Mount Sinai researchers develop novel therapy that could be effective in many cancers

New York, NY (July 23, 2021) — Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery , a…

Toward one drug to treat all coronaviruses

Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever. Now, researchers…

New study investigates formation of dangerous compounds by e-cigarettes

Scientists with the Desert Research Institute (DRI) Organic Analytical Laboratory in Reno, Nev., led by Andrey Khlystov, Ph.D., have been awarded a $1.5M grant from the National Institutes of Health (NIH) to study the formation of dangerous compounds by electronic…

Artificial sweeteners enable delivery of carbon monoxide to treat organ injury

ATLANTA–An oral prodrug developed by a team of scientists led by Binghe Wang, Regents’ Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science .…

Prevention, detection and various approaches on coronaviruses

In this difficult period of the SARS-CoV-2 (and its variants) infection responsible for Covid-19 diseases, the importance of scientific works and reviews dealing with these viruses has never been more essential. This book Coronavirus brings together essential data regarding prevention…

Microcrystal electron diffraction supports a new drug development pipeline

CAMBRIDGE July 13, 2021 – To date, solving structures of potential therapeutics using X-ray diffraction (XRD) has been an assumed, pivotal step in the drug development process. But a recent paper by a team of researchers led by NanoImaging Services…

TSUBAME supercomputer predicts cell-membrane permeability of cyclic peptides

Scientists at Tokyo Institute of Technology have developed a computational method based on large-scale molecular dynamics simulations to predict the cell-membrane permeability of cyclic peptides using a supercomputer. Their protocol has exhibited promising accuracy and may become a useful tool…

Harnessing AI to discover new drugs

Nature has a vast store of medicinal substances. “Over 50 percent of all drugs today are inspired by nature,” says Gisbert Schneider, Professor of Computer-Assisted Drug Design at ETH Zurich. Nevertheless, he is convinced that we have tapped only a…

New game-changing zeolite catalysts synthesized

A research team at POSTECH has uncovered a promising new zeolite, anticipated to be a turning point for the oil refining and petrochemical industries. This research was recently published in the scientific journal Science on July 2, 2021. The team…

Women’s use of preventive health services during COVID-19

What The Study Did: Changes in the use of women’s preventive health services during the COVID-19 pandemic, including screening for sexually transmitted infections, breast and cervical cancer, and obtaining contraceptives from pharmacies are described by researchers in this study. Authors:…

Clinical and pre-clinical antimicrobial drug development

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. It covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry,…

Nanomaterials: Evolution and Advancement Towards Therapeutic Drug Delivery

‘Nanomaterials: Evolution and Advancement Towards Therapeutic Drug Delivery’ gives the present status and future perspective of Polymeric nanoparticles, Liposomes, Carbon Nanotubes, Magnetic Nanoparticles, Silica Based nanomaterial, Hydrogels, Metallic Nanoparticles, Cyclodextrins, Poly (Lactide-Co-Glycolide) and its Copolymers. Improvement of a vector for…

Had COVID-19? One vaccine dose enough; boosters for all, study says

Two mRNA vaccines against COVID-19 have proven safe and effective in clinical trials, as well as in the millions of people who have been vaccinated so far. But how prior SARS-CoV-2 infection affects vaccine response, and how long that response…

Seeking a treatment for IBS pain in tarantula venom

For patients who have inflammatory bowel syndrome (IBS), the condition is literally a pain in the gut. Chronic — or long-term — abdominal pain is common, and there are currently no effective treatment options for this debilitating symptom. In a…

Four-component, and asymmetric radical 1,4-oxy-trifluoromethylation to olefins

Vanadium oxo (VO) species were often used to oxidise sulfide/amine compounds and alkenes when combined with peroxide oxidants. VO species are well known as important vitamin supplements for potential diabetic prevention. They are highly prevalent as metalloenzyme like haloperoxidase. The…

New AI model helps understand virus spread from animals to humans

A new model that applies artificial intelligence to carbohydrates improves the understanding of the infection process and could help predict which viruses are likely to spread from animals to humans. This is reported in a recent study led by researchers…

