A new study suggests that some neurological disorders share a common underlying thread. Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, along with other neurological disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, according to University of Utah Health scientists.
In APL Bioengineering, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments. They are urging their colleagues to remember those differences when researching treatments and cures.
Researchers report that hearing loss and high blood sugar are associated with poor cognitive performance among middle-aged and older Latinos.
Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease
These aspects may have important implications for the design of new drugs and therapeutic interventions for these progressive and incurable diseases.
PDE5 inhibitors, such as sildenafil, activate protein quality-control systems and improve cells’ ability to dispose of misfolded proteins. Researchers find lowered accumulation of mutant proteins and reduced cell death and anatomical defects in zebrafish models of neurodegeneration after treatment.
Researchers found that repeats in the gene that causes Fragile X Syndrome normally regulate how and when proteins are made in neurons.