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UrduRutgers MicroRNA expert available to comment on today’s Nobel Prize in Medicine Enver Cargri Izgu, an assistant professor in the Department of Chemistry and Chemical Biology at Rutgers University – New Brunswick, is available to speak about the work of…
Tag: Physiology
Endurance Exercise without Weight Loss May Reduce Body Fat
Participating in a high volume of exercise over a short period of time, such as cycling hundreds of miles in a few days, could reduce body fat levels without weight loss. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism and has been chosen as an APSselect article for September.
UM School of Medicine Aims to Accelerate Basic Science Research and Advance Drug Therapies with Newly-Created Department
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, has announced the formation of a new Department of Pharmacology, Physiology and Drug Development, which merges the Department of Physiology and Department of Pharmacology. This new Department aligns the basic science research efforts of both entities with a strong emphasis on the development of new drug therapies.
Combining Two Diabetes Drugs Helps Promote Weight Loss and Blood Sugar Control
New research finds a combination of drugs improves weight loss, glucose control and insulin resistance better than either drug alone. Using two diabetes medications together, such as a semaglutide like Ozempic or Rybelsus, with a second, newer class of drug, may offer a noninvasive solution to help people with Type 2 diabetes lose weight and manage their condition without the need for bariatric surgery.
Exercise More, Sit Less to Manage Frailty and Hypertension Risk in Aging
A new study of middle-age and older adults looks at sex differences in frailty levels and their link with heart health. The findings suggest that moving your body more through regular exercise and sitting less can help keep both heart disease and frailty at bay as we age.
‘Good’ Fat Metabolism Changes Tied to Estrogen Loss, Not Necessarily to Aging
Brown fat metabolism decreases in older men and women, but the decrease in women is not necessarily tied to age, according to new research. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism and has been chosen as an APSselect article for May.
Synchronisation between the central circadian clock and the circadian clocks of tissues preserves their functioning and prevents ageing
• Two complementary research articles, published simultaneously in the journals Science and Cell Stem Cell by a team of scientists from the UPF and IRB Barcelona, reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles.
• The coordination between the two clocks (central and peripheral) guarantees 50% of the circadian functions of tissues, including vital processes such as the cell cycle, DNA repair, mitochondrial activity, and metabolism.
• Synchronisation between the central brain clock and peripheral ones prevents premature muscle ageing and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.
Contracting RSV Before Age 2 Can Cause Long-term Lung Changes and Impairment
Infants and children who have severe cases of respiratory syncytial virus (RSV) before age 2 are likely to have changes to their lung structure and function that could affect respiratory health later in life.
Acetaminophen May Be Less Heart-safe than Previously Thought
The common painkiller acetaminophen was found to alter proteins in the heart tissue when used regularly at moderate doses, according to a new study conducted in mice. Researchers will present their work this week at the American Physiology Summit in Long Beach, California.
Skin Wetting Helps Cool Older Adults in Very Hot, Dry Weather
Spraying the skin with water helps reduce core and skin temperature in older adults during extremely hot and dry weather.
Black Men Have Greater Microvascular Dysfunction than White Men after Prostate Cancer Diagnosis
Microvascular function is lower in Black men following a recent diagnosis of prostate cancer, compared to white men.
Regular Exercise Prevents DNA Damage with Aging
Regular aerobic exercise later in life prevents genomic instability characterized by DNA damage and telomere dysfunction
Gymnasts’ Injury Risk Increases on Stiffer Competition Floors
Gymnasts who compete on stiffer floors than their training floors have a higher risk of experiencing an Achilles tendon rupture due to the positioning of their ankles, according to new research from the Burrell College of Osteopathic Medicine in New Mexico.
Short On Time? A 15-minute Workout May Help Boost Your Immune System
Exercising at moderate intensity for just 15 minutes may be all that is needed to boost immunity by increasing levels of natural killer (NK) cells. Researchers will present their work this week at the American Physiology Summit in Long Beach, California.
Heavy Alcohol Use May Increase Type 2 Diabetes Risk in Middle-aged Adults
Heavy alcohol use may increase middle-aged adults’ risk of developing Type 2 diabetes, according to research to be presented this week at the American Physiology Summit in Long Beach, California. The Summit is the flagship annual meeting of the American Physiological Society (APS).
Intermittent Fasting May Help Preserve Intestinal Health as We Age
A study in mice found that intermittent fasting brought benefits beyond weight loss, suggesting it could help the body better process glucose and reduce age-related declines in intestinal function. Researchers will present their work this week at the American Physiology Summit.
Prebiotics Could Help Space Travelers Stay Healthy
New research suggests that cultivating a healthy gut microbiome could help astronauts weather the stresses of altered gravity. Researchers will present their work this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society, in Long Beach, California
Resistant Starch Could Help Combat Leading Cause of End-stage Kidney Failure
Combining a low dose of blood pressure medication with a higher intake of dietary-resistant starch might help stave off diabetic kidney disease, according to results from a new animal study. Researchers will present their work this week at the American Physiology Summit.
