Researchers Find Immune Component to Rare Neurodegenerative Disease

UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition known as Niemann-Pick disease type C. The finding, made in mouse models and published online in Nature, could offer a powerful new therapeutic target for Niemann-Pick disease type C, a condition that was identified more than a century ago but still lacks effective treatments.

Engineered Neural Networks Help ID Responses Associated with Abnormalities in Parkinson’s Disease

Article title: Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks Authors: Vibeke D. Valderhaug, Kristine Heiney, Ola Huse Ramstad, Geir Bråthen, Wei-Li Kuan, Stefano Nichele, Axel Sandvig, Ioanna Sandvig From the authors: “In this study, we investigate the…

Deciphering Gene-Environment Interactions in Parkinson’s Disease

The interaction between an individual’s genetics and their local environment plays a critical role in an individual’s likelihood of getting Parkinson’s disease. In this perspective, researchers highlight how a common fly could be used to better understand the complex interactions…

Research Highlights from 2021 ACSM Virtual Annual Meeting: Exercise in Regenerative Medicine

The 2021 Virtual ACSM Basic Science World Congress focuses on regenerative medicine. Chaired by Marcas M. Bamman, Ph.D., FACSM, from the University of Alabama at Birmingham, this world congress brings together researchers to discuss cutting-edge science in this rapidly developing field.

The Novel Role of Microglia as Modulators of Neurons in the Brain Is Discovered by Mount Sinai Researchers

Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease

World’s First ‘Pathoconnectome’ Could Point Toward New Treatments for Neurodegenerative Diseases

Scientists from the John A. Moran Eye Center at the University of Utah have achieved another first in the field of connectomics, which studies the synaptic connections between neurons. The National Institutes of Health (NIH)-funded lab has produced the first pathoconnectome, showing how eye disease alters retinal circuitry.

Concussion discovery reveals dire, unknown effects of even mild brain injury

Even mild concussions cause severe and long-lasting impairments in the brain’s ability to clean itself, and this may seed it for Alzheimer’s, dementia and other neurodegenerative problems.

Researchers discover how cells clear misfolded proteins from tissues

Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published February 18 in the Journal of Cell Biology, finds that the Clusterin protein and heparan sulfate proteoglycans combine to bring misfolded proteins into cells for degradation. The findings may lead to new therapeutic targets for neurodegenerative disorders, including Alzheimer’s disease.