In Science, researchers describe a “’macro’ microbe” – a giant filamentous bacterium composed of a single cell discovered in the mangroves of Guadeloupe. Using various microscopy techniques, the team also observed novel, membrane-bound compartments that contain DNA clusters dubbed “pepins.”
University of California San Diego computer scientist Vineet Bafna is part of a team of world-class researchers that has been awarded a five-year, $25 million Cancer Grand Challenges grant to learn how the destructive genetic lesion extrachromosomal DNA (ecDNA) influences numerous cancers and to identify possible therapies.
Rutgers researcher, Grace Brannigan, has co-authored a study published in The Proceedings of the National Academy of Sciences (PNAS) that centers around the connection between gene mutations in protein sequences and diseases.
Mount Sinai researchers have for the first time identified genes that predict a good response to a vital new therapy for a blood cancer that can have serious side effects for some patients.
The American College of Medical Genetics and Genomics (ACMG) has released its second, highly anticipated systematic evidence-based review (SER): “The Application of Noninvasive Prenatal Screening Using Cell-free DNA in General Risk Pregnancies.”
Too many women are getting unnecessary mastectomies and other invasive procedures because of a knowledge gap about differences in cancer genes. A new study offers a path to closing the gap.
A Rutgers researcher will use genomics, genetics, and cell biology to identify and understand the corals’ response to heat stress conditions and to pinpoint master regulatory genes involved in coral bleaching due to global warming and climate change. The researcher and his team will use a novel gene-editing tool as a resource to knock down some gene functions with the goal of boosting the corals’ abilities to survive.
Researchers at UC San Diego have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.
Alzheimer’s disease is marked by a loss of functional neurons in the brain.
Scientists at UC San Diego School of Medicine and Rady Children’s Institute of Genomic Medicine describe novel methods for inferring the movement of human brain cells during fetal development by studying healthy adult individuals who have recently passed away from natural causes.
UC San Diego School of Medicine researchers asked more than 132,000 23andMe research participants of European ancestry “Have you ever in your life used prescription painkillers, such as Vicodin and Oxycontin, not as prescribed?” More than 21 percent said yes.…
The Howard Hughes Medical Institute (HHMI) has selected Ian Maze, PhD, Associate Professor of Neuroscience, and Pharmacological Sciences, at the Icahn School of Medicine at Mount Sinai, as an HHMI Investigator.
A study recently published in Nature Communications suggests that displacing cold-water communities of algae with warm-adapted ones threatens to destabilize the delicate marine food web. The team was led by University of East Anglia researchers and included DOE Joint Genome Institute researchers.
A significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in their gut, according to new research from Mayo Clinic’s Center for Individualized Medicine.
The study, published in Genome Medicine, found that predicting a patient’s future rheumatoid arthritis prognosis could be possible by zeroing in on the trillions of bacteria, viruses and fungi that inhabit their gastrointestinal tract, known as the gut microbiome. The findings suggest that gut microbes and a patient’s outcome of rheumatoid arthritis are connected.
UC San Diego School of Medicine researchers will receive $6.4 million in National Institutes of Health grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas.
The transatlantic slave trade may have introduced new pathogenic viruses from Africa to North America that affected Indigenous communities, shows an analysis of ancient DNA published in eLife.
Researchers at the Icahn School of Medicine at Mount Sinai found that a tool commonly used in research for evaluating a person’s genetic risk for a disease, called a polygenic risk score, was no better at predicting the outcome of a schizophrenia patient’s disease over time than written reports. The results raise important questions about the use of polygenic risk scores in real-world, clinical situations, and also suggest that a doctor’s written report may be an untapped source of predictive information.
A new platform housing data from over 100 apple varieties could shave years off of the breeding process and enable data-driven assessments of how to boost the health benefits of America’s favorite fruit.
Researchers identified 579 locations in the human genome associated with a predisposition to self-regulation-related behaviors, such as addiction. With data from 1.5 million people of European descent, the effort is one of the largest genome-wide association studies to date.
Raquel Assis, Ph.D., associate professor, College of Engineering and Computer Science, and a fellow of FAU’s Institute for Human Health and Disease Intervention, has received a five-year, $1.8 million “Maximizing Investigators’ Research Award” from the NIH. The goal of this early career award is to enhance the ability of investigators to take on ambitious scientific projects and approach problems more creatively.
Researchers at the Case Western Reserve University School of Medicine, with colleagues from multiple research centers, will study the genomics of Alzheimer’s disease (AD) in people with African heritage throughout the United States.
An untapped trove of desirable drug-like molecules is hidden in the genomes of Streptomyces bacteria — the same bacteria responsible for the first bacterial antibiotics to treat tuberculosis back in the 1940s. Isolating them, however, has proved challenging. Now, biologists at Washington University in St. Louis are using comparative metabologenomics to try to uncover what may be “silencing” Streptomyces and preventing it from producing desirable compounds encoded by its genes.
A new study confirms the low likelihood that coronavirus contamination on hospital surfaces is infectious. The study is the original report on recovering near-complete SARS-CoV-2 genome sequences directly from surface swabs.
Leading scientist known for working to complete the human genome will join UCSC faculty; Karen Miga is a longtime Genomics Institute researcher, recently named “one to watch” by the journal Nature.
Zhongming Zhao, PhD, MS, with The University of Texas Health Science Center at Houston (UTHealth), has been awarded nearly $4 million from the Cancer Prevention and Research Institute of Texas (CPRIT) to provide research training to help with cancer prevention.
By mapping its genetic underpinnings, researchers at University of California San Diego School of Medicine have identified a predictive causal role for specific cell types in type 1 diabetes, a condition that affects more than 1.6 million Americans.
