Insulin resistance pinned to cell signaling defects that could act as therapy targets

Insulin resistance in the general population seems likely to be caused by a series of cell-specific signaling defects some of which appear to be sex-specific. In addition, only a portion of the defects are shared with those seen in diabetes, pointing towards the existence of novel pathways behind insulin resistance in the general population. According to researchers, this could also be the starting point for new therapeutics to tackle insulin resistance, which is the major driver of type 2 diabetes and metabolic syndrome and is present in 20-30% of the general population in the United States.

Researchers find that blocking a protein in liver cells protects against insulin resistance and fatty liver disease

A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice. ABCB10 activity also prompted insulin resistance in human liver cells.

Break Up Your Work Day with Healthy Stair Climbing Exercise Snacks

Sitting for long periods is known to have negative effects on metabolic and cardiovascular health. Building on recent work showing that brief bouts of vigorous exercise (exercise “snacks”) can improve fitness, investigators from the University of British Columbia in Canada…

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes

Researchers have developed a novel ‘disease-in-a-dish’ model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Insulin Resistance Contributes to Racial Disparities in Breast Cancer Prognosis in U.S. Women, Mount Sinai Researchers Reveal

New study identifies that differences in insulin resistance can explain in part the disparities in breast cancer survival between black and white women