Study Reveals How Obesity Could Accelerate Aging in the Brain
A new study conducted in mice traces how obesity and a high-fat diet may accelerate aging in the blood vessels that supply blood to the brain. The work is being presented this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society.
American Physiological Society Announces 2024 Award Recipients
The American Physiological Society (APS) is pleased to announce the recipients of the Society’s most prestigious and highly competitive awards. Awardees will be recognized for their achievements at the American Physiology Summit, APS’ flagship annual meeting, to be held April 4–7, 2024, in Long Beach, California.
Nobel Laureate and NASA Astronaut to Speak at American Physiology Summit
Nobel Laureate Brian Kobilka, MD, and NASA Astronaut Jessica Meir, PhD, are among the highlighted speakers who will attend the American Physiology Summit, the American Physiological Society’s (APS) flagship annual meeting. The Summit will be held April 4–7, 2024, in Long Beach, California.
High-salt Diet Alters Kidney Metabolism, Other Metabolic Functions
Rockville, Md. (February 23, 2024)—A high-salt diet leads to alterations in kidney metabolism, according to researchers from the University Medical Center Hamburg-Eppendorf in Germany. Kidneys are critical metabolic organs that are responsible for filtering, reabsorbing, secreting and metabolizing “vast amounts…
Tawny owl’s pale grey color linked to vital functions ensuring survival in extreme conditions
A recent genetic discovery has revealed that the pale grey plumage of the tawny owl is linked to crucial functions that aid the bird’s survival in cold environments.
Heat Stress May Affect the Muscles for Longer Than We Think
People who experience heat stress during exercise may need more recovery time to let their muscles heal, according to a new mouse study published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
Elite Athletic Events May Not Be Out of Reach for Recreational Athletes
A new case study finds that recreationally trained athletes—“regular” people, as compared to elite athletes—may be able to achieve the extremely high levels of energy expenditure needed to complete high-endurance athletic events.
Device keeps brain alive, functioning separate from body
Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.
UT Southwestern women’s groups earn national leadership award
UT Southwestern Medical Center has been recognized for its decades of commitment to developing female leaders in medicine and science and its far-reaching impact in supporting and advancing women’s careers.
Study Explores How Kidneys Adapt to High Potassium Diet
Article title: Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect Authors: Lama Al-Qusairi, Mohammed Z. Ferdaus, Truyen D. Pham, Dimin Li, P. Richard Grimm, Ava M. Zapf, Delaney C. Abood, Ebrahim Tahaei, Eric Delpire,…
Researchers Explore Proteins’ Roles in Cilia Associated with Polycystic Kidney Disease
Article title: CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease Authors: Murali K. Yanda, Cristian Ciobanu, William B. Guggino, Liudmila Cebotaru From the authors: “Here we show that [cystic fibrosis transmembrane conductance regulator (CFTR)]…
Menstrual Cycle Phase Doesn’t Affect Fuel Provision during Exercise
Article title: The impact of natural menstrual cycle and oral contraceptive pill phase on substrate oxidation during rest and acute submaximal aerobic exercise Authors: Jennifer S. Williams, Jenna C. Stone, Zaryan Masood, William Bostad, Martin J. Gibala, Maureen J. MacDonald…
Transplanting Muscle Mitochondria among Species May Create Opportunity for New Treatments
Article title: Muscle mitochondrial transplantation can rescue and maintain cellular homeostasis Authors: Debasmita Bhattacharya, Mikhaela B. Slavin, David A. Hood From the authors: “Our study illustrates the feasibility of using mouse skeletal muscle-derived mitochondria for transplantation in intraspecies- and interspecies-specific…
Urban Pollution Changes Properties of Lung Cells, Causes Fibrosis
Article title: Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis Authors: Randa Belgacemi, Bruno Ribeiro Baptista, Grégoire Justeau, Marylène Toigo, Andrew Frauenpreis, Rojda Yilmaz, Audrey Der Vartanian, Mathieu Cazaunau, Edouard Pangui, Antonin Bergé, Aline Gratien,…
Study Gives 3D Picture of Age-related Changes in Heart Muscle Mitochondria
Article title: Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging Authors: Zer Vue, Kit Neikirk, Larry Vang, Edgar Garza-Lopez, Trace A. Christensen, Jianqiang Shao, Jacob Lam, Heather K. Beasley, Andrea G. Marshall, Amber Crabtree, Josephs…
APS Congratulates 2023 Nobel Laureates Katalin Karikó and Drew Weissman
The American Physiological Society (APS) extends congratulations to Katalin Karikó, PhD, and Drew Weissman, MD, PhD, the 2023 recipients of the Nobel Prize in Physiology or Medicine.
