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UrduUsing a sophisticated brain-imaging system, neuroscientists at Johns Hopkins Medicine say they have successfully reactivated a specific memory circuit in mice, causing them to seek out shelter when no shelter is actually present.
Tag: Neurodegenerative Disease
Penny for Your Thoughts? Master Copper Regulator Discovery May Offer Alzheimer’s Clues
A groundbreaking study using a tiny roundworm could pave the way for new treatments for neurodegenerative disorders. Researchers have linked the worm gene swip-10 to copper regulation – a vital element for brain health found in everyday items like wiring and cookware. Understanding the roles of swip-10 and MBLAC1, a protein involved in processing cellular materials, could lead to the development of effective medications and opens new avenues for advancing brain disease treatments.
New technology allows researchers to precisely, flexibly modulate brain
Researchers at Washington University in St. Louis have developed a noninvasive technology combining a holographic acoustic device with genetic engineering that allows them to precisely target affected neurons in the brain, creating the potential to precisely modulate selected cell types in multiple diseased brain regions.
Sniffing our way to better health
Imagine if we could inhale scents that delay the onset of cancer, inflammation, or neurodegenerative disease. Researchers at the University of California, Riverside, are poised to bring this futuristic technology closer to reality.
Better together: Beckman imaging facilities share $3M Alzheimer’s research grant
Beckman researchers and collaborators received $3 million from the U.S. National Institute on Aging to develop diagnostic tools and imaging agents for the early detection of Alzheimer’s disease.
These Foods Can Help You Live Longer and Protect the Planet
Eating more planet-friendly foods could help you live a longer, healthier life, according to new research.
Lewy body disease can be detected before symptoms
Lewy body disease is the second most common neurodegenerative disease after Alzheimer’s disease. A research group from Lund University has now shown that the disease can be detected before symptoms appear, using a spinal fluid test.
Faster progression of multiple sclerosis associated with newly identified genetic variant
In a new study of more than 22,000 people with multiple sclerosis (MS), an international team identified for the first time a genetic variant associated with faster progression of the disease and accumulation of disability. Despite the development of effective…
Novel genetic scoring system helps determine ALS disease risk
A newly created polygenic scoring system — one that weighs the combined effects of common genetic variants — can improve the ability to predict an individual’s risk of developing ALS, a study shows.
Mount Sinai Scientists Awarded Grant from Chan Zuckerberg Initiative to Advance Understanding and Therapeutics for Rare Blood Vessel Disease
Physician-scientist Fanny Elahi, MD, PhD, to lead research team in collaboration with non-profit organization
Parkinson’s Disease: Uncovering Why Nicotine May Be Protective (for Some)
Parkinson’s disease is caused by a combination of genetic and environmental factors, one curious example being that people who smoke appear to be less likely to develop Parkinson’s. This may be due to interactions between nicotine and genetic variations in…
Multiple System Atrophy: Identifying Cells that Accelerate Disease Progression
There is currently no cure for the rare neurodegenerative disorder multiple system atrophy (MSA), and its rarity has made it difficult to understand how the disease progresses. Now a research team has created a successful mouse model of aggressive cerebellar-type…
Aerobic Exercise May Help More than Balance Training to Hold Off Symptoms of Cerebellar Ataxia
Currently, no medications exist to combat spinocerebellar ataxias, debilitating neurodegenerative diseases that cause loss of balance and coordination. Physicians recommend balance training to improve symptoms, but a new study suggests that rigorous aerobic exercise may provide greater benefit for adults…
Study Finds Untreated Sleep Apnea May Increase Risk for Neurodegenerative Disease, PAP Therapies Crucial in Treating the Sleep Condition
Mount Sinai researchers have conducted one of the first studies to show the acute effect of obstructive sleep apnea on Alzheimer’s disease biomarkers, and the ability to even measure Alzheimer’s disease biomarkers from blood.
Gold Ribbon Not Necessary—Healthy Brain and Body Function Are the Rewards in This Game
As human lifespans increase, new societal challenges arise. In a “superaging society,” in which young people are few and older people are many, caring for the older adult population adequately with limited resources is a difficult balancing act to perform.
Studies Point to Role of Lifestyle Factors in Alzheimer’s Risk and Disparities
Two new studies offer insights into the factors that may contribute to the disproportionate burden of dementia in non-White and low-income U.S. populations.
New Study Provides Structural Insights into How Cholesterol in the Brain Regulates Ion Channels and Alters Their Function; Findings Could Facilitate the Development of Therapeutics for Neurological Diseases
UNDER EMBARGO UNTIL 11am EST on August 24: Cell Reports Senior Author: Paul A. Slesinger, PhD, Lillian and Henry M. Stratton Professor of Neuroscience and Director of the Center for Neurotechnology and Behavior, Icahn School of Medicine at Mount Sinai,…
Researchers Find Immune Component to Rare Neurodegenerative Disease
UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition known as Niemann-Pick disease type C. The finding, made in mouse models and published online in Nature, could offer a powerful new therapeutic target for Niemann-Pick disease type C, a condition that was identified more than a century ago but still lacks effective treatments.
Engineered Neural Networks Help ID Responses Associated with Abnormalities in Parkinson’s Disease
Article title: Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks Authors: Vibeke D. Valderhaug, Kristine Heiney, Ola Huse Ramstad, Geir Bråthen, Wei-Li Kuan, Stefano Nichele, Axel Sandvig, Ioanna Sandvig From the authors: “In this study, we investigate the…
Deciphering Gene-Environment Interactions in Parkinson’s Disease
The interaction between an individual’s genetics and their local environment plays a critical role in an individual’s likelihood of getting Parkinson’s disease. In this perspective, researchers highlight how a common fly could be used to better understand the complex interactions…
Research Highlights from 2021 ACSM Virtual Annual Meeting: Exercise in Regenerative Medicine
The 2021 Virtual ACSM Basic Science World Congress focuses on regenerative medicine. Chaired by Marcas M. Bamman, Ph.D., FACSM, from the University of Alabama at Birmingham, this world congress brings together researchers to discuss cutting-edge science in this rapidly developing field.
A Cheap, Potent Pathway to Pandemic Therapeutics
By capitalizing on a convergence of chemical, biological and artificial intelligence advances, scientists have developed an unusually fast and efficient method for discovering tiny antibody fragments with big potential for development into therapeutics against deadly diseases.
Researchers Discover Clue to How to Protect Neurons and Encourage Their Growth
Researchers have identified a family of enzymes whose inhibition both protects neurons and encourages their growth, a pathway to potential new treatments for neurodegenerative diseases from Alzheimer’s to glaucoma.
The Novel Role of Microglia as Modulators of Neurons in the Brain Is Discovered by Mount Sinai Researchers
Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease
World’s First ‘Pathoconnectome’ Could Point Toward New Treatments for Neurodegenerative Diseases
Scientists from the John A. Moran Eye Center at the University of Utah have achieved another first in the field of connectomics, which studies the synaptic connections between neurons. The National Institutes of Health (NIH)-funded lab has produced the first pathoconnectome, showing how eye disease alters retinal circuitry.
Concussion discovery reveals dire, unknown effects of even mild brain injury
Even mild concussions cause severe and long-lasting impairments in the brain’s ability to clean itself, and this may seed it for Alzheimer’s, dementia and other neurodegenerative problems.
Researchers discover how cells clear misfolded proteins from tissues
Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published February 18 in the Journal of Cell Biology, finds that the Clusterin protein and heparan sulfate proteoglycans combine to bring misfolded proteins into cells for degradation. The findings may lead to new therapeutic targets for neurodegenerative disorders, including Alzheimer’s disease.