New Research Reveals How the Heart Repairs After a Heart Attack

Immune response and the lymphatic system are central to cardiac repair after a heart attack, according to a study from Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg Cardiovascular Research Institute. These insights into the basic mechanisms of cardiac repair are the first step towards developing novel therapeutic approaches to preserve heart function. Findings were published in the Journal of Clinical Investigation.

Piezo1 Possible Key to Supporting Muscle Regeneration in Duchenne Muscular Dystrophy

Tracing the impact of a single protein, Piezo1, Penn researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently

Spontaneous Mammary Neoplasia, Cannabidiol Exposure, Aryl Hydrocarbon Receptors, and More Featured in July 2021 Toxicological Sciences

Toxicological Sciences delivers the latest toxicology research in the July 2021 issue. The issue features investigations in delivers the latest toxicology research in areas such as exposure to delta-9-tetrahydrocannabinol and cannabidiol, effects of ENDS vapors on amino acid metabolism, and more.

Tissue Repair, Mitochondrial Function and Wound Healing Explored in 2021 APS President’s Symposium

Top researchers in physiology will present a three-part series exploring cellular regulation of mitochondrial function, tissue repair and wound healing. The APS President’s Symposium Series will be part of the APS annual meeting at Experimental Biology 2021, which will be held on a virtual platform April 27–30.

Injectable Porous Scaffolds Promote Better, Quicker Healing After Spinal Cord Injuries

In APL Bioengineering, researchers have developed materials that can interface with an injured spinal cord and provide a scaffolding to facilitate healing. To do this, scaffolding materials need to mimic the natural spinal cord tissue, so they can be readily populated by native cells in the spinal cord, essentially filling in gaps left by injury. The researchers show how the pores improve efficiency of gene therapies administered locally to the injured tissues, which can further promote tissue regeneration.

Study Explores Role of Extracellular Vesicles in Tissue Repair after Heart Attack

Article title: CDC-derived extracellular vesicles reprogram inflammatory macrophages to an arginase 1-dependent pro-angiogenic phenotype Authors: Kyle I. Mentkowski, Asma Mursleen, Jonathan D. Snitzer, Lindsey M. Euscher, Jennifer K. Lang From the authors: “Our study was designed to gain mechanistic insight into the…