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UrduAn intricate simulation performed by UT Southwestern Medical Center researchers using one of the world’s most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse.
Tag: Neurodegenerative Diseases
Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson’s
Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.
Largest Brain Autopsy Study of Female Intimate Partner Violence Decedents Reveals Brain Injury Pathology Unlike That Seen Among Male Contact Sports Athletes
The largest brain autopsy study of women who had experienced intimate partner violence reveals substantial vascular and white matter damage in the brain, but no evidence of chronic traumatic encephalopathy (CTE), the neurodegenerative disease recognized among male contact sports athletes who sustain repeated head trauma.
FAU Receives $750,000 Philanthropic Grant for Alzheimer’s Disease
A $750,000 philanthropic grant from the Carl Angus DeSantis Foundation will help FAU develop partnerships and programs that will establish best practice for coordinated care and research for Alzheimer’s disease and related dementias.
Artificially grown ‘mini-brains’ without animal components bring opportunities for neuroscience
Researchers at University of Michigan developed a method to produce artificially grown miniature brains — called human brain organoids — free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated. The work offers a solution to overcome Matrigel’s weaknesses.
Engineered approach to remove protein aggregates from cells
Protein aggregates accumulate during aging and are linked to neurodegenerative diseases like Alzheimer’s, Parkinson’s or Huntington’s disease.
Brain-Belly Connection: Gut Health May Influence Likelihood of Developing Alzheimer’s
UNLV study pinpoints 10 bacterial groups associated with Alzheimer’s disease, provides new insights into the relationship between gut makeup and dementia.
FAU and Insightec Partner to Use Focused Ultrasound to Treat Neurological Disorders
This agreement will enable FAU and Insightec to collaborate to advance scientific knowledge about the use of focused ultrasound to treat brain diseases, including Parkinson’s disease and Alzheimer’s disease. By harnessing acoustic energy, Insightec’s innovative technology uses focused ultrasound to treat diseases in different ways.
Nanopore-Based Sensing Device Explores Neurodegenerative Diseases
In Journal of Applied Physics, researchers present a special silicon nitride nanopore-based sensing device that is designed to provide volume information about tau and tubulin protein molecules and their aggregation states. To create the sensor, the team explored how the proteins change the current and voltage flowing through a nanopore system.
Controversial Alzheimer’s drug approval sparks surprising impact
When the U.S. Food and Drug Administration gave controversial accelerated approval to the first Alzheimer’s drug in nearly 20 years, it had a surprising impact on attitudes about research into the disease.
Alzheimer’s Disease: Making Connections between Air Pollution and Neurodegeneration
Exposure to urban air pollutants such as ozone (O3) is increasingly linked with Alzheimer’s disease; yet because ozone cannot travel from the lungs to the brain, the mechanism by which it contributes to development of Alzheimer’s has been poorly understood.…
Biochemistry: Peptide “Fingerprint” Enables Earlier Diagnosis of Alzheimer’s Disease
Neurodegenerative diseases like Alzheimer’s disease or Parkinson’s disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the result of minute deviations in the chemical composition of the biomolecules. Researchers at the Karlsruhe Institute of Technology (KIT) have developed a simple and effective method for detecting such misfolding at an early stage of the disease. Misfolding is revealed by the structure of dried residue from protein and peptide solutions.
Study Finds Untreated Sleep Apnea May Increase Risk for Neurodegenerative Disease, PAP Therapies Crucial in Treating the Sleep Condition
Mount Sinai researchers have conducted one of the first studies to show the acute effect of obstructive sleep apnea on Alzheimer’s disease biomarkers, and the ability to even measure Alzheimer’s disease biomarkers from blood.
Faecal transplants reverse hallmarks of ageing
In the search for eternal youth, poo transplants may seem like an unlikely way to reverse the ageing process.
Researchers Shed New Light on Molecular Mechanisms in Brain Diseases
Rutgers researchers have discovered some of the first molecular insights into how toxic proteins are regulated in neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
UIC researchers find evidence of possible link between herpes simplex and neurogenerative diseases
A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1.In a “first of its kind” study, researchers also found a potential direct connection between neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), glaucoma, and the herpesvirus.
Flawed quality control in the brain
Proteins are the “tools” of our cells – they are essential to all vital tasks.
Hopkins Med News Update
NEWS STORIES IN THIS ISSUE:
– Johns Hopkins Medicine Celebrates Its Contributions to Keto Therapy as Diet Turns 100
– COVID-19 News: Can Dietary Supplements Help the Immune System Fight Coronavirus Infection?
– Johns Hopkins Medicine Helps Develop Physician Training to Prevent Gun Injuries, Deaths
– COVID-19 News: Study Says Pandemic Impaired Reporting of Infectious Diseases
– Johns Hopkins Medicine Helps Create Treatment Guide for Neurodegenerative Disorders
– Johns Hopkins Pediatrics Says, ‘Get Kids Required Vaccines Before Going Back to School’
Protein Linked to ALS/Ataxia Could Play Key Role in Other Neurodegenerative Disorders
A new study suggests that some neurological disorders share a common underlying thread. Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, along with other neurological disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, according to University of Utah Health scientists.
Brain Disease Research Reveals Differences Between Sexes
In APL Bioengineering, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments. They are urging their colleagues to remember those differences when researching treatments and cures.
Hearing Loss and High Blood Sugar Linked to Poorer Learning and Memory among Older Latinos
Researchers report that hearing loss and high blood sugar are associated with poor cognitive performance among middle-aged and older Latinos.
The Novel Role of Microglia as Modulators of Neurons in the Brain Is Discovered by Mount Sinai Researchers
Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease
Understanding Neurodegenerative Disease Such as Alzheimer’s and ALS by Examining the Overlap of microRNAs, Oxidative Stress, and Mitochondria Dysfunction
These aspects may have important implications for the design of new drugs and therapeutic interventions for these progressive and incurable diseases.
Erectile dysfunction drugs can help cells destroy misfolded proteins
PDE5 inhibitors, such as sildenafil, activate protein quality-control systems and improve cells’ ability to dispose of misfolded proteins. Researchers find lowered accumulation of mutant proteins and reduced cell death and anatomical defects in zebrafish models of neurodegeneration after treatment.
Study: Disease-causing repeats help human neurons function
Researchers found that repeats in the gene that causes Fragile X Syndrome normally regulate how and when proteins are made in neurons.