They are some of the most beautiful, and elusive, animals on the plant. Leopards. In a major scientific step, the whole genome DNA sequence of 23 individual leopards have been interpreted.
Hertz Fellow Ravi Sheth was awarded the 2020 Hertz Thesis Prize for developing new tools used in microbial research.
Unprecedented novel discoveries have implications for characterizing biodiversity for all life, conservation and human health and disease.
CUR’s Health Sciences Division announces the 2021 recipients of its NCUR Presentation Awards. The awards cover the cost of registration for undergraduates presenting original research at the 2021 National Conference on Undergraduate Research.
Irvine, Calif., April 15, 2021 — By analyzing gains and losses in the genes of phytoplankton samples collected in all major ocean regions, researchers at the University of California, Irvine have created the most nuanced and high-resolution map yet to show where these photosynthetic organisms either thrive or are forced to adapt to limited quantities of key nutrients, nitrogen, phosphorus and iron.
A team of University of Colorado School of Medicine researchers recently published a paper offering new insight into the role that oxygen deprivation, or hypoxia, plays in cancer development. CU Cancer Center member Joaquin Espinosa, PhD, is the senior researcher on the paper, which he hopes will help lead to more targeted treatments for cancer.
Hertz Fellow David Schaffer uses high throughput genetic sequencing technology to identify gene variants that can potentially help restore sight, repair hearts damaged by Fabry disease, and improve lung function in patients with cystic fibrosis.
Hackensack Meridian Health and Genomic Testing Cooperative (GTC) in Irvine, California, have teamed up to establish the first-of-its-kind genomic profiling laboratory called Anthology Diagnostics, to generate more personalized, precise, and real-time insights for cancer patients, oncologists and hospitals.
Andrea Eveland received the Marcus Rhoades Early Career Award at the 63rd Maize Genetics Conference. Malia Gehan received the 2021 North American Plant Phenotyping Network (NAPPN) Early Career Award at the NAPPN annual conference.
Combining computational mining of big data with experimental testing in the lab, researchers at Children’s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, the phenotypic manifestation of that expression. In analyzing so-called A-to-I RNA editing, in which the adenosine of an RNA molecule is chemically modified into an inosine, the researchers describe how a single nucleotide change by RNA editing can have large downstream effects. The findings were published today in Genome Biology.
The National Cancer Institute’s Genomic Data Commons (GDC), launched in 2016 by then-Vice President Joseph Biden and hosted at the University of Chicago, has become one of the largest and most widely used resources in cancer genomics, with more than 3.3 petabytes of data from more than 65 projects and over 84,000 anonymized patient cases, serving more than 50,000 unique users each month.
Article title: Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase (PAK1) positive breast cancer Authors: Emily L. Duderstadt, Sarah A. McQuaide, Mary Ann Sanders, David J. Samuelson From the authors: “Our finding of elevated [p21 activated…
After analyzing the genomes of more 250,000 military veterans, researchers have identified 18 specific, fixed positions on chromosomes that appear associated with post-traumatic stress disorder. The findings may point to new therapeutic drug targets.
In Nature, a multi-institutional team including DOE Joint Genome Institute researchers has produced a high-quality reference sequence of the complex switchgrass genome. Building off this work, bioenergy researchers are exploring targeted genome editing techniques to customize the crop.
A new Cornell University study found that harmful mutations in sorghum landraces – early domesticated crops – decreased compared to their wild relatives through the course of domestication and breeding.
In a large study of pediatric cancer patients, researchers from Children’s Hospital of Philadelphia (CHOP) have analyzed the frequency, fusion partners, and clinical outcome of neurotrophic tyrosine receptor kinase (NTRK) fusions, which are clinical biomarkers that identify patients suitable for treatment with FDA-approved TRK inhibitors. The researchers found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors.
In a study published today in the journal Science Advances, a team from Roswell Park details a method to measure the abundance of cancer-related early changes to skin tissue long before the damage becomes visible to the eye.
UC San Diego and Ludwig Cancer Research scientists describe how a phenomenon known as “chromothripsis” breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth.
In the paper, “Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes,” published in eLife, researchers identified genes that respond differently in response to high glucose in individuals with and without diabetic retinopathy.
Article title: Implementation of convolutional neural network approach for COVID-19 disease detection Author: Emrah Irmak From the author: “In this paper, two novel and fully automatic studies using deep convolutional neural networks [CNN] are presented for COVID-19 detection and virus…
A new study details the latest efforts to predict traits in corn based on genomics and data analytics. The data management technique could help to “turbo charge” the seemingly endless amount of genetic stocks contained in the world’s seed banks, leading to faster and more efficient development of new crop varieties.
UNLV researcher Edwin Oh and colleagues have implemented wastewater surveillance programs to screen samples for the presence of COVID-19 and to extract the RNA from the SARS-COV-2 virus to find targets that make vaccines more effective.
Researchers at UC San Diego School of Medicine and Rady Children’s Institute for Genomic Medicine have been awarded a five-year, $8.3 million grant from the National Institutes of Health to investigate the causes of spina bifida, the most common structural defect of the central nervous system.
Researchers at Children’s Hospital of Philadelphia (CHOP) have resolved a severe lymphatic disorder in a girl with Noonan Syndrome that had led to upper gastrointestinal bleeding, fluid collection around the lungs, and numerous surgeries that had been unable to resolve her symptoms. By identifying a genetic mutation along a pathway related to lymphatic vessel development and function, the research team was able to target the pathway using an existing drug they had used in a previous case to remodel a patient’s lymphatic system.