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UrduProtein molecules lie at the heart of biology. Our typical understanding of proteins states that each type of protein has a specific three-dimensional shape that enables it to perform its function.
Tag: Bioinformatics
Capacity building and knowledge transfer in genomics and bioinformatics
The African BioGenome Project, a large-scale international research project involving Konstanz bioinformatician Abdoallah Sharaf, successfully launched its “Open Institute”. The institute’s mission: accelerating knowledge exchange in biodiversity genomics and bioinformatics.
Climate Change Threatens Military Readiness
The growing frequency and intensity of heat waves around the globe pose “a substantial, persistent ‘non-combat threat’” to military training and operations, according to experts in environmental, thermoregulatory and cardiovascular physiology.
AI and health care: DePaul and Rosalind Franklin award interdisciplinary research grants
DePaul University and Rosalind Franklin University of Science and Medicine are funding three faculty research projects that bring together artificial intelligence, biomedical discovery and health care. The competitive grants kickstart research among interdisciplinary teams, which include biologists, computer scientists, a geographer and a physicist.
Family tree secrets: Island tree populations older, more diverse than expected
It’s often assumed that island plant and animal populations are just the simple, fragile cousins of those on the mainland.
Adapting language models to track virus variants
Groundbreaking research by Argonne National Laboratory finds new method to quickly identify COVID-19 virus variants. Their work wins the Gordon Bell Special Prize.
UC San Diego Joins NIH ‘Bridge to Artificial Intelligence’ Program
UC San Diego scientists will lead several components of Bridge2AI, a new NIH-funded program to promote the use of AI in health and research.
Family ties: Inherited genetic variants increase risk of Hodgkin lymphoma
Large populations studies have previously demonstrated that Hodgkin lymphoma occurs in families, pointing to a likely genetic predisposition that makes these families more likely to develop this cancer.
New tool integrates microbiome and host genetic sequencing analysis
A new software tool makes it easier to study relationships between a host, its microbiome and pathogens like HIV or SARS-CoV-2.
CHOP-led Pediatric Hospital Network Receives Critical Government Support for Genetic Research of Pediatric Tumors
The Center for Data Driven Discovery at CHOP will procure molecular characterization for thousands of these brain tumor samples providing an unprecedented level of insight into devastating cancers and paving the way for future therapeutic interventions.
International collaboration of scientists rewrite the rulebook of flowering plant genetics
How do you study a group of organisms with over 300,000 species, dispersed across all seven continents, and with up to 50 times as much DNA content as the human genome? This is the question posed to biologists studying the…
Southeastern US herbaria digitize three million specimens, now freely available online
A network of over 100 herbaria spread out across the southeastern United States recently completed the herculean task of fully digitizing more than three million specimens collected by botanists and naturalists over a span of 200 years. The project, which…
DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins
Partners use AlphaFold, the AI system recognised last year as a solution to the protein structure prediction problem, to release more than 350,000 protein structure predictions including the entire human proteome to the scientific community
How does the structure of cytolysins influence their activity?
Although Enterococcus faecalis is usually an innocuous member of the bacterial community in the human gut, it can also cause several infections, including liver disorders. The bacteria produce cytolysins, which are molecules that destroy cells. In a new study, researchers…
The international ENABLE conferences get the green light for another four years
The ENABLE international conferences, which have been held annually since 2017, are scientific gatherings organised by and for young researchers that seek to ensure the next generation of scientific leaders. Initially funded by the European Commission’s Horizon2020 programme, the first…
How a butterfly tree becomes a web
Evolution is often portrayed as a tree, with new species branching off from existing lineages, never again to meet. The truth however is often much messier. In the case of adaptive radiation, in which species diversify rapidly to fill different…
The cells combating a deadly lung disease
A subset of fibroblasts located in small foci of tissue on the edges of extensive scarring produce a protein that protects against cell aging.
Sperm migration in the genital tract: computer simulations identify factors for success
During mating in wildlife species, males transfer millions of sperm into the female genital tract. On the way to the egg cell the sperm have to pass through the genital tract. Very few of the sperm cells actually succeed in…
Zero Childhood Cancer to continue mission of curing childhood cancer with $600k donation
Today we’d like to say a big thank you to the Lott for their generous donation to the Zero Childhood Cancer Program.
Seven degrees from one trillion species of microbes
Global Microbiome Transition Network hints at origins and evolution paths of microbiomes
Deep Longevity releases psychological aging clocks and announces Scientific Advisory Board
Deep Longevity, a fully-owned subsidiary of Endurance RP Limited (SEHK stock code: 0575), released the new MindAge psychological aging clock and announced the formation of a Scientific Advisory Board (SAB) comprised of experts in longevity biotechnology
TSUBAME supercomputer predicts cell-membrane permeability of cyclic peptides
Scientists at Tokyo Institute of Technology have developed a computational method based on large-scale molecular dynamics simulations to predict the cell-membrane permeability of cyclic peptides using a supercomputer. Their protocol has exhibited promising accuracy and may become a useful tool…
Standigm secures SI investment for expanding its AI-drug development capacity
SK Chemicals-Standigm will collaborate for the development of Standigm’s AI-driven drug candidate
First actionable clock that predicts immunological health and chronic diseases of aging
Research highlights the critical role of the immune system in the aging process
Computer-assisted biology: Decoding noisy data to predict cell growth
Tokyo, Japan – Scientists from The University of Tokyo Institute of Industrial Science have designed a machine learning algorithm to predict the size of an individual cell as it grows and divides. By using an artificial neural network that does…
More ancestral enzyme
Molecular evolution of enzyme beyond recruit hypothesis
Arab participation in global genomic study could lead to new therapies for COVID patients
Researchers from Qatar Foundation Research, Development, and Innovation’s Qatar Genome Programme contribute toward global initiative that can lead to therapeutic targets in addition to the protection conferred by the vaccines
Next generation cytogenetics is on its way
Does optical genome mapping turn cytogenetics upside down?
