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UrduArticle title: The bottlenose dolphin (Tursiops truncatus): A novel model for studying healthy arterial aging Authors: Yara Bernaldo de Quirós, Sophia A. Mahoney, Nicholas S. VanDongen, Nathan T. Greenberg, Ravinandan Venkatasubramanian, Pedro Saavedra, Gregory Bossart, Vienna E. Brunt, Zachary S. Clayton, Antonio…
Tag: American Physiological Society
Cannabis Exposure during Pregnancy Had Sex-dependent Effects on Rats’ Breathing in Adult Offspring
Article title: Long-term effects on cardiorespiratory and behavioral responses in male and female rats prenatally exposed to cannabinoid Authors: Luis Gustavo A. Patrone, Alana T. Frias, Gabriel T. Fantinatti, Angelita M. Stabile, Wilfried Klein, Kênia C. Bicego, Luciane H. Gargaglioni From the…
Older Women Are at Greater Risk of Heat Stress Than Older Men
Article title: Sex differences in heat stress vulnerability among middle-aged and older adults (PSU HEAT project) Authors: Olivia K. Leach, Rachel M. Cottle, Kat G. Fisher, S. Tony Wolf, W. Larry Kenney From the authors: “Our data confirm that women…
Type 2 Diabetes Medication Improves Liver Health in Mice Fed High Fat Diet
Article title: SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis Authors: Ileana Mendez Espinoza, Elijah N. D. Choos, Carolyn M. Ecelbarger, Blythe D. Shepard From the authors: “Here, we…
77-year-old Marathon World-record Holder Showed Elevated VO2Max, Heart Remodeling after Lifetime of Endurance Exercise
Article title: Lifelong physiology of a former marathon world-record holder – the pros and cons of extreme cardiac remodeling Authors: Stephen J. Foulkes, Mark J. Haykowsky, Peter M. Kistler, Glenn McConell, Scott Trappe, Mark Hargreaves, David Costill, André La Gerche…
Disruptions to Cholesterol in Cells Is an Early Sign of Beta Cell Damage in Model of Type 2 Diabetes
Article title: Dysregulation of cholesterol homeostasis is an early signal of beta cell proteotoxicity characteristic of type 2 diabetes Authors: Tatyana Gurlo, Ruoshui Liu, Zhongying Wang, Jonathan Hoang, Sergey Ryazantsev, Marie Daval, Alexandra E. Butler, Xia Yang, Montgomery Blencowe, Peter…
Disruptions to Fatty Compounds Inside Muscle Cells Coincides with Model of Cancer-induced Muscle Wasting
Article title: Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia Authors: Thomas D. Cardaci, Brandon N. VanderVeen, Alexander R. Huss, Brooke M. Bullard, Kandy T. Velazquez, Norma Frizzell, James A. Carson, Robert L. Price, E.…
Model of Running Outcomes Could Inform Training for Different Groups
Article title: An empirical model for world record running speeds with distance, age, and sex: anaerobic and aerobic contributions to performance Authors: Tuhin K. Roy, Michael J. Joyner, Jonathon W. Senefeld, Chad C. Wiggins, Timothy W. Secomb From the authors: “This empirical…
Genome Study Identifies Predictors of Individual Responsiveness to Muscle-building Exercise
Article title: Genome-wide association study of exercise-induced skeletal muscle hypertrophy and the construction of predictive model Authors: Xiaolin Yang, Yanchun Li, Tao Mei, Jiayan Duan, Xu Yan, Lars McNaughton, Zihong He From the authors: “We identified genetic variants that underlie [resistance training]…
Eating Patterns and the Neural Respiratory Clock Coordinate Daily Rhythms of Breathing
Article title: Time-restricted feeding reveals a role for neural respiratory clocks in optimizing daily ventilatory-metabolic coupling in mice. Authors: Aaron A. Jones, Gabriella M. Marino, Deanna M. Arble From the authors: “We find that central circadian timing synergizes with metabolism to optimize…
