Researchers ID Low Immune Cell Responsiveness and High Level of Proteins as Features of COVID-19 Severity

Article title: Chemokines, soluble PD-L1 and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness Authors: Eric D. Morrell, Pavan K. Bhatraju, Neha A. Sathe, Jonathan Lawson, Linzee Mabrey, Sarah E. Holton, Scott R. Presnell, Alice Wiedeman, Carolina Acosta-Vega,…

Intestinal Abnormalities in People with Posttraumatic Stress Disorder Don’t Improve Even When PTSD Symptoms Abate

Article title: Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms Authors: Robin M. Voigt, Alyson K. Zalta, Shohreh Raeisi, Lijuan Zhang, J. Mark Brown, Christopher B. Forsyth, Randy A. Boley, Philip Held, Mark…

Men Performing Heavy Resistance Exercise Have Disruptions to Gene Expression in Muscles

Article title: Human skeletal muscle acetylcholine receptor gene expression in elderly males performing heavy resistance exercise Authors: Casper Soendenbroe, Mette F. Heisterberg, Peter Schjerling, Michael Kjaer, Jesper L. Andersen, Abigail L. Mackey From the authors: “Taken together, the results demonstrate…

Heart of Aging Female Mice Produce More Collagen than Males, Develops More Scarring

Article title: Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis Authors: Aude Angelini, Jesus Ortiz-Urbina, JoAnn Trial, Anilkumar K. Reddy, Anna Malovannaya, Antrix Jain, Mark L. Entman, George E. Taffet, Katarzyna A. Cieslik From the authors:…

Peptide Treatment May Improve High White Blood Cell Count Associated with Smoking

Article title: Recombinant human β-defensin 2 delivery improves smoking-associated lung neutrophilia and bacterial exacerbation Authors: Nadia Milad, Marie Pineault, Gabrielle Bouffard, Michaël Maranda-Robitaille, Ariane Lechasseur, Marie-Josée Beaulieu, Sophie Aubin, Benjamin A. H. Jensen, Mathieu C. Morissette From the authors: This…

Exercise + Sauna = Better Cardiovascular Function

New research suggests that adding a regular 15-minute sauna to an exercise routine may improve cardiovascular risk factors more than exercise alone. The study is the first randomized controlled trial to explore the long-term combination of exercise and sauna bathing in a non-clinical population. It is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

Researchers Suggest Continued Heart and Lung Monitoring after COVID-19 for People with Highly Physical Jobs

Article title: The effect of medium-term recovery status after COVID-19 illness on cardiopulmonary exercise capacity in a physically active adult population Authors: Peter Ladlow, Oliver O’Sullivan, Alexander N. Bennett, Robert Barker-Davies, Andrew Houston, Rebecca Chamley, Samantha May, Daniel Mills, Dominic…

Omicron Variant of COVID-19 Does Not Cause Long-term Vascular Damage in Vaccinated Young Adults

Article title: Impact of breakthrough COVID-19 cases during the Omicron wave on vascular health and cardiac autonomic function in young adults Authors: Rachel J. Skow, Damsara Nandadeva, Ann-Katrin Grotle, Brandi Y. Stephens, Alexis N. Wright Paul J. Fadel From the…

Selective Autophagy Process Protects Heart Muscle Cells from Death

Article title: Chaperone-mediated autophagy protects cardiomyocytes against hypoxic cell death Authors: Rajeshwary Ghosh, Jennifer Jason Gillaspie, Kenneth S. Campbell, J. David Symons, Sihem Boudina, James Scott Pattison From the authors: “In summary, the present study demonstrated the importance of [chaperone-mediated…

Flozin Drugs Lower Salt-Induced Hypertension, Maintain Circadian Rhythm in Rats

Article title: SGLT2 inhibition effect on salt-induced hypertension, RAAS and Na+ transport in Dahl SS rats Authors: Olha Kravtsova, Ruslan Bohovyk, Vladislav Levchenko, Oleg Palygin, Christine A. Klemens, Timo Rieg, Alexander Staruschenko From the authors: “The main findings of the…

Common Prebiotic Fiber Mitigates Harm of High-salt Diet in Rats

New research in rats finds a diet high in the fiber inulin offered a protective effect against the damage of a high-salt diet. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference

Past Kidney Disease May Increase Preeclampsia Risk, Impair Blood Vessel Health during Pregnancy

A history of kidney problems may put people at a higher risk for impaired blood vessel function, which could lead to high blood pressure, preterm labor and other adverse outcomes, according to the results of a study in rats. The researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.

