the Case Western Reserve University School of Medicine reveals that the popular diabetes and weight-loss drugs Wegovy and Ozempic are linked to reduced incidence and recurrence of alcohol abuse or dependence.
Two medication classes reduced cardiovascular and liver events in people with type 2 diabetes
GLP-1 receptor agonists (GLP-1s) and SGLT-2 inhibitors lower the risk of major cardiovascular events like heart attacks and severe liver complications compared to other diabetes treatments, according to data being presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
High insulin levels contribute to worse outcomes for Black women with aggressive form of breast cancer
High insulin levels contribute to worse outcomes for Black women compared to white women who have an aggressive form of breast cancer called triple-negative breast cancer, according to a study presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
Almost 20% of breast cancer survivors may experience excess weight gain
Almost one out of five breast cancer survivors may experience weight gain of more than 10%, suggests a study presented Monday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. A number of factors are associated with excessive weight gain, the researchers found.
GLP-1 medications for type 2 diabetes and obesity may lower risk of acute pancreatitis
Medications for type 2 diabetes and obesity known as GLP-1 receptor agonists may lower the risk of acute pancreatitis recurrence in people with obesity and those with type 2 diabetes, according to a study presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
Risk for heart attack and stroke increases in people with obesity for a decade or more
People under age 50 have a greater risk for heart attack or stroke if they’ve lived with obesity for 10 years, according to industry-sponsored research being presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.