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UrduWith the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is…
Tag: LIVER
Melanoma of the eye: Preclinical tests show path toward treatment
A small molecule inhibitor has been identified that reduces the growth of uveal melanoma, a rare and deadly cancer of the eye
Scientists identify new gut-liver drug recycling process
Implications for developing treatments for intestinal diseases
Revealing the mystery behind the threat of non-alcoholic liver disease
Non-alcoholic fatty liver disease is the most common liver disorder worldwide and is present in approximately 25 percent of the world’s population. Over 90 percent of obese, 60 percent of diabetic, and up to 20 percent of normal-weight people develop…
Keeping the world up to date on irritable bowel syndrome research in China
Scientists condense Chinese studies over the past decade on this common gastrointestinal disorder in a review article
Selective, Toxin-Bearing Antibodies Could Help Treat Liver Fibrosis
UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease.
The ethics of split liver transplantation: Analyzing case studies to make the right decision
Split liver transplantation (SLT) provides an opportunity to divide a donor liver and offer transplants to two small patients, one or both of whom could be a child. SLT, which is underused in the United States, could be used more…
Scientists find liver drug candidates among pesticides
Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies — among pest control chemicals.…
NYU Abu Dhabi researchers unlock secrets behind liver regrowth and regenerative medicine
New insight into the liver’s unique ability to regenerate holds promise for developing treatments for the lung, heart, and other organs that currently must be replaced by transplants
Missing bile ducts offer clues to mechanism of liver injury
PITTSBURGH, July 6, 2021 – Scientists from the University of Pittsburgh School of Medicine described a new phenomenon in which the deletion of a single gene involved in liver embryogenesis completely wipes out bile ducts of newborn mice. But despite…
Evidence based recommendations to support physical exercise for adults with obesity
Synthesis of the evidence and recommendations from the European Association for the Study of Obesity Physical Activity Working Group
Liver cancer call for help
Indigenous communities missing care — expert
About the beginning of life, bacteria in the gut and collective intelligence in bees
News from the life sciences
Compounds derived from hops show promise as treatment for common liver disease
CORVALLIS, Ore. – Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis. The findings, published today in eLife , are important…
Malaysia registers first hepatitis C treatment developed through South-South cooperation
New treatment combination for hepatitis C virus (HCV) is an additional affordable option for millions still waiting for access to lifesaving treatments in middle-income countries
Higher alcohol content beer popularity growing, as overall beer consumption down
PITTSBURGH, June 10, 2021 – Americans are consuming more craft beer with higher alcohol content but are drinking less beer by volume, according to a new analysis led by epidemiologists at the University of Pittsburgh Graduate School of Public Health.…
New Potential Therapy for Fatty Liver Disease
In a subset of patients with partial lipodystrophy and/or NASH, the hormone leptin can be leveraged as a therapeutic agent to move fat out of the liver.
People who use methamphetamine likely to report multiple chronic conditions
Medical, mental, and substance use issues all more prevalent among adults who use methamphetamine
Diet plays critical role in NASH progressing to liver cancer in mouse model
When fed diet high in fat and cholesterol, mice that overate became obese, diabetic and developed NASH, which progressed to kidney and cardiovascular disease and liver cancer
Corning launches HepGo™ assay-ready 3D liver spheroid kits
Corning expands cell culture portfolio with 3D liver models that better recapitulate in vivo behavior and deliver a more physiologically relevant model for improved drug safety and efficacy screening
AGA recommends early use of biologics in patients with moderate-to-severe Crohn’s disease
The American Gastroenterological Association (AGA) issues new clinical guidelines on drug therapy for the management of moderate-to-severe luminal and fistulizing Crohn’s disease.
Microbial gene discovery could mean greater gut health
URBANA, Ill. – As the owner of a human body, you’re carrying trillions of microbes with you everywhere you go. These microscopic organisms aren’t just hitching a ride; many of them perform essential chemical reactions that regulate everything from our…
Researchers find that blocking a protein in liver cells protects against insulin resistance and fatty liver disease
A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice. ABCB10 activity also prompted insulin resistance in human liver cells.
Gut Check
At a glance:
Researchers identify links between genetic makeup of bacteria in human gut and several human diseases
Clusters of bacterial genes present in conditions including cardiovascular illness, inflammatory bowel disease, liver cirrhosis, and cancer
Work brings scientist closer to developing tests that could predict disease risk or identify disease presence based on a sampling of the genetic makeup of a person’s microbiome
Cancer has ripple effect on distant tissues
A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research from Washington University in St. Louis suggests that these other tissues could potentially be targeted to help treat cancer.“Tumors rely on a constant supply of nutrients to grow.
Which medications are most toxic to the liver?
