Fields of Breeders’ Dreams: A Team Effort Toward Targeted Crop Improvements

In Nature, a multi-institutional team including DOE Joint Genome Institute researchers has produced a high-quality reference sequence of the complex switchgrass genome. Building off this work, bioenergy researchers are exploring targeted genome editing techniques to customize the crop.

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CHOP Researchers Find NTRK Fusions More Common than Expected in Pediatric Tumors

In a large study of pediatric cancer patients, researchers from Children’s Hospital of Philadelphia (CHOP) have analyzed the frequency, fusion partners, and clinical outcome of neurotrophic tyrosine receptor kinase (NTRK) fusions, which are clinical biomarkers that identify patients suitable for treatment with FDA-approved TRK inhibitors. The researchers found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors.

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Making sense of a universe of corn genetics

A new study details the latest efforts to predict traits in corn based on genomics and data analytics. The data management technique could help to “turbo charge” the seemingly endless amount of genetic stocks contained in the world’s seed banks, leading to faster and more efficient development of new crop varieties.

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Testing Wastewater for COVID-19

UNLV researcher Edwin Oh and colleagues have implemented wastewater surveillance programs to screen samples for the presence of COVID-19 and to extract the RNA from the SARS-COV-2 virus to find targets that make vaccines more effective.

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New Grant Seeks to Fill Knowledge Gaps Regarding Spina Bifida

Researchers at UC San Diego School of Medicine and Rady Children’s Institute for Genomic Medicine have been awarded a five-year, $8.3 million grant from the National Institutes of Health to investigate the causes of spina bifida, the most common structural defect of the central nervous system.

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CHOP Researchers Reverse Severe Lymphatic Disorder in Patient with Noonan Syndrome by Targeting Genetic Pathway

Researchers at Children’s Hospital of Philadelphia (CHOP) have resolved a severe lymphatic disorder in a girl with Noonan Syndrome that had led to upper gastrointestinal bleeding, fluid collection around the lungs, and numerous surgeries that had been unable to resolve her symptoms. By identifying a genetic mutation along a pathway related to lymphatic vessel development and function, the research team was able to target the pathway using an existing drug they had used in a previous case to remodel a patient’s lymphatic system.

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What We Know: Mount Sinai to Host COVID-19 Research Symposium

The COVID-19 Research Symposium, hosted by the Mount Sinai Clinical Intelligence Center (MSCIC), is a one-day comprehensive review of advances in research by the Mount Sinai Health System to better understand and treat the coronavirus known as COVID-19.

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