Vitamin D Supplements May Offset Bone Loss Caused by Diabetes Drug

Vitamin D supplementation may help offset damaging bone loss that occurs in some people who take canagliflozin, a commonly prescribed diabetes drug. Researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.

Giving Students Frequent Quizzes May Help Bridge Achievement Gap in Physiology

Frequent small stakes assessments may help marginalized students bridge an achievement gap in physiology education, according to research that will be presented this week at the American Physiological Society (APS) Institute on Teaching and Learning in Madison, Wisconsin.

Interactive Discussion Boards May Clarify Confusing Concepts in Advanced-level Physiology Courses

Using an online, interactive discussion board helped increase student understanding and engagement in a large enrollment course, according to new research from The Ohio State University College of Nursing. Physiology educator-researchers will present their findings this week at the American Physiological Society (APS) Institute on Teaching and Learning in Madison, Wisconsin.

Physiology Educators to Discuss Inclusive Teaching, Mentoring and Assessment at the APS Institute for Teaching and Learning

Physiology educators will gather in Madison, Wisconsin, June 21–24, 2022, for the American Physiological Society (APS) Institute on Teaching and Learning (ITL). The interactive multiday workshop will engage educators in sessions focused on the latest research and best practices in teaching, learning and assessment.

Artificial Intelligence Analyzes Gut Microbiota of Fish to Detect Waters Compromised by Climate Change

Article title: Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning Authors: John W. Turner Jr., Xi Cheng, Nilanjana Saferin, Ji-Youn Yeo, Tao Yang Bina Joe From the authors: “Overall, this study represents the…

Temperature Plays a Role in Brain Activity Related to Episodic Memory and Planning

Article title: Brain temperature affects quantitative features of hippocampal sharp wave ripples Authors: Peter C. Petersen, Mihály Vöröslakos, György Buzsáki From the authors: “Here, we show that features of hippocampal ripples, including the rate of occurrence, peak frequency, and duration…

Breakthrough Omicron COVID-19 Variant Cases Don’t Impair Vascular Health Post-infection in Young Otherwise Healthy Adults

New research finds vaccinated young adults who were diagnosed with COVID-19 during the “omicron wave” of late 2021 and early 2022 did not have lasting vascular impairment after active infection. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.

Blood Protein Levels and Birth Control Pills May Increase Blood Clot Risk in Female Astronauts

Article title: Albumin, oral contraceptives and venous thromboembolism risk in astronauts Authors: Sara R. Zwart, Serena M. Auñón-Chancellor, Martina Heer, M. Mark Melin, Scott M. Smith From the authors: “We report here evidence of an association between oral contraceptive use…

Researchers Identify Potential Target for Treating Autoimmune Diseases

New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.

Reversal of Heart Enlargement Differs in the Sexes; Doesn’t Use Universal Signaling Pathways

Article title: Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific Authors: Deanna L. Muehleman, Claudia Crocini, Alison R. Swearingen, Christopher D. Ozeroff, Leslie A. Leinwand From the authors: “This work highlights that the reversal of pathological hypertrophy…

Researchers ID Post-exercise Changes in MicroRNA as Potential Markers for Coronary Artery Disease

Article title: Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise Authors: Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen From the authors: “This exploratory study demonstrated six miRs associated with coronary necrotic…

Extracellular Vesicles in Lung Fluid May Point to Acute Respiratory Distress Syndrome Severity

Article title: CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome Authors: Rahul Y. Mahida, Joshua Price, Sebastian T. Lugg, Hui Li, Dhruv Parekh, Aaron Scott, Paul Harrison, Michael A. Matthay, David R.…

Study Explores Function and Characteristics of Enteric Nervous System Cells in Context of Injury

Article title: Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury Authors: Moritz Middelhoff, Giovanni Valenti, Lorenzo Tomassoni, Yosuke Ochiai, Bryana Belin, Ryota Takahashi, Ermanno Malagola, Henrik Nienhüser, Michael Finlayson, Yoku Hayakawa, Leah B. Zamechek,…

Calorie Count More Important than Nutrient Composition in Development of Obesity-related Kidney Disease

Article title: High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat Authors: Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton From the authors: “This work suggests that macronutrient…

Stress during Pregnancy May Lead to Heart Disease, Accelerated Aging in Next Generation

Prenatal stress can cause damage in the aorta in offspring, which may contribute to the development of atherosclerosis and accelerate aging, according to a new study in mice. The article is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.