MIT engineers have developed a small ultrasound sticker that can monitor the stiffness of organs deep inside the body.
A study spearheaded by Oregon State University has shown why certain polyunsaturated fatty acids work to combat a dangerous liver condition, opening a new avenue of drug research for a disease that currently has no FDA-approved medications.
Researchers at University of California San Diego have discovered a process in which liver cells share molecules in order to multiply under conditions that would ordinarily suppress cell proliferation. They also found evidence that this process occurs in various types of cancer cells.
BACKGROUNDMesenchymal stem cells (MSCs) have been used in liver transplantation and have certain effects in alleviating liver ischemia-reperfusion injury (IRI) and regulating immune rejection. However, some studies have indicated that the e
MitoQ, a mitochondrial antioxidant that is available to the public as a diet supplement, was found in a mouse study to reverse the detrimental effects that HIV and antiretroviral therapy (ART) have on mitochondria in the brain, heart, aorta, lungs, kidney and liver.
The University of Chicago Medicine liver transplant teams performed their 2,000th liver transplant in 2022, a milestone figure for the South Side academic medical center.
In support of our unwavering commitment to champion diversity, equity and inclusion in the field of hepatology, AASLD is pleased to announce the development of our own hepatology award.
After a rare disease caused organ failure, UC San Diego Heath transplant teams performed a heart, liver and kidney transplant on a patient. The surgery is a first for UC San Diego Health and a first in the nation to use three organs from a donor after circulatory death.
A national policy change to facilitate the broader sharing of donor livers through “acuity circles” has resulted in procurement delays, according to a researcher at the University of Miami Miller School of Medicine.
Results from a preclinical study add new evidence that a multi-mineral dietary supplement known as Aquamin could be a simple and effective way to reduce the long-term health consequences of non-alcoholic fatty liver disease. Aquamin, which is derived from calcified red marine algae, is rich in calcium, magnesium and 72 other minerals and trace elements.
With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is…
A small molecule inhibitor has been identified that reduces the growth of uveal melanoma, a rare and deadly cancer of the eye
Implications for developing treatments for intestinal diseases
Non-alcoholic fatty liver disease is the most common liver disorder worldwide and is present in approximately 25 percent of the world’s population. Over 90 percent of obese, 60 percent of diabetic, and up to 20 percent of normal-weight people develop…
Scientists condense Chinese studies over the past decade on this common gastrointestinal disorder in a review article
UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease.
Split liver transplantation (SLT) provides an opportunity to divide a donor liver and offer transplants to two small patients, one or both of whom could be a child. SLT, which is underused in the United States, could be used more…
Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies — among pest control chemicals.…
New insight into the liver’s unique ability to regenerate holds promise for developing treatments for the lung, heart, and other organs that currently must be replaced by transplants
PITTSBURGH, July 6, 2021 – Scientists from the University of Pittsburgh School of Medicine described a new phenomenon in which the deletion of a single gene involved in liver embryogenesis completely wipes out bile ducts of newborn mice. But despite…
Synthesis of the evidence and recommendations from the European Association for the Study of Obesity Physical Activity Working Group
Indigenous communities missing care — expert
News from the life sciences
CORVALLIS, Ore. – Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis. The findings, published today in eLife , are important…
New treatment combination for hepatitis C virus (HCV) is an additional affordable option for millions still waiting for access to lifesaving treatments in middle-income countries
PITTSBURGH, June 10, 2021 – Americans are consuming more craft beer with higher alcohol content but are drinking less beer by volume, according to a new analysis led by epidemiologists at the University of Pittsburgh Graduate School of Public Health.…
In a subset of patients with partial lipodystrophy and/or NASH, the hormone leptin can be leveraged as a therapeutic agent to move fat out of the liver.
Medical, mental, and substance use issues all more prevalent among adults who use methamphetamine
When fed diet high in fat and cholesterol, mice that overate became obese, diabetic and developed NASH, which progressed to kidney and cardiovascular disease and liver cancer
Corning expands cell culture portfolio with 3D liver models that better recapitulate in vivo behavior and deliver a more physiologically relevant model for improved drug safety and efficacy screening
The American Gastroenterological Association (AGA) issues new clinical guidelines on drug therapy for the management of moderate-to-severe luminal and fistulizing Crohn’s disease.
URBANA, Ill. – As the owner of a human body, you’re carrying trillions of microbes with you everywhere you go. These microscopic organisms aren’t just hitching a ride; many of them perform essential chemical reactions that regulate everything from our…
A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice. ABCB10 activity also prompted insulin resistance in human liver cells.
At a glance:
Researchers identify links between genetic makeup of bacteria in human gut and several human diseases
Clusters of bacterial genes present in conditions including cardiovascular illness, inflammatory bowel disease, liver cirrhosis, and cancer
Work brings scientist closer to developing tests that could predict disease risk or identify disease presence based on a sampling of the genetic makeup of a person’s microbiome
A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research from Washington University in St. Louis suggests that these other tissues could potentially be targeted to help treat cancer.“Tumors rely on a constant supply of nutrients to grow.
A new study published in the British Journal of Clinical Pharmacology ¬provides insights on how common hospitalized patients develop liver injury from taking different medications. When investigators analyzed the records of 156,570 hospitalized patients, they found 499 cases of drug-induced…
Singapore, 3 May 2021 – A first of its kind cohort study on patients at high risk of developing primary liver cancer also known as hepatocellular carcinoma (HCC), has been launched to diagnose HCC more accurately at an earlier stage…
Niigata, Japan–Researchers from Niigata University , the University of Tokyo, Osaka University and Tokyo Medical University, Japan have developed a new approach that could revolutionize the treatment, prevention, and possibly reversal of the damages caused by liver diseases. This novel…
New findings could lead to ways to keep transplanted adult liver cells functioning long term
New findings lay groundwork for turning previously unusable donor livers into transplantable organs
Reporters are invited to join a live Q&A discussion of exciting research announcements at the forefront of the life sciences during a virtual press conference for the Experimental Biology (EB) 2021 meeting. The press conference will be held online from 1–1:45 p.m. EDT on Monday, April 26, 2021 (RSVP by Friday, April 23).
Researchers from Aarhus University and Aarhus University Hospital replace sick intestinal bacteria with intestinal bacteria from healthy donors in a treatment intended to help patients with cirrhosis of the liver. The Novo Nordisk Foundation supports the
Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. “NAFLD has been difficult to study mainly because we had no good animal model,”…
Researchers from the University of Science and Technology of China (USTC) of the Chinese Academy of Science (CAS), teamed up with scientists from Aix Marseille University, discovered that hematopoietic progenitors possessed the differentiation potential to type 1 innate lymphoid cells…
International study led by MedUni Vienna appears in “Hepatology”
Reduction in global consumption of added fructose would yield a positive impact
Researchers at Baylor College of Medicine, Shandong University in China and other institutions may have found an explanation for dawn phenomenon, an abnormal increase of blood sugar only in the morning, observed in many patients with type 2 diabetes. They…
A noninvasive method for quantifying fat content in liver can aid medical research and diagnosis of liver diseases
Immunotherapy also appears to fuel tumor growth in these cancers
Non-alcoholic steatohepatitis (NASH), often called ‘fatty liver hepatitis’, can lead to serious liver damage and liver cancer. A team of researchers at the Technical University of Munich (TUM) has discovered that this condition is caused by cells that attack healthy…