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UrduResearchers at the UNC School of Medicine have found that a metabolic enzyme called Acetyl-CoA Carboxylase causes T cells to store fat when they are in solid tumors, rather than burning fat for energy.
Tag: Cell Metabolism
Attack on 2 fronts leads ocean bacteria to require carbon boost
The types of ocean bacteria known to absorb carbon dioxide from the air require more energy – in the form of carbon – and other resources when they’re simultaneously infected by viruses and face attack from nearby predators, new research has found.
Liver Cancer’s Supercharged Metabolism Offers a New Treatment Strategy, Penn Study Suggests
Data published in Cell Metabolism on liver cancer’s rapid growth which leads to a vulnerability in its energy-production and cell-building processes that may be potently exploited with a new combination-treatment strategy, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.
Turning a pancreatic cancer cell’s addiction into a death sentence
Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them.
Led by Princess Margaret Cancer Centre Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or “addicted” to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell. This addiction, which is vital for the cancer cell’s survival, makes it a precise, potential target against the cancer.
Developing precise medicines for triple negative breast cancer
Taking advantage of a cancer cell’s altered metabolism that drives its runaway growth, Princess Margaret researchers are zeroing in on these molecular changes to help them develop more precise drug targets for one of the most deadly breast cancers.
Study: Neuron Found in Mice Could Have Implications for Effective Diet Drugs
A cell found in mice may be able to stop feeding in humans without subsequential nauseating effects as well as influence the long term intake of food.
Automated technique helps identify cancer cell metabolism inhibitors
UCLA Jonsson Comprehensive Cancer Center researchers have developed a new automated method for testing hundreds of molecules at a time to find out which ones block cancer cells from consuming glucose — the sugars they need to spread and grow.