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UrduA noninvasive method for quantifying fat content in liver can aid medical research and diagnosis of liver diseases
Tag: LIVER
New study implicates disease-driving B cells in fatty liver disease development
University of Minnesota Medical School research suggests a Western diet and changes in gut microbes turn pathogen-fighting B-cells into ‘disease-promoters’
Consumption of added sugar doubles fat production
Sugar is added to many common foodstuffs, and people in Switzerland consume more than 100 grams of it every day. The high calorie content of sugar causes excessive weight and obesity, and the associated diseases. But does too much sugar…
Metabolic derangements caused by a high-fat diet may be possible to eliminate
Intake of a high-fat diet leads to an increased risk for obesity, type 2 diabetes, cardiovascular diseases and fatty liver. A study in mice from Karolinska Institutet in Sweden shows that it is possible to eliminate the deleterious effects of…
Multicellular liver-on-a-chip for modeling fatty liver disease
(LOS ANGELES) – Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. It is found in 30% of people in developed countries and occurs in approximately 25% of people in the United States. Risk factors for…
Study shows simple blood test could detect liver injury earlier
Researchers describe how gold nanoparticles may play part in finding damage
Post-Fontan liver fibrosis goes under the radar
Osaka City University shows current diagnostic methodology for liver fibrosis does not accurately track the disease when it occurs as a result of Fontan surgery
Albumin provides no benefit to hospitalized patients with advanced liver disease
Peer reviewed; randomized controlled trial; people
Protein Controlling Magnesium Identified as Therapeutic Target for Non-alcoholic Fatty Liver Disease
Patients with liver disease have significantly elevated expression of CNNM4 protein, which modulates magnesium in the liver
Division of labor within regenerating liver maintains metabolism, mouse study finds
CHAMPAIGN, Ill. — The liver has a rare superpower among body organs – the ability to regenerate, even if 70% of its mass is removed. It also keeps up its metabolic and toxin-removing work during the process of regeneration, thanks…
New journal launched, The International Journal of Gastroenterology & Hepatology Diseases
Bentham Science is pleased to announce the launch of new subscription-based journal, The International Journal of Gastroenterology and Hepatology Diseases. The first issue of the journal will be available online by the start of the year, 2021. Dr. N. Mendez-Sanchez,…
Scientists Identify Cells Responsible For Liver Tissue Maintenance And Regeneration
While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. Now, research from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has identified the cells responsible for liver maintenance and regeneration while also pinpointing where they reside in the liver.
Many genes associated with the risk of coronary artery disease act through the liver
According to a new study published in The American Journal of Human Genetics , more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have…
Lab-grown ‘mini-bile ducts’ used to repair human livers in regenerative medicine first
Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique…
Cytoglobin: key player in preventing liver disease
Osaka City University paves way for liver health by discovering the use of cytoglobin in anti-fibrotic therapy
Harmful alcohol use rising during pandemic, UArizona Health Sciences researchers say
A six-month-long study led by researchers in the Department of Psychiatry found hazardous alcohol use increased monthly for those under stay-at-home orders
Going the distance–insights into how cancer cells spread
Most tumors consist of a heterogenous mix of cells. Genetic mutations found only in some of these cells are known to aid with the spread and progression of cancer. However, oncologists often find that when tumors metastasize to distant organs,…
Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue
PHOENIX — A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed…
An end to invasive biopsies?
Hebrew University researchers advance simple and inexpensive diagnostic blood test
Peginterferon-lambda shows strong antiviral action to accelerate clearance of COVID-19
A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year.
New combination therapy offers chance of healing hepatitis B
The new therapeutic approach is based on shutting down the viral hepatitis B genome located in the nucleus of infected liver cells. Upon infection of the liver cell, the viral genome is transformed inside the nucleus into a closed circular…
Combining PD-1inhibitor with VEGF inhibitor in chemotherapy of cholangiocarcinoma patient
The article by Dr. Liangshuai Liu et al. is published in Recent Patents on Anti-Cancer Drug Discovery, 2021
International research network identifies triggers for severe course of liver cirrhosis
Findings of the PREDICT study on acute decompensation and acute-on-chronic liver failure
Our gut-brain connection
‘Organs-on-a-chip’ system sheds light on how bacteria in the human digestive tract may influence neurological diseases
Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
Uses same science as newly FDA approved COVID-19 vaccines
A stem cell based cell culture model for nonalcoholic fatty liver disease
Recent publication in Biology Open
CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)
Multiparametric CT findings can distinguish patients with high-risk NAFLD (advanced fibrosis or cirrhosis); however, the presence of nonalcoholic steatohepatitis (NASH) remains elusive for the modality
ACSL1 as a main catalyst of CoA conjugation of propionic acid-class NSAIDs in liver
Researchers from Kanazawa University find that propionic acid-class NSAIDs are conjugated with CoA by hepatic ACSL1, leading to liver toxicity via covalent binding with hepatic proteins
Green med diet cuts non-alcoholic fatty liver disease by half – Ben-Gurion U. study
BEER-SHEVA, Israel…January 18, 2021 – A green Mediterranean (MED) diet reduces intrahepatic fat more than other healthy diets and cuts non-alcoholic fatty liver disease (NAFLD) in half, according to a long-term clinical intervention trial led by Ben-Gurion University of the…
Drug-Induced Liver Injury, Translational microRNA Biomarkers, and More Featured in January 2021 Toxicological Sciences
in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.
