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UrduThe American Society for Pharmacology and Experimental Therapeutics (ASPET) and Elsevier, a global leader in information and analytics, are partnering to publish the Society’s four journals.
Tag: pharmacology
Simulation reveals new mechanism for membrane fusion
An intricate simulation performed by UT Southwestern Medical Center researchers using one of the world’s most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse.
UTSW discovers protective ‘acid wall’ formed by cancer cells
Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.
Nanoparticles developed at UTSW effectively fight tumors
A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types. Their findings, published in Science Immunology, offer a new way to potentially harness the power of the body’s immune system against cancer.
Hahn Awarded CZI Grant to Monitor, Manipulate Proteins Important in Nervous System Function, Neurological Disease
Klaus Hahn, PhD, the Ronald G. Thurman Distinguished Professor of Pharmacology at the UNC School of Medicine, will co-lead this Chan Zuckerberg Initiative project with colleagues at Duke University and North Carolina State University.
RUDN doctors scanned medications through the packaging and inside the body
RUDN University doctors demonstrated the capabilities of a new method for remote analysis of drugs in packaging and after entering the body. They can be assessed using radio thermal emission of nanoparticles in drugs. Scientists were able to check the suitability of the medicine without opening the packaging or monitor it inside the body.
Study Could Help Clear Up Confusion and Hesitancy Surrounding RSV Vaccines
Efforts to vaccinate vulnerable populations against respiratory syncytial virus (RSV) faced an uphill battle this season. However, now a new study by researchers at New York Institute of Technology College of Osteopathic Medicine (NYITCOM) could help to combat RSV vaccine misinformation and quell vaccine…
Pharmacology Expert Comments on RSV Vaccination Errors
The Centers for Disease Control and Prevention (CDC) reports that some pregnant Americans may have been given the wrong RSV vaccine, and some young children received a vaccine approved for use in adults only. Now, a pharmacology expert at New York Institute…
Researchers Show SARS-Cov-2 Infection Affects Energy Stores in the Body, Causing Organ Failure
An international research team, including Jonathan C. Schisler, PhD, in the UNC School of Medicine, has found how SARS-CoV-2 causes widespread “energy outages” throughout major organs, and how these effects contribute to debilitating long COVID symptoms.
New strategy for eye condition could replace injections with eyedrops
A new compound developed at the University of Illinois Chicago potentially could offer an alternative to injections for the millions of people who suffer from an eye condition that causes blindness
Researchers use Argonne X-rays to find the best antibodies
Antibody therapies are only effective if the antibodies do what we want them to do. This research can help scientists determine if an antibody is likely to stick to something other than the intended target, which should lessen the amount of time wasted with overly sticky antibodies.
Towards new antibiotics with the first artificial synthesis of tanzawaic acid b
The discovery of antibiotics in 1928 was a major turning point in the history of medicine. For the first time since the dawn of human civilization, doctors had gained access to an extremely powerful and effective tool to fight against a wide variety of bacterial infections.
$1.5 Million Donation Supports Research on Effects of Psychedelic DMT on the Brain
A gift of $1.5 million from Eugene Jhong will help launch a new research program within the UC San Diego Psychedelic and Health Research Initiative to learn more about the biological and psychological effects of DMT in humans.
Scientists use Argonne supercomputer to detail HIV protein mechanism crucial for drug development
Researchers from the University of Illinois Chicago used the Theta supercomputer at the Argonne Leadership Computing Facility to run simulations on and determine the molecular mechanisms behind the ways that new HIV antivirals could work.
Study: Spice May Improve Ovarian Cancer Treatment
New research makes the case for why curcumin could help enhance treatment for ovarian cancer.
UT Southwestern scientists discover agent that reverses effects of intoxication
A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn’t receive this treatment, UT Southwestern researchers report in a new study. The findings, published in Cell Metabolism, could lead to effective treatments for acute alcohol intoxication, which is responsible for about 1 million emergency room visits in the U.S. each year.
Researchers Uncover Mechanisms of Brexanolone and the Role of Inflammation in Post-partum Depression
Brexanolone, an IV infusion comprised of a derivative of progesterone, was approved by the U.S. Food and Drug Administration for the treatment of PPD in 2019. The fast-acting medication significantly reduces depression symptoms and provides effects for up to 90 days. However, exactly how the drug provides these therapeutic effects has remained a mystery – until now.
