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UrduArticle title: Differential sensitivity to Wnt signaling gradients in human gastric organoids derived from corpus and antrum Authors: Kevin P. McGowan, Elizabeth Delgado, Elise S. Hibdon, Linda C. Samuelson From the authors: “[Our] study highlights the key role Wnt signaling…
Tag: Gastrointestinal Physiology
Post-injury Intestinal Regeneration Enhanced by Calorie Restriction, Requires Autophagy
Article title: Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction Authors: Patrick A. Williams, Kaitlyn E. Naughton, Lauren A. Simon, Gloria E. Soto, Louis R. Parham, Xianghui Ma, Charles H. Danan, Weiming Hu, Elliot S. Friedman,…
Researchers Examine Dynamics of C. Difficile Toxins and How Leaky Gut Affects Toxicity
Article title: A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure Authors: Meryem T. Ok, Jintong Liu, R. Jarrett Bliton, Caroline M. Hinesley, Ekaterina Ellyce T. San Pedro, Keith A. Breau, Ismael Gomez-Martinez, Joseph…
Researchers ID Protein Involved in Regulating Gastrointestinal Function
Article title: Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse Authors: Crystal Woods, Amanda R. Flockton, Laurie E. Wallace, Catherine M. Keenan, Wendy B. Macklin, Keith A. Sharkey, Jaime Belkind-Gerson From…
New Research on Neuronal Response to Calcium Imaging Aid Interpretation of Data without Electrophysiology Recordings
Article title: Simultaneous whole-cell patch-clamp and calcium imaging on myenteric neurons Authors: Zhiling Li, Werend Boesmans, Youcef Kazwiny, Marlene M. Hao, Pieter Vanden Berghe From the authors: “Our findings will help in the interpretation of calcium imaging data without the…
Absence of Protein Signaling Pathway in Mice Is Associated with Defects in Intestinal Tissue Development
Article title: Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa Authors: Stamatia Papoutsopoulou, Joseph Tang, Ahmed H. Elramli, Jonathan M. Williams, Nitika Gupta, Felix I. Ikuomola, Raheleh Sheibani-Tezerji, Mohammad T. Alam, Juan…
Intestinal Abnormalities in People with Posttraumatic Stress Disorder Don’t Improve Even When PTSD Symptoms Abate
Article title: Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms Authors: Robin M. Voigt, Alyson K. Zalta, Shohreh Raeisi, Lijuan Zhang, J. Mark Brown, Christopher B. Forsyth, Randy A. Boley, Philip Held, Mark…
Researchers Use Human Intestine, Liver Stem-cell Cultures to Explore Bile Signaling
Article title: Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation Authors: Sarah Elizabeth Blutt, Sue Crawford, Carolyn Bomidi, Xi-Lei Zeng, James Broughman, Matthew Robertson, Cristian Coarfa, Mary Elizabeth Tessier, Tor C. Savidge, F. Blaine Hollinger, Steven…
Chronic Alcohol Consumption Inhibits Intestinal Absorption of Vitamin B7, May Lead to Deficiency
Article title: Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites Authors: Kalidas Ramamoorthy, Subrata Sabui, Padmanabhan Srinivasan, Saleh Al-Juburi, Quang Pham, Brian D. Chu, Rita D. Simoes, James M.…
Gut Protein + ACE2 Form Functional Unit, Explains COVID-19 Gastrointestinal Symptoms
Research published ahead of print in the journal Function suggests the relationship between angiotensin converting enzyme 2 (ACE2) and the sodium-dependent neutral amino acid transporter B(0)AT1, a protein found in the intestines, form a physiological “functional unit.” ACE2, an enzyme…
IL-28 Cytokine’s Epithelial Barrier Regulation May Lead to Targeted Treatment for Crohn’s Disease
Article title: Interleukin-28A induces epithelial barrier dysfunction in [Crohn’s disease] patient-derived intestinal organoids Authors: Pan Xu, Heike Becker, Montserrat Elizalde, Marieke Pierik, Ad A.M. Masclee, Daisy M.A.E. Jonkers From the authors: “These results identified IL-28A as a novel regulator of…
Researchers ID New Mechanism to Promote Healing of Digestive System’s Mucus Barrier
Article title: Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function Authors: Bridie Jane Goggins, Kyra Minahan, Simonne Sherwin, Wai S. Soh, Jennifer Pryor, Jessica Bruce, Gang Liu, Andrea Mathe, Darryl A. Knight, Jay C.…