Novel Molecule Shows Promise Combatting Treatment-resistant Leukemia in Cell Culture Study
Article title: ASP210: a potent oligonucleotide-based inhibitor effective against TKI-resistant CML cells Authors: Veronika Nemethova, Petra Babiakova, Boglarka Teglasova, Lucia Uhelska, Andrea Babelova, Michal Selc, Kristina Jakic, Ondrej Mitrovsky, Denisa Myslivcova, Marketa Zackova, Alexandra Poturnayova, Angelika Batorova, Lubos Drgona, Filip Razga From…
Researchers Identify How Kidneys Protect Themselves from Too Much Phosphate
Article title: Endogenous activation of peroxisome proliferator-activated receptor alpha in proximal tubule cells in counteracting phosphate toxicity Authors: Yusuke Katsuma, Isao Matsui, Ayumi Matsumoto, Hiroki Okushima, Atsuhiro Imai, Yusuke Sakaguchi, Takeshi Yamamoto, Masayuki Mizui, Shohei Uchinomiya, Hisakazu Kato, Akio Ojida,…
Lung Surfactant Changes Implicated in COVID-19 Acute Respiratory Failure in Mice
Article title: Activation of alveolar epithelial ER stress by β-coronavirus infection disrupt surfactant homeostasis in mice: implications for COVID-19 respiratory failure Authors: Aditi Murthy, Luis R. Rodriguez, Thalia Dimopoulos, Sarah Bui, Swati Iyer, Katrina Chavez, Yaniv Tomer, Valsamma Abraham, Charlotte…
Fentanyl May Increase or Decrease Oxygen Levels Depending on Dosage
Article title: Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: effects of dose and drug experience Authors: Shinbe Choi, Michael R. Noya, Eugene A. Kiyatkin From the authors: “We report that fentanyl’s effects are highly dose-dependent, drawing…
American Physiological Society Launches Women’s Health Research Initiative
The American Physiological Society announces the launch of the 2024–2025 Women’s Health Research Initiative. This groundbreaking initiative aims to advance women’s health research, addressing critical gaps in understanding conditions that uniquely or disproportionately affect women.
Modification of Common Diabetes Drug Improved Blood Sugar Control in Mouse Model
Article title: Reduced incretin receptor trafficking upon activation enhances glycemic control and reverses obesity in diet-induced obese mice Authors: Rathin Bauri, Shilpak Bele, Jhansi Edelli, Neelesh C. Reddy, Sreenivasulu Kurukuti, Tom Devasia, Ahamed Ibrahim, Vishal Rai, Prasenjit Mitra From the authors: “Chronic…
Researchers Find Link between Immune Cell Traits and Parkinson’s Disease
Article title: Genetic causal relationship between multiple immune cell phenotypes and Parkinson’s disease: a two-sample bidirectional Mendelian randomization study Authors: Hong Chen, Xie Wang, Ze Chang, Juan Zhang, Daojun Xie From the authors: “Our study identified a close link between immune cells and…
Oral Probiotic Delivers Colitis Treatment Directly to Gut in Multiple Animal Models
Article title: Oral administration of CXCL12-expressing Limosilactobacillus reuteri improves colitis by local immunomodulatory actions in preclinical models Authors: Emelie Öhnstedt, Cristian Doñas, Kristel Parv, Yanhong Pang, Hava Lofton Tomenius, Macarena Carrasco López, Venkata Ram Gannavarapu, Jacqueline Choi, Maria Ovezik, Peter Frank, Margareth…
Intake Reduction and Pre-surgery Body Weight Explain Efficacy of Weight Loss Surgery
A new study finds that pre-surgery weight plays a role in how much weight loss occurs after gastric bypass. The study is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology and has been chosen as an APSselect article for June.
