Heat Stress May Affect the Muscles for Longer Than We Think

People who experience heat stress during exercise may need more recovery time to let their muscles heal, according to a new mouse study published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

Device keeps brain alive, functioning separate from body

Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.

Transplanting Muscle Mitochondria among Species May Create Opportunity for New Treatments

Article title: Muscle mitochondrial transplantation can rescue and maintain cellular homeostasis Authors: Debasmita Bhattacharya, Mikhaela B. Slavin, David A. Hood From the authors: “Our study illustrates the feasibility of using mouse skeletal muscle-derived mitochondria for transplantation in intraspecies- and interspecies-specific…

Urban Pollution Changes Properties of Lung Cells, Causes Fibrosis

Article title: Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis Authors: Randa Belgacemi, Bruno Ribeiro Baptista, Grégoire Justeau, Marylène Toigo, Andrew Frauenpreis, Rojda Yilmaz, Audrey Der Vartanian, Mathieu Cazaunau, Edouard Pangui, Antonin Bergé, Aline Gratien,…

Excess Testosterone Can Lead to Increased Cardiovascular Risks in People with Polycystic Ovary Syndrome

Article title: Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome Authors: Tori Stone, Licy L. Yanes Cardozo, Toni N. Oluwatade, Cheryl A. Leone, Melanie Burgos, Faith Okifo, Lubna Pal, Jane F. Reckelhoff, Nina. S. Stachenfeld From…

Enzyme in T Cells Worsens Salt-sensitive Hypertension and Related Kidney Damage

Article title: Functional NADPH oxidase 2 (NOX2) in T cells amplifies salt-sensitive hypertension and associated renal damage Authors: Samuel D. Walton, John Henry Dasinger, Emily C. Burns, Mary Cherian-Shaw, Justine M. Abais-Battad, David L. Mattson From the authors: “The results…

Climate Change Threatens Military Readiness

The growing frequency and intensity of heat waves around the globe pose “a substantial, persistent ‘non-combat threat’” to military training and operations, according to experts in environmental, thermoregulatory and cardiovascular physiology.

Blocking Signals from Receptor Involved in Fat Metabolism, Inflammation Improves Fatty Liver and Insulin Resistance in Mice

Article title: Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding Authors: Takuma Yasuda, Norio Harada, Tomonobu Hatoko, Atsuhiko Ichimura, Eri Ikeguchi-Ogura, Yuki Murata, Naoki Wada, Sakura Kiyobayashi, Shunsuke Yamane, Akira Hirasawa, Nobuya…

Sex Differences in Fat Storage during Military Training Help Women Preserve Lean Mass

Article title: Sex differences in body composition and serum metabolome responses to sustained, physical training suggest enhanced fat oxidation in women compared with men Authors: Meaghan E. Beckner, Lauren Thompson, Patrick N. Radcliffe, Rebecca Cherian, Marques Wilson, Nicholas Barringer, Lee…

Gene Expression in Kidneys Is Regulated by the Microbiome in Sex- and Tissue-specific Ways

Article title: Commensal microbiota regulate renal gene expression in a sex-specific manner Authors: Brittni N. Moore and Jennifer L. Pluznick From the authors: “This report demonstrates that renal gene expression is modulated by the microbiome in a sex- and tissue-specific…

Exercise May Prevent Stress-induced Hypertension through Regulation of Brain-bone Marrow Interaction

Article title: Impact of exercise on brain-bone marrow interactions in chronic stress: potential mechanisms preventing stress-induced hypertension Authors: Thu Van Nguyen, Ko Yamanaka, Keisuke Tomita, Jasenka Zubcevic, Sabine S. S. Gouraud,  Hidefumi Waki From the authors: “Our findings provide new…

Post-injury Intestinal Regeneration Enhanced by Calorie Restriction, Requires Autophagy

Article title: Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction Authors: Patrick A. Williams, Kaitlyn E. Naughton, Lauren A. Simon, Gloria E. Soto, Louis R. Parham, Xianghui Ma, Charles H. Danan, Weiming Hu, Elliot S. Friedman,…

Selenoprotein P Could Become Therapeutic Target for Muscle Loss Caused by Inactivity

Article title: Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases Authors: Halimulati Abuduwaili, Kyoko Kamoshita, Kiyo-Aki Ishii, Kenta Takahashi, Tuerdiguli Abuduyimiti, Li Qifang, Yuki Isobe, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Hiroaki Takayama, Kenichi…

Women Have Less Age-related Decrease of Gray Matter in Brain than Men

Article title: Differential reduction of gray matter volume with age in 35 cortical areas in men (more) and women (less) Authors: Peka Christova and Apostolos P. Georgopoulos From the authors: “This study showed an overall decrease of cortical gray matter…

UT Southwestern Physiology Chair, molecular geneticist elected to prestigious National Academy of Sciences

The National Academy of Sciences elected two more UT Southwestern Medical Center scientists in the fields of molecular genetics and physiology into its membership, one of the highest honors for American scientists. Russell DeBose-Boyd, Ph.D., Professor of Molecular Genetics, and Duojia Pan, Ph.D., Chair of Physiology and a Howard Hughes Medical Institute Investigator, were elected by their peers in recognition of the importance of their scientific discoveries.

American Physiological Society Announces 2023 Award Recipients

The American Physiological Society (APS) is pleased to announce the recipients of the Society’s most prestigious and highly competitive awards. Awardees will be recognized for their achievements at the American Physiology Summit, APS’ flagship annual meeting, to be held April 20–23, 2023, in Long Beach, California.

Chemotherapy Drug Increases Kidney Injury in Mouse Model of Lung Cancer

Article title: Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity Authors: Andrew Orwick, Sophia M. Sears, Cierra N. Sharp, Mark A. Doll, Parag P. Shah, Levi J. Beverly, Leah J. Siskind From the authors: “This…

Researchers Use Liquid Chromatography–Mass Spectrometry to Explore Circadian Gene Expression in Mouse Kidneys

Article title: Circadian gene expression in mouse renal proximal tubule Authors: Molly A. Bingham, Kim Neijman, Chin-Rang Yang, Angel Aponte, Angela Mak, Hiroaki Kikuchi, Hyun Jun Jung, Brian G. Poll, Viswanathan Raghuram, Euijung Park, Chung-Lin Chou, Lihe Chen, Jens Leipziger,…

Researchers Explore Sex Differences in Cardiovascular and Congenital Heart Diseases in People with Down Syndrome

Article title: Sex differences in cardiovascular disease and dysregulation in Down syndrome Authors: Melissa L. Bates, Anastasiia Vasileva, Laura D.M. Flores, Yana Pryakhina, Michelle Buckman, Michael H. Tomasson, Lara R. DeRuisseau From the authors: “Based on the results of our…

Succinate Protects against Obesity, Metabolic Disease through Brown Fat Protein Expression

Article title: Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide Authors: Rodrigo S. Gaspar, Jeany Delafiori, Giuliana Zuccoli, Victor Corasolla Carregari, Thais P. Prado, Joseane Morari, Davi Sidarta-Oliveira, Carina S. Solon,…