Article title: AICAR and Compound C negatively modulate HCC-induced primary human hepatic stellate cell activation…
Older individuals are at an increased risk of developing primary central nervous system lymphoma (PCNSL). In a retrospective study of patients with newly diagnosed PCNSL, researchers at Rutgers Cancer Institute of New Jersey and colleagues used geriatric assessments to analyze detailed characteristics, treatment, and outcomes in patients across 17 academic centers.
Astrocytes—star-shaped non-neuronal cells in the brain and spinal cord—are the primary regulating cells of the…
A fast-acting antidote to mitigate the effects of organophosphate poisoning requires a reactivator that can effectively and efficiently cross the blood-brain barrier, bind loosely to the enzyme, chemically snatch the poison and then leave quickly. Oak Ridge National Laboratory is using neutron diffraction data towards improving a novel reactivator design.
Two top scientists are seeking answers to questions about spinal cord injuries that have long frustrated the development of effective treatments.
Improper removal of faulty brain cells during neurodevelopment may cause lifelong behavioral issues, new research from the University of Virginia School of Medicine suggests. The finding also could have important implications for a wide range of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s.
Granulocyte colony-stimulating factor (GCSF) is currently used to treat neutropenia due to chemotherapy and has been successfully used for patients who require bone marrow transplants. The study is the first to report on the neuroprotective effect of GCSF in vivo and showed that it improved neurological deficits that occur in the first few days following cerebral ischemia. GCSF improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response in a mouse model.
Long-term treatment with gabapentin, a commonly prescribed drug for nerve pain, could help restore upper limb function after a spinal cord injury, new research in mice suggests.