White Blood Cell Changes Develop in Acute Kidney Injury, Regardless of Cause
Article title: Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species Authors: Michal Mrug, Elias Mrug, Frida Rosenblum, Jiandong Chen, Xiangqin Cui, Anupam Agarwal, Abolfazl Zarjou From the authors: “Our findings identify robust acute kidney injury (AKI)-induced…
Men with Chronic Kidney Disease Have Higher Resting Activity in ‘Fight-or-Flight’ System than Women
Article title: Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD) Authors: Matias G. Zanuzzi, Jinhee Jeong, Dana R. DaCosta, Jeanie Park From the authors: “We show for the first time that males with…
Exercise Testing Uncovers Cardiovascular Disease Risk Factor in Black Postmenopausal Women
Article title: Exercise testing unmasks exaggerated blood pressure independent of fibrinolytic response in Black but not White postmenopausal females Authors: João L. Marôco, Linda M Szymanski, Tracy Baynard, Bo Fernhall From the authors: “Our findings show that maximal exercise unmasks…
Timing of Both Fasting and Meals Affects Degree of DNA Damage to Small Intestine Caused by Chemotherapy
Article title: Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine Authors: Kali Deans-Fielder, Timothy Wu, Thanh Nguyen, Sarah To, Yang-Zhe Huang, Steven J. Bark, Jason C. Mills, Noah F. Shroyer From the authors: “Our results also showed…
New American Physiological Society Leaders Take Office
The American Physiological Society (APS) is pleased to announce its new member leaders for 2024–2025.
Study Bolsters Evidence that Effects of Puberty Blockers Are Reversible
Medications commonly known as puberty blockers were found to delay development of female reproductive organs but allow for restoration of reproductive functioning after the medications were withdrawn, according to a new study being presented this week at the American Physiology Summit.
Intermittent Fasting May Help Preserve Intestinal Health as We Age
A study in mice found that intermittent fasting brought benefits beyond weight loss, suggesting it could help the body better process glucose and reduce age-related declines in intestinal function. Researchers will present their work this week at the American Physiology Summit.
Prebiotics Could Help Space Travelers Stay Healthy
New research suggests that cultivating a healthy gut microbiome could help astronauts weather the stresses of altered gravity. Researchers will present their work this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society, in Long Beach, California
Resistant Starch Could Help Combat Leading Cause of End-stage Kidney Failure
Combining a low dose of blood pressure medication with a higher intake of dietary-resistant starch might help stave off diabetic kidney disease, according to results from a new animal study. Researchers will present their work this week at the American Physiology Summit.
Study Reveals How Obesity Could Accelerate Aging in the Brain
A new study conducted in mice traces how obesity and a high-fat diet may accelerate aging in the blood vessels that supply blood to the brain. The work is being presented this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society.
Acetaminophen May Be Less Heart-safe than Previously Thought
The common painkiller acetaminophen was found to alter proteins in the heart tissue when used regularly at moderate doses, according to a new study conducted in mice. Researchers will present their work this week at the American Physiology Summit in Long Beach, California.
Skin Wetting Helps Cool Older Adults in Very Hot, Dry Weather
Spraying the skin with water helps reduce core and skin temperature in older adults during extremely hot and dry weather.
Black Men Have Greater Microvascular Dysfunction than White Men after Prostate Cancer Diagnosis
Microvascular function is lower in Black men following a recent diagnosis of prostate cancer, compared to white men.
Short On Time? A 15-minute Workout May Help Boost Your Immune System
Exercising at moderate intensity for just 15 minutes may be all that is needed to boost immunity by increasing levels of natural killer (NK) cells. Researchers will present their work this week at the American Physiology Summit in Long Beach, California.
Heavy Alcohol Use May Increase Type 2 Diabetes Risk in Middle-aged Adults
Heavy alcohol use may increase middle-aged adults’ risk of developing Type 2 diabetes, according to research to be presented this week at the American Physiology Summit in Long Beach, California. The Summit is the flagship annual meeting of the American Physiological Society (APS).