Easy, inexpensive, efficient: Researchers improve efficacy of new malaria drug

Artemisone is a promising substance in the fight against malaria. However, the active ingredient has yet to be used due its instability and because it is not easily absorbed by the body. A team from Martin Luther University Halle-Wittenberg (MLU)…

Srinivas Rangarajan wins NSF CAREER award for catalytic transfer hydrogenation research

Lehigh University computational chemical engineer to advance fundamental understanding of promising approach for safe, streamlined, cost-effective biomass and CO2 conversion

SLAS Technology June special issue on 3D cell culture

Oak Brook, IL – The June edition of SLAS Technology is a Special Issue entitled, “Emerging Trends in 3D Cell Culture: High-Throughput Screening, Disease Modeling and Translational Medicine.” Free online access to the articles in this collection is courtesy of…

First cells reprogrammed to make synthetic polymers; also making them resistant to viruses

Scientists create cells – with a synthetic genome – and instruct them to make polymers from artificial building blocks for the first time; the new bacteria are also resistant to viral infections

Fight against antibiotic-resistant bacteria has a glowing new weapon

AUSTIN, Texas — In the perpetual arms races between bacteria and human-made antibiotics, there is a new tool to give human medicine the edge, in part by revealing bacterial weaknesses and potentially by leading to more targeted or new treatments…

Conquering COVID-19 with antivirals

The COVID-19 pandemic has seen scientists perform incredible feats in a short amount of time, from developing tests to new types of vaccines. Despite these victories, experts are still working to develop an effective antiviral drug to kill the SARS-CoV-2…

Measuring opioid-related mortality in Canada during COVID-19 pandemic

What The Study Did: Researchers quantified the added burden of fatal opioid overdoses occurring in Ontario, Canada, during the first six months of the COVID-19 pandemic. Authors: Tara Gomes, Ph.D., of the Keenan Research Centre of the Li Ka Shing…

Effectiveness of tocilizumab in patients hospitalized with COVID-19

What The Study Did: This follow-up study of a randomized clinical trial examines the association between survival and C-reactive protein levels in patients hospitalized with COVID-19 who were treated with tocilizumab. Authors: Xavier Mariette, M.D., Ph.D., of the Hôpital Bicêtre…

A peptide that allows cannabis-derived drugs to relieve pain without side effects

Scientists from the Proteomics and Protein Chemistry Research Group and the Neuropharmacology-Neurophar Laboratory have developed a peptide which is an ideal candidate for reducing the cognitive side effects of pain treatment with cannabis derivatives.

CCNY team makes single photon switch advance

The ability to turn on and off a physical process with just one photon is a fundamental building block for quantum photonic technologies. Realizing this in a chip-scale architecture is important for scalability, which amplifies a breakthrough by City College…

SLAS Technology April issue dives into reactive oxygen species

Oak Brook, IL – The April edition of SLAS Technology features the cover article “Therapeutic Potential of Reactive Oxygen Species: State of the Art and Recent Advances” by Valeria Graceffa, Ph.D. (Institute of Technology Sligo, Sligo, Ireland). The cover article…

Remdesivir and clinical improvement in hospitalized patients with COVID-19

What The Study Did: This comparative effectiveness research study that included a high proportion of non-White individuals assesses whether remdesivir administered alone or with corticosteroids is associated with time to clinical improvement or time to death in patients hospitalized with…

Double-duty catalyst generates hydrogen fuel while cleaning up wastewater

Hydrogen is a pollution-free energy source when it’s extracted from water using sunlight instead of fossil fuels. But current strategies for “splitting” or breaking apart water molecules with catalysts and light require the introduction of chemical additives to expedite the…

Solving the puzzle of polymers binding to ice for Cryopreservation

Cryoprotectants are used to protect biological material during frozen storage They have to be removed when defrosting, and how much to use and how exactly they inhibit ice recrystallisation is poorly understood The polymer poly(vinyl)alcohol (PVA) is arguably the most…