Studying the Blood Transcriptome May Improve Understanding of Variability in Exercise Response
Article title: Novel whole blood transcriptome signatures of changes in maximal aerobic capacity in response to endurance exercise training in healthy women Authors: Thomas J. LaRocca, Meghan E. Smith, Kaitlin A. Freeberg, Daniel H. Craighead, Timothy Helmuth, Matthew M. Robinson,…
Researchers Study Changes in Brain’s Gray Matter Over Time, between Sexes
Article title: Changes of cortical gray matter volume during development: a Human Connectome Project study Authors: Peka Christova and Apostolos P. Georgopoulos From the authors: “The rates of volume reduction with age did not differ significantly between the two sexes,…
Study Explores Role of Wnt Signaling Pathway in Gastric Cells
Article title: Differential sensitivity to Wnt signaling gradients in human gastric organoids derived from corpus and antrum Authors: Kevin P. McGowan, Elizabeth Delgado, Elise S. Hibdon, Linda C. Samuelson From the authors: “[Our] study highlights the key role Wnt signaling…
Excess Testosterone Can Lead to Increased Cardiovascular Risks in People with Polycystic Ovary Syndrome
Article title: Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome Authors: Tori Stone, Licy L. Yanes Cardozo, Toni N. Oluwatade, Cheryl A. Leone, Melanie Burgos, Faith Okifo, Lubna Pal, Jane F. Reckelhoff, Nina. S. Stachenfeld From…
Food Temperature Linked to Taste Bud Nerve Activity
Article title: Effects of temperature on action potentials and ion conductances in type II taste-bud cells Authors: Zhongming Ma, Usha Paudel, J. Kevin Foskett From the authors: “Here we show that the electrical activity of type II taste-bud cells that…
Enzyme in T Cells Worsens Salt-sensitive Hypertension and Related Kidney Damage
Article title: Functional NADPH oxidase 2 (NOX2) in T cells amplifies salt-sensitive hypertension and associated renal damage Authors: Samuel D. Walton, John Henry Dasinger, Emily C. Burns, Mary Cherian-Shaw, Justine M. Abais-Battad, David L. Mattson From the authors: “The results…
Researchers Use Raman Microspectroscopy to Learn about Cardiomyopathy Mechanisms
Article title: Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy Authors: Lucas Becker, Ivonne A. Montes-Mojarro, Shannon Lee Layland, Ali Nsair, Falko Fend, Julia Marzi, Katja Schenke-Layland From the authors: “In this study, we used…
APS Recognized with Marketing and Communications Awards
The American Physiological Society (APS) has been recognized with seven awards for excellence in the areas of marketing and communications. The awards were given by three different organizations and recognize a wide array of publications and marketing pieces.
“You (might) have cancer” – on certainty and probability
An LMU study reveals: Whether patients are able to correctly assess risks depends partly on how physicians convey statistical information to them.
Climate Change Threatens Military Readiness
The growing frequency and intensity of heat waves around the globe pose “a substantial, persistent ‘non-combat threat’” to military training and operations, according to experts in environmental, thermoregulatory and cardiovascular physiology.
Bicarbonate Promotes Potassium Chloride Cotransporter Expression in Kidney Cells
Article title: Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells Authors: Mohammed Z. Ferdaus, Andrew S. Terker, Rainelli Koumangoye, Susan M. Wall, Eric Delpire From the authors: “KCC3a expression is stimulated in alkalemia. This…
Blocking Signals from Receptor Involved in Fat Metabolism, Inflammation Improves Fatty Liver and Insulin Resistance in Mice
Article title: Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding Authors: Takuma Yasuda, Norio Harada, Tomonobu Hatoko, Atsuhiko Ichimura, Eri Ikeguchi-Ogura, Yuki Murata, Naoki Wada, Sakura Kiyobayashi, Shunsuke Yamane, Akira Hirasawa, Nobuya…
Researchers Explore Role of MicroRNA in Development of Muscle Cells
Article title: MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16 Authors: Seongkyun Lim, David Lee, Francielly Morena Da Silva, Pieter Koopmans, Ivan J. Vechetti Jr., Ferdinand von Walden, Nicholas P. Greene, Kevin A. Murach From…
Sex Differences in Fat Storage during Military Training Help Women Preserve Lean Mass
Article title: Sex differences in body composition and serum metabolome responses to sustained, physical training suggest enhanced fat oxidation in women compared with men Authors: Meaghan E. Beckner, Lauren Thompson, Patrick N. Radcliffe, Rebecca Cherian, Marques Wilson, Nicholas Barringer, Lee…
Researchers Find Age-related Differences in Lung Extracellular Matrix
Article title: Age-associated differences in the human lung extracellular matrix Authors: Maunick Lefin Koloko Ngassie, Maaike de Vries, Theo Borghuis, Wim Timens, Don D. Sin, David Nickle, Philippe Joubert, Peter Horvatovich, György Marko-Varga, Jacob J. Teske, Judith M. Vonk, Reinoud…
Gene Expression in Kidneys Is Regulated by the Microbiome in Sex- and Tissue-specific Ways
Article title: Commensal microbiota regulate renal gene expression in a sex-specific manner Authors: Brittni N. Moore and Jennifer L. Pluznick From the authors: “This report demonstrates that renal gene expression is modulated by the microbiome in a sex- and tissue-specific…