Cleveland Clinic Researchers Identify Diabetes Drug Metformin as Potential Atrial Fibrillation Treatment in Collaborative Research

Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation.

The study, published in Cell Reports Medicine, built on ongoing collaborative Cleveland Clinic research to support further investigation into metformin as a drug repurposing candidate. Researchers used advanced computation and genetic sequencing to determine that metformin’s targets overlap significantly with genes dysregulated in atrial fibrillation.

Spontaneous Mammary Neoplasia, Cannabidiol Exposure, Aryl Hydrocarbon Receptors, and More Featured in July 2021 Toxicological Sciences

Toxicological Sciences delivers the latest toxicology research in the July 2021 issue. The issue features investigations in delivers the latest toxicology research in areas such as exposure to delta-9-tetrahydrocannabinol and cannabidiol, effects of ENDS vapors on amino acid metabolism, and more.

ACSM Annual Meeting Research Highlights for June 3

ACSM’s comprehensive sports medicine and exercise science conference takes place virtually from June 1 to 5 with programming covering the science, practice, public health and policy aspects of sports medicine, exercise science and physical activity.

Diabetes Drug May Protect Breastfed Children from Future Metabolic Disorder

A new study suggests that treating a breastfeeding parent with a common diabetes drug may provide male offspring lifelong protection against diabetes and obesity. The study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism. It was chosen as an APSselect article for May.

Diabetes Drug May Protect Breastfed Sons from Future Metabolic Disorder

Article title: Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner Authors: Zach Carlson, Hannah Hafner, Molly Mulcahy, Kaylie Bullock, Allen Zhu, Dave Bridges, Ernesto Bernal-Mizrachi, Brigid Gregg From the authors: “Future…

Human Gut-in-a-Dish Model Helps Define ‘Leaky Gut,’ and Outline a Pathway to Treatment

UC San Diego researchers use 3D human gut organoids to reveal the molecular system that keeps intestinal linings sealed, demonstrate how the system breaks down and how it can be strengthened with the diabetes drug metformin.