A new study published in the British Journal of Clinical Pharmacology ¬provides insights on how common hospitalized patients develop liver injury from taking different medications. When investigators analyzed the records of 156,570 hospitalized patients, they found 499 cases of drug-induced…
Landscape study launched to detect liver cancer early in Singapore
Singapore, 3 May 2021 – A first of its kind cohort study on patients at high risk of developing primary liver cancer also known as hepatocellular carcinoma (HCC), has been launched to diagnose HCC more accurately at an earlier stage…
A glimmer of hope: New weapon in the fight against liver diseases
Niigata, Japan–Researchers from Niigata University , the University of Tokyo, Osaka University and Tokyo Medical University, Japan have developed a new approach that could revolutionize the treatment, prevention, and possibly reversal of the damages caused by liver diseases. This novel…
Toward a feasible alternative to liver organ transplant
New findings could lead to ways to keep transplanted adult liver cells functioning long term
Researchers work to increase number of transplantable livers
New findings lay groundwork for turning previously unusable donor livers into transplantable organs
Announcing Virtual Press Conference for Experimental Biology 2021 Meeting
Reporters are invited to join a live Q&A discussion of exciting research announcements at the forefront of the life sciences during a virtual press conference for the Experimental Biology (EB) 2021 meeting. The press conference will be held online from 1–1:45 p.m. EDT on Monday, April 26, 2021 (RSVP by Friday, April 23).
Can cirrhosis of the liver be treated with faeces transplantation?
Researchers from Aarhus University and Aarhus University Hospital replace sick intestinal bacteria with intestinal bacteria from healthy donors in a treatment intended to help patients with cirrhosis of the liver. The Novo Nordisk Foundation supports the
Closer to human — Mouse model more accurately reproduces fatty liver disease
Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. “NAFLD has been difficult to study mainly because we had no good animal model,”…
Pathways leading to the extramedullary development of tissue-resident lymphocytes found
Researchers from the University of Science and Technology of China (USTC) of the Chinese Academy of Science (CAS), teamed up with scientists from Aix Marseille University, discovered that hematopoietic progenitors possessed the differentiation potential to type 1 innate lymphoid cells…
Chronic inflammatory liver disease: cell stress mechanisms identified
International study led by MedUni Vienna appears in “Hepatology”
TGen-ASU review suggests added sugars are contributing to liver disease among children
Reduction in global consumption of added fructose would yield a positive impact
Circadian clock gene Rev-erb linked to dawn phenomenon in type 2 diabetes
Researchers at Baylor College of Medicine, Shandong University in China and other institutions may have found an explanation for dawn phenomenon, an abnormal increase of blood sugar only in the morning, observed in many patients with type 2 diabetes. They…
Quantitative detection of fatty liver disease by assessing fat distribution in the liver
A noninvasive method for quantifying fat content in liver can aid medical research and diagnosis of liver diseases
Liver cancer appears to be resistant to immunotherapy in patients with liver condition
Immunotherapy also appears to fuel tumor growth in these cancers
Fatty liver hepatitis is caused by auto-aggressive immune cells
Non-alcoholic steatohepatitis (NASH), often called ‘fatty liver hepatitis’, can lead to serious liver damage and liver cancer. A team of researchers at the Technical University of Munich (TUM) has discovered that this condition is caused by cells that attack healthy…
New study implicates disease-driving B cells in fatty liver disease development
University of Minnesota Medical School research suggests a Western diet and changes in gut microbes turn pathogen-fighting B-cells into ‘disease-promoters’
Consumption of added sugar doubles fat production
Sugar is added to many common foodstuffs, and people in Switzerland consume more than 100 grams of it every day. The high calorie content of sugar causes excessive weight and obesity, and the associated diseases. But does too much sugar…
Metabolic derangements caused by a high-fat diet may be possible to eliminate
Intake of a high-fat diet leads to an increased risk for obesity, type 2 diabetes, cardiovascular diseases and fatty liver. A study in mice from Karolinska Institutet in Sweden shows that it is possible to eliminate the deleterious effects of…
Multicellular liver-on-a-chip for modeling fatty liver disease
(LOS ANGELES) – Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. It is found in 30% of people in developed countries and occurs in approximately 25% of people in the United States. Risk factors for…
Study shows simple blood test could detect liver injury earlier
Researchers describe how gold nanoparticles may play part in finding damage
Post-Fontan liver fibrosis goes under the radar
Osaka City University shows current diagnostic methodology for liver fibrosis does not accurately track the disease when it occurs as a result of Fontan surgery
Albumin provides no benefit to hospitalized patients with advanced liver disease
Peer reviewed; randomized controlled trial; people
Protein Controlling Magnesium Identified as Therapeutic Target for Non-alcoholic Fatty Liver Disease
Patients with liver disease have significantly elevated expression of CNNM4 protein, which modulates magnesium in the liver
Division of labor within regenerating liver maintains metabolism, mouse study finds
CHAMPAIGN, Ill. — The liver has a rare superpower among body organs – the ability to regenerate, even if 70% of its mass is removed. It also keeps up its metabolic and toxin-removing work during the process of regeneration, thanks…
New journal launched, The International Journal of Gastroenterology & Hepatology Diseases
Bentham Science is pleased to announce the launch of new subscription-based journal, The International Journal of Gastroenterology and Hepatology Diseases. The first issue of the journal will be available online by the start of the year, 2021. Dr. N. Mendez-Sanchez,…