Future physicians persevere through pandemic to reach milestone moment
Tag: Pediatrics
CHOP Researchers Discover Key Metabolic Process Responsible for Rapid Immune Responses
Researchers identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.
Researchers Find That Length of Opioid Treatment for Hospitalized Infants Differs by Institution and Geography
Los Angeles (March 12, 2024) – Opioids such as fentanyl and morphine can provide effective pain relief for infants with complex medical conditions when used carefully. But who decides what careful actually means? In a study published in JAMA Network…
This Injectable Hydrogel Mitigates Damage to the Right Ventricle of the Heart
An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journals of the American College of Cardiology: Basic to Translational Science. The study, by a research team from the University of California San Diego, Georgia Institute of Technology and Emory University, was conducted in rodents.
Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson’s
Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.
Children’s Hospital Los Angeles RECOVER Study Collaborators Publish Comprehensive Report on Long COVID Symptoms in Children
Children’s Hospital Los Angeles is one of 10 pediatric sites involved in the nationwide Researching COVID to Enhance Recovery (RECOVER) Initiative, sponsored by the National Institutes of Health to improve the diagnosis, treatment and prevention of long COVID in children.
Study Finds Adolescents with Concussion May Benefit from More Activity Earlier
Researchers at Nationwide Children’s Hospital have found that when it comes to concussion recovery, activity type matters.
Which Antibiotics Best Prevent Infections for Children With Vesicoureteral Reflux?
Children with vesicoureteral reflux often need to take continuous antibiotics to reduce the risk of urinary tract infections (UTIs). But which antibiotics do the best job at preventing these infections?
A Noninvasive Way to Measure Placental Health
A healthy placenta is critical for a healthy baby. But unfortunately, there’s no direct way to measure how well this important organ is working.
What’s on Your Plate?
The Food Pyramid that many of us learned about in school is now ancient history. That old guideline on food groups and servings has been replaced by MyPlate.
Inaugural class of Damon Runyon–St. Jude Pediatric Cancer Research Fellows announced
The initiative aims to provide support for early-career scientists to study pediatric cancer, addressing a funding gap that drives top talent to seek more prevalent opportunities in adult cancer research or the pharmaceutical sector.
Device keeps brain alive, functioning separate from body
Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.
Risk of serious infection even in low-active IBD
IBD patients with low disease activity are still at increased risk of serious infections. Aiming for full intestinal healing may reduce this risk.
Earlier detection of cardiometabolic risk factors for kids may be possible through next generation biomarkers
American Heart Association statement finds potential future measures, reiterates importance of heart-healthy lifestyle from birth through adulthood
Hospital Care for Children Has Shifted from General Hospitals to Children’s Hospitals Over Last 20 Years
Children’s hospital care is now concentrated in fewer locations, because of a shift in children’s care from general hospitals to higher volume children’s specialty centers, and this has important implications for hospital planning and readiness, according to a new study led Michael Steiner, MD, MPH, of UNC Health.
Study reveals how estrogen exerts its anti-diabetic effects
The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2 diabetes, UT Southwestern Medical Center researchers report. The findings, published in Nature Communications, could eventually lead to new therapies for Type 2 diabetes, a disease that affects hundreds of millions of people around the globe and continues to grow more prevalent.
Nationwide Children’s Hospital to Expand Mental and Behavioral Health Research
Nationwide Children’s Hospital has created a new Institute for Mental and Behavioral Health Research, significantly expanding opportunities to seek a better understanding of mental and behavioral health in children and to develop better diagnostics, treatment and preventative strategies.
HMH Physician Awarded $5.6 Million NIH Grant as part of National ECHO Study To Assess Environmental Influences on Health and Development of Children with Disabilities
Dr. Judy Aschner continues her investigations into childhood development
Iron supplements provided in prenatal visits improved outcomes
Giving free prenatal iron supplements to medically underserved pregnant patients rather than only recommending them significantly reduced anemia and postpartum blood transfusions, researchers at UT Southwestern Medical Center and Parkland Health report in a study published in JAMA Network Open.
The Latest in Science and Medical Advancement in Otolaryngology-Head and Neck Surgery to be Presented at AAO-HNSF Annual Meeting
The latest research and advances in otolaryngology-head and neck surgery will be presented in Nashville, Tennessee, during the AAO-HNSF 2023 Annual Meeting & OTO Experience, September 30 – October 4.
Study Shows Nearly 300% Increase in ADHD Medication Errors
In a new study, published in Pediatrics, researchers at the Center for Injury Research and Policy and Central Ohio Poison Center at Nationwide Children’s Hospital investigated the characteristics and trends of out-of-hospital ADHD medication errors among people younger than 20 years old reported to U.S. poison centers from 2000 through 2021.