How AI Can Help Design Drugs to Treat Opioid Addiction
ROCKVILLE, MD – Approximately three million Americans suffer from opioid use disorder, and every year more than 80,000 Americans die from overdoses. Opioid drugs, such as heroin, fentanyl, oxycodone and morphine, activate opioid receptors. Activating mu-opioid receptors leads to pain relief and euphoria, but also physical dependence and decreased breathing, the latter leading to death in the case of drug overdose.
Trigger for world’s most common liver disease identified
University of Virginia School of Medicine researchers have discovered a key trigger for non-alcoholic fatty liver disease, a mysterious condition that causes fat to build up in the liver for no clear reason.
CDC-UNC Collaboration Yields Potential Long-term HIV Protection
Since 2017, the lab of Rahima Benhabbour, PhD, MSc, associate professor in the UNC/NCSU Joint Department of Biomedical Engineering, has been working with a research team at the Centers for Disease Control and Prevention (CDC) and others at UNC to develop an injectable implant that can release HIV pre-exposure prophylaxis (PrEP) medications into the body for a long period of time.
Their latest research, published in Nature Communications, shows that the team’s latest formulation can provide up to six months of full protection.
New live bacterial product for stubborn superbug improves quality of life
Kevin Garey, professor of pharmacy practice and translational research at the University of Houston College of Pharmacy is reporting the first well-controlled study to demonstrate that a microbiome therapeutic, SER-109, is associated with significant quality of life improvement in patients with the debilitating recurrent infection and disease caused by Clostridium difficile (or C. diff).
UTSW Pharmacologist James Collins receives 2023 TAMEST Edith and Peter O’Donnell Award
James Collins III, Ph.D., Associate Professor of Pharmacology at UT Southwestern Medical Center, will receive the 2023 Edith and Peter O’Donnell Award in Biological Sciences from The Academy of Medicine, Engineering and Science of Texas (TAMEST) for broadening understanding of schistosomiasis.
Getting to the Heart of Chemotherapeutic Cardiotoxicity
On any given Tuesday, you will find Brian C. Jensen, MD, cardiologist and physician-scientist, tending to patients in his cardio-oncology clinic. His schedule is packed to the brim with cancer patients. But not patients with heart cancer. The largest number of patients he sees are cancer patients who have developed, or are at risk of developing, heart damage in response to their chemotherapy regimens.
A New Way to Make Asthma Drugs Last Longer
New research into making asthma and COPD medication more potent could also improve how long they work in patients who need frequent doses
New drug combination offers hope for improved treatment of cervical cancer
A new combination of drugs slowed the growth of cancer cells by an unexpected mechanism that may one day lead to improved treatment of cervical cancer, a UT Southwestern-led study published in Molecular Cancer Research suggests.
Popular Pharmaceutical Target in Cells May Prove Even More Useful
Researchers at UC San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs. The discovery opens the possibility of new therapies, including for multiple forms of cancer.
People respond differently to psychedelic drugs — genetics could be the reason
Psychedelic drugs have shown benefits as treatments for cluster headaches, anxiety and depression in clinical studies, but not for everyone. Now, in ACS Chemical Neuroscience, researchers report that one reason could be common genetic variations in one serotonin receptor.
Smartphone App to Assess Stool Form, Rural-Urban Disparities in Cirrhosis Mortality, Lung Infection Risk in Severe Alcoholic Hepatitis in July Issue of AJG
The July issue of The American Journal of Gastroenterology highlights new clinical science including using a smartphone app to assess stool form, rural-urban disparities in cirrhosis mortality, and lung infection risk in severe alcohol-related hepatitis. This issue also includes articles on pediatric IBD, therapy options for Crohn’s disease, a novel endoscopic suturing device, proton pump inhibitors, and more.
Do a Mom’s Medications Affect Her Breast Milk and Baby? New Center Investigates
UC San Diego School of Medicine receives $6.1M to launch a new research center studying the effects of maternal antibiotic use on breast milk and infant health. The center is funded by National Institutes of Health, as part of their new Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub.
Existing drug is shown to inhibit virus that causes COVID-19
Scientists using the Advanced Photon Source have discovered that a drug used to fight tumors in animals might be effective against many types of coronaviruses, including SARS-CoV-2.
Cooked Crustaceans, Cannabis and a Budder Way
Researchers expose live lobsters to vaporized cannabis and confirm the crustaceans absorb THC. Whether the psychoactive compound affects behavior remains open question.