American Physiological Society Announces 2024 Award Recipients
The American Physiological Society (APS) is pleased to announce the recipients of the Society’s most prestigious and highly competitive awards. Awardees will be recognized for their achievements at the American Physiology Summit, APS’ flagship annual meeting, to be held April 4–7, 2024, in Long Beach, California.
Older Adults Show Greater Increase in Body Temperature in Simulated Heatwave Than Previously Reported
Under conditions designed to better mirror real-world conditions, a new study finds that adults 65 and older are affected more by heatwave-like temperatures than previously reported. The study included intermittent bouts of light activity and was published in the Journal of Applied Physiology.
Mitochondrial Changes Linked to High Blood Pressure in Pregnancy
A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.
Women with Long COVID May Develop High Blood Pressure
New research identifies parts of the cardiovascular system that are disrupted by long COVID. The study is published in the American Journal of Physiology-Heart and Circulatory Physiology and was chosen as an APSselect article for June.
Climate Change Threatens Military Readiness
The growing frequency and intensity of heat waves around the globe pose “a substantial, persistent ‘non-combat threat’” to military training and operations, according to experts in environmental, thermoregulatory and cardiovascular physiology.
Blood Flow-restricted Resistance Exercise Could Help Counteract Age-related Muscle Loss
Low-load blood flow-restricted resistance exercise helped counter age-related muscle decay “with a modest exercise volume and in a very time-efficient manner.” The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for May.
Scientists Better Understand How People with Cantu Syndrome Develop Lymphedema
Ion channels in people with Cantu syndrome produce varying degrees of contractile dysfunction (when muscles and tendons function ineffectively) in the lymphatic system, according to a new research study in the journal Function.
New APS Leaders Take Office at Inaugural American Physiology Summit
The American Physiological Society (APS) is pleased to announce its new member leaders for 2023–24: President Willis K. “Rick” Samson, PhD, DSc, FAPS; President-elect Timothy Musch, PhD, FAPS, FACSM; and Councilors Michael Caplan, MD, PhD, FAPS; Karla Haack, PhD; and Gina Yosten, PhD. The new officers were elected by APS membership and took office April 23, 2023, at the American Physiology Summit, APS’ flagship annual meeting, in Long Beach, California.
Study of College Athletes Shows that Nutrition and Sleep May Go Hand in Hand
What you eat might influence when you go to sleep, according to a new study of elite female college athletes.
Diabetes Drug Could Aid Recovery from Bouts of Food Insecurity or Anorexia
New research results suggest that the widely used diabetes drug metformin may be beneficial for recovering from short periods of severe food insecurity or anorexia.
Opioid Exposure in the Womb Could Raise the Risk of Heart Disease Later in Life
A new study sheds light on an understudied aspect of today’s opioid crisis: What happens to the cardiovascular health of babies exposed to opioids in the womb.
American Physiological Society Announces 2023 Award Recipients
The American Physiological Society (APS) is pleased to announce the recipients of the Society’s most prestigious and highly competitive awards. Awardees will be recognized for their achievements at the American Physiology Summit, APS’ flagship annual meeting, to be held April 20–23, 2023, in Long Beach, California.
Brown Fat May Help Improve Cancer Survival Rates
Brown fat is not linked to cancer-associated loss of body weight and muscle mass, a common condition known as cachexia, according to a new joint study from The Rockefeller University and Memorial Sloan Kettering Cancer Center in New York City.
Personalized Exercise Program Improves Long COVID Symptoms
A supervised, eight-week exercise program improved symptoms of patients with long COVID better than the current standard self-managed rehabilitation recommendations. The study is published ahead of print in the Journal of Applied Physiology and was chosen as an APSselect article for February.
Migraine Drug Shows Promise in Treatment of Acute Kidney Injury
The drug lasmiditan, which is used to treat migraines, shows promise as a possible treatment for acute kidney injury, according to a new study from the University of Arizona.
Vitamin A May Protect Heart from Some Effects of Obesity
Research in a mouse model of diet-induced obesity found greater disruption to genes involved in heart function when coupled with vitamin A deficiency. The study is published in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for January.