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UrduSylvester Comprehensive Cancer Center researchers Lluis Morey, Ph.D., and Ramiro Verdun, Ph.D., have received a $1.8 million NIH R01 grant to study the epigenetic mechanisms that drive head and neck cancers.
Tag: genes
Blood cancer scientists developing powerful new tools to improve diagnosis and treatment for patients
Australian researchers will use new technology to improve the diagnosis and treatment of blood cancers, which affect 1.24 million people globally, including 720,000 who die from leukemia, lymphoma or myeloma each year.
Study of Body Weight-associated Genes in Rats May Inform Regulation of Obesity in Humans
Article title: Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity Authors: Wesley L. Crouse, Swapan K. Das, Thu Le, Gregory Keele, Katie Holl, Osborne Seshie, Ann L. Craddock, Neeraj K. Sharma, Mary…
FAU Receives NSF Grant to Explore Trait Evolution Across Species
The NSF grant will enable scientists to elucidate trait evolution across species using statistical and supervised machine learning approaches to vigorously and accurately predict general and specific evolutionary mechanisms that also will be applicable to various genomic and transcriptomic data for evolutionary discovery.
Food Science Meets Cell Science in Bid to Explain Inner Workings of Membrane-Free Cell Compartments
Johns Hopkins Medicine researchers report that food science principles have helped them determine how unusual droplets within cells stay organized and avoid dissolving into the rest of the cell’s gelatinous interior.
Massive Study Links Nearly 600 Genomic Regions to Self-Regulating Behaviors
Researchers identified 579 locations in the human genome associated with a predisposition to self-regulation-related behaviors, such as addiction. With data from 1.5 million people of European descent, the effort is one of the largest genome-wide association studies to date.
Juicy past of favorite Okinawan fruit revealed
Citrus fruits from the mandarin family have important commercial value but how their diversity arose has been something of a mystery Researchers analyzed the genomes of the East Asian varieties and found a second center of diversity in the Ryukyu…
Comprehensive clinical sequencing opens door to the promise of precision medicine
St. Jude Children’s Research Hospital study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient’s cancer.
Mount Sinai researchers develop novel therapy that could be effective in many cancers
New York, NY (July 23, 2021) — Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery , a…
Untwisting DNA reveals new force that shapes genomes
Transcription generates a force that moves across DNA strands like ripples through water
Study on chromosomal rearrangements in yeast reveals potential avenue for cancer therapy
Researchers from Osaka University uncover a mechanism by which chromosomal rearrangements occur, with implications for novel cancer therapies
Geneticists reveal how mutation causes childhood cancer; use drug to reverse its effects
Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and – in lab studies working with model cell types – successfully reverse its…
Cattle losing adaptations to environment, MU researchers find
Researchers pave the way for genetic tests of cattle that can look for the presence of specific adaptations, such as heat resistance
Precision treatment for severe asthma targets a specific mutation
Drug blocks a cell receptor that is mutated disproportionately in people of color
Toward one drug to treat all coronaviruses
Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever. Now, researchers…
Chromosomes separation under focus
A UNIGE team has identified important regulatory mechanisms of the protein responsible for chromosome separation during cell division.
No IgA leads to intestinal inflammation in mice
Tokyo, Japan – While researchers have known for years that immunoglobulin A (IgA) is important for gut health, it has remained unclear exactly what role it plays in preventing infection and disease. But now, researchers from Japan have found that…
Study identifies MET amplification as driver for some non-small cell lung cancers
CU Cancer Center researchers get positive results treating patients with MET-inhibitor drug crizotinib
Recovering DNA from challenging forensic evidence in forensic genomics
New Rochelle, NY, July 19, 2021–Duct tape and items retrieved from the water are common pieces of evidence in forensic cases. A new study evaluates the recovery of DNA from folded duct tape that has been submerged in ocean water…
Scientists uncover drivers of phenotypic innovation and diversification in gymnosperms
Determining the major drivers of species diversification and phenotypic innovation across the Tree of Life is one of the grand challeges in evolutionary biology. Facilitated by the Germplasm Bank of Wild Species of the Kunming Institute of Botany (KIB) of…
CNIO researchers clarify the role of the two isoforms of KRAS, the most common oncogene in humans
These findings suggest that for therapies to be effective, they must be targeted at both gene products
Genetics/biotech expert offers comments & availability on IVG (in vitro gametogenesis) major breakthrough
A groundbreaking study demonstrating the most advanced form of in vitro gametogenesis (making eggs from stem cells, IVG) was published Thursday in Science. See STAT’s coverage of the study. Regarding the study and breakthrough, Dr. Kevin Doxzen offers the below comments…
The virus trap
Hollow nano-objects made of DNA could trap viruses and render them harmless
Children’s National Hospital joins the Mendelian Genomics Research Consortium, receiving $12.8 million
