CNIO researchers explain the toxicity of USP7 inhibitors, under development for cancer treatment
Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate
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CityU biologists discover super-enhancers that switch on breast cancer genes
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high fatality rate. Currently, chemotherapy is the
Read moreResearchers demonstrate very high specificity of prime editors in plants
Prime editing (PE), a “search-and-replace” CRISPR-based genome editing technique, has great potential for gene therapy and agriculture. It can introduce
Read moreJapanese-European research team discovers novel genetic mitochondrial disorder
Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families
Read moreAdam Guenzel, PhD is the recipient of the 2021 Richard King Trainee Award
Adam Guenzel, PhD receives the 2021 Richard King Award for Best Publication by a Trainee in Genetics in Medicine
Read moreScientists program microalgae’s ‘oil factory’ to produce various oils
By combining the ‘chassis’ of an oil-producing microalgae with genes from a Cuphea plant, scientists from the Single-Cell Center, Qingdao
Read moreSimple genetic modification aims to stop mosquitoes spreading malaria
Genetically modifying mosquitoes to express antimalarial genes and pass them on to their offspring is being tested as a new strategy to eliminate malaria
Read moreDNA structure itself is involved in genome regulation
DNA supercoiling is an important contributor to the control of gene expression, and not just collateral damage that cells have to solve
Read moreCNIO scientists discovers a combination therapy for aggressive brain tumors
Glioblastomas are the most common and most aggressive brain tumours. Their survival rate has barely increased over the last 50
Read moreFor tomato genes, one plus one doesn’t always make two
Both people and tomatoes come in different shapes and sizes. That is because every individual has a unique set of
Read moreHow to tame a restless genome
Short pieces of DNA–jumping genes–can bounce from one place to another in our genomes. When too many DNA fragments move
Read moreReversing a genetic cause of poor stress responses in mice
Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well
Read moreCarnegie Mellon/Yale PNA-based technique an essential part of the gene editing toolkit
In an article published in the April 8 issue of Nature , the National Institutes of Health’s Somatic Cell Gene
Read moreAn international study reveals how the ‘guardian’ of the genome works
The study is published in ‘Nature Structural & Molecular Biology’
Read moreNew perspective to understand and treat a rare calcification disease
Researchers developed a new animal model to study a rare genetic disease that can lead to blindness at the age of 40-50.
Read moreThirteen new Alzheimer’s genes identified in first-of-its-kind human genome study
In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer’s disease (AD), researchers have identified 13 such variants (or mutations).
Read moreScientists launch ‘herculean’ project creating atlas of human genome variants
SEATTLE (April 1, 2021) – An international consortium of geneticists, biologists, clinicians, mathematicians, and other scientists is determined to take
Read moreBringing gene editing into high schools
Toolkit easily incorporates into any laboratory science course
Read more$1.7 million grant to unlock barley’s genetic superpowers
Project to groom undergrads for agricultural science careers
Read morePrime editing enables precise gene editing without collateral damage
The latest gene editing technology, prime editing, expands the “genetic toolbox” for more precisely creating disease models and correcting genetic
Read moreUC consortium launches first clinical trial using CRISPR to correct sickle cell gene
Project uses Nobel-Prize-winning technology to directly correct sickle mutation in blood stem cells, addressing underlying cause of debilitating disorder
Read moreEveryone poops: Monitoring COVID-19 in wastewater
University of Missouri scientists receive $4 million grant from the National Institutes of Health to examine clues about the rate of infection in communities and virus variants
Read moreUMD reports six novel variants for CRISPR-Cas12a in plants, expanding genome engineering
New publication in Nature Communications offers patentable tools to improve the efficiency of food production
Read moreGenetic sleuthing reveals endangered river dolphins in Asia as different species
Tissue collection at NOAA Fisheries lab helps reveal genetic distinction
Read moreInflammation-fighting protein could improve treatment of rheumatoid arthritis
SPOKANE, Wash. – New research led by scientists at Washington State University has found that a protein known as GBP5
Read moreStudy shows survival mechanism for cells under stress
New research reveals how cancer cells endure stress and survive. Publishing in Molecular Cell , an international research team identified
Read moreJohn D. Carpten elected fellow of AACR Academy
American Association for Cancer Research honors distinguished USC Norris Comprehensive Cancer Center scientist
Read moreA mouse’s bite holds venomous potential, finds new study
Startling new evidence shows mammal salivary glands and snake venom glands share a common genetic foundation.