Common Diabetes Drug Shows Promise as Treatment for COVID-19 Lung Inflammation
Researchers identify molecular mechanism for the anti-inflammatory activity of diabetes drug metformin and, in mouse studies, say it prevents lung inflammation in animals infected with SARS-CoV-2, the virus that causes COVID-19.
Noted Researcher and Scientific Leader Jack E. Dixon Retires
Jack E. Dixon, whose distinguished and varied 48-year career ranged from helping reveal how cells communicate to becoming a renowned scientific leader at UC San Diego School of Medicine and Howard Hughes Medical Institute, is retiring.
Speakers Announced for Virtual Experimental Biology 2021 Meeting
Renowned scientists—including Nobel laureates, research pioneers and celebrated educators—will speak at the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. Bringing together thousands of life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.
Why the lovable llama might be a secret weapon against COVID-19
As the fight against COVID-19 continues, scientists have turned to an unlikely source for a potentially effective treatment: tiny antibodies naturally generated by llamas.
Press Registration Now Open for Virtual Experimental Biology 2021 Meeting
Complimentary press passes are now available for the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. EB is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.
10 ways Argonne science is combatting COVID-19
Argonne scientists and research facilities have made a difference in the fight against COVID-19 in the year since the first gene sequence for the virus was published.
APS plays foundational role in development of COVID-19 vaccines
More than a decade of virus research at the APS laid the groundwork for more effective COVID-19 vaccines and helped speed their rapid development.
100th structure of COVID-19 virus from Advanced Photon Source data released
The APS has been a powerful tool in the battle against the novel coronavirus, contributing more information about the structure of the virus to the International Protein Databank than any other light source in the United States.
J. Silvio Gutkind, PhD, Named Chair of the Department of Pharmacology
J. Silvio Gutkind, PhD, has been named chair of the Department of Pharmacology at UC San Diego School of Medicine.
Finding The Achilles’ Heel of A Killer Parasite
DALLAS – Sept. 24, 2020 – Two studies led by UT Southwestern researchers shed light on the biology and potential vulnerabilities of schistosomes – parasitic flatworms that cause the little-known tropical disease schistosomiasis. The findings, published online today in Science, could change the course of this disease that kills up to 250,000 people a year.
Global Summit on Interventional Pharmacoeconomics
The University of Chicago Medicine’s Center for Personalized Therapeutics is hosting a virtual summit from June 9 to July 1 to discuss interventional pharmacoeconomics.
Seeing Corneal Degeneration in A New Light
DALLAS – June 17, 2020 – The molecular changes that lead to Fuchs’ endothelial corneal dystrophy (FECD) occur decades before the disease causes blurry vision and other noticeable symptoms in patients, new research by UT Southwestern scientists shows. This insight into this earliest stage of FECD may eventually lead to new ways of screening for and treating the common condition, which affects an estimated 4 percent of U.S. adults over the age of 40.
Argonne’s researchers and facilities playing a key role in the fight against COVID-19
Argonne scientists are working around the clock to analyze the virus to find new treatments and cures, predict how it will propagate through the population, and make sure that our supply chains remain intact.
Coriell Life Sciences to Provide Coronavirus COVID-19 Reporting to Laboratories
Coriell Life Sciences (CLS), a leading provider of molecular test interpretation and reporting, is offering its coronavirus analysis and reporting services to laboratories throughout the United States at no cost during this period of public health crisis.
Coriell Life Sciences Wins PBMI Excellence Award
Coriell Life Sciences, a trusted bioinformatics company, was proud to accept the Excellence Award in the Cost Containment category at the Pharmacy Benefit Management Institute’s (PBMI) 25th Annual National Conference in Orlando, FL.
Choosing Common Pain Relievers: It’s Complicated
About 29 million Americans use over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain. Every year in the U.S., NSAID use is attributed to approximately 100,000 hospitalizations and 17,000 deaths. All of these drugs have benefits and risks, but deciding which one to use is complicated for health care providers and their patients. To assist in clinical decision-making, researchers address cardiovascular risks and beyond, which include gastrointestinal and kidney side effects of pain relievers.
Press registration now open for 2020 Experimental Biology meeting
Complimentary press passes and virtual newsroom access are now available for the Experimental Biology (EB) 2020 meeting, to be held April 4–7 in San Diego.