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UrduResearchers from UC San Diego have discovered the biochemical workings of an old-fashioned diabetes drug, and it’s helping them develop new, safer alternatives.
Tag: Insulin Resistance
Heavy Alcohol Use May Increase Type 2 Diabetes Risk in Middle-aged Adults
Heavy alcohol use may increase middle-aged adults’ risk of developing Type 2 diabetes, according to research to be presented this week at the American Physiology Summit in Long Beach, California. The Summit is the flagship annual meeting of the American Physiological Society (APS).
Insulin resistance in shift workers not affected by melatonin treatment
Melatonin treatment does not affect the insulin resistance or the glucose tolerance of night shift workers, according to a new study from the University of Surrey and the University Medical Centre Hamburg. Melatonin treatment does, however, significantly improve the sleep quality of those working shifts.
Disrupted cellular function behind type 2 diabetes in obesity
Disrupted function of “cleaning cells” in the body may help to explain why some people with obesity develop type 2 diabetes, while others do not.
Van Andel Institute scientist awarded $2.9 million to tackle insulin resistance, a driver of Type 2 diabetes
Nick Burton, Ph.D., has earned a five-year, nearly $2.9 million New Innovator Award from the National Institutes of Health Common Fund to find new ways to fix or prevent insulin resistance, a key driver of Type 2 diabetes.
For Type 2 Diabetics Who Exercise, Some Approaches Are Better Than Others
An analysis on the positive effects of exercise on blood sugar levels in people with Type 2 diabetes shows that while all exercise helps, certain activities – and their timing – are extremely good for people’s health. The study, published in The American Journal of Medicine, provides a comprehensive but straightforward summary of the benefits of exercise on controlling blood glucose levels in people with Type 2 diabetes.
Blocking Signals from Receptor Involved in Fat Metabolism, Inflammation Improves Fatty Liver and Insulin Resistance in Mice
Article title: Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding Authors: Takuma Yasuda, Norio Harada, Tomonobu Hatoko, Atsuhiko Ichimura, Eri Ikeguchi-Ogura, Yuki Murata, Naoki Wada, Sakura Kiyobayashi, Shunsuke Yamane, Akira Hirasawa, Nobuya…
Women with Obesity and Type 2 Diabetes May Improve Vascular Insulin Resistance through Weight Loss
Article title: Impact of sex and diet-induced weight loss on vascular insulin sensitivity in type 2 diabetes Authors: Camila Manrique-Acevedo, Rogerio Nogueira Soares, James A. Smith, Lauren K. Park, Katherine Burr, Francisco I. Ramirez-Perez, Neil J. McMillan, Larissa Ferreira-Santos, Neekun…
Study reveals obesity-related trigger that can lead to diabetes
Researchers at Washington University School of Medicine in St. Louis have found that a defect in an enzyme called APT1 interferes with the ability to secrete insulin, contributing to the development of Type 2 diabetes in people who are overweight or obese.
CUVET Successfully Developed the First Stem Cell Transplantation Technology to Treat Pet Diabetes
For the first time in Thailand, a research team from Chula’s Faculty of Veterinary Science (CUVET) is the first to have successfully developed a method to culture dog pancreatic cells from stem cells and cell transplantation technology. They aim to test the method in the lab and sick animals suffering from diabetes.
Long term high-fat diet expands waistline and shrinks brain
New research led by the University of South Australia shows that fatty foods may not only be adding to your waistline but also aggravating Alzheimer’s disease, and causing depression and anxiety.
Insulin resistance pinned to cell signaling defects that could act as therapy targets
Insulin resistance in the general population seems likely to be caused by a series of cell-specific signaling defects some of which appear to be sex-specific. In addition, only a portion of the defects are shared with those seen in diabetes, pointing towards the existence of novel pathways behind insulin resistance in the general population. According to researchers, this could also be the starting point for new therapeutics to tackle insulin resistance, which is the major driver of type 2 diabetes and metabolic syndrome and is present in 20-30% of the general population in the United States.
Researchers find that blocking a protein in liver cells protects against insulin resistance and fatty liver disease
A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice. ABCB10 activity also prompted insulin resistance in human liver cells.
Heat Treatment Improves Glucose Intolerance, Insulin Resistance and Fatty Liver
Rockville, Md. (January 28, 2021)—New research shows chronic heat treatment (HT) mitigates glucose intolerance, insulin resistance and non-acholic fatty liver disease—also referred to as hepatic steatosis—in rodent models of obesity. There is currently no cure for fatty liver disease, the…
Break Up Your Work Day with Healthy Stair Climbing Exercise Snacks
Sitting for long periods is known to have negative effects on metabolic and cardiovascular health. Building on recent work showing that brief bouts of vigorous exercise (exercise “snacks”) can improve fitness, investigators from the University of British Columbia in Canada…
Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel ‘disease-in-a-dish’ model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.
Researchers discover sex-specific differences in neural mechanisms for glucose regulation
Researchers from Tufts have discovered neural mechanisms in mice specific to females that switch estrogen from playing a protective role in glucose metabolism to a disruptive role. The discovery could provide clues to the increased risk of insulin resistance and diabetes among post-menopausal women.
Study Explores Statins’ Role in Insulin Resistance
Article title: Statins activate the NLRP3 inflammasome and impair insulin signalling via p38 and mTOR Authors: Brandyn D. Henriksbo, Akhilesh K. Tamrakar, Jobanjit S. Phulka, Nicole G. Barra, Jonathan D. Schertzer From the authors: “We propose that dysregulated [mammalian target of rapamycin]…
Insulin Resistance Contributes to Racial Disparities in Breast Cancer Prognosis in U.S. Women, Mount Sinai Researchers Reveal
New study identifies that differences in insulin resistance can explain in part the disparities in breast cancer survival between black and white women