Children’s Hospital Los Angeles Names Alan S. Wayne, MD, as Pediatrician-in-Chief and Senior Vice President of Academic Affairs
A nationally renowned medical leader, clinician and researcher in cancer and blood diseases, Alan S. Wayne, MD, has been appointed as the Senior Vice President of Academic Affairs and Pediatrician-in-Chief at Children’s Hospital Los Angeles (CHLA), and Chair of the Department of Pediatrics at the Keck School of Medicine of the University of Southern California (USC).
Medical Care publishes article collection on integrating evidence-based programs into clinical practice
As part of its partnership with the Patient-Centered Outcomes Research Institute (PCORI), Medical Care has published its first PCORI-sponsored article collection, which provides specific information about the costs that healthcare systems can expect to incur in promoting the uptake of specific evidence-based programs.
Study tracks Texas youths being treated for depression
Nearly half of Texas youths being treated for depression or suicidal thoughts reported at least one suicide attempt, and 90% had experienced suicidal ideation, according to a study led by UT Southwestern Medical Center researchers.
Study: health equity an important aspect of improving quality of care provided to children in emergency departments
A new multi-site study led by Indiana University School of Medicine found increasing pediatric readiness in emergency departments reduces, but does not eliminate, racial and ethnic disparities in children and adolescents with acute medical emergencies.
Firearm Injuries and the Pandemic: Lower Opportunity Neighborhoods are Disproportionately Affected
In a new study, investigators at Children’s Hospital Los Angeles reveal that children from lower opportunity neighborhoods had a significantly higher rate of firearm-related injury during the pandemic.
New primary care model created to dispense nutrition advice
Expert advice on nutrition delivered to patients electronically saved physicians time, improved patient satisfaction, and was reimbursable by insurance, UT Southwestern Medical Center researchers report.
Obesity plays key role in children’s sleep apnea
Obesity and older age are significant predictors of the severity of obstructive sleep apnea (OSA) in children, researchers at UT Southwestern Medical Center and Children’s Health found. The study is published in Laryngoscope Investigative Otolaryngology.
Medical experts available: Backpack safety, Child Eye Health & Safety Month, preventing injuries in young athletes, and National Breastfeeding Month
As you plan your health coverage for this week and next, Ochsner Health has medical experts on standby to discuss backpack safety as kids head back to school, Child Eye Health & Safety Month, preventing injuries in young athletes, and…
Research pinpoints inflammation source behind atherosclerosis
Scientists at UT Southwestern Medical Center and Children’s Medical Center Dallas have discovered in mice how high cholesterol causes blood vessels to become inflamed, a necessary prerequisite for atherosclerosis – the “hardening of the arteries” responsible for most heart attacks and strokes. The findings, published in Nature Communications, could lead to new interventions to protect against cardiovascular diseases (CVD), the leading cause of death globally.
Wake Forest University School of Medicine Approved for $4.4 Million PCORI Funding Award to Study Telehealth
A team of researchers at Wake Forest University School of Medicine has been approved for a $4.4 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) to assess the benefits of expanding telehealth by primary care physicians to children with complex chronic conditions and their caregivers. The project is a collaboration with Atrium Health Wake Forest Baptist Brenner Children’s in Winston-Salem and Atrium Health Levine Children’s in Charlotte.
Juvenile Arthritis Awareness Month — 10-Year-Old Johns Hopkins Children’s Center Patient’s Journey Living with Juvenile Arthritis
In December 2021, 9-year-old Bryce Lampe of Edgewater, Maryland, began experiencing serious symptoms — a fever, vomiting, diarrhea, and body aches so intense he could barely move, causing him to sleep like a corpse, recalls his mother, Alexandra.
CRI’s Sean Morrison elected to European Molecular Biology Organization
Stem cell biologist Sean J. Morrison, Ph.D., Howard Hughes Medical Institute Investigator and founding Director and Professor of the Children’s Medical Center Research Institute at UT Southwestern (CRI), has been elected by his peers as an associate member of the European Molecular Biology Organization (EMBO).
Public-private consortium will fund three gene therapy clinical trials at UT Southwestern and Children’s Health
A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three different rare diseases at UT Southwestern Medical Center and Children’s Health, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.
