UIC research identifies potential pathways to treating alcohol use disorder, depression

A discovery from researchers at the University of Illinois Chicago may lead to new treatments for individuals who suffer from alcohol use disorder and depression. The study, “Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure,” is published in the journal Translational Psychiatry by researchers at UIC’s Center for Alcohol Research in Epigenetics.

Mount Sinai identifies the causes of racial disparity in prostate cancer in a multi-institutional study

MEDIA ADVISORY Senior Author:  Ash Tewari, MBBS, MCh, Professor and System Chairman of the Milton and Carroll Petrie Department of Urology at the Icahn School of Medicine at Mount Sinai and Director of the Center of Excellence for Prostate Cancer…

Mount Sinai Researchers Identify Mechanisms That Are Essential for Proper Skin Development

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.

Biochemistry researcher receives National Science Foundation Award

The five-year, $680,500 NSF Faculty Early Career Development Program award will be utilized to gain a better understanding of how improper DNA replication and compaction can cause changes in gene expression in offspring while creating a comprehensive learning environment for aspiring high school-aged and undergraduate scientists who will have significant roles in the research.

Biologists Create “Atlas” of Gene Expression in Neurons, Documenting the Diversity of Brain Cells

New York University researchers have created a “developmental atlas” of gene expression in neurons, using gene sequencing and machine learning to categorize more than 250,000 neurons in the brains of fruit flies. Their study, published in Nature, finds that neurons exhibit the most molecular diversity during development and reveals a previously unknown type of neurons only present before flies hatch.

Faculty Receives Grant to Develop Method That Will Integrate Biomedical Gene Expression Data

Rutgers School of Public Health assistant professor, Wei (Vivian) Li, has received a Busch Biomedical Grant to develop a statistical method and software package that will integrate single-cell level gene expression data from multiple patients, studies, and technological platforms to understand disease-associated cell types and RNA contents, helping researchers develop personalized treatments.

September Edition of SLAS Discovery Highlights “Applications of Functional Genomics for Drug Discovery”

September’s edition of SLAS Discovery features the cover article, “Applications of Functional Genomics for Drug Discovery” by Ami M. Kabadi, Ph.D., (Element Genomics), Eoin McDonnell, Ph.D. (Element Genomics), Christopher L. Frank, Ph.D., (Element Genomics), and Lauren Drowley, Ph.D., (UCB Biosciences). The article reviews how functional genomic tools are better able to understand the biological interplay between genes, improving disease modeling and identifying novel drug targets.

The Gut Microbiome, CRISPR/Cas-9, and More Featured in August 2020 Toxicological Sciences

The August 2020 issue of Toxicological Sciences includes exciting advances in toxicology research. The edition features pieces on biotransformation, toxicokinetics, and pharmacokinetics; developmental and reproductive toxicology; and more.

Silencing Expression of Specific Gene Variants May Provide Insight for Treatment of Mutation-associated Cardiomyopathy

Article title: Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes Authors: Alexandra Dainis, Kathia Zaleta-Rivera, Alexandre Ribeiro, Andrew Chia Hao Chang, Ching Shang, Feng Lan, Paul W. Burridge, W. Robert Liu, Joseph C. Wu, Alex Chia Yu Chang, Beth…

Some types of prostate cancer may not be as aggressive as originally thought

Researchers at the UCLA Jonsson Comprehensive Cancer Center analyzed gene-expression patterns in the most aggressive prostate cancer grade group — known as Gleason grade group 5 — and found that this grade of cancer can actually be subdivided into four subtypes with distinct differences. The findings may affect how people are treated for the disease.

Stress during Pregnancy May Negatively Affect Baby’s Muscles

Research in sheep suggests that high levels of a stress hormone during pregnancy may alter gene expression in multiple muscle groups of offspring. These shifts may affect heart, breathing and skeletal muscle function, and could potentially increase risks of inflammation and infection. The study is published ahead of print in Physiological Genomics.

Surprise discovery shakes up our understanding of gene expression

A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality. Rather than directions going one-way from DNA to RNA to proteins, the latest study shows that RNA itself modulates how DNA is transcribed—using a chemical process that is increasingly apparent to be vital to biology. The discovery has significant implications for our understanding of human disease and drug design.

A Snapshot in Time: Study Captures Fleeting Cell Differences That Can Alter Disease Risk

In cinema and science fiction, one small change in the past can have major, sometimes life-changing effects in the future. Using a series of snapshots, researchers recently captured such so-called “butterfly effects” in heart muscle cell development, and say this…