Neurodegenerative diseases like Alzheimer’s disease or Parkinson’s disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the result of minute deviations in the chemical composition of the biomolecules. Researchers at the Karlsruhe Institute of Technology (KIT) have developed a simple and effective method for detecting such misfolding at an early stage of the disease. Misfolding is revealed by the structure of dried residue from protein and peptide solutions.
Mount Sinai researchers have conducted one of the first studies to show the acute effect of obstructive sleep apnea on Alzheimer’s disease biomarkers, and the ability to even measure Alzheimer’s disease biomarkers from blood.
In the search for eternal youth, poo transplants may seem like an unlikely way to reverse the ageing process.
Rutgers researchers have discovered some of the first molecular insights into how toxic proteins are regulated in neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1.In a “first of its kind” study, researchers also found a potential direct connection between neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), glaucoma, and the herpesvirus.
Proteins are the “tools” of our cells – they are essential to all vital tasks.
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– Johns Hopkins Medicine Celebrates Its Contributions to Keto Therapy as Diet Turns 100
– COVID-19 News: Can Dietary Supplements Help the Immune System Fight Coronavirus Infection?
– Johns Hopkins Medicine Helps Develop Physician Training to Prevent Gun Injuries, Deaths
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– Johns Hopkins Medicine Helps Create Treatment Guide for Neurodegenerative Disorders
– Johns Hopkins Pediatrics Says, ‘Get Kids Required Vaccines Before Going Back to School’
A new study suggests that some neurological disorders share a common underlying thread. Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, along with other neurological disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, according to University of Utah Health scientists.
In APL Bioengineering, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments. They are urging their colleagues to remember those differences when researching treatments and cures.
Researchers report that hearing loss and high blood sugar are associated with poor cognitive performance among middle-aged and older Latinos.
Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease
These aspects may have important implications for the design of new drugs and therapeutic interventions for these progressive and incurable diseases.
PDE5 inhibitors, such as sildenafil, activate protein quality-control systems and improve cells’ ability to dispose of misfolded proteins. Researchers find lowered accumulation of mutant proteins and reduced cell death and anatomical defects in zebrafish models of neurodegeneration after treatment.
Researchers found that repeats in the gene that causes Fragile X Syndrome normally regulate how and when proteins are made in neurons.