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UrduPOSTECH team develops deep-learning powered label-free photoacoustic histology for virtual staining, segmentation, and classification of human liver cancers.
Tag: Liver Cancer
Study: Transplant Possible After Immunotherapy for Advanced Liver Cancer Patients
Liver transplant is considered the best treatment for liver cancer, but only available for patients with early-stage disease. Now a study led by Cedars-Sinai Cancer investigators has concluded that immunotherapy could make liver transplant an option for patients with later-stage cancer as well.
Combined therapy makes headway for liver cancer
A drug that targets a protein known as phosphatidylserine boosted the response rate for hepatocellular carcinoma (HCC) patients receiving immunotherapy without compromising their safety, according to results of a phase two clinical trial conducted by UT Southwestern Medical Center.
Promising Personalized Approach to Liver Cancer Therapy Made Possible by DNA-based Neoantigen Research Designed at The Wistar Institute
Results of a new clinical trial published in Nature Medicine show that a novel, personalized neoantigen vaccine therapy demonstrated promising anti-tumor efficacy in patients with liver cancer who failed their original front-line treatment. The foundational biomedical research leading to this important study and important outcome originated from research in the Vaccine & Immunotherapy Center at The Wistar Institute.
Debanjan Dhar looks at links among liver cancer, heart health and kidney function
As an associate professor at Sanford Burnham Prebys, Dhar focuses on how lifestyle factors such as high-calorie diets, excessive alcohol consumption and minimal exercise—along with genetic predispositions—can lead to problematic changes in the liver, heart and kidneys. By studying the conversation among the liver, the immune system, heart and kidneys, Dhar hopes to discover signals that could be used to detect metabolic disorders, especially metabolic-associated steatohepatitis (MASH), and liver cancer much earlier, when they’re easier to treat.
New research from Case Western Reserve University aims to block tumor growth in colorectal cancer patients
Researchers at Case Western Reserve University’s School of Medicine believe they have found information that could lead to developing new treatment options for people with metastatic colorectal cancer.
Personalized Vaccine for Liver Cancer Shows Promise in Clinical Trial
Adding a personalized anti-tumor vaccine to standard immunotherapy is safe and about twice as likely to shrink cancer as standard immunotherapy alone for patients with hepatocellular carcinoma.
Tumor-destroying soundwaves receive FDA approval for liver treatment in humans
The U.S. Food and Drug Administration has approved the use of sound waves to break down tumors—a technique called histotripsy—in humans for liver treatment.
Study: Race, Ethnicity May Play a Role in Cause of Liver Cancer
Race and ethnicity may play a role in liver cancer, which disproportionately affects people of low socioeconomic status, as well as immigrants, veterans and incarcerated populations.
Gene therapy study identifies potential new treatment for liver cancer
Gene therapy with microRNA-22 produced better survival outcomes than the current FDA-approved drug for liver cancer and without noticeable toxicity in new mouse study.
Pediatric hepatoblastoma model hints at DNA damage repair pathway for novel therapeutics
Scientists at St. Jude Children’s Research Hospital used genomics to inform the creation of genetic and new cell-line models for hepatoblastoma, which pointed toward the DNA damage repair pathway as a promising therapeutic route.
Alcohol Use, Even at Low Levels, Increases Risk of Developing Disease
Even low levels of alcohol use can increase the likelihood of developing diseases like cancer and heart disease. A systematic review of studies of the relationship between alcohol use and risk of disease published in Alcohol: Clinical and Experimental Research found that disease risk increases as alcohol use increases and high levels of alcohol use have clear detrimental health effects. While lower-level alcohol use can be protective against certain diseases, it can have significant adverse health effects for many other diseases. The authors urge greater awareness that any level of alcohol use can increase a person’s risk of developing serious, even fatal, diseases.
New Study Shows Mortality Rates for All Major Cancers Decreasing Globally, Except Liver Cancer in Men and Lung Cancer in Women
A new study conducted by scientists at the American Cancer Society and Brookdale University Hospital Medical Center reveals recent mortality rates for all major cancers decreased in most of the studied countries except lung cancer in females and liver cancer in males, where increasing rates were observed in most countries. The research also showed that cancer-specific mortality rates varied substantially across countries, with rates of lung and cervical cancer varying by 10-fold. The study was published today in the journal Cancer Epidemiology, Biomarkers & Prevention, a publication of the American Association for Cancer Research.
AACR 2023: Ohio State experts share new findings on immuno-oncology, ‘smart-drugs,’ obesity-related endometrial cancers and other research topics
New smart-drug treatment options for pancreatic cancer, immuno-oncology treatments and real-time immune-monitoring strategies are among the research topics to be presented by investigators at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) at the American Association for Cancer Research (AACR) annual meeting held April 14-19 at the Orange County Convention Center in Orlando, Florida.
MD Anderson Research Highlights: AACR 2023 Special Edition
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the American Association for Cancer Research (AACR) Annual Meeting 2023.
