New Articles on Using Machine Learning to Predict Mammalian Acute Oral Toxicity and the Effects of Vinyl Chloride on Metabolism

The May 2023 issue of Toxicological Sciences includes articles on profiling mechanisms that drive acute oral toxicity in mammals and its prediction via machine learning and how vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction.

Exploring How Diethylene Glycol Poisons the Kidney and the Combined Effects of St. John’s Wort and Acetaminophen on the Liver

A ToxSpotlight article in the November 2022 issue of ToxSci assesses the mechanism for cellular accumulation of diglycolic acid while another explores the effect of long-term St. John’s wort administration on acetaminophen-induced acute hepatotoxicity and the involved mechanisms.

A Need to Consistently Characterize Aerosol Research Associated with E-cigarettes Is Featured in New Issue of ToxSci

Other featured research in October 2022 issue involves an exploration of a pharmacokinetic model for quantifying the mother-to-child transfer of environmental chemicals and how febuxostat may increase the risk for cardiovascular events by dysregulating calcium dynamics.

The Effects of Copper, Patient-Relevant Tissue Models, and Artificial Intelligence Featured in Sept. 2022 Issue of ToxSci

A new ToxPoint articles argues that “Copper Is the New Showstopper,” while a commentary calls for patient-relevant tissue models in the September 2022 issue of Toxicological Sciences (ToxSci), the official journal of the Society of Toxicology (SOT). Other featured articles…

May 2022 Toxicological Sciences Features Leading Research in Respiratory Hazards, Proteomics, and More

The May 2022 issue of Toxicological Sciences, the Society of Toxicology’s official journal, is now available and features leading research in carcinogenesis, computational toxicology and databases, and more.

Pituitary Reproductive Regulatory Factors, Mercury Levels, and More Featured in November 2021 Toxicological Sciences

In the November 2021 issue, Toxicological Science features leading toxicology research in areas such as biomarkers, carcinogenesis, and environmental toxicology.

Drug-Induced Liver Injury, Prenatal Developmental Toxicity, and More Featured in September 2021 Toxicological Sciences

The September 2021 issue of Toxicological Sciences contains leading toxicological research, exploring nanotoxicology, neurotoxicology, immunotoxicology, and more.

Spontaneous Mammary Neoplasia, Cannabidiol Exposure, Aryl Hydrocarbon Receptors, and More Featured in July 2021 Toxicological Sciences

Toxicological Sciences delivers the latest toxicology research in the July 2021 issue. The issue features investigations in delivers the latest toxicology research in areas such as exposure to delta-9-tetrahydrocannabinol and cannabidiol, effects of ENDS vapors on amino acid metabolism, and more.

Metal Contamination, Gene Signatures, Bisphenol F, and More Featured in June 2021 Toxicological Sciences

Toxicological Sciences delivers the latest research in toxicology, in areas such as clinical and translational toxicology; emerging technologies, methods, and models; and environmental toxicology.

Deciphering Gene-Environment Interactions in Parkinson’s Disease

The interaction between an individual’s genetics and their local environment plays a critical role in an individual’s likelihood of getting Parkinson’s disease. In this perspective, researchers highlight how a common fly could be used to better understand the complex interactions…

Epitranscriptomics, Xenobiotic Nuclear Receptors, Arsenic Exposure, and More Featured in May 2021 Toxicological Sciences

Research on biomarkers, carcinogenesis, regulatory science, and more is available in the latest issue of Toxicological Sciences.

Bisphenol A, Metabolic Profiling, and More Featured in April 2021 Toxicological Sciences

Toxicological Sciences features leading research in toxicology in the April 2021issue, including on the topics of organ-specific toxicology as well as regulatory science, risk assessment, and decision-making.

Health Disparities and COVID-19, Toxicity of E-cigarette Generated Aerosols, and More Featured in February 2021 Toxicological Sciences

Toxicological Sciences continues to feature leading toxicology research in the areas of developmental and reproductive toxicology; endocrine toxicology; neurotoxicology; molecular, biochemical, and systems toxicology; and more.

Drug-Induced Liver Injury, Translational microRNA Biomarkers, and More Featured in January 2021 Toxicological Sciences

in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.

Multiomics, Gentational Cd Exposure, Estrogen Receptor Transactivation, and More Featured in December 2020 Toxicological Sciences

The December 2020 issue of the Society of Toxicology’s official journal, Toxicological Sciences, delivers cutting-edge toxicological research in endocrine toxicology, environmental toxicology, organ-specific toxicology, and more.

