Bidirectional impact of cardiovascular disease, cancer in Blacks focus of new AHA center

Cardiovascular disease and cancer, the nation’s top two killers, share common ground like obesity and chronic inflammation, as well as a disproportionate impact on Black Americans. A new American Heart Association-funded center at the Medical College of Georgia is working…

Study innovates in gluten-free formulations, creating more palatable and nutritious bread

Study at the Federal University of São Paulo developed a recipe combining chickpea flour and psyllium, a plant-derived soluble fiber. The product is nourishing and rated highly by consumers in qualitative surveys.

New genetic driver of autism and other developmental disorders identified

A research group including Kobe University’s Professor TAKUMI Toru (also a Senior Visiting Scientist at RIKEN Center for Biosystems Dynamics Research) and Assistant Professor TAMADA Kota, both of the Physiology Division in the Graduate School of Medicine, has revealed a…

Climate changed the size of our bodies and, to some extent, our brains

The average body size of humans has fluctuated significantly over the last million years and is strongly linked to temperature. Colder, harsher climates drove the evolution of larger body sizes, while warmer climates led to smaller bodies. Brain size also…

Prize winner uncovers the link between the microbiome, metabolites and neurodegeneration

Eran Blacher is the 2021 winner of the NOSTER & Science Microbiome Prize for his work in exploring the relationship between the microbiome and neurodegenerative diseases such as Alzheimer’s disease (AD) and Amyotrophic Lateral Sclerosis (ALS). The findings reveal new…

‘Smart collar’ could prevent tapeworms in dogs

Dogs infected with echinococcosis play a major role in spreading tapeworms across human populations around the world. Now, researchers have developed a “smart collar” which gradually delivers a steady dose of a deworming drug to dogs. The collar successfully reduces…

Protein supplements work for women and not men, during fasted carb-restricted training

Consuming a protein supplement, specifically protein hydrolysate, during carbohydrate-restricted training was helpful for improving training intensity in women, but not in men. That’s according to new research which will be part of a presentation this week at The Physiological Society’s…

Human-driven habitat change leads to physical, behavioral change in mosquitofish

Bahamian mosquitofish in habitats fragmented by human activity are more willing to explore their environment, more stressed by change and have smaller brain regions associated with fear response than mosquitofish from unaffected habitats. The new study from North Carolina State…

Missing bile ducts offer clues to mechanism of liver injury

PITTSBURGH, July 6, 2021 – Scientists from the University of Pittsburgh School of Medicine described a new phenomenon in which the deletion of a single gene involved in liver embryogenesis completely wipes out bile ducts of newborn mice. But despite…

Study shows the mechanism how loss of de-N-glycosylation enzyme causes ill effect

Peptide: N-glycanase (NGLY1) is an evolutionarily conserved enzyme for removing N-linked glycans (N-glycans) from glycoproteins and is involved in proteostasis of N-glycoproteins in the cytosol. In 2012, a rare genetic disorder called NGLY1 deficiency was discovered by an exome analysis.…

Protein Deficiency Impairs Muscle Clock, Mitochondrial Function in Muscular Dystrophy

Article title: Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice Authors: Justin P. Hardee, Marissa K. Caldow, Audrey S.M. Chan, Stuart K. Plenderleith, Jennifer Trieu, Rene Koopman, Gordon S. Lynch From the authors: “These findings suggest that…

Fat Tissue Protein Signaling May Lead to Treatment to Improve Heart Health in People Who Can’t Exercise

Article title: Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin Authors: Jacob T. Caldwell, Karissa M. Dieseldorff Jones, Hyerim Park, Jose R. Pinto, Payal Ghosh, Emily C. Reid-Foley, Brody Ulrich, Michael D. Delp, Brad…

Reduced Expression of Dual Oxidase 1 Enzyme May Contribute to Age-related Emphysema

Article title: Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema Authors: Caspar Schiffers, Lennart K.A. Lundblad, Milena Hristova, Aida Habibovic, Christopher M. Dustin, Nirav Daphtary, Minara Aliyeva, David J. Seward, Yvonne M.…

Engineered Neural Networks Help ID Responses Associated with Abnormalities in Parkinson’s Disease

Article title: Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks Authors: Vibeke D. Valderhaug, Kristine Heiney, Ola Huse Ramstad, Geir Bråthen, Wei-Li Kuan, Stefano Nichele, Axel Sandvig, Ioanna Sandvig From the authors: “In this study, we investigate the…

Methylglyoxal detoxification deficits causes schizophrenia-like behavioral abnormalities

Methylglyoxal (MG) is a highly reactive α-ketoaldehyde formed endogenously as a byproduct of the glycolytic pathway. MG accumulates under conditions of hyperglycemia, impaired glucose metabolism, or oxidative stress. An excess of MG formation causes mitochondrial impairment and reactive oxygen species…