As Summer Heats Up, CHOP Researchers Study Caregiver Attitudes Toward Pediatric Vehicular Heatstroke
Despite prevention efforts, a child dies of heatstroke in a vehicle approximately once every 10 days. According to a new survey, most caregivers report they never leave children in their vehicles for any length of time. However, the attitudes toward those who were thought to put their children at risk for pediatric vehicular heatstroke are largely negative, which may cause some caregivers not to adopt important mitigation efforts to prevent these tragic deaths.
Public-private consortium will fund three gene therapy clinical trials at UT Southwestern
A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three rare diseases at UT Southwestern Medical Center, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.
Nationwide Children’s Hospital Marks A Decade as One of the Nation’s Best
Nationwide Children’s Hospital has been named to U.S. News & World Report’s Best Children’s Hospitals Honor Roll for the 10th consecutive year. The Honor Roll is a top distinction awarded to only 10 children’s hospitals nationwide recognized by U.S. News as the “Best of the Best.” Nationwide Children’s is ranked sixth on the 2023-24 Honor Roll list.
Debriefing After Critical Events Combines Review, Reflection
The PICU bereavement/wellness committee at Lurie Children’s Hospital of Chicago developed a tailored debriefing process to allow time for reflection and communication after critical patient events. The process was designed as a hot debriefing to be completed during the current shift, with all staff members who were involved in the event invited to participate.
Mortality high for children whose caregivers decline tracheostomies, UTSW study shows
Forty percent of critically ill children whose parents or other caregivers declined tracheostomies died within 24 months, and half of all deaths occurred within six weeks, researchers at UT Southwestern Medical Center and Children’s Medical Center Dallas found.
CHOP Researchers Show that IgA Fine Tunes the Body’s Interactions with Microbes
A new study by researchers at Children’s Hospital of Philadelphia (CHOP) has demonstrated that IgA acts as a “tuner” that regulates the number of microbes the body sees every day, restraining the systemic immune response to these commensal microbes and limiting the development of systemic immune dysregulation.
CHOP Researchers Comprehensively Assess the Safety of Using Your Head in Youth Soccer
Repeatedly heading a soccer ball has been previously associated with negative long-term brain health for professional players. However, a new study found that a small number of repeated soccer headers equivalent to a throw-in did not cause immediate neurophysiological deficits for teens, suggesting that limited soccer heading exposure in youth sports may not result in irreversible harm if players are properly trained.
New Computational Tool Identifies Novel Targets for Cancer Immunotherapy
Researchers at Children’s Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets. The tool, called “Isoform peptides from RNA splicing for Immunotherapy target Screening” (IRIS), was described in a paper published today in the Proceedings of the National Academy of Sciences.
Pandemic stress reshapes the placentas of expectant moms
Elevated maternal stress during the COVID-19 pandemic changed the structure, texture and other qualities of the placenta in pregnant mothers – a critical connection between mothers and their unborn babies – according to new research from the Developing Brain Institute at Children’s National Hospital.
When rural hospitals stop delivering babies, fewer mothers receive adequate pre-natal care
A study of Iowa hospitals finds that when a rural county loses its last labor and delivery unit, fewer expectant mothers who live there get adequate pre-natal care, even though that care is still available.
Children’s Hospital of Philadelphia, Princeton Researchers Identify Novel Genetic Disorder
Researchers have discovered a novel genetic disorder associated with neurodevelopmental differences. The discovery identified the disorder in 21 families from all over the world.
UT Southwestern, Children’s Health to lead clinical trial on pediatric cancer patients
UT Southwestern Medical Center will lead a national multicenter clinical trial to test a treatment strategy for pediatric cancer patients that has shown promising results in adults. The trial will examine the effects of combining several chemotherapy agents with an immunotherapy drug in children with solid tumors that have recurred or shown no significant response after initial treatment.
Extreme poverty a key driver for relapse in kids with ALL
Children with acute lymphoblastic leukemia (ALL) who live in extreme poverty and were undergoing maintenance therapy faced an almost two-fold greater risk of relapse compared with kids who weren’t as poor, according to a study published in today’s issue of Blood.
Scientists narrow down pool of potential height genes
When it comes to height, our fate is sealed along with our growth plates—cartilage near the ends of bones that hardens as a child develops. Research publishing April 14 in the journal Cell Genomics shows that cells in these plates determine the length and shape of our bones and can hint at our stature.
Researchers Find Earlier Intervention Leads to Greater Improvements in Young Children on the Autism Spectrum
Researchers have demonstrated that starting intervention coaching parents of autistic toddlers as early as 18 months leads to better gains in language, social communication, and daily living skills.
From tragedy, a new potential cancer treatment
Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors’ location. Chemotherapy has debilitating side effects. New treatment options are desperately needed.