Agricultural Toxicity, Hepatic Effects of Phenobarbital, and More Featured in October 2020 Toxicological Sciences

Toxicological Sciences features leading research biotransformation, toxicokinetics, and pharmacokinetics; computational toxicology and databases; mixtures toxicology; and more in the October 2020 issue.

Smoke Chemistry, In Vitro Cytotoxicity, and Genotoxicity Demonstrate Enhanced Toxicity of Cigarillos Compared to Cigarettes

This study found that there is significantly greater toxicity in the tested US-marketed cigarillos than cigarettes for tobacco constituent levels, cytotoxicity, and genotoxicity. These findings are important, not only for improved understanding of the toxicity from the use of cigarillos…

T Cell Therapy, Gut Microbiome, Tumorigenicity, and More Featured in September 2020 Toxicological Sciences

Toxicological Sciences features leading research in toxicology in the areas of biomarkers, environmental toxicology, and more in the September 2020 issue.

The Gut Microbiome, CRISPR/Cas-9, and More Featured in August 2020 Toxicological Sciences

The August 2020 issue of Toxicological Sciences includes exciting advances in toxicology research. The edition features pieces on biotransformation, toxicokinetics, and pharmacokinetics; developmental and reproductive toxicology; and more.

Early Life Exposure to Nicotine: Postnatal Neurobehavioral and Metabolic Outcomes and the Development of Childhood Cancers

Animal studies suggest that nicotine may be a key chemical responsible for long-term effects associated with maternal cigarette smoking and increased risk of adverse health consequences in the offspring. However, postnatal outcomes of nicotine exposure from maternal use of e-cigarettes…

Next-Generation Risk Assessment, Antimicrobials, and More Featured in July 2020 Toxicological Sciences

Published in this month’s edition of Toxicological Sciences are articles on biotransformation, toxicokinetics, and pharmacokinetics; developmental and reproductive toxicology; nanotoxicology; and more.

Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences

During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.

Read-Across of Chemical Hepatotoxicants; Exposure-Based Cholinergic Synaptic Functional Deficits; and More Featured in April 2020 Toxicological Sciences

The April 2020 issue of the Society of Toxicology’s official journal, Toxicological Sciences, features leading research in toxicology, including several manuscripts covering emerging technologies, methods, and models.

Vinyl Chloride, Nerve Growth Factor, Chemical Warfare, and More Examined in March 2020 Toxicological Sciences

The March 2020 issue of Toxicological Sciences features leading research in toxicology, covering investigations in biotransformation, toxicokinetics, and pharmacokinetics in addition to work in exposure sciences and environmental toxicology.

Serum Biomarkers, Metabolite Indicators for Kidney Toxicity, Estrogenic Compound Screening, and More Featured in February 2020 Toxicological Sciences

The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.

Tissue-Engineering, Estrogenic Chemical–Induced Responses, and Life-Stage Physiologically Based Pharmacokinetic Modeling Featured in January 2020 Toxicological Sciences

In addition to research exploring such areas as biomarkers, nano- and neurotoxicology, and developmental and reproductive toxicology, the January 2020 issue of Toxicological Sciences features a new article category, ToxPoint, to underscore cutting-edge topics in toxicology.

Articles on Chronic Hexavalent Chromium Exposure, Titanium Dioxide Nanoparticles, and Bisphenol A Featured in December 2019 Toxicological Sciences

The December 2019 issue of Toxicological Sciences features research on the leading edge of toxicology, including in the areas of carcinogenesis, developmental and reproductive toxicology, and more.

Cyp2F2-Mediated Lung Cancer, Rapid Risk Assessment of Color Additives, and More Featured in November 2019 Toxicological Sciences

Toxicological Sciences continues to deliver cutting-edge research in toxicology in the November 2019 issue. This issue features research on computational toxicology and databases, developmental and reproductive toxicology, and more.

Mechanisms of Chronic Fialuridine Hepatotoxicity; Comparison of Models for Predicting Cardiotoxicity in Humans; and More Featured in October 2019 Toxicological Sciences

Papers on the epigenetic changes to mouse livers induced by a specific ligand and prenatal dexamethasone exposure-induced alterations in neurobehavior in female rat offspring are featured in latest issue of Toxicological Sciences.