Previously Healthy Young Adults with ‘Long COVID’ Show Vascular Dysfunction in Limbs, but Not Brain

A first-of-its-kind study of young adults with positive COVID-19 tests from more than 4 weeks ago found that those who were still symptomatic (i.e., long-haulers) had impaired blood vessel function in their limbs, but not brains. Asymptotic participants had blood vessel function similar to controls.

Protein Inhibitor May Lead to New Treatment for Low Oxygen Associated with Sleep Apnea

Article title: Lysine demethylase KDM6B regulates HIF-1α mediated systemic and cellular responses to intermittent hypoxia Authors: Jayasri Nanduri, Ning Wang, Benjamin L. Wang, Nanduri R. Prabhakar From the authors: “[The] current study demonstrates that pharmacological disruption of [Hypoxia-inducible factor]-1α activation…

Exercise May Not Offset Genetic Predisposition for Low Exercise Capacity, Impaired Insulin Sensitivity

Article title: Genetically determined exercise capacity affects systemic glucose response to insulin in rats Authors: Michael Schwarzer, Annika Molis, Christina Schenkl, Andrea Schrepper, Steven L. Britton, Lauren Gerard Koch, Torsten Doenst From the authors: “In our model of [high capacity…

Frequent Breaks from Sitting May Improve Daily Blood Sugar Fluctuations

Frequent activity breaks from sitting may improve fasting blood sugar (glucose) levels and stabilize daily fluctuations, according to new research. The study, the first of its length to explore the effects of activity breaks in “free-living” conditions, is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism. It was chosen as an APSselect article for August.

New UK Study Offers Insight on How Resistance Training Burns Fat

Findings from a new University of Kentucky College of Medicine and College of Health Sciences study add to growing evidence that resistance exercise has unique benefits for fat loss.

The Department of Physiology and Center for Muscle Biology study published in the FASEB Journal found that resistance-like exercise regulates fat cell metabolism at a molecular level.

Mouse Model of COVID-19–induced Lung Injury May Aid Development of Coronavirus Treatments

Article title: The SARS-CoV-2 spike protein subunit 1 induces COVID-19–like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells Authors: Ruben Colunga Biancatelli, Pavel Solopov, Elizabeth R. Sharlow, John S. Lazo, Paul Ellis Marik, John…

Chronic Alcohol Consumption Inhibits Intestinal Absorption of Vitamin B7, May Lead to Deficiency

Article title: Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites Authors: Kalidas Ramamoorthy, Subrata Sabui, Padmanabhan Srinivasan, Saleh Al-Juburi, Quang Pham, Brian D. Chu, Rita D. Simoes, James M.…

Rat Model of Preeclampsia Gives new Insight into Immunological Changes during Pregnancy

Article title: Immunological comparison of pregnant Dahl salt-sensitive and Sprague-Dawley rats commonly used to model characteristics of preeclampsia Authors: Erin B. Taylor, Eric M. George, Michael J. Ryan, Michael R. Garrett, Jennifer M. Sasser From the authors: “The current study…

Intrauterine Growth Restriction in Rats Causes Long-term Increases in Offspring’s Blood Pressure, Impairs Renal Artery Vascular Tone

Article title: Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction Authors: Jenny Voggel, Lubomir Lubomirov, Felix Lechner, Gregor Fink, Eva Nüsken, Maria Wohlfarth, Gabriele Pfitzer, Kija Shah-Hosseini, Martin Hellmich, Miguel A. Alejandre…

Lack of DUSP5 Protein Leads to Pulmonary Hypertension and Heart Enlargement in Mice

Article title: DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy Authors: Bradley S. Ferguson, Sara A. Wennersten, Kimberly M. Demos-Davies, Marcello Rubino, Emma L. Robinson, Maria A. Cavasin, Matthew S. Stratton, Andrew M. Kidger, Tianjing…

Neuroscientists posit that brain region is a key locus of learning

Small and seemingly specialized, the brain’s locus coeruleus (LC) region has been stereotyped for its outsized export of the arousal-stimulating neuromodulator norepinephrine. In a new paper and with a new grant from the National Institutes of Health, an MIT neuroscience…

Bidirectional impact of cardiovascular disease, cancer in Blacks focus of new AHA center

Cardiovascular disease and cancer, the nation’s top two killers, share common ground like obesity and chronic inflammation, as well as a disproportionate impact on Black Americans. A new American Heart Association-funded center at the Medical College of Georgia is working…

Study innovates in gluten-free formulations, creating more palatable and nutritious bread

Study at the Federal University of São Paulo developed a recipe combining chickpea flour and psyllium, a plant-derived soluble fiber. The product is nourishing and rated highly by consumers in qualitative surveys.