Children’s Hospital of Philadelphia Researchers Find Parent and Caregiver Support Linked to Decreased Depression and Suicidal Thoughts in LGBTQ+ and non-LGBTQ+ Youth

A new study from researchers found that LGBTQ+ youth were more likely to experience depression and thoughts and attempts of suicide than non-LGBTQ+ youth, yet the prevalence of these mental health symptoms were significantly reduced when LGBTQ+ youths reported support from their parents.

Pulmonologist Receives National Award from the American Academy od Sleep Medicine

Iris Perez, MD, a pediatric pulmonologist and sleep medicine specialist at Children’s Hospital Los Angeles, has received the Excellence in Education Award from the American Academy of Sleep Medicine (AASM).Dr. Perez was one of five individuals in the country to be recognized with a 2024 AASM award for contributions to the field of sleep medicine.

Children’s Hospital of Philadelphia Researchers Find Elementary Age Children Experience More Concussions During Activities Unrelated to Sports

Researchers found that young children between the ages of 5 and 12 were more likely to experience a concussion from recreation and other non-sport activities, yet those injuries were not seen by specialists until days later compared with sports-related concussions in the same age group.

Children’s Hospital Los Angeles Neurology Expert Available to Discuss FDA-Approved Gene Therapy Label Expansion for Patients with Duchenne Muscular Dystrophy

June 20, 2024 (Los Angeles) — Neurologist Leigh Ramos-Platt, MD, Medical Director of the Muscular Dystrophy Association Neuromuscular Clinic at Children’s Hospital Los Angeles (CHLA), is available to comment on the FDA expanded approval of gene therapy for patients with…

Nationwide Children’s Hospital Receives HRSA Grant, Strives to Improve Maternal and Infant Health in Southeast Ohio

The Health Resources and Services Administration (HRSA) has awarded Nationwide Children’s Hospital a $4.7 million grant for the implementation of the Healthy Start Initiative, striving to improve the health of moms and babies in three Appalachian Ohio counties.

Injury Prediction Rule Could Decrease Radiographic Imaging Exposure in Children, Study Shows

In a study published today in The Lancet Child & Adolescent Health, researchers in the Pediatric Emergency Care Applied Research Network (PECARN) created a highly accurate cervical spine injury prediction rule. When applied, the rule decreases the use of CT by more than 50% without missing clinically significant injuries or increasing normal X-ray use.

Cancer cell–immune cell interactions predict immunotherapy response

By examining which genes were turned on and off in a mix of cell types from breast cancer biopsies, a team led by UT Southwestern Medical Center researchers developed a tool that can accurately predict which patients with breast cancer will respond to immunotherapies.

CHOP Researchers Discover Underlying Biology Behind Fontan-Associated Liver Disease

As patients with congenital heart diseases live longer, researchers are attempting to understand some of the other complications they may face as they age. In a new study, a team from Children’s Hospital of Philadelphia (CHOP) used state-of-the-art technologies to understand the underlying biology of Fontan-associated liver disease (FALD).

CHOP, Stanford Researchers Identify Protein That Controls CAR T Cell Longevity

CAR T cell therapy has revolutionized the way certain types of cancer are treated, and the longer those CAR T cells live in a patient’s body, the more effectively they respond to cancer. Now, researchers have found that a protein called FOXO1 improves the survival and function of CAR T cells, which may lead to more effective CAR T cell therapies and could potentially expand its use in difficult-to-treat cancers.

Youths with Mood Disorders 30 Percent Less Likely to Acquire Driver’s License Than Peers

Researchers found that teens and young adults with mood disorders, such as depression and bipolar disorder, were 30% less likely to obtain their driver’s license than peers without such disorders. Additionally, those youths with mood disorders experienced a slightly elevated risk of crashing.

UTSW discovers protective ‘acid wall’ formed by cancer cells

Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

Gene therapy offers hope for giant axonal neuropathy patients

A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports. Findings from the phase one clinical trial, published in the New England Journal of Medicine, could offer hope for patients with this rare condition and a host of other neurological diseases.

CHOP Researchers Find Branched Chain Amino Acid Supplementation May Aid in Concussion Recovery

In the first clinical trial of a targeted pharmacologic therapeutic for mild traumatic brain injury in pediatric patients, scientists have found preliminary evidence that adolescents and young adults with concussion who take a specific formulation of branched chain amino acid (BCAA) supplements after injury experience faster symptom reduction and return to physical activity.

This Injectable Hydrogel Mitigates Damage to the Right Ventricle of the Heart

An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journals of the American College of Cardiology: Basic to Translational Science.  The study, by a research team from the University of California San Diego, Georgia Institute of Technology and Emory University, was conducted in rodents.

Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson’s

Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.

Device keeps brain alive, functioning separate from body

Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.

Hospital Care for Children Has Shifted from General Hospitals to Children’s Hospitals Over Last 20 Years

Children’s hospital care is now concentrated in fewer locations, because of a shift in children’s care from general hospitals to higher volume children’s specialty centers, and this has important implications for hospital planning and readiness, according to a new study led Michael Steiner, MD, MPH, of UNC Health.

Study reveals how estrogen exerts its anti-diabetic effects

The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2 diabetes, UT Southwestern Medical Center researchers report. The findings, published in Nature Communications, could eventually lead to new therapies for Type 2 diabetes, a disease that affects hundreds of millions of people around the globe and continues to grow more prevalent.

Nationwide Children’s Hospital to Expand Mental and Behavioral Health Research

Nationwide Children’s Hospital has created a new Institute for Mental and Behavioral Health Research, significantly expanding opportunities to seek a better understanding of mental and behavioral health in children and to develop better diagnostics, treatment and preventative strategies.

Iron supplements provided in prenatal visits improved outcomes

Giving free prenatal iron supplements to medically underserved pregnant patients rather than only recommending them significantly reduced anemia and postpartum blood transfusions, researchers at UT Southwestern Medical Center and Parkland Health report in a study published in JAMA Network Open.

The Latest in Science and Medical Advancement in Otolaryngology-Head and Neck Surgery to be Presented at AAO-HNSF Annual Meeting

The latest research and advances in otolaryngology-head and neck surgery will be presented in Nashville, Tennessee, during the AAO-HNSF 2023 Annual Meeting & OTO Experience, September 30 – October 4.

Study Shows Nearly 300% Increase in ADHD Medication Errors

In a new study, published in Pediatrics, researchers at the Center for Injury Research and Policy and Central Ohio Poison Center at Nationwide Children’s Hospital investigated the characteristics and trends of out-of-hospital ADHD medication errors among people younger than 20 years old reported to U.S. poison centers from 2000 through 2021.