The National Institutes of Health’s National Human Genome Research Institute award will help discover inherited rare diseases and conditions in children
Modified yeast inhibits fungal growth in plants
External application could reduce agricultural reliance on fungicides
Role of subnuclear NSrp70 in immunity-studied at Gwangju Institute of Science & Technology
Scientists report that the alternative-splicing regulator NSrp70 influences immune T cell development
The path(way) less traveled in DNA double-strand break repair
Researchers from Osaka University find that protein phosphatase 1 helps protect the ends of double-strand DNA breaks to promote their repair through the non-homologous end joining pathway
Long-term memory setup requires a reliable delivery crew
Synaptic plasticity depends on molecular hauler KIF5C, carrier of more than 650 RNAs, study finds
A common ancestor for cells involved in hearing and touch
USC Stem Cell scientists point to developmental and evolutionary similarities between sensory cells in the inner ear and the skin
New technique reduces nicotine levels, harmful compounds simultaneously in tobacco
North Carolina State University researchers have developed a new technique that can alter plant metabolism. Tested in tobacco plants, the technique showed that it could reduce harmful chemical compounds, including some that are carcinogenic. The findings could be used to…
Genetic analysis to help predict sunflower oil properties
Skoltech researchers and their colleagues from the University of Southern California have performed genetic analysis of a Russian sunflower collection and identified genetic markers that can help predict the oil’s fatty acid composition. The research was published in BMC Genomics.…
Genome editing for food: how do people react?
Research team from the Universities of Göttingen and British Columbia investigates evaluations of breeding technology
Using genomics to save the bees
2021 Agricultural Greater Good Grant awarded to Göttingen University molecular biologist
Sweet success: CABBI demonstrates first precision breeding of sugarcane with CRISPR-Cas9
Gene-editing offers a targeted, efficient way to develop new varieties of this productive but complex plant
Match matters: The right combination of parents can turn a gene off indefinitely
UMD scientists discover that mating can cause epigenetic changes in nematode worms that last for 300 generations
Discovery of a mechanism for efficient autophagosome formation
Revealing the molecular role of the most famous autophagy factor
New Alzheimer’s treatment targets identified
Study points to FDA-approved drugs that have potential to slow or reverse brain damage
Cell-type-specific insight into the function of risk factors in coronary artery disease
Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin…
Genetic analysis technique finds missing link between thyroid function and lipid profile
Using a genetic analysis called Mendelian randomization, researchers suggest causal association between thyroid function and serum lipid profiles
Research reveals structure of nanomachine that assembles a cell’s energy control system
Sussex researchers have determined the structure of a tiny multi-protein biological machine, furthering our understanding of human cells and helping to enhance research into cancer, neurodegeneration and other illnesses
Rare genetic variants confer largest increase in type 2 diabetes risk seen to date
Scientists at the University of Cambridge have identified rare genetic variants – carried by one in 3,000 people – that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect. Type 2…
Next generation cytogenetics is on its way
Does optical genome mapping turn cytogenetics upside down?
New generation anti-cancer drug shows promise for children with brain tumours
A genetic map of an aggressive childhood brain tumour called medulloblastoma has helped researchers identify a new generation anti-cancer drug that can be repurposed as an effective treatment for the disease. This international collaboration, led by researchers from The University…
New generation anti-cancer drug shows promise for children with brain tumors
A genetic map of an aggressive childhood brain tumour called medulloblastoma has helped researchers identify a new generation anti-cancer drug that can be repurposed as an effective treatment for the disease. This international collaboration, led by researchers from The University…
Protein’s ‘silent code’ affects how cells move
A University of Pennsylvania-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences
Leonardo Da Vinci: New family tree spans 21 generations, 690 years, finds 14 living male descendants
Paper offers foundation to advance search for Leonardo’s DNA
Relationship between chromosomal instability and senescence revealed in the fly Drosophila
Chromosomal instability is a feature of solid tumours such as carcinoma. Likewise, cellular senescence is a process that is highly related to cellular ageing and its link to cancer is becoming increasingly clear. Scientists led by ICREA researcher Dr. Marco…
Muscles retain positional memory from fetal life
New perspectives on the pathological mechanisms of muscle diseases and regenerative medicine development
Memory making involves extensive DNA breaking
The urgency to remember a dangerous experience requires the brain to make a series of potentially dangerous moves: Neurons and other brain cells snap open their DNA in numerous locations–more than previously realized, according to a new study–to provide quick…
Personalized medicine for cats with heart disease
Study finds genetic makeup influences response to common feline heart disease medication