Gut bacteria are crucial for liver repair
When parts of the liver are removed, the body can replace the missing tissue.
Liver cancer treatment costly for Medicare patients, UT Southwestern study finds
Hepatocellular carcinoma (HCC), the most common type of liver cancer, can place a significant financial burden on patients, according to an analysis led by a researcher at UT Southwestern Medical Center.
Tool to predict the impact of diets on cancerous & healthy cells
Researchers at the Francis Crick Institute and King’s College London have created a tool to predict the effects of different diets on both cancerous cells and healthy cells.
Exposure to toxic blue-green algae, exacerbated by climate change, shown to cause liver disease in mouse models
Algal blooms or cylindrospermopsin, exacerbated by climate change, shown to have a connection with several adverse health effects.
Liver cancer study encourages caution with certain gene therapies
A newly discovered link between protein misfolding and liver cancer could help improve gene therapy for hemophilia.
Novel AI Blood Test Detects Liver Cancer
A novel artificial intelligence blood testing technology developed and used by Johns Hopkins Kimmel Cancer Center researchers to successfully detect lung cancer in a 2021 study has now detected more than 80% of liver cancers in a new study of 724 people.
CANCER RESEARCH INSTITUTE TO HOST ANNUAL VIRTUAL IMMUNOTHERAPY PATIENT SUMMIT ON NOVEMBER 11-12, 2022
Free online event for cancer patients and caregivers featuring immunotherapy experts and patient advocates taking place Nov. 11-12, 2022.
Adding radiation to systemic therapy extends overall survival for patients with advanced liver cancer
Adding radiation therapy to systemic therapy for patients with advanced liver cancer can extend overall survival and delay tumor progression without compromising patients’ quality of life, a randomized phase III clinical trial shows.
Increased mitochondria and lipid turnover reduces risk for liver cancer
A study by UChicago researchers identifies the role that the BNIP3 protein plays in the development of fatty liver and liver cancer.
Radiation oncology research and clinical trial results to be featured at ASTRO’s Annual Meeting in San Antonio
The American Society for Radiation Oncology (ASTRO) announced today the 10 studies that will be highlighted in the 2022 ASTRO Annual Meeting press program. Researchers will discuss their findings in two news briefings to be held October 24 and 25 in the Henry B. Gonzalez Convention Center in San Antonio and via live webcast. Reporters can register for the meeting at astro.org/annualmeetingpress.
AASLD Foundation Funds Over $1.5 Million in Hepatology Research and Career Development in 2022
The American Association for the Study of Liver Diseases (AASLD) Foundation, the largest medical society supporter of liver disease research and training in the United States, today announced its combined investment of over $1.5 million in Research and Career Development Awards, Abstract Awards, Emerging Liver Scholars (ELS) Program for medical residents and its new Emerging Liver Advanced Practice Provider (APP) Program.
The 2022 award recipients — selected from a highly competitive applicant pool — demonstrate both exceptional aptitude and deep interest in liver disease research and treatment. Their work will further advance the mission of the AASLD Foundation and hepatology as a medical specialty.
Liver Cancer’s Supercharged Metabolism Offers a New Treatment Strategy, Penn Study Suggests
Data published in Cell Metabolism on liver cancer’s rapid growth which leads to a vulnerability in its energy-production and cell-building processes that may be potently exploited with a new combination-treatment strategy, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.
New Study Shows Hope, Options for Older Patients With Liver Cancer
Physicians and researchers from UK HealthCare’s Transplant Center and the University of Kentucky Markey Cancer Center conducted a study of patients over the age of 70 with a type of liver cancer called hepatocellular carcinoma (HCC) and how the outcomes of ablative treatments compare to liver transplants. The findings were published in the May 2022 issue of the Journal of the American College of Surgeons.
Shrinking Liver Cancer Tumors Before Transplant Yields Excellent Outcomes, Researchers Report
Treating liver cancer tumors to shrink them in order to allow the patient to qualify for a liver transplant leads to excellent 10-year post-transplant outcomes, according to new Mount Sinai research published in JAMA Surgery. The results validate current national policies around transplant eligibility.
p53 in liver cancer: The ultimate betrayal?
p53 is one of the most important proteins in cancer biology. Often referred to as a “guardian of the genome,” p53 becomes activated in response to various cellular stressors like DNA damage.
Prenatal Exposure to Chemicals in Consumer and Industrial Products Is Associated With Rising Liver Disease in Children
The growing incidence of a potentially cancer-causing liver disease in children is associated with prenatal exposure to several endocrine-disrupting chemicals, Mount Sinai researchers report.
UTSW researchers develop blood test to predict liver cancer risk
An estimated one-quarter of adults in the U.S. have nonalcoholic fatty liver disease (NAFLD), an excess of fat in liver cells that can cause chronic inflammation and liver damage, increasing the risk of liver cancer. Now, UT Southwestern researchers have developed a simple blood test to predict which NAFLD patients are most likely to develop liver cancer.