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Dogs (not) gone wild: DNA tests show most ‘wild dogs’ in Australia are pure dingoes
Almost all wild canines in Australia are genetically more than half dingo, a new study led by UNSW Sydney shows – suggesting that lethal measures to control ‘wild dog’ populations are primarily targeting dingoes.
Read moreCorrecting altered brain circuit could tackle coinciding obesity and depression
Research has found that obesity and mental disorders such as depression and anxiety seem to often go hand in hand.
Read moreGray’s beaked whales ‘resilient’ to ecosystem changes
An elusive whale species in the Southern Ocean could be resilient to near-future ecosystem changes, according to a new study
Read moreDogs (not) gone wild: DNA tests show most ‘wild dogs’ in Australia are pure dingoes
It’s time to take dingoes out of the doghouse
Read moreResearchers discover why cold induces tooth pain and hypersensitivity — and how to stop it
Odontoblasts, the cells that form a tooth’s dentin, have a newly discovered function: Sensing cold, which can trigger pain in teeth; but scientists have also found a way to block the pathway to cold-sensitive teeth
Read moreAncient genomes trace the origin and decline of the Scythians
Because of their interactions and conflicts with the major contemporaneous civilizations of Eurasia, the Scythians enjoy a legendary status in
Read moreCircadian clock gene Rev-erb linked to dawn phenomenon in type 2 diabetes
Researchers at Baylor College of Medicine, Shandong University in China and other institutions may have found an explanation for dawn
Read moreResearchers improve plant prime editing efficiency with optimized pegRNA designs
Precision genome editing enables the precise modification of DNA in living cells, thus enabling a breadth of opportunities for plant
Read morePlant gene found in insect, shields it from leaf toxins
Millions of years ago, aphid-like insects called whiteflies incorporated a portion of DNA from plants into their genome. A Chinese
Read moreStudy links genes with function across the human brain
Comparing two neural maps reveals the roles of genes in cognition, perception and feeling
Read moreGene required for jumping identified in rabbits
Experiments with a rare type of rabbit that can’t jump pinpointed the necessary gene
Read moreGenome sequenced for pesky pumpkin pathogen
URBANA, Ill. – Pumpkin growers dread the tiny tan scabs that form on their fruit, each lesion a telltale sign
Read moreScientists discover how humans develop larger brains than other apes
A new study is the first to identify how human brains grow much larger, with three times as many neurons,
Read moreHow human cells coordinate the start of DNA replication
Cold Spring Harbor Laboratory (CSHL) President and CEO Bruce Stillman has been dissecting DNA replication, a critical step in cell
Read moreLarge-scale genome analysis identifies differences by sex in major psychiatric disorders
Investigators in a multinational study scanned genomes of nearly 200,000 people to find interactions with genes and sex for schizophrenia, major depressive disorder and bipolar disorder.
Read moreMassey researcher finds new strategy for fighting brain cancer
Most people relate cholesterol to heart health, but it is also a critical component in the growth and spread of
Read moreRare genetic variant puts some younger men at risk of severe COVID-19
A subset of young men carry a genetic variant that dampens innate immunity to COVID-19 and may benefit from genetic testing and interferon treatment
Read moreResearchers hunt for drugs that keep HIV latent
When the human immunodeficiency virus infects cells, it can either exploit the cells to start making more copies of itself
Read moreDirect reprogramming of oral epithelial cells into mesenchymal-like cells
Point Epithelial cell rests of Malassez derived from the periodontal ligament were transformed into progenitor stem-like cells by stimulation with
Read moreUpgrade for CRISPR/Cas: Researchers knock out multiple genes in plants at once
Using an improved version of the gene editing tool CRISPR/Cas9, researchers knocked out up to twelve genes in plants in
Read moreCholesterol accumulation contributes to genetic movement disorder
Family finds hope in research breakthrough for rare diagnosis
Read moreBudget impact of gene therapy for sickle cell disease
What The Study Did: This economic evaluation estimates the budget impact and affordability of a gene therapy for severe sickle
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