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UrduKabrena Rodda, manager of the Analytical Chemistry and Instrumentation Group at PNNL, received the distinction of ACS Fellow.
Tag: TOXICOLOGY
‘Molecular Compass’ points way to Reduction of Animal Testing
In recent years, machine learning models have become increasingly popular for risk assessment of chemical compounds. However, they are often considered ‘black boxes’ due to their lack of transparency, leading to scepticism among toxicologists and regulatory authorities. To increase confidence in these models, researchers at the University of Vienna proposed to carefully identify the areas of chemical space where these models are weak. They developed an innovative software tool (‘MolCompass’) for this purpose and the results of this research approach have just been published in the prestigious Journal of Cheminformatics.
Commonly Used Herbicide is Harmful to Adolescent Brain Function
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science researchers report in a new study that exposures to two of the most popular herbicides were associated with worse brain function among adolescents.
Chemical Found in Common Sweetener Damages DNA
A new study finds a chemical formed when we digest a widely used sweetener is “genotoxic,” meaning it breaks up DNA. The finding raises questions about how the sweetener may contribute to health problems.
New Articles on Using Machine Learning to Predict Mammalian Acute Oral Toxicity and the Effects of Vinyl Chloride on Metabolism
The May 2023 issue of Toxicological Sciences includes articles on profiling mechanisms that drive acute oral toxicity in mammals and its prediction via machine learning and how vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction.
Air pollution worsens movement disorder after stroke
Air pollution has been shown to have a negative effect on the prognosis of ischemic stroke, or stroke caused by reduced blood flow to the brain, but the exact mechanism is unknown. A team of researchers recently conducted a study to determine whether or not increased inflammation of the brain, also known as neuroinflammation, is the main culprit.
Cocaine damage routinely misdiagnosed as nonthreatening nasal disease
A new paper in Rheumatology Advances in Practice, published by Oxford University Press, indicates that Granulomatosis With Polyangiitis, a nasal disease that causes inflammation of the blood vessels and commonly presents with symptoms in sinuses, throat, lungs, and kidneys, may be commonly misdiagnosed.
New Safety Assessment Assays Explored in Latest Issue of Toxicological Sciences
The December 2022 issue features 10 articles on the latest research in toxicology.
EPA grant to Wayne State to evaluate chemical mixture health risks
There are hidden metabolic health impacts in things that most people encounter every day. From surface cleaners to silicone wristbands, from fracking fluids to wastewater — even household dust — these diverse environmental mixtures have a potential to disrupt human health. A grant from the EPA to Wayne State University will evaluate the risks of chemical mixtures on health.
Exploring How Diethylene Glycol Poisons the Kidney and the Combined Effects of St. John’s Wort and Acetaminophen on the Liver
A ToxSpotlight article in the November 2022 issue of ToxSci assesses the mechanism for cellular accumulation of diglycolic acid while another explores the effect of long-term St. John’s wort administration on acetaminophen-induced acute hepatotoxicity and the involved mechanisms.
Alligators Exposed to PFAS Show Autoimmune Effects
A recent study of alligators in the Cape Fear River found the animals had elevated levels of 14 different per- and polyfluoroalkyl (PFAS) chemicals in their blood serum, as well as clinical and genetic indicators of immune system effects.
A Need to Consistently Characterize Aerosol Research Associated with E-cigarettes Is Featured in New Issue of ToxSci
Other featured research in October 2022 issue involves an exploration of a pharmacokinetic model for quantifying the mother-to-child transfer of environmental chemicals and how febuxostat may increase the risk for cardiovascular events by dysregulating calcium dynamics.
The Effects of Copper, Patient-Relevant Tissue Models, and Artificial Intelligence Featured in Sept. 2022 Issue of ToxSci
A new ToxPoint articles argues that “Copper Is the New Showstopper,” while a commentary calls for patient-relevant tissue models in the September 2022 issue of Toxicological Sciences (ToxSci), the official journal of the Society of Toxicology (SOT). Other featured articles…
WVU toxicologist calls passage of burn pit bill ‘critical step in improving veteran health’
A West Virginia University researcher with expertise in air pollution and inhalation exposures is available to discuss burn pits following this week’s U.S. Senate passage of a bill expanding health care benefits for veterans who developed illnesses after being exposed…
Cannabinoid Vaping Products, Genomic Biomarkers, a Novel In Vitro Testing System, and More in New Toxicological Sciences
Cannabinoid vaping products, genomic biomarkers to determine tumorigenic potential, and analyses of various testing assays are just a few of the article topics in the July 2022 issue of Toxicological Sciences.