Researcher Developing Scoring System to Redefine How U.S. Patients are Prioritized for Liver Transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation.
Discovery of a new approach to inhibiting a highly treatment-refractory liver cancer
The approach could pave the way for combination therapies, including chemotherapy and immune checkpoint blockade.
How the circadian clock regulates liver genes in time and space
Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given…
Study explains why patients with cancer spread to the liver have worse outcomes
The liver siphons critical immune cells to render immunotherapy ineffective; radiation to the liver may block this process
UMD paves the way for growing human organs for transplantation with new proof-of-concept
Start-up company, Renovate Bioscience Inc., wins Invention of the Year and Inventor Pitch Award for this work at UMD
USPSTF statement on screening for hepatitis B virus infection in adolescents, adults
Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends screening for hepatitis B virus infection in adolescents and adults at increased risk for infection. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this statement is consistent with the…
Beta-blockers display anti-inflammatory effects in advanced liver disease
Beneficial effects on systemic inflammation translate into improved clinical outcomes
Researchers discover treatment that suppresses liver cancer
Radiofrequency ablation and chemotherapy drug combine to extend survival in mouse model
A library of mice to look up the best liver cancer treatment
Researchers from Osaka University find that certain liver cancer subtypes identifiable by a serum biomarker are especially susceptible to treatment
UAB startup company receives FDA clearance for liver imaging software
A Birmingham, Alabama, early-stage startup has been approved for low-cost, low-risk, non-invasive procedures for patients with chronic liver disease.
Sensor can detect scarred or fatty liver tissue
Diagnosing liver damage earlier could help to prevent liver failure in many patients.
Antimicrobial Soap Additive Worsens Fatty Liver Disease in Mice
Triclosan, an antimicrobial found in many soaps and other household items, worsens fatty liver disease in mice fed a high-fat diet.
Maraxilibat reduces debilitating itching in children with Alagille syndrome
Houston – (Nov 18, 2020) – On behalf of Childhood Liver Disease Research Network (ChiLDReN), Texas Children’s Hospital and Baylor College of Medicine researchers report that prolonged treatment with Maraxilibat resulted in clinically meaningful improvements in debilitating itching (pruritus) and…
Researchers Find County Differences in Liver Mortality in the U.S.
University of Miami Miller School of Medicine and Emory researchers found significant differences in death rates even within the same state, according to a recently published study in Gastroenterology.
Normothermic Machine Perfusion (NMP) in rat livers extended from 6 to 24 hours
In a paper published in TECHNOLOGY , a team of researchers from Massachusetts General Hospital (MGH) have demonstrated 24-hour rat liver viability in a normothermic machine perfusion (NMP) system. Rat liver perfusion is an efficient and cost-effective method to study…
Liver condition identified in patients using urine samples: new research
Fifty fragments of proteins, termed peptides, have been identified in the urine of liver fibrosis patients in a new study that could pave the way for a potential diagnostic urine test for the condition if further validated
New source of lymphatic system leak discovered in children with rare open heart surgery complication
Liver lymphatic system connection with chest opens treatment options for certain plastic bronchitis cases
Internal clocks drive beta cell regeneration
Scientists from UNIGE and HUG identify the essential role of circadian clocks in the regeneration of insulin-producing cells.
USRDS releases 2020 Interactive Annual Data Report
The Chronic Disease Research Group ( CDRG ), in partnership with the National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ), is proud to announce the next evolution of the United States Renal Data System ( USRDS…
Induced liver regeneration enhances CRISPR/Cas9-mediated gene repair
New Rochelle, NY, November 9, 2020–Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair…