Researchers Identify Potential Target for Treating Autoimmune Diseases

New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.

Reversal of Heart Enlargement Differs in the Sexes; Doesn’t Use Universal Signaling Pathways

Article title: Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific Authors: Deanna L. Muehleman, Claudia Crocini, Alison R. Swearingen, Christopher D. Ozeroff, Leslie A. Leinwand From the authors: “This work highlights that the reversal of pathological hypertrophy…

Researchers ID Post-exercise Changes in MicroRNA as Potential Markers for Coronary Artery Disease

Article title: Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise Authors: Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen From the authors: “This exploratory study demonstrated six miRs associated with coronary necrotic…

Extracellular Vesicles in Lung Fluid May Point to Acute Respiratory Distress Syndrome Severity

Article title: CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome Authors: Rahul Y. Mahida, Joshua Price, Sebastian T. Lugg, Hui Li, Dhruv Parekh, Aaron Scott, Paul Harrison, Michael A. Matthay, David R.…

Study Explores Function and Characteristics of Enteric Nervous System Cells in Context of Injury

Article title: Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury Authors: Moritz Middelhoff, Giovanni Valenti, Lorenzo Tomassoni, Yosuke Ochiai, Bryana Belin, Ryota Takahashi, Ermanno Malagola, Henrik Nienhüser, Michael Finlayson, Yoku Hayakawa, Leah B. Zamechek,…

Calorie Count More Important than Nutrient Composition in Development of Obesity-related Kidney Disease

Article title: High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat Authors: Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton From the authors: “This work suggests that macronutrient…

Stress during Pregnancy May Lead to Heart Disease, Accelerated Aging in Next Generation

Prenatal stress can cause damage in the aorta in offspring, which may contribute to the development of atherosclerosis and accelerate aging, according to a new study in mice. The article is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

High Caffeine Consumption Disrupts Heart Rhythms in Middle-aged Rats

New research finds that excess caffeine is more likely to cause irregular heart rhythms in middle aged rats than in young adult rats. The study will be presented this week at the American Physiological Society annual meeting at Experimental Biology 2022 in Philadelphia.

A Prune—Or Six—a Day May Keep Inflammation at Bay

A study in postmenopausal people suggests eating nutrient-rich prunes every day may be beneficial to bone health, reducing inflammatory factors that contribute to osteoporosis. The research will be presented this week in Philadelphia at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2022.

Antioxidant, Inflammation Levels May Reveal New Diagnostic Tool for Breast Cancer

A new study that analyzes levels of antioxidants and stress markers in the blood could lead to a new diagnostic tool for breast cancer. The research will be presented this week in Philadelphia at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2022.

Blueberry Extract May Aid Wound Healing

Treating wounds with an extract taken from wild blueberries may improve healing, according to a new study. The research will be presented this week in Philadelphia at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2022.

E-cigarette Exposure during Pregnancy Changes Autophagy Signaling, Leads to Brain Defects in Rats

Article title: Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway Authors: Andrew Walayat, Yong Li, Yanyan Zhang, Yingjie Fu, Bailin Liu, Xuesi M. Shao, Lubo Zhang, Daliao Xiao From…

Metabolic Syndrome during Pregnancy Leads to Abnormal Development of Fat Tissue in Mouse Offspring

Article title: Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction Authors: Anna Mikolajczak, Nada A. Sallam, Radha D. Singh, Taylor B. Scheidl, Emma J. Walsh, Sebastian Larion, Carol Huang, Jennifer…

Study Is First to Examine Fibrocyte Levels in People Hospitalized with COVID-19 Pneumonia

Article title: Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia Authors: Mada Ghanem, Méline Homps-Legrand, Marc Garnier, Lise Morer, Tiphaine Goletto, Justine Frija-Masson, Paul-Henri Wicky, Pierre Jaquet, Catherine Bancal, Margarita Hurtado-Nedelec, Luc de Chaisemartin, Madeleine Jaillet, Arnaud…

Exercise May Correct Leakage of Blood-brain Barrier Caused by High Blood Pressure

Article title: Transcytosis within PVN capillaries: a mechanism determining both hypertension-induced blood-brain barrier dysfunction and exercise-induced correction Authors: Matheus Garcia Fragas, Vanessa Brito Cândido, Gustavo Gastão Davanzo, Carla Rocha-Santos, Alexandre Ceroni, Lisete C. Michelini From the authors: “The present set…

Previously Healthy Young Adults with ‘Long COVID’ Show Vascular Dysfunction in Limbs, but Not Brain

A first-of-its-kind study of young adults with positive COVID-19 tests from more than 4 weeks ago found that those who were still symptomatic (i.e., long-haulers) had impaired blood vessel function in their limbs, but not brains. Asymptotic participants had blood vessel function similar to controls.

Protein Inhibitor May Lead to New Treatment for Low Oxygen Associated with Sleep Apnea

Article title: Lysine demethylase KDM6B regulates HIF-1α mediated systemic and cellular responses to intermittent hypoxia Authors: Jayasri Nanduri, Ning Wang, Benjamin L. Wang, Nanduri R. Prabhakar From the authors: “[The] current study demonstrates that pharmacological disruption of [Hypoxia-inducible factor]-1α activation…

Exercise May Not Offset Genetic Predisposition for Low Exercise Capacity, Impaired Insulin Sensitivity

Article title: Genetically determined exercise capacity affects systemic glucose response to insulin in rats Authors: Michael Schwarzer, Annika Molis, Christina Schenkl, Andrea Schrepper, Steven L. Britton, Lauren Gerard Koch, Torsten Doenst From the authors: “In our model of [high capacity…

Frequent Breaks from Sitting May Improve Daily Blood Sugar Fluctuations

Frequent activity breaks from sitting may improve fasting blood sugar (glucose) levels and stabilize daily fluctuations, according to new research. The study, the first of its length to explore the effects of activity breaks in “free-living” conditions, is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism. It was chosen as an APSselect article for August.

New UK Study Offers Insight on How Resistance Training Burns Fat

Findings from a new University of Kentucky College of Medicine and College of Health Sciences study add to growing evidence that resistance exercise has unique benefits for fat loss.

The Department of Physiology and Center for Muscle Biology study published in the FASEB Journal found that resistance-like exercise regulates fat cell metabolism at a molecular level.