Many eco-friendly children’s products found to contain toxic PFAS chemicals
With more consumers demanding products free of toxic ingredients, discerning which ones might be harmful and which ones are safe isn’t easy.
Pituitary Reproductive Regulatory Factors, Mercury Levels, and More Featured in November 2021 Toxicological Sciences
In the November 2021 issue, Toxicological Science features leading toxicology research in areas such as biomarkers, carcinogenesis, and environmental toxicology.
Rutgers Toxicologist Available to Discuss Dangers of Taking Iodine to Treat COVID-19
Professor Lewis Nelson, M.D., is available to discuss the dangers of gargling, snorting, or ingesting Betadine, an iodine-based antiseptic to treat COVID-19. “Although many topical disinfectants such as povidone-iodine, which, is also known as Betadine, generally destroy viruses on direct…
Drug-Induced Liver Injury, Prenatal Developmental Toxicity, and More Featured in September 2021 Toxicological Sciences
The September 2021 issue of Toxicological Sciences contains leading toxicological research, exploring nanotoxicology, neurotoxicology, immunotoxicology, and more.
Rutgers Toxicologist Available to Discuss Dangers of Taking Livestock Deworming Drug for COVID-19
Rutgers Professor Lewis Nelson is available to discuss the dangers of people taking the livestock deworming drug ivermectin to try to treat COVID-19. Demand for the drug is surging nationwide despite warnings from the Food and Drug Administration and the…
Using silicone wristbands to measure air quality
A Texas A&M study found that these inexpensive, convenient devices can measure exposure to a class of chemicals that can be harmful during pregnancy
Hundreds of chemicals, many in consumer products, could increase breast cancer risk
List includes potential carcinogens that act by stimulating production of hormones that fuel breast tumors
Coffee doesn’t raise your risk for heart rhythm problems
UCSF Cardiology researchers report no link between coffee consumption and arrhythmia
Spontaneous Mammary Neoplasia, Cannabidiol Exposure, Aryl Hydrocarbon Receptors, and More Featured in July 2021 Toxicological Sciences
Toxicological Sciences delivers the latest toxicology research in the July 2021 issue. The issue features investigations in delivers the latest toxicology research in areas such as exposure to delta-9-tetrahydrocannabinol and cannabidiol, effects of ENDS vapors on amino acid metabolism, and more.
No Sign of COVID-19 Vaccine in Breast Milk
Messenger RNA vaccines against COVID-19 were not detected in human milk, according to a small study by UC San Francisco, providing early evidence that the vaccine mRNA is not transferred to the infant.
Silicon in drinking water caused irreversible lung pathologies in rodents
Scientists of Immanuel Kant Baltic Federal University examined the effect of long-term silicon intake on the health of mice and rats.
Prevention, detection and various approaches on coronaviruses
In this difficult period of the SARS-CoV-2 (and its variants) infection responsible for Covid-19 diseases, the importance of scientific works and reviews dealing with these viruses has never been more essential. This book Coronavirus brings together essential data regarding prevention…
How does exhaled heated tobacco aerosol behave in the air?
Considerable research informs the dynamics of exhaled e-cigarette aerosols, but how much do we know about the same processes for heated tobacco? Liz Mason picks over the particles
Experts recommend a varied and moderate consumption of sushi limiting quantities of tuna
A research group from the Universitat Rovira i Virgili and the Pere Virgili Health Research Institute have analysed the concentration of various toxic elements in these foods and evaluated the risk of consuming them in infant, adolescent and adult populat
Scientists find liver drug candidates among pesticides
Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies — among pest control chemicals.…
Between fear and confidence
The new issue of the Science Magazine BfR2GO deals with fear
Is global plastic pollution nearing an irreversible tipping point?
Common press release: Stockholm University, Norwegian Geotechnical Institute, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Helmholtz Centre for Environmental Research
How lead (maybe) caused the downfall of ancient Rome (video)
WASHINGTON, June 28, 2021 — Ancient Rome’s emperors did some pretty bizarre stuff — bursting into uncontrollable fits of laughter, appointing a horse as a priest, dressing in animal skins and attacking people … the list goes on. Why were…
Glyphosate pesticides persist for years in wild plants and cause flower infertility
Researchers show for first time that commonly used herbicides can persist within wild forest plants for years, reducing fertility long-term and potentially also impacting pollinators
Research study suggests BAT’s Modern Oral products have similar toxicant profile to NRT
Results show BAT’s Modern Oral nicotine pouches have a comparable toxicant profile to NRTs, which are currently considered the least risky of all nicotine products *† The Modern Oral products have far fewer and significantly lower levels of toxicants‡ than…
Unlabeled PFAS chemicals detected in makeup
Makeup wearers may be absorbing and ingesting potentially toxic per- and polyfluoroalkyl substances (PFAS), according to a new study published today in Environmental Science & Technology Letters . The researchers found high fluorine levels–indicating the probable presence of PFAS–in most…
Antidepressant pollution alters crayfish behavior, with impacts to stream ecosystems
Increased foraging and reduced aggression have the potential to alter stream functioning
Not acting like themselves: Antidepressants in environment alter crayfish behavior
Crayfish exposed to low levels of antidepressant medication behaved in ways that could make them more vulnerable to predators
Accomplished University of Ottawa professors earn Canada Research Chairs
The University of Ottawa has been awarded four new Canada Research Chairs
Study effects paradigm shift in the understanding of how red rot attacks sugarcane
Researchers at the University of São Paulo discover that the fungus Fusarium verticillioides uses volatile compounds to manipulate insects and plants, promoting its own dissemination
Toxin-adapted fish pass down epigenetic mutations to freshwater offspring
PULLMAN, Wash. – You can take a fish out of toxic water, but its epigenetic mutations will remain for at least two generations. A research team led by Washington State University scientists analyzed the epigenetics–molecular factors and processes that determine…
Higher alcohol content beer popularity growing, as overall beer consumption down
PITTSBURGH, June 10, 2021 – Americans are consuming more craft beer with higher alcohol content but are drinking less beer by volume, according to a new analysis led by epidemiologists at the University of Pittsburgh Graduate School of Public Health.…
Nicotinamide can ‘immunize’ plants to protect from fungal disease
Research led by Kanazawa University shows that application of the nicotinamide to wheat spike activated plant immunity and then effectively suppressed the disease symptoms and mycotoxin accumulation of Fusarium head blight
UN: More harmful algal bloom impacts emerge amid rising seafood demand, coastal development
UNESCO IOC delivers 1st global assessment report after 7 years’ work by 109 experts in 35 countries, creating a baseline to detect and gauge the changing distribution, frequency, and intensity of harmful — often poisonous — algal blooms
Mapping a successful recovery
Novel methods and dedicated fieldwork offer good news for cleaning up mining pollution in rivers
Researchers find toxin from maple tree in cow’s milk
Cows can pass on the hypoglycin A toxin through their milk, a study by the Martin Luther University Halle-Wittenberg (MLU) and the Leibniz Institute of Plant Biochemistry (IPB) in Toxins shows. The substance can cause severe symptoms in humans and…
Metal Contamination, Gene Signatures, Bisphenol F, and More Featured in June 2021 Toxicological Sciences
Toxicological Sciences delivers the latest research in toxicology, in areas such as clinical and translational toxicology; emerging technologies, methods, and models; and environmental toxicology.
Deciphering Gene-Environment Interactions in Parkinson’s Disease
The interaction between an individual’s genetics and their local environment plays a critical role in an individual’s likelihood of getting Parkinson’s disease. In this perspective, researchers highlight how a common fly could be used to better understand the complex interactions…
The Varroa mite dsRNA is not toxic to monarch butterflies
The Varroa mite dsRNA which could help save honeybees is not toxic to monarch butterflies, despite them having the same target gene as the mite