Study Links Sugar-Sweetened Beverage Consumption with Liver Cancer
A study of more than 90,000 postmenopausal women found that those who consumed at least one sugar-sweetened beverage daily faced a 78% higher risk of developing liver cancer compared with people who consumed less than three servings per month of such beverages.
Henry Ford Health is First in the World to Offer Latest Advancement in MR-Guided Radiation Therapy
Henry Ford Health is the first in the world to complete a full course of patient treatments using the latest advancement in magnetic resonance (MR)-guided radiation therapy, which integrates real-time magnetic resonance imaging (MRI) and linear acceleration to deliver precise and accurate radiation treatment more rapidly than ever before.
External-beam radiation therapy underused for people with liver cancer awaiting transplant
People with liver cancer awaiting transplantation could benefit from non-invasive radiation treatments but are rarely given this therapy, according to a new analysis of U.S. national data. Findings will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Peter Adams and Gerald Shadel awarded $13 million from NIH to study aging and liver cancer
Sanford Burnham Prebys professor Peter D. Adams, Ph.D., and Salk Institute professor Gerald Shadel, Ph.D., have been awarded a grant from the NIH’s National Institute on Aging for $13 million, funding a five-year project to explore the connection between aging and liver cancer.
Study reveals rates of the most common form of liver cancer are rising in rural areas while slowing in urban areas
Study reveals rates of the most common form of liver cancer are rising in rural areas while slowing in urban areas
Radio-wave Therapy Is Safe for Liver Cancer Patients and Shows Improvement in Overall Survival
Researchers at Wake Forest School of Medicine have shown that a targeted therapy using non-thermal radio waves is safe to use in the treatment of hepatocellular carcinoma (HCC), the most common type of liver cancer. The therapy also showed a benefit in overall survival. The study findings appear online in 4Open, a journal published by EDP Sciences.
World Trade Center Responders with the Greatest Exposure to Toxic Dust Have a Higher Likelihood of Liver Disease
Mount Sinai researchers have found evidence for the first time that World Trade Center responders had a higher likelihood of developing liver disease if they arrived at the site right after the attacks as opposed to working at Ground Zero later in the rescue and recovery efforts. Their study links the increase in liver disease risk to the quantity of toxic dust the workers were exposed to, which was greatest immediately after the September 11, 2001, attacks.
Drug Combination Gets Advanced Liver Cancer Patients to Surgery
A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates.
Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model
Researchers at University of California San Diego School of Medicine found in a mouse model that when fed a Western diet rich in calories, fat and cholesterol, the mice progressively became obese, diabetic and developed NASH, which progressed to HCC, chronic kidney and cardiovascular disease.
Liver Cancer Tumors Appear to Be Resistant to Immunotherapy in Patients With Underlying Non-alcoholic Steatohepatitis (NASH)
Immunotherapy is not only significantly less effective in liver cancer patients who previously had a liver disease called non-alcoholic steatohepatitis (NASH), but actually appears to fuel tumor growth, according to a Mount Sinai study published in Nature in March. NASH affects as many as 40 million people worldwide and is associated with obesity and diabetes.
NYU Langone Brings Top Talent to Advance Cancer Care in Brooklyn
To help develop the latest treatment methods and expand cancer care service, Thomas Daniels, MD, has been appointed service chief of the Department of Radiation Oncology at Perlmutter Cancer Center–Sunset Park in Brooklyn.
Study Explores Way to Block Liver Cancer Interaction with Nervous System
Article title: AICAR and Compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro Authors: Katrin Böttcher, Lisa Longato, Giusi Marrone, Giuseppe Mazza, Leo Ghemtio, Andrew Hall, Tu Vinh Luong, Stefano Caruso, Benoit Viollet, Jessica Zucman-Rossi, Massimo…
Current Liver Cancer Screenings May Leave African Americans at Greater Risk
Early detection could reduce the number of African Americans dying from liver cancer, but current screening guidelines may not find cancer soon enough in this community, according to a study published in Cancer in February.
Ionic liquid formulation uniformly delivers chemotherapy to tumors while destroying cancerous tissue
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab.
Study Explores Changes in Liver Cancer Cell Metabolism in Response to Galactose Sugar
Article title: Global changes to HepG2 cell metabolism in response to galactose treatment Authors: Robert A. Skolik, Jason Solocinski, Mary E. Konkle, Nilay Chakraborty, Michael A. Menze From the authors: “Here we demonstrate that the metabolic poise in tumor-derived HepG2 cells…
Researcher Developing Scoring System to Redefine How U.S. Patients are Prioritized for Liver Transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation.
A First-in-Human Clinical Trial Shows Microbubbles May Improve Effectiveness of Radiation Therapy in Patients with Liver Cancer
Bursting gas-filled microbubbles using ultrasound waves sensitizes tumors to targeted radiation, reducing tumor growth and improving overall survival after treatment.
Researchers Find County Differences in Liver Mortality in the U.S.
University of Miami Miller School of Medicine and Emory researchers found significant differences in death rates even within the same state, according to a recently published study in Gastroenterology.