One-two punch drug combination offers hope for pancreatic cancer therapy

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Drug Administration (FDA)–approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. The study was published in Nature Cell Biology.

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Mount Sinai Researcher’s Examine the Metabolic Effects of an Oral Blood Cancer Drug

Recent study found that an effective blood cancer treatment was associated with weight gain, obesity, and increased systolic blood pressure

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Subtle Mitochondrial DNA Mutations Alter Expression of Nuclear Genes, with Profound Clinical Effects

Subtle changes in the DNA of mitochondria, the tiny power plants in cells, can have profound consequences for a patient’s health. Research on biological mechanisms suggests that relatively minor changes in mitochondrial energy flow and metabolism could offer significant future benefits to patients with complex diseases.

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Researchers Discover New, Treatable Pathway Known to Cause Hypertension in Obese People

There’s no question that as body weight increases, so too does blood pressure. Now, in a study of mice, Johns Hopkins researchers have revealed exactly which molecules are likely responsible for the link between obesity and blood pressure. Blocking one of these molecules — a signaling channel that’s found in a tiny organ on the side of your neck — effectively lowers blood pressure in obese mice, the researchers reported recently in the journal Circulation Research.

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Researchers Identify Metabolic Cycles in Baby Teeth Linked to ADHD and Autism in Children

Mount Sinai researchers have identified elemental signatures in baby teeth that are unique to attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and cases when both neurodevelopment conditions are present, which suggests that the metabolic regulation of nutrients and toxins play a role in these diseases, according to a study published in Translational Psychiatry in September.

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