Development of the world’s first digital model of a cancer cell
With the first cancer cell model, researchers at TU Graz were able to launch an essential tool for modern cancer research and drug development
SARS-CoV-2 replication targets nasal ciliated cells early in COVID-19 infection
The establishment of nasal mucosal immunity against SARS-CoV-2 through a nasal vaccine could be the most efficient way to combat COVID-19 infection
Folate deficiency demystified — why some people may be at a greater risk of disease
As many expectant mothers know, getting enough folate is key to avoiding neural tube defects in the baby during pregnancy. But for the individuals who carry certain genetic variants, dealing with folate deficiency can be a life-long struggle which can…
‘Genomics of Rare Diseases. Understanding Disease Genetics Using Genomic Approaches’
In 2018, Dr. Claudia Gonzaga-Jáuregui, who years before had completed her doctorate studies in Dr. James R. Lupski’s lab at Baylor College of Medicine, received an email from an editor at Elsevier’s Academic Press with a proposal that immediately caught…
Foresight diagnostics to show vision of the new standard of lymphoma MRD detection at ICML
AURORA, COLORADO, June 16, 2021 — Foresight Diagnostics, the emerging leader in blood-based lymphoma disease monitoring, announced today that clinical performance of its minimal residual disease (MRD) detection platform in diffuse large B-cell lymphoma (DLBCL) will be presented at the…
Algorithm uses mass spectrometry data to predict identity of molecules
New method saves time, money in developing new drugs
UCLA receives $4.8M to improve genetic disease risk estimates in diverse populations
LOS ANGELES (June 16, 2021) – UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates – polygenic risk scores – for specific diseases in people from…
Untapped rice varieties could sustain crop supplies in face of climate change
Local rice varieties in Vietnam could be used to help breed improved crops with higher resilience to climate change, according to a new study published in Rice . Earlham Institute researchers are part of an international collaboration with genebanks and…
Reference genome comparison finds exome variant discrepancies in 206 genes
HOUSTON – (June 14, 2021) – In the two decades since the Human Genome Project mapped the entire human genome, improvements in technology have helped in developing updated reference genomes used for sequencing. But while the GRCh38 (hg38) human reference…
Persistence pays off in the human gut microbiome
The human gut microbiome is a complex community of trillions of microbes that are constantly interacting with each other and our bodies. It supports our wellbeing, immune system and mental health – but how is it sustained? Researchers in the…
AI Predicts How Patients with Viral Infections, Including COVID-19, Will Fare
UC San Diego School of Medicine researchers discovered gene expression patterns associated with pandemic viral infections, providing a map to help define patients’ immune responses, measure disease severity, predict outcomes and test therapies — for current and future pandemics.
Big data: IPK researchers double accuracy in predicting wheat yields
The enormous potential of Big Data has already been demonstrated in areas such as financial services and telecommunications. An international team of researchers led by the IPK Leibniz Institute has now tapped the potential of big data for the first…
A new mechanism behind continuous stem cell activity in plants
Family rivalry between transcription factors
CWRU researcher secures $1.2M to develop MS diagnostic tests
CLEVELAND–Case Western Reserve University researcher Farren Briggs was awarded $1.2 million over three years from the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health to identify biomarkers to improve the diagnoses of multiple sclerosis…
Combating maritime litter
Helmholtz-Zentrum Hereon categorizes innovative solutions for fighting pollution in the oceans
Microscopic imaging without a microscope?
New technique visualizes all gene expression from a tissue sample
Cincinnati children’s awarded grant to develop AI system for preventing school violence
CINCINNATI – Scientists at Cincinnati Children’s have been awarded a five-year grant totaling $2.8 million from the National Institute of Child Health and Human Development to develop an automated risk assessment (ARIA) system, which is designed to detect and prevent…
SARS-CoV-2 Detectable — Though Likely Not Transmissible — on Hospital Surfaces
UC San Diego School of Medicine researchers discovered that SARS-CoV-2, or at least its genetic signature, abounds on hospital surfaces, often co-locating with one particular type of bacteria.
Localized the gene for blue plum skin
Researchers from CRAG and IRTA find the gene that determines Japanese plum skin colour due to the presence or absence of anthocyanins, a group of plant antioxidant pigments with health-promoting effects
Scientists use public databases to leap over scourge of publication bias
Scientists have leapt over the emerging problem of publication bias within genetic research by performing a meta-analysis of publicly available databases of ‘transcriptomes’, or the full range of messenger RNA molecules produced by an organism. Researchers from Hiroshima University applied…
The Indiana Biosciences Research Institute deploys Insilico PandaOmics AI for target discovery
Insilico Medicine collaborates with the Indiana Biosciences Research Institute to apply novel artificial intelligence-powered approaches to multi-omics data analysis and discovery of potential therapeutic targets
SARS-CoV-2 detectable — though likely not transmissible — on hospital surfaces
The coronavirus that causes COVID-19 also tends to co-locate with one particular type of bacteria