First Mutation-Targeted Bladder Cancer Drug May Be Under-Used

The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a JAMA Oncology study led by the University of Pennsylvania. Researchers analyzed a large, nationwide database of cancer cases and found that bladder cancer patients potentially eligible for erdafitinib (Balversa) treatment, fewer than half had a record of being tested for the relevant gene mutation. Of those who were tested and found to have the mutation, fewer than half received the treatment.

MAPPING COVID RISK IN URBAN AREAS: A WAY TO KEEP THE ECONOMY OPEN

As COVID-19 vaccines slowly roll out across the world, government officials in densely populated countries must still manage vulnerable communities at highest risk of an outbreak. In a new study published in the journal Risk Analysis, researchers in India propose a COVID Risk Assessment and Mapping (CRAM) framework that results in a zoned map that officials can use to place more targeted restrictions on high-risk communities. Successfully used by officials in Jaipur at the peak of the pandemic last spring, their framework could help other vulnerable countries avoid a shutdown of their regional economies.

Use of Pembrolizumab Provided Long-Term Benefits in Patients With Metastatic Melanoma, 10-Year Look Shows

A new 10-year analysis led by Igor Puzanov, MD, MSci, FACP, Director of Early Phase Clinical Trials and Chief of Melanoma at Roswell Park Comprehensive Cancer Center and published today in the journal JAMA Oncology provides new insights into an important question: whether BRAF V600E/K mutation status or previous BRAF inhibitor (BRAFi) therapy with or without a MEK inhibitor (MEKi) affects response to pembrolizumab (brand name Keytruda) in patients with advanced melanoma.