Mount Sinai Researchers Receive $7 Million to Improve Outcomes for High-risk Blood Cancer Patients From the Multiple Myeloma Research Foundation

The Mount Sinai Health System has received a $7 million grant from the Multiple Myeloma Research Foundation for a three-year project that aims to fast-track novel translational concepts to improve outcomes for people with high risk myeloma, the second most common blood cancer in the United States.

Researchers create a neural network for genomics—one that explains how it achieves accurate predictions

A team of New York University computer scientists has created a neural network that can explain how it reaches its predictions. The work reveals what accounts for the functionality of neural networks—the engines that drive artificial intelligence and machine learning—thereby illuminating a process that has largely been concealed from users.

CHOP Researchers Develop Versatile and Low-Cost Technology for Targeted Long-read RNA Sequencing

In a development that could accelerate the discovery of new diagnostics and treatments, researchers at Children’s Hospital of Philadelphia (CHOP) have developed a versatile and low-cost technology for targeted sequencing of full-length RNA molecules.

Newly discovered RNA molecules hold promise for detecting and treating esophageal cancer

Irregularities in the body’s genetic coding to make proteins are linked to cancerous tumors. But most genetic material contains elements whose function isn’t clear. Could abnormalities in non-coding material also impact a person’s health, or even be linked to cancers as well? A new study by researchers at the Case Western Reserve University School of Medicine suggests that the non-coding genetic molecules also play a key role in health and disease, including tumor development.

Scientists Sequence Genome of Little Skate, the Stingray’s Cousin

Rutgers geneticists, working with an international team of scientists, have conducted the most comprehensive sequencing yet of the complete DNA sequence of the little skate – which, like its better-known cousin, the stingray, has long been viewed as enigmatic because of its shape. The scientists, writing in Nature, reported that by studying the intricacies of Leucoraja erinacea’s genome, they have gained a far better understanding of how the fish evolved from its ancestor – which possessed a much narrower body – over a period of 300 million years to become a flat, winged bottom-dweller.

Advanced computing at UNC Charlotte indicates current antibodies effective against newly emergent SARS-CoV-2 XBB.1.5

A team at UNC Charlotte and Tuple, a Charlotte-based genomics consulting firm, has used artificial intelligence to rapidly assess the public health implications of the newly emergent SARS-CoV-2 XBB.1.5 variant. Results from simulations run by the team indicate the antibodies currently in our arsenal are effective to neutralize SARS-CoV-2 XBB.1.5.

Discovering Unique Microbes Made Easy with DOE Systems Biology Knowledgebase (KBase)

The Department of Energy Systems Biology Knowledgebase (KBase) recently released a suite of features and a protocol for performing sophisticated microbiome analysis that can accelerate research in microbial ecology. KBase helps researchers understand which organisms live in an environment and how they interact. The tool’s new features reduce the time required to process sequencing data and characterize genomes and help scientists collaboratively analyze genomics data and build research communities.

CHOP and NJIT Researchers Develop New Tool for Studying Multiple Characteristics of a Single Cell

Researchers from Children’s Hospital of Philadelphia (CHOP) and New Jersey Institute of Technology (NJIT) developed new software that integrates a variety of information from a single cell, allowing researchers to see how one change in a cell can lead to several others and providing important clues for pinpointing the exact causes of genetic-based diseases.

CHOP Researchers Identify Potential Genetic Variants Linked to Increased Cancer Risk in Children with Birth Defects

Researchers have identified several genetic variants associated with increased risk of cancer in children with non-chromosomal birth defects, such as congenital heart disease and defects of the central nervous system. While the risk of developing cancer is not as high as children with chromosomal birth defects, it is significantly higher than children with no birth defects at all, and the findings may provide a basis for early detection in these understudied patients.

UC San Diego Computer Scientist Plays Major Role in $25M Cancer Grand Challenges Project

University of California San Diego computer scientist Vineet Bafna is part of a team of world-class researchers that has been awarded a five-year, $25 million Cancer Grand Challenges grant to learn how the destructive genetic lesion extrachromosomal DNA (ecDNA) influences numerous cancers and to identify possible therapies.

The Application of Noninvasive Prenatal Screening Using Cell-free DNA in General Risk Pregnancies – The American College of Medical Genetics and Genomics Publishes its Highly Anticipated Evidence-based Review

The American College of Medical Genetics and Genomics (ACMG) has released its second, highly anticipated systematic evidence-based review (SER): “The Application of Noninvasive Prenatal Screening Using Cell-free DNA in General Risk Pregnancies.”

Rutgers Researcher Aims to Protect and Regenerate Corals Through Coral Genomics with $500K NSF Grant and Award-Winning Video

A Rutgers researcher will use genomics, genetics, and cell biology to identify and understand the corals’ response to heat stress conditions and to pinpoint master regulatory genes involved in coral bleaching due to global warming and climate change. The researcher and his team will use a novel gene-editing tool as a resource to knock down some gene functions with the goal of boosting the corals’ abilities to survive.

For Neurons, Where They Begin Isn’t Necessarily Where They End

Scientists at UC San Diego School of Medicine and Rady Children’s Institute of Genomic Medicine describe novel methods for inferring the movement of human brain cells during fetal development by studying healthy adult individuals who have recently passed away from natural causes.

Mount Sinai Neurobiologist Selected as a Howard Hughes Medical Institute Investigator

The Howard Hughes Medical Institute (HHMI) has selected Ian Maze, PhD, Associate Professor of Neuroscience, and Pharmacological Sciences, at the Icahn School of Medicine at Mount Sinai, as an HHMI Investigator.

Climate Change Threatens Base of Polar Oceans’ Bountiful Food Webs

A study recently published in Nature Communications suggests that displacing cold-water communities of algae with warm-adapted ones threatens to destabilize the delicate marine food web. The team was led by University of East Anglia researchers and included DOE Joint Genome Institute researchers.

Mayo researchers link gut microbiome to rheumatoid arthritis prognosis

A significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in their gut, according to new research from Mayo Clinic’s Center for Individualized Medicine.

The study, published in Genome Medicine, found that predicting a patient’s future rheumatoid arthritis prognosis could be possible by zeroing in on the trillions of bacteria, viruses and fungi that inhabit their gastrointestinal tract, known as the gut microbiome. The findings suggest that gut microbes and a patient’s outcome of rheumatoid arthritis are connected.

Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate

Researchers at the Icahn School of Medicine at Mount Sinai found that a tool commonly used in research for evaluating a person’s genetic risk for a disease, called a polygenic risk score, was no better at predicting the outcome of a schizophrenia patient’s disease over time than written reports. The results raise important questions about the use of polygenic risk scores in real-world, clinical situations, and also suggest that a doctor’s written report may be an untapped source of predictive information.

FAU Researcher Receives $1.8 Million NIH ‘Maximizing Investigators’ Research Award’

Raquel Assis, Ph.D., associate professor, College of Engineering and Computer Science, and a fellow of FAU’s Institute for Human Health and Disease Intervention, has received a five-year, $1.8 million “Maximizing Investigators’ Research Award” from the NIH. The goal of this early career award is to enhance the ability of investigators to take on ambitious